TITLE

IN VIVO AND EX VIVO GENE TRANSFER INTO RENAL TISSUE USING GUTLESS ADENOVIRUS VECTORS

[001] This claims priority from U.S Application Serial No. 12/320,434, filed January 26, 2009. The entirety of all of the aforementioned application is incorporated herein by reference. Field

[002] The present invention is directed to methods and compositions for the gene transfer into renal tissues and, in particular, is directed to methods and compositions for in vivo or ex vivo gene transfer to renal tissue using gutless adenovirus vector.

BACKGROUND

[003] Kidney-targeted gene transfer has the potential to revolutionize the treatment of renal diseases. Transplanted kidneys also provide an ideal setting for ex vivo gene transfer. Several in vivo gene transfer methods have been attempted to target certain renal structures, for example, the HVJ-liposome method and renal perfusion of adenovirus for glomerular cells, intravenous injection of oligonucleotides (ODNs) for proximal tubule, intra-arterial injection of adenovirus followed by cold incubation with a vasodilator for interstitial vasculature of the outer medulla and adenoviral injection into the renal pelvis for the inner medullary collecting duct. As an ex vivo gene transfer method targeting the glomerulus, the transfusion of genetically-modified mesangial cells has been attempted. Implantation of genetically-modified tubular epithelial cells into the subcapsular region has been employed for ex vivo transfection to the interstitium. [004] However, although gene therapy theoretically has the distinct potential to treat renal disease at the most fundamental level, its application has been limited by the availability of an adequate system for long term gene delivery to the kidney. There still exists a need for improved gene transfer techniques, especially gene transfer vectors that are capable of mediating effective gene transfer into renal tissues with low toxicity.

SUMMARY

[005] One aspect of the present invention relates to methods for treating a renal disease in a mammal. In one embodiment, the method comprises the step of infusing the kidney with a gutless adenoviral vector comprising a polynucleotide encoding a therapeutic agent and a regulatory element operably linked to the polynucleotide, wherein the gutless adenoviral vector comprises the nucleotide sequence of SEQ ID NO: 13 or SEQ ID NO: 15. In a related embodiment, the gutless adenovirus vector is infused through the vena renalis. m another related embodiment, the gutless adenovirus vector is infused through the superior mesenteric artery.

[006] In another embodiment, the method comprises the steps of: administering a therapeutically effective amount of a gutless adenovirus vector into a segment of a renal blood vessel in vivo, wherein the gutless adenovirus vector comprises the nucleotide sequence of SEQ ID NO: 13 or SEQ ID NO: 15, and is capable of expressing a therapeutic agent. In a related embodiment, the gutless adenovirus vector is administered using a stent.

[007] Another aspect of the present invention pertains to a method for improving allograft survival. The method comprises the steps of: perfusing a kidney harvested from an organ donor with a gutless adenovirus vector carrying a nucleotide sequence encoding a immune modulator and a regulatory element operably linked to the nucleotide sequence; and transplanting the perfused kidney into a subject. In a related embodiment, the immune modulator is indoleamine dioxygenase.

[008] Another aspect of the present invention pertains to a gutless adenovirus vector comprising a polynucleotide encoding a therapeutic protein, a renal tissue specific regulatory element operably linked to the polynucleotide sequence; and a stuffer comprising the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15.

[009] Another aspect of the present invention pertains to a gutless adenovirus vector comprising a polynucleotide encoding an indoleamine dioxygenase, a regulatory element operably linked to the polynucleotide sequence; and a stuffer comprising the nucleotide sequence of SEQ ID NO: 13 or SEQ ID NO: 15.

[010] Yet another aspect of the present invention pertains to a pharmaceutical composition for treating a renal vascular disease, comprising the gutless adenovirus vector described above and a pharmaceutically acceptable carrier.

BRIEF DESCRIPTION OF THE DRAWINGS

[011] Figure 1 is a schematic drawing of an embodiment of the backbone shuttle vector pShuttle-ITR-HPRT.

[012] Figure 2 is a schematic drawing of an embodiment of the full length backbone vector pTM-final.

[013] Figure 3 is a picture of a Western blot showing hTM expression in HEK 293 cells transfected with pTM-fϊnal (the full size backbone of gutless Ad.hTM). Lanes 1-3: lysate from control cells; Lanes 4-6, lysate from pTM-final transfected cells.

[014] Figure 4 is a picture of a Western slot blot showing hTM expression in 293FLP cells (passage number 2 (P2) during viral amplification). Row 1, lane 1-3: TM detection using 5ul cell lysate of P2. Row 2, lane 1-3: TM detection using 30ul cell lysate of P2. Row 3, lane 1-3: negative control cells.

[015] Figure 5 is a picture of a Western blot showing hTM expression in rat vena cava infected with gutless TM virus.

[016] Figure 6 is a picture of a Western bolt showing TM expression in CRE cells at passage number 1-6 (P1-P6).

[017] Figure 7 is a composite of images showing gutless adeno virus-mediated luciferase expression in rat tail vein.

[018] Figure 8 is a diagram showing TM expression in livers of non-infected rats (con) and TM gutless virus infected rats (TM virus).

[019] Figure 9 is a picture of Western blots using a anti-TM antibody (blot 1) and plasma from animals infected with TM virus (blots 2-4).

[020] Figure 10 is a schematic drawing of an embodiment of the rat IDO expression cassette.

[021] Figure 11 is a schematic drawing of an embodiment of the human IDO expression cassette.

[022] Figure 12 is a schematic drawing of a gutless backbone vector.

[023] Figure 13 is a schematic drawing of an embodiment of the rat gutless IDO backbone vector.

[024] Figure 14 is a schematic drawing of an embodiment of the human gutless IDO backbone vector.

[025] Figure 15 is a picture of a Western blot showing gutless adenovirus mediated IDO expression in transplanted kidney (lane 1 = hIDO control, other lanes as indicated)

[026] Figure 16 is a composite of graphs showing reduction of plasma creatinin levels (panel A), ED-I staining (panel B), CD8 staining (panel C) and smooth muscle actin score (panel D) in kidney tissue infected by gutless adenovirus carrying the IDO gene. DETAILED DESCRIPTION

[027] The practice of the present invention will employ, unless otherwise indicated, conventional methods of histology, virology, microbiology, immunology, and molecular biology within the skill of the art. Such techniques are explained fully in the literature. All publications, patents and patent applications cited herein, whether supra or infra, are hereby incorporated by reference in their entirety .

[028] The primary object of the present invention is to provide methods for treating renal diseases and improving kidney allograft survival using gene transfer technologies. One aspect of the present invention relates to a method for treating a renal disease by infusing the kidney in vivo with an effective amount of gutless adenovirus vector carrying a DNA sequence encoding a therapeutic agent. The virus-mediated expression of the therapeutic agent in renal tissue ameliorates symptoms of the renal diseases. This local approach eliminates the need to inject a large quantity of virus into a patient and hence significantly reduces the viral-related toxicity.

[029] As used herein, the term "effective amount" means that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, system, animal or human that is being sought, for instance, by a researcher or clinician. Furthermore, the term "therapeutically effective amount" means any amount which, as compared to a corresponding subject who has not received such amount, results in improved treatment, healing, prevention, or amelioration of a disease, disorder, or side effect, or a decrease in the rate of advancement of a disease or disorder. The term also includes within its scope amounts effective to enhance normal physiological function. The Gutless Adenovirus Vector

[030] Adenoviruses (Ad) are double-stranded DNA viruses with a linear genome of about 36 kb. The adenovirus genome is complex and contains over 50 open reading frames (ORFs). These ORFs are overlapping and genes encoding one protein are often embedded within genes coding for other Ad proteins. Expression of Ad genes is divided into an early and a late phase. The early genes comprise EIa, EIb, E2a, E2b, E3 and E4, which are transcribed prior to replication of the viral genome. The late genes (e.g., Ll-5) are transcribed after replication of the viral genome. The products of the late genes are predominantly components of the virion, as well as proteins involved in the assembly of virions.

