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Title:
IN VITRO HUMAN ANGIOGENESIS MODEL
Document Type and Number:
WIPO Patent Application WO2002020729
Kind Code:
A3
Abstract:
The present invention relates to a tridimensional living tissue construct free of exogenous extracellular matrix material, and in which angiogenesis occurs. Network of capillaries formed into the living tissue construct allows to provide blood vessels for replacement or repair in human and animals, and is also useful in screening compounds or agents potentially having capability of modulating the angiogenesis in vitro or in vivo .

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Inventors:
GERMAIN LUCIE (CA)
AUGER FRANCOIS A (CA)
ROCHON MARIE-HELENE (CA)
BLACK ANNIE F (FR)
Application Number:
PCT/CA2001/001276
Publication Date:
October 03, 2002
Filing Date:
September 05, 2001
Export Citation:
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Assignee:
UNIV LAVAL (CA)
GERMAIN LUCIE (CA)
AUGER FRANCOIS A (CA)
ROCHON MARIE-HELENE (CA)
BLACK ANNIE F (FR)
International Classes:
A61L27/38; C12N5/071; (IPC1-7): C12N5/08; A61L27/38; G01N33/50
Foreign References:
US20010055804A12001-12-27
Other References:
BLACK A F ET AL: "A novel approach for studying angiogenesis: A human skin equivalent with a capillary-like network.", CELL BIOLOGY AND TOXICOLOGY, vol. 15, no. 2, April 1999 (1999-04-01), pages 81 - 90, XP008006259, ISSN: 0742-2091
BLACK A F ET AL: "In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent.", FASEB JOURNAL, vol. 12, no. 13, October 1998 (1998-10-01), pages 1331 - 1340, XP002208122, ISSN: 0892-6638
HUDON V ET AL: "Development of an endotheliazed reconstructed dermis to study angiogenic and angiostatic drug potentials in vitro.", WOUND REPAIR AND REGENERATION, vol. 8, no. 4, July 2000 (2000-07-01), 10th Annual Meeting of the Wound Healing Society; Toronto, Canada; 4-6 June 2000, pages 335, XP008006271, ISSN: 1067-1927
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