Title:
IN VITRO SCREENING AND SELECTION OF SPECIFIC DNA APTAMERS AGAINST THE NON-HUMAN SIALIC ACID, N-GLYCOLYL NEURAMINIC ACID (NEU5GC)
Document Type and Number:
WIPO Patent Application WO/2018/158247
Kind Code:
A3
Abstract:
The invention relates to methods, assays and compositions for the determination of sialic acid forms. In particular, the invention provides protein and nucleic acid based recognition molecules, for application in the detection, measurement and discrimination of the sialic acid forms N-glycolylneuraminic acid (Neu5Gc) and N-acetylneuraminic acid (Neu5Ac) when presented as either biologically or chemically bound forms or free forms available in suspension.
Inventors:
RAJESH SHARMA (IE)
CUNNINGHAM STEPHEN (IE)
LOKESH JOSHI (IE)
CUNNINGHAM STEPHEN (IE)
LOKESH JOSHI (IE)
Application Number:
PCT/EP2018/054803
Publication Date:
October 25, 2018
Filing Date:
February 27, 2018
Export Citation:
Assignee:
NAT UNIV IRELAND GALWAY (IE)
International Classes:
C07K16/28; C12N15/115; C40B30/04; G01N33/532; G01N33/563
Domestic Patent References:
| WO2009060129A1 | 2009-05-14 | |||
| WO2013151649A1 | 2013-10-10 |
Foreign References:
| EP2287202A1 | 2011-02-23 |
Other References:
SHARMA R.K.: "Generation of recombinant anti-N-glycolylneuraminic acid (Neu5Gc) scFv and its applications for detection and quantitation of Neu5GcGeneration of recombinant anti-N-glycolylneuraminic acid (Neu5Gc(scFv and its applications for detection and quantitation of Neu5Gc", 12 May 2016 (2016-05-12), NUI, Galway, Ireland, pages i,i-xvii,1 - 219, XP002781335, Retrieved from the Internet [retrieved on 20180524]
Attorney, Agent or Firm:
TOMKINS & CO (IE)
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