[031] The genome of an adenovirus can be manipulated such that it encodes and expresses a gene product of interest but is inactivated in terms of its ability to replicate in a normal lyric viral life cycle (Curie DT, Ann N Y Acad Sci 886, 158-171 [1991]). Suitable adenoidal vectors derived from the adenovirus strain Ad type 5 dl324 or other strains of adenovirus (e.g., Ad2, Ad3, Ad7 etc.) are well known to those skilled in the art. Recombinant adenoviruses are advantageous in that they do not require dividing cells to be effective gene delivery vehicles and can be used to infect a wide variety of cell types, including airway epithelium, endothelial cells, muscle cells and renal cells Additionally, introduced adenoidal DNA (and foreign DNA contained therein) is not integrated into the genome of a host cell but remains episomal, thereby avoiding potential problems that can occur as a result of insertional mutagenesis in situations where introduced DNA becomes integrated into the host genome (e.g., retroviral DNA).

[032] The so-called "gutless" adenovirus vectors contain a minimal amount of adenovirus DNA (i.e., the inverted terminal repeats and encapsidation signal) and are incapable of expressing any adenovirus antigens (hence the term "gutless"). The gutless adenovirus vectors provide the significant advantage of accommodating large inserts of foreign DNA while completely eliminating the problem of expressing adenoviral genes that result in an immunological response to viral proteins when a gutless rAd vector is used in gene therapy. Methods for producing gutless rAd vectors have been described, for example, in U.S. Patent No. 5,981,225 to Kochanek et al., and U.S. Patent Nos. 6,063,622 and 6,451,596 to Chamberlain et al; Parks et al., PNAS 93:13565 (1996) and Lieber et al., J. Virol. 70:8944-8960 (1996).

[033] The "inverted terminal repeats (ITRs)" of adenovirus are short elements located at the 5' and 3' termini of the linear adenoviral genome, respectively and are required for replication of the viral DNA. The left ITR is located between 1-130 bp in the Ad genome (also referred to as 0-0.5 mu). The right ITR is located from about 3,7500 bp to the end of the genome (also referred to as 99.5-100 mu). The two ITRs are inverted repeats of each other. For clarity, the left ITR or 5 ¹ end is used to define the 5' and 3' ends of the ITRs. The 5' end of the left ITR is located at the extreme 5' end of the linear adenoviral genome; picturing the left ITR as an arrow extending from the 5' end of the genome, the tail of the 5' ITR is located at mu 0 and the head of the left ITR is located at about 0.5 mu (further the tail of the left ITR is referred to as the 5' end of the left ITR and the head of the left ITR is referred to as the 3' end of the left ITR). The tail of the right or 3 ¹ ITR is located at mu 100 and the head of the right ITR is located at about mu 99.5; the head of the right ITR is referred to as the 5' end of the right ITR and the tail of the right ITR is referred to as the 3' end of the right ITR. In the linear adenoviral genome, the ITRs face each other with the head of each ITR pointing inward toward the bulk of the genome. When arranged in a "tail to tail orientation" the tails of each ITR (which comprise the 5' end of the left ITR and the 3' end of the right ITR) are located in proximity to one another while the heads of each ITR are separated and face outward. The "encapsidation signal" or "packaging sequence" of adenovirus refers to the ψ sequence which comprises five (AI-AV) packaging signals and is required for encapsidation of the mature linear genome; the packaging signals are located from about 194 to 358 bp in the Ad genome (about 0.5-1.0 mμ).

[034] In one embodiment, a viral backbone shuttle vector is used for the construction of gutless adenovirus vectors. The viral backbone shuttle vector contains a left and a right inverted terminal repeats of adenovirus, an encapsidation signal (ψ) of adenovirus, a pBR322 replication origin, a kanamycin resistance gene, and a stuffer sequence, which is the hypoxanthine phosphoribosyltransferase (HPRT) intron fragment with an approximately 10 kb (SEQ ID NO: 1). In one embodiment, the viral backbone shuttle vector of the present invention comprises at least 15 contiguous bases of SEQ ID NO: 1, preferably comprises at least 90 contiguous bases of SEQ ID NO: 1, more preferably comprises at least 300 contiguous bases of SEQ ID NO: 1, and most preferably comprises 3000 or more contiguous bases of SEQ ID NO: 1. In another embodiment, the viral backbone shuttle vector of the present invention comprises the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15.

[035] The viral backbone shuttle vector of the present invention contains multiple restriction endonuclease sites for the insertion of a foreign DNA sequence of interest, hi one embodiment, the viral backbone shuttle vector contains seven unique cloning sites where the foreign DNA sequence can be inserted by molecular cloning techniques that are well known in the DNA cloning art. The foreign DNA sequence of interest typically comprises cDNA or genomic fragments that are of interest to transfer into mammalian cells. Foreign DNA sequence of interest may include any naturally occurring or synthetic DNA sequence. The foreign DNA may be identical in sequence to naturally-occurring DNA or may be mutated relative to the naturally occurring sequence. The foreign DNA need not be characterized as to sequence or function. [036] The size of foreign DNA that may be included in the shuttle vector will depend upon the size of the rest of the vector. If necessary, the stuffer sequence may be removed to adapt large size foreign DNA fragment. The total size of foreign DNA may vary from lkb to 35kb. Preferably, the total size of foreign DNA is from 15kb to 35 kb.

[037] The foreign DNA may contain coding sequence for a protein, an iRNA agent, or an antisense RNA. The foreign DNA may further contain regulatory elements operably linked to the coding sequence. The term "operably linked," as used herein, refers to an arrangement of elements wherein the components so described are configured so as to perform their usual function. Thus, control elements operably linked to a coding sequence are capable of effecting the expression of the coding sequence. The control elements need not be contiguous with the coding sequence, so long as the function to direct the expression thereof. Thus, for example, intervening untranslated yet transcribed sequences can be present between a promoter sequence and the coding sequence and the promoter sequence can still be considered "operably linked" to the coding sequence. Similarly, intervening untranscribed sequences can be present between an enhancer sequence and the coding sequence and the enhancer sequence can still be considered "operably linked" to the coding sequence.

[038] Examples of regulatory elements include, but are not limited to, transcription factor binding sites, promoters, enhancers, silencers, ribosome binding sequences, recombination sites, origins of replication, sequences which regulate RNA stability and polyadenylation signals. The promoters used may vary in their nature, origin and properties. The choice of promoter depends in fact on the desired use and on the gene of interest, in particular. Thus, the promoter may be constitutive or regulated, strong or weak, ubiquitous or tissue/cell-specifϊc, or even specific of physiological or pathophysiological states (activity dependent on the state of cell differentiation or the step in the cell cycle). The promoter may be of eukaryotic, prokaryotic, viral, animal, plant, artificial or human origin. Renal Specific Expression

[039] In one embodiment, the therapeutic agent is expressed in a tissue-specific manner either using a renal-specific regulatory element or using an inducible regulatory element combined with kidney-specific induction. Examples of renal-specific regulatory element include, but are not limited to, high-capacity (type 2) Na ⁺ /glucose cotransporter gene (iSgfr2)promoter, Ksp-cadherin promoter, ClC-Kl chloride channel gene promoter, uromodulin promoter, Nkcc2ISlcl2al gene promoter, and the pi promoter of the parathyroid hormone (PTH)/PTH-related peptide receptor gene.

[040] Examples of inducible regulatory elements include, but are not limited to, regulatory elements that responded to exogenous signals or stresses, such as heat, hormones, hypoxia, cytokines or metal ions, as well as artificial inducible systems such as the tetracycline inducible system;, the FK506/rapamycin inducible system, the RU486/mifepristone inducible system, and the ecdysone inducible system. These systems are briefly described below.

[041] Tet-onloff system. The Tet-system is based on two regulatory elements derived from the tetracycline-resistance operon of the E. coli Tn 10 transposon: the tet repressor protein (TetR) and the Tet operator DNA sequence (tetO) to which TetR binds. The system consists of two components, a "regulator" and a "reporter" plasmid. The "regulator" plasmid encodes a hybrid protein containing a mutated Tet repression (tetr) fused to the VP 16 activation domain of herpes simplex virus. The "reporter" plasmid contains a tet-responsive element (TRE), which controls the "reporter" gene of choice. The tetr-VP16 fusion protein can only bind to the TRE, therefore activate the transcription of the "reporter" gene, in the presence of tetracycline. The system has been incorporated into a number of viral vectors including retrovirus, adenovirus (Gossen and Bujard, PNAS USA 89: 5547-5551, [1992]; Gossen et al, Science 268: 1766-1769, [1995]; Kistner et al., PNAS USA 93: 10933-10938, [1996]).

[042] Ecdysone system. The Ecdysone system is based on the molting induction system found in Drosophila, but modified for inducible expression in mammalian cells. The system uses an analog of the drosophila steroid hormone ecdysone, muristerone A, to activate expression of the gene of interest via a heterodimeric nuclear receptor. Expression levels have been reported to exceed 200-fold over basal levels with no effect on mammalian cell physiology (No et al., PNAS USA 93: 3346-3351, [1996]).

[043] Progesterone-system. The progesterone receptor is normally stimulated to bind to a specific DNA sequence and to activate transcription through an interaction with its hormone ligand. Conversely, the progesterone antagonist mifepristone (RU486) is able to block hormone-induced nuclear transport and subsequent DNA binding. A mutant form of the progesterone receptor that can be stimulated to bind through an interaction with RU486 has been generated. To generate a specific, regulatable transcription factor, the RU486- binding domain of the progesterone receptor has been fused to the DNA-binding domain of the yeast transcription factor GAL4 and the transactivation domain of the HSV protein VP 16. The chimeric factor is inactive in the absence of RU486. The addition of hormone, however, induces a conformational change in the chimeric protein, and this change allows binding to a GAL4-binding site and the activation of transcription from promoters containing the GAL4- binding site (Wang et al., PNAS USA 93: 8180-8184, [1994]; Wang et al., Nat. Biotech 15: 239-243, [1997]).

[044] Rapamycin-system. Immunosuppressive agents, such as FK506 and rapamycin, act by binding to specific cellular proteins and facilitating their dimerization. For example, the binding of rapamycin to FK506-binding protein (FKBP) results in its heterodimerization with another rapamycin binding protein FRAP, which can be reversed by removal of the drug. The ability to bring two proteins together by addition of a drug potentiates the regulation of a number of biological processes, including transcription. A chimeric DNA-binding domain has been fused to the FKBP, which enables binding of the fusion protein to a specific DNA-binding sequence. A transcriptional activation domain also has been used to FRAP. When these two fusion proteins are co-expressed in the same cell, a fully functional transcription factor can be formed by heterodimerization mediated by addition of rapamycin. The dimerized chimeric transcription factor can then bind to a synthetic promoter sequence containing copies of the synthetic DNA-binding sequence. This system has been successfully integrated into adenoviral vectors. Long-term regulatable gene expression has been achieved in both mice and baboons (Magari et al., J. Clin. Invest. 100: 2865-2872, [1997]; Ye et al., Science 283:88-91, [1999]).

[045] In one embodiment, a kidney tissue is infected with a gutless virus containing an inducible regulatory element. The infected tissue is then exposed to an inducing agent, such as tetracycline or rapamycin, or an inducing condition such as local heating or hypoxia, to induce expression of the therapeutic agent. The inducible system thus allows kidney specific expression of the therapeutic agent and minimizes the side effect of the therapeutic agent. In addition, the level and duration of the therapeutic agent expression may also be controlled by the dose of the inducing agent and the frequency of inducing agent administration. In one embodiment, the coding sequence of the therapeutic agent is controlled by the tet-on system and the expression of the therapeutic agent can be induced by an oral dose of tetracycline. The Renal Diseases

[046] The renal disease can be any disease or disorder that affects the function of the kidneys and for which a therapeutic gene or genes have been identified. Examples of the renal diseases include, but are not limited to, glomerulonephritis, renal vein thrombosis, diabetic nephropathy, ischemia/reperfusion injury (shock kidneys), hypertension, proteinuric kidney diseases (post glomerulonephritis), ischemic nephropathy, obstruction nephropathy, atheroembolic renal disease, chronic nephritis, congenital nephrotic syndrome, interstitial nephritis, lupus nephritis, membranoproliferative glomerulonephritis, membranous nephropathy, minimal change disease, necrotizing glomerulonephritis, nephropathy - IgA, nephrosis (nephrotic syndrome), poststreptococcal GN, reflux nephropathy, renal artery embolism, renal artery stenosis, and renal underperfusion. The Therapeutic Agents

[047] The therapeutic agent can be any molecule that is, when expressed in a renal tissue or in the proximity of a renal tissue, capable of ameliorating symptoms of a renal disease. The therapeutic agents include, but are not limited to, proteins, iRNA agents and antisense RNA. The term "expression," as used herein, refers to the process of transcription of mRNA from a coding sequence and/or translation of mRNA into a polypeptide.

[048] The term "iRNA agent," as used herein, refers to small nucleic acid molecules used for RNA interference (RNAi), such as short interfering RNA (siRNA), double-stranded RNA (dsRNA), microRNA (miRNA) and short hairpin RNA (shRNA) molecules. The iRNA agents can be unmodified or chemically-modified nucleic acid molecules. The iRNA agents can be chemically synthesized or expressed from a vector or enaymatically synthesized. The use of a chemically-modified iRNA agent can improve one or more properties of an iRNA agent through increased resistance to degradation, increased specificity to target moieties, improved cellular uptake, and the like.

[049] The term "antisense RNA," as used herein, refers to a nucleotide sequence that comprises a sequence substantially complementary to the whole or a part of an mRNA molecule and is capable of binding to the mRNA. Protein As a Therapeutic Agent

[050] In one embodiment, the therapeutic agent is a protein or peptide capable of ameliorates symptoms of the renal disease. For example, the therapeutic agent can be thrombomodulin for treating renal vein thrombosis (RVT) or an antibody that binds specifically to a target molecule which is involved in a renal disease (e.g., an inflammatory cytokine which has been found to be associated with the chronic kidney disease (CKD)).

[051] The term "antibody", as used herein, is defined as an immunoglobulin that has specific binding sites to combine with an antigen. The term "antibody" is used in the broadest possible sense and may include but is not limited to an antibody, a recombinant antibody, a genetically engineered antibody, a chimeric antibody, a monospecific antibody, a bispecific antibody, a multispecific antibody, a chimeric antibody, a heteroantibody, a monoclonal antibody, a polyclonal antibody, a camelized antibody, a deimmunized antibody, a humanized antibody and an anti-idiotypic antibody. The term "antibody" may also include but is not limited to an antibody fragment such as at least a portion of an intact antibody, for instance, the antigen binding variable region. Examples of antibody fragments include Fv, Fab, Fab', F(ab'), F(ab') ₂ , Fv fragment, diabody, linear antibody, single-chain antibody molecule, multispecific antibody, and/or other antigen binding sequences of an antibody.

[052] Examples of the therapeutic protein include, but are not limited to, thrombomodulin (TM), cytokines such as IL-I, IL-2, EL-3, IL-4, EL-5, IL-6, IL-7, IL-8, JL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15 and other interleukins; hematopoetic growth factors such as erythropoietin; colony stimulating factors such as G-CSF, GM-CSF, M-CSF, SCF and thrombopoietin; growth factors such as BNDF, BMP, GGRP, EGF, FGF, GDNF, GGF, HGF, IGF-I, IGF-2; KGF, myotrophin, NGF, OSM, PDGF, somatotrophin, TGF-α, TGF-β, and VEGF; antiviral cytokines such as interferons, antiviral proteins induced by interferons, TNF-α, and TNF-β; proteins involved in immune responses such as antibodies, CTLA4, hemagglutinin, MHC proteins, VLA-4, and kallikrein-kininogen-kinin system; ligands such as CD4; growth factor receptors including EGFR, PDGFR, FGFR, and NGFR, GTP-binding regulatory proteins, interleukin receptors, ion channel receptors, leukotriene receptor antagonists, lipoprotein receptors, steroid receptors, T-cell receptors, thyroid hormone receptors, TNF receptors; tissue plasminogen activator; transmembrane receptors; transmembrane transporting systems, such as calcium pump, proton pump, Na/Ca exchanger, MRPl, MRP2, P170, LRP, and cMOAT; transferrin; and tumor suppressor gene products such as APC ₅ brcal, brca2, DCC, MCC, MTSl, NFl, NF2, nm23, p53 and Rb, and variants thereof.

[053] A "variants" of a polypeptide is a polypeptide that differs from a native polypeptide in one or more substitutions, deletions, additions and/or insertions, such that the bioactivity of the native polypeptide is not substantially diminished or enhanced. In other words, the bioactivity of a variant maybe enhanced or diminished by, less than 50%, and preferably less than 20%, relative to the native protein. Preferred variants include those in which one or more portions, such as an N-terminal leader sequence or transmembrane domain, have been removed. Other preferred variants include variants in which a small portion (e.g., 1-30 amino acids, preferably 5-15 amino acids) has been removed from the - and/or C-terminal of the mature protein.

[054] Preferably, a variant contains conservative substitutions. A "conservative substitution" is one in which an amino acid is substituted for another amino acid that has similar properties, such that one skilled in the art of peptide chemistry would expect the secondary structure and hydropathic nature of the polypeptide to be substantially unchanged. Amino acid substitutions may generally be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity and/or the amphipathic nature of the residues. For example, negatively charged amino acids include aspartic acid and glutamic acid; positively charged amino acids include lysine and arginine; and amino acids with uncharged polar head groups having similar hydrophilicity values include leucine, isoleucine and valine; glycine and alanine; asparagine and glutamine; and serine, threonine, phenylalanine and tyrosine. A variant may also, or alternatively, contain nonconservative changes. In a preferred embodiment, variant polypeptides differ from a native sequence by substitution, deletion or addition of five amino acids or fewer. Variants may also (or alternatively) be modified by, for example, the deletion or addition of amino acids that have minimal influence on the bioactivity, secondary structure and hydropathic nature of the polypeptide.

[055] A variant preferably exhibits at least about 70%, more preferably at least about 90% and ήiost preferably at least about 95% sequence homology to the original polypeptide.

[056] The term "variant' also includes a polypeptides that is modified from the original polypeptides by either natural processes, such as posttranslational processing, or by chemical modification techniques which are well known in the art. Such modifications are well described in basic texts and in more detailed monographs, as well as in a voluminous research literature. Modifications can occur anywhere in a polypeptide, including the peptide backbone, the amino acid side-chains and the amino or carboxyl termini. It will be appreciated that the same type of modification may be present in the same or varying degrees at several sites in a given polypeptide. Also, a given polypeptide may contain many types of modifications. Polypeptides maybe branched, for example, as a result of ubiquitination, and they may be cyclic, with or without branching. Cyclic, branched, and branched cyclic polypeptides may result from posttranslation natural processes or may be made by synthetic methods. Modifications include acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent cross links, formation of cysteine, formation of pyroglutamate, formulation, gammacarboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, pegylation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer- RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination.

[057] In one embodiment, the therapeutic protein is a native TM or a TM variant for the treatment of renal vein thrombosis (RVT). RVT has numerous etiologies, it occurs most commonly in patients with nephrotic syndrome (i.e., > 3 g/d protein loss in the urine, hypoalbuminemia, hypercholesterolemia, edema). The syndrome is responsible for a hypercoagulable state. The excessive urinary protein loss is associated with decreased antithrombin HI, a relative excess of fibrinogen, and changes in other clotting factors; all lead to a propensity to clot. Numerous studies have demonstrated a direct relationship between nephrotic syndrome and both arterial and venous thromboses. Why the renal vein is susceptible to thrombosis is unclear. The renal vein also may contain thrombus after invasion by renal cell cancer. Other less common causes include renal transplantation, Behcet syndrome, hypercoagulable states, and antiphospholipid antibody syndrome.

[058] Thrombomodulin (TM) is an integral membrane glycoprotein expressed on the surface of endothelial cells (Sadler et al., Trhomb Haemost., 78:392-95 [1997]). It is a high affinity thrombin receptor that converts thrombin into a protein C activator. Activated protein C then functions as an anticoagulant by inactivating two regulatory proteins of the clotting system, namely factors Va and VI [I]a (Esmon et al., Faseb J., 9:946-55 [1995]). The latter two proteins are essential for the function of two of the coagulation proteases, namely factors DCa and Xa. TM thus plays an active role in blood clot formation in vivo and can function as a direct or indirect anticoagulant. [059] TM and several other proteins or enzymes have been shown to reduce the process of intimal hyperplasia, whose evolution is the causes of late graft failure. For instance, Nitric oxide synthase, an enzyme expressed by endothelial cells has been shown in animal models to inhibit intimal hyperplasia, especially the inducible enzyme (iNOS) (Salmaa et al., Lancet, 353:1729-34 [1999]; Palmer et al., Nature, 327:524-26 [1987]; Kubes et al., PNAS USA., 88:4651-5 [1991]).

[060] The term "native thrombomodulin" refers to both the natural protein and soluble peptides having the same characteristic biological activity of membrane-bound or detergent solubilized (natural) thrombomodulin. These soluble peptides are also referred to as "wild-type" or "non-mutant" analog peptides. Biological activity is the ability to act as a receptor for thrombin, increase the activation of protein C, or other biological activity associated with native thrombomodulin. Oxidation resistant TM analogs are these soluble peptides that in addition to being soluble contain a specific artificially induced mutation in their amino acid sequence. siRNA As the Therapeutic Agent

[061] m another embodiment, short interfering RNAs (siRNA) are used as a therapeutic agent to inhibit a disease-related gene expression. For example, elevated levels of transforming growth factor-βi (TGF-βi) and platelet-derived growth factor (PDGF) have been associated with the development of glomerular injury. Therefore, inhibition of the expression of TGF-P ₁ and/or PDGF in kidney tissues may be used to prevent or reduce glomerular injury.

[062] siRNAs are dsRNAs having 19-25 nucleotides. siRNAs can be produced endogenously by degradation of longer dsRNA molecules by an RNase Hi-related nuclease called Dicer. siRNAs can also be introduced into a cell exogenously or by transcription of an expression construct. Once formed, the siRNAs assemble with protein components into endoribonuclease-containing complexes known as RNA-induced silencing complexes (RISCs). An ATP-generated unwinding of the siRNA activates the RISCs, which in turn target the complementary mRNA transcript by Watson-Crick base-pairing, thereby cleaving and destroying the mRNA. Cleavage of the mRNA takes place near the middle of the region bound by the siRNA strand. This sequence specific mRNA degradation results in gene silencing.

[063] siRNAs can be expressed in vivo from adenovirus vectors. This approach can be used to stably express siRNAs in kidney tissues. In one embodiment, siRNA expression vectors are engineered to drive siRNA transcription from polymerase HI (pol EH) transcription units. Pol HI transcription units are suitable for hairpin siRNA expression, since they deploy a short AT rich transcription termination site that leads to the addition of 2 bp overhangs (UU) to hairpin siRNAs— a feature that is helpful for siRNA function. Any 3' dinucleotide overhang, such as UU, can be used for siRNAs. In some cases, G residues in the overhang may be avoided because of the potential for the siRNA to be cleaved by RNase at single- stranded G residues.

[064] With regard to the siRNA sequence itself, it has been found that siRNAs with 30-50% GC content can be more active than those with a higher G/C content in certain cases. Moreover, since a 4-6 nucleotide poly(T) tract may act as a termination signal for RNA pol HI, stretches of >4 Ts or As in the target sequence may be avoided in certain cases when designing sequences to be expressed from an RNA pol HI promoter. In addition, some regions of mRNA may be either highly structured or bound by regulatory proteins. Thus, it may be helpful to select siRNA target sites at different positions along the length of the gene sequence. Finally, the potential target sites can be compared to the appropriate genome database. Any target sequences with more than 16-17 contiguous base pairs of homology to other coding sequences may be eliminated from consideration in certain cases. [065] The siRNA targets can be selected by scanning an mRNA sequence for AA dinucleotides and recording the 19 nucleotides immediately downstream of the AA. Other methods can also been used to select the siRNA targets. In one example, the selection of the siRNA target sequence is purely empirically determined (see e.g., Sui et al., Proc. Natl. Acad. Sci. USA 99: 5515-5520, 2002), as long as the target sequence starts with GG and does not share significant sequence homology with other genes as analyzed by BLAST search. In another example, a more elaborate method is employed to select the siRNA target sequences. This procedure exploits an observation that any accessible site in endogenous mRNA can be targeted for degradation by synthetic oligodeoxyribonucleotide/RNase H method (Lee et al., Nature Biotechnology 20:500-505, 2002).

[066] In one embodiment, siRNA can be designed to have two inverted repeats separated by a short spacer sequence and end with a string of Ts that serve as a transcription termination site. This design produces an RNA transcript that is predicted to fold into a short hairpin siRNA. The selection of siRNA target sequence, the length of the inverted repeats that encode the stem of a putative hairpin, the order of the inverted repeats, the length and composition of the spacer sequence that encodes the loop of the hairpin, and the presence or absence of 5'-overhangs, can vary to achieve desirable results.

[067] In another embodiment, the hairpin siRNA expression cassette is constructed to contain the sense strand of the target, followed by a short spacer, the antisense strand of the target, and 5-6 Ts as transcription terminator. The order of the sense and antisense strands within the siRNA expression constructs can be altered without affecting the gene silencing activities of the hairpin siRNA. hi certain instances, the reversal of the order may cause partial reduction in gene silencing activities. [068] The length of nucleotide sequence being used as the stem of siRNA expression cassette can range, for instance, from 19 to 29. The loop size can range from 3 to 23 nucleotides. Other lengths and/or loop sizes can also be used. Route of Administration

[069] The gutless adenovirus may be introduced into the kidney by intravenous, intrarterial, or retrograde infusion. In one embodiment, the virus is infused through the vene renalis. hi another embodiment, the virus is infused through the superior mesenteric artery. In yet another embodiment, the virus is infused through a retrograde catheter into the pyelic cavity. Since only a relatively small amount of virus is needed for the kidney infusion, the virus-related toxicity is reduced, hi yet another embodiment, the kidney is perfused with the virus, i.e., the virus enters the kidney through the vene renalis or the superior mesenteric artery, and is collected through the superior mesenteric artery or vene renalis. Since the leftover virus does not enter the blood circulation, a large amount of virus may be used for the perfusion. In addition, a close-circuit perfusion allows constant exposure to virus over an extended period of time (e.g., 10-60 minutes) and hence significantly increases the number of infected cells.

[070] hi another embodiment, the virus is administered into a segment of a renal blood vessel in vivo. In a related embodiment, the gutless adenovirus vector is administered using a stent. The viral vector is embedded in the stent and is released only at a treatment site. Since the viral infection is restricted at the treatment site and the surrounding area, only a small amount of the virus is needed and the virus-related toxicity is reduced.

[071] Another aspect of the present invention relates to a method for improving allograft survival. The method comprises the steps of perfusing a kidney harvested from an organ donor with a gutless adenovirus vector carrying a nucleotide sequence encoding an immune modulator and a regulatory element operably linked to the nucleotide sequence; and transplanting the perfused kidney into a subject. The term "immune modulator," as used herein, refers to a polypeptide or a polynucleotide capable of modulating an immune response and improving allograft survival.

[072] In one embodiment, the immune modulator is indoleamine dioxygenase (IDO). IDO is an enzyme that is expressed in the placenta and plays an important role in foeto- maternal tolerance. IDO metabolizes the amino acid tryptophan. The function of T cells, the most important cell-type involved in organ transplant rejection, is dependent on tryptophan. In addition, the metabolites of tryptophan (kynurenines) are toxic to T-cells. It has been shown that over-expression of EDO in renal tissues protects against renal transplant damage.

[073] Typically, kidneys must be preserved prior to transplantation to obtain proper pathology assessment of the suitability of the organ for transplantation. Lack of proper preservation leads to degradation of organ function due to thrombosis (blood clotting), ischemia (lack of oxygen), or ischemia followed by reperfusion (the restoration of blood flow upon transplantation). These events bring about inflammation, cell death, and eventually failure of the organ. Kidney preservation is a process in which the renal artery is connected to a kidney perfusion machine in order to simulate the normal process by which nutrients are supplied to the kidney. A solution is continuously perfused through a closed circuit which includes the kidney, which is typically maintained at a low temperature (e.g., 5°C) to reduce the cell metabolic rate and oxygen consumption. During the perfusion process, the perfusion pressure, flow, and vascular resistance, as well as the organ's chemistries, including base excess, oxygen saturation, calcium, potassium, hematocrit, pθ ₂ , pH, and bicarbonate, are monitored closely to prevent tissue damage. The adenovirus vectors can be added to the perfusion solution and infect the kidney tissue during the perfusion period . Kidney perfusion solutions are commercially available. In one embodiment, the kidney perfusion solution is Lactated Ringer's solution. [074] In one embodiment, the regulatory element is a constitutive promoter, such as CMV or RSV promoter. In another embodiment, the gutless adenovirus contains the nucleotide sequence of SEQ ID NO:25 or SEQ ID NO:26.

[075] hi another embodiment, the gutless adenovirus is suspended in the perfusion solution to a final concentration of 10 ⁹ -10 ¹² particles/ml and perfused for a period of 10-120 minutes.

[076] Another aspect of the present invention pertains to a gutless adenovirus vector comprising a polynucleotide encoding a therapeutic agent, a renal-specific regulatory element or inducible regulatory element operably linked to the polynucleotide sequence; and a sniffer comprising the nucleotide sequence of SEQ ID NO: 13 or SEQ ID NO: 15.

[077] In one embodiment, the renal-specific regulatory element is selected from the group consisting of high-capacity (type 2) Na ⁺ /glucose cotransporter gene (SgItI) promoter, Ksp-cadherin promoter, ClC-Kl chloride channel gene promoter, uromodulin promoter, Nkcc2ISlcl2al gene promoter, and the pi promoter of the parathyroid hormone (PTH)/PTH- related peptide receptor gene.

[078] In another embodiment, the inducible regulatory element is selected from the group consisting of heat inducible regulatory elements, hormone inducible regulatory elements, hypoxia inducible regulatory elements, cytokine inducible regulatory elements, metal ion inducible regulatory elements, and artificial inducible regulatory elements.

[079] Yet another aspect of the present invention pertains to a pharmaceutical composition for treating a renal vascular disease, comprising the gutless adenovirus vector described above and a pharmaceutically acceptable carrier. As used herein, a "pharmaceutically acceptable carrier" is intended to include any and all solvents, solubilizers, stabilizers, absorbents, bases, buffering agents, controlled release vehicles, diluents, emulsifying agents, humectants, dispersion media, antibacterial or antifungal agents, and the like, compatible with pharmaceutical administration. The use of such media and agents for pharmaceutically active substances is well-known in the art. Except insofar as any conventional media or agent is incompatible with the active compound, use thereof in the compositions is contemplated. Supplementary agents can also be incorporated into the compositions.

[080] The pharmaceutical composition is formulated to be compatible with its intended route of administration. Solutions or suspensions used for parenteral application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine; propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfate; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic.

[081] In all cases, the injectable composition should be sterile and should be fluid to the extent that easy syringability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. [082] It is especially advantageous to formulate parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein includes physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. The specification for the dosage unit forms of the invention are dictated by and directly dependent on the unique characteristics of the active compound and the particular therapeutic effect to be achieved, and the limitations inherent in the art of compounding such an active compound for the treatment of individuals.

[083] The present invention is further illustrated by the following examples which should not be construed as limiting. The contents of all references, patents and published patent applications cited throughout this application, as well as the Figures and Tables are incorporated herein by reference. EXAMPLE 1. Construction of Gutless Viral Backbone Shuttle Vector pShuttle-ITR-HPRT

1.1 Creation of pShuttle-ITR

[084] An embodiment of a gutless viral backbone shuttle vector pShuttle-ITR-HPRT is shown in Figure 1. Sequence portion containing R-ITR, PBR322 ori, Kan, L-ITR, and encapsidation signal was obtained from the pAdEasy® system from STRATEGENE®. At bp 3667 of the original pShuttle sequence, there is a BamHI site just beyond the R-ITR. PCR primers were designed to include the BamHI site and then were to create an EcoRI site at the end of the R-ITR. The R-ITR was PCR replicated and then digested with BamHI and EcoRI to create sticky ends. The viral backbone was then cut with both BamHI and EcoRI. The BamHI cut the backbone at bp 3667 and there was also an EcoRI site inside the MCS at bp 377. The backbone portion of the plasmid was then gel purified and the PCR replicated R- ITR was recloned into position. This essentially puts the L-ITR, encapsidation signal, MCS, and R-ITR all in close proximity to each other.

1.2 Creation of pShuttle-ITR-HPRT

[085] Insertion of the HPRT nitrons was a two step cloning process. First, the viral backbone pShuttle-ITR was digested with EcoRI and Xbal, both enzyme sites are in the MCS. The HPRT source was also digested with EcoRI and Xbal yielding a 7477 bp fragment that was cloned into the EcoRI/Xbal digested viral backbone. Then the HPRT source was digested with only Xbal yielding a 2715 bp fragment. One of the Xbal sites in this cut is the same Xbal site that was cut from the EcoRI/Xbal double digest in step 1. The viral backbone was cut with only Xbal and the 2715 bp fragment was inserted.

[086] Overall, from the HPRT source, the HPRT stuffer sequence is inserted into the viral backbone in reverse orientation, hence intron 5, then 4, then 3. The 2715 bp fragment was inserted and checked to follow the original source sequence. The new plasmid is designated as pShuttle-ITR-HPRT (SEQ ID NO:1).

EXAMPLE 2. Construction and Preparation of Gutless Viral Shuttle Vector Carrying Human Thrombomodulin or lacZ Gene

2(a) Construction and preparation of gutless viral shuttle vector carrying human thrombomodulin gene

2(a)-l Creation of pCMV-hTM

[087] The insertion of hTM into the gutless adenovirus backbone first required the creation of a CMV-hTM expression cassette. The intermediate vector used was pcDNA3.1/Zeo(+) (Invitrogen). A CMV promoter is available commercially and a CMV promoter was cloned into the multiple cloning sites (MCS) at the Xbal/EcoRV restriction enzyme site locations. The CMV from ps5 was removed using XbaFEcoRV. pcDNA3.1/Zeo(+) was cleaved inside the MCS using both Xbal and EcoRV as well. The CMV promoter was then ligated. Due to the location of the enzyme sites in the MCS, the CMV promoter (SEQ ID NO:4) was inserted in a backwards orientation relative to the pcDNA3.1/Zeo (+) plasmid. The amino acid sequence of human thrombomodulin (SEQ ID NO: 2) and the DNA sequence encoding human thrombomodulin (SEQ ID NO: 3) have been reported (Suzuki et al. EMBOJ. 6:1891-1897, [1987]). The human TM cDNA (SEQ ID NO:5) was obtained from Dr. Sadler (Dittman et al., Biochemistry, 26(14):4350-4357 [1987]) which the sequence was also submitted to ATCC and to GenBank. The human TM gene was removed from the plasmid using EcoRI and inserted into pcDNA3.1/Zeo(+), also in the reverse orientation to pcDNA3.1/Zeo(+) downstream of the inserted CMV promoter.

2(a)-2 Creation of pShuttle-ITR-HPRT-CMV-TM

[088] The expression cassette in pCMV-hTM was removed by digesting with Pmel. The gutless adenovirus backbone pshuttle-ITR-HPRT was linearized using Smal which cuts the plasmid at bp 381. The CMV-hTM cassette was ligated to the gutless virus in the forwards orientation. Sequence of the expression cassette (from Pmel site to Pmel site) is shown in SEQ ID NO:6. The new plasmid is designated as pShuttle-ITR-HPRT-CMV-TM.

2(a)-3 Creation of pTMadap

[089] The following linker containing a BstEII and Sfil site was inserted into the BstEII and Bsu36I sites of pShuttle-ITR-HPRT-CMV-TM, resulting in the vector pTMadap (SEQ ID NO:7).

5'-gtaacactgg cccaggaggc ctttctggtg acccc-3' (SEQ ID NO: 8)

3'-tgacc gggtcctccg gaaagaccac tggggatt-5' (SEQ ID NO: 9) Creation of pTMadap -stufferl

[090] Based on the published sequence HSU71148 of the human X chromosome region q28 the following PCR primers were synthesized:

Forward: 5' TAGTTCCTTCTGCCTGGAATAC 3 ¹ (SEQ ID NO: 10)

Reverse: 5' CAAGTCACAAGGATGGACTACA 3' (SEQ ID NO: 11) [091] Amplification of a human DNA sample resulted in the amplification of a 18524bp DNA fragment (sniffer 1, SEQ ID NO: 12). Shaffer 1 was cut with the restriction enzymes BstEII and Sfil and the resulting fragment of approximately 18371 bp was inserted into the BsteII and Sfil sites of pTMadap, resulting in pTMadap-stufferl .

2(a)- 4 Creation of pTMadap-stufferl -short

[092] To reduce the size of the staffer 1 fragment in pTMadap-stufferl, pTMadap- stufferl was digested with SanDI and BstEII and the resulting DNA ends were modified by a fill-in reaction with Klenow. Re-ligation resulted in the 25207 bp vector pTMadap-stufferl - short. The sequence of staffer 1 -short fragment is shown in SEQ ID NO: 13. 2(a)-5 Creation of pTMadap-stafferl-short-stuffer2

[093] The plasmid p2-2 (SEQ ID NO: 14, obtained from GenBank) was cut with Notl and the resulting fragment of approximately 5954 bp (staffer 2, SEQ ID NO: 15) was inserted into the Notl site of pTMadap-stafferl short, resulting in pTMadap-stufferl -short- staffed.

2(a)-6 Removal of Pad site from pTMadap-stafferlshort-staffer2

[094] Plasmid pTMadap-stuffer 1 -short-staffer2 was cut with AcII and BsiWl . The resulting 28790 bp fragment was isolated from gel. pShuttle-ITR-HPRT (SEQ ID NO: 1) was cut with AcII and Acc65I. The resulting 1966 bp fragment was ligated into the isolated 28790 bp fragment, resulting in the full length backbone vector pTM-final (Figure 2 and SEQ ID NO: 16).

2(b) Construction and preparation of gutless viral shuttle vector carrying LacZ gene

[095] The insertion of LacZ also required creation of an intermediate vector to create the expression cassette. pcDNA3.1/Zeo (+) was again used. First, a portion of the vector from the end of the MCS, restriction enzyme site Apal, to the beginning of the SV40 poly A, restriction site Nael, was removed and the vector relegated to itself. Then the LacZ gene was inserted into the vector MCS using Notl/Xbal. The expression cassette, containing CMV promoter, LacZ gene, and SV40 poly A, was removed using Nrul/Sall retraction enzymes and blunt-end cloned into the gutless adenovirus at the Smal restriction enzyme site. EXAMPLE 3. Preparation of Gutless Adenovirus Carrying Human Thrombomodulin Gene (gutless Ad.hTM)

[096] The gutless Ad.hTM was prepared according to the following protocol:

[097] 1. Linearize pTM-final by digestion with Pad. The completeness of the digestion is confirmed by electrophoresis using a small aliquot of the digestion product. It's not necessary to gel purify the digested pTM-final for transfection described in step 2).

[098] 2. Transfect 293FLP cells grown in a 60mm dish at about 80% confluence with about 5μg of Pad-digested pTM-final using lipofectamine. 293FLP cells are 293 cells engineered to express the flp gene product, which recognizes the FRS flanking the encapsidation signal and cleaves out the encapsidation signal thereby not allowing helper- viral DNA to be packaged. (Beauchamp et al., Molecular Therapy, 3(5):809-815 [2001]; Umana et al., Nature Biotechnology, 19:582-585 [2001]).

[099] 3. Twenty-four hours after the transfection, infect the cells with helpervirus HlO in 2% DMEM-F12 at a multiplicity of infection (MOI) of 10.

[0100] 4. Remove the cells from the plate (preferably with a cell scraper) after the appearance of cytopathic effect (CPE), place the cells in a sterile 15ml tube, and lyse the cells by three freeze-and-thaw cycles. Precipitate the cell debris by spinning the lysate for 5 minutes at 4000 rpm and harvest the supernatant. The supernantant is designated as PO (passage number 0) supernantant.

[0101] 5. Infect 293FLP cells in two T75 flask at 80% confluency with 4 ml of PO supernatant and with the helpervirus at MOI of 1. [0102] 6. Continue passaging virus in the manner described in steps 4 and 5 until passage 6 and confirm that helpervirus is added at an MOI of 1 at each passage.

[0103] 7. Add the P6 supernatant to 8 T500 flasks containing 293FLP cells at 80% confluency and infect the cells with the helpervirus at a MOI of 1.

[0104] 8. Following CPE, harvest the cells into 500ml sterile tubes. Centrifuge the cell suspension at 4500 rpm, 4°C for 10 minutes.

[0105] 9. Resuspend the cell pellet in 2% DMEM-F12 (the pellet can be stored at - 80 ⁰ C at this stage).

[0106] 10. Freeze-thaw the resuspended cell pellet three times. Spin down the cell debris by centrifugation at 4000 rpm, 4°C for 10 minutes.

[0107] 11. Transfer the supernatant, which contains the released virus, to a fresh sterile culture tube and subject the supernatant to a second round of centrifugation to further remove cell debris.

[0108] 12. Transfer the supernatant to a fresh sterile tube. The virus is ready for CsCl-purifϊcation.

[0109] 13. To purify the virus, ultra-clear SW41 (Beckman) tubes were prepared by soaking in Ultra Pure Water, then 70% ETOH. Cotton swabs (one swab for each tube) were used to completely dry out the tube, and two tubes were used per sample.

[0110] 14. Preparation of the first gradient: 2.5 niL CsCl - Density 1.25, and 2.5 mL CsCl - Density 1.40. Place the 1.25 density CsCl into the Beckman tubes first. Underlay slowly the high density, 1.40 CsCl using a sterile pasteur pipette, and overlay an equal amount (in mL) of CVL, about 4.25 ml/tube. Samples were centrifuged in a SW41 rotor with speed: 35,000 rpm at 20° C for 1 hour and with acceleration: 1 and deceleration: 4. The lower opalescent band was collected using 1 or 3 mL syringe with green cap needles. [0111] Preparation of second gradient: CsCl was prepared to density 1.33 g/ml. Two fresh ultra-clear tubes were placed 8 mL of CsCl and overlay the band just recovered after the first spin. (To equilibrate the tubes, measure before the volume of the recovered band and divide equally in the 2 tubes). Samples were centrifuged at the conditions above for 18 hours. The opalescent band was recovered and collected in a sterile eppendorf tube. (From this moment, keep the tube always on ice). Samples were dialyze with dialysis buffer: (1) 1OX Dialysis Buffer: 100 mM Tris - pH 7.4, 10 mM MgCl ₂ ; (2) IX Dialysis Buffer (2 Liters): 400 mL Glycerol,200 mL 1OX Dialysis Buffer 140 mL, and Ultra Pure Water. The dialyzed samples were immediately stored at -70 ° C. (c) Determination of virus titer

[0112] BioRad protein estimation kit was used with 1:5 diluting, and placing 1 ml in each disposable cuvette. Standards were set up at 0, 1, 2, 5 10, and 15 μg/ml. (BSA is fine). Sample cuvettes were prepared using 1-10 μl of sample, depending on estimate of titer. (Sample OD must be within the linear range of the standard line.) OD was taken at 595λ and formula of the line was calculated from standards. The protein concentration of the samples was calculated using this formula. The following formula was used to convert protein concentration to titer: [12.956 + 224.15 (μg/ml)] x 10 ⁸ .

EXAMPLE 4. Expression of Human Thrombomodulin ChTM) in vitro (A) Expression of hTM in HEK 293 cells transfected with pTM-final [0113] HEK 293 cells were cultured in a 6 well cluster and transfected with lμg of pTM-fmal. After 24 hours, the cells were washed with PBS and lysed in 125μl RIPA buffer with protease inbitors Protein samples (16μl) were separated on 7.5% polyacrylamide/ SDS gel and transferred to nitrocellulose membrane. Primary antibody TM (c-17) (1:2000, Santa Cruz) and secondary antibody Polyclonal Rabbit Anti-Goat Lnmunoglobulins/HRP (1:4000, DakoCytomation) was used to detect the proteins. As shown in Figure 3, hTM expression was detectable in cells transfected with pTM-final.

[0114] The RIPA buffer was prepared according the following recipe: mixing 100 μl Igepal ca-630, 50 mg sodium deoxycholate, 500 μl 20 % SDS, 10 mM β-mercapto ethanol, and 1 ml 10x PBS, and add water to a final volume of 10 ml at room temperature. A cocktail of protease inhibitors containing 11.5 μl PMSF (from 34.8 mg/ml in isopropanol, 64 μl Benzamidine (from 15.6 mg/ml stock), 100 μl sodium orthovanadate (100 mM), 5 μl pepstadine (from 1 mg/ml stock), 1 μl leupeptine (from 5 mg/ml stock), and 1 μl aprotin (from 5 mg/ml stock) was added to the RIPA buffer immediately before use.

(B) Expression of hTM in P2 lysate of 293FLP cells

[0115] The P2 lysate was generated as described in Example 3. After CPE was observed, 293FLP cells were detached from the bottom of the culture flask by repeated tapping of the flask. 1 ml of the total of 10 ml of cell suspension was used for the detection of TM expression. The cells in the ImI cell suspension were collected by centrifugation for 10 min at 300xg and lysed in 250μl RTPA buffer. 7ul of 5x loading buffer was added to 35μl of the lysed cells and the resulting solution was immersed in boiling water for 3 minutes. 5 and 30 ul of boiled cell lysate were diluted with 250 ul TBS (137mM sodium chloride, 1OmM Tris, pH is 7.4 at +25°C) and transferred to a nitrocellulose membrane using a slotblot device (Bio-Dot SF, Biorad). Primary antibody (goat anti-hTM (c-17) 1 :2000 dilution, Santa Cruz) and secondary antibody (polyclonal rabbit anti-goat immunoglobulins/HRP, 1 :4000 dilution, DakoCytomation)) were used to detect the proteins. As shown in Figure 4, hTM was detectable in the P2 lysate.

[0116] The 5x loading buffer was prepared by mixing 20.0 ml 30% SDS, 11.5 ml 2M sucrose, 6.5 ml 2M Tris-HCL pH 6.8, 2.0 ml beta-mercaptoethanol and bromophenolblue. The RTP A buffer was prepared as described in Example 4(A). A cocktail of protease inhibitors containing 11, 5 μl PMSF (from 34, 8 mg/ml in isopropanol, 64 μl Benzamidine (from 15, 6 mg/ml stock), 100 μl sodium orthovanadate (100 mM), 5 μl pepstadine (from 1 mg/ml stock), 1 μl leupeptine (from 5 mg/ml stock), and 1 μl aprotin (from 5 mg/ml stock) was added to the RIPA buffer immediately before use.

(C) Expression of TM in virus infected vena cava

[0117] Vena cava was excised from rats and cut into six segments of approximately 3mm long. The segments were incubated for 30 minutes in medium containing gutless luc or TM virus. After incubation, the segments were washed three times and transferred to a 24- well plate containing DMEM. The segments were incubated overnight in an atmosphere of 95%O ₂ and 5%CO ₂ with gentle shaking. After 24 hours of incubation the segments were frozen. The frozen sections were thawed in lysis buffer and loaded onto a 7.5% SDS acrylamide gel. After blotting, the blot was probed with an antibody against human TM.

[0118] The Western blot clearly shows that within 24 hours TM expression can be detected (Figure 5).

[0119] As a control, the same HUVEC cells will be infected the gutless adenovirus expressing LacZ. These cells will subsequently be stained with X-gal to look for blue cells. This will demonstrate the viability of the gutless adenovirus backbone itself.

(D) TM expression in HEK 293 cells infected with TM gutless virus passage 1-6 [0120] The TM-vector backbone was released by digestion with Pad. 293CRE cells were cultured in a 60mm dish at 80% confluency. Cells were transfected with 5μg of Pad digested TM-vector backbone. After 24 hours, 2% DMEM-F 12 containing helper virus with a MOI of 10 was added. Following CPE, cells were removed from the dish and medium and cells were collected a in a sterile 15ml tube. Cells went through three freeze/ thaw cycles and the resulting suspension was centrifuged for 5 minutes at 4000 rpm. The cleared lysate was collected and name P=O. [0121] 4 ml OfP=O supernatant was added to 2 T75 dish containing 293CRE cells at 80% confluence. Cells were subsequently infected with helpervirus at MOI of 1. Following CPE, cells were removed from the dish and medium and cells were collected a in a sterile 15 ml tube. Cells went through three freeze/ thaw cycles and the resulting suspension was centrifuged for 5 minutes at 4000 rpm. The cleared lysate was collected and name P=I. This procedure was repeated until P=6.

[0122] HEK 293 cells were cultured in a 6 well cluster and transfected with 200 μl of TM gutless virus of passage 1-6. After 24 hours, the cells were washed with PBS and lysed in 125μl PJPA buffer. Protein samples (16μl) were separated on a 7.5% polyacrylamide/ SDS gel and transferred to nitrocellulose membrane. Primary antibody TM (c-17) (1:2000, Santa Cruz) and secondary antibody Polyclonal Rabbit Anti-Goat hnmunoglobulins/HRP (1:4000, DakoCytomation) were used to detect the proteins. As shown in Figure 6, TM expression is higher in cells infected with virus of higher passage numbers , indicating successful amplification of TM gutless virus in 293CRE cells.

[0123] The RIPA buffer (10 ml) was prepared as follows: 100 μl Igepal ca-630, 50 mg sodium deoxycholate, 500 μl 20 % SDS, 10 mM β-mercapto ethanol, 1 ml 10x PBS, add water to make up 10 ml. Immediately before use, the following protease inhibitors were added to the RIPA buffer: 115 μl PMSF (from 34,8 mg/ml in isopropanol), 64 μl Benzamidine (from 15,6 mg/ml stock), 100 μl sodium orthovanadate (100 mM), 5 μl pepstatin (from 1 mg/ml stock), 1 μl leupeptin (from 5 mg/ml stock), 1 μl aprotin (from 5 mg/ml stock). EXAMPLE 5. Composition of The Complete Viral Delivery System (CVDS)

[0124] The Complete Viral Delivery System composes of 1 : 1 mixture of Ham's F12 medium and DMEM, an effective amount of a gutless virus vector carrying a polynucleotide encoding a thrombomodulin protein or a variant of a thrombomodulin protein, and an a cellular oxygen carrier. Preferred oxygen carrier includes: unmodified or chemically modified hemoglobin in the range of 3 g/dl to 10 g/dl and perfluorochemical emulsions. The CVDS may optionally contain 1 niM L-glutamine (Sigma), 1.5 g/L sodium bicarbonate (Sigma), IX antibiotic-antimycotic (GIBCO® 15240). The CVDM maintains tissue viability during the viral treatment of blood vessel. EXAMPLE 6. Ex vivo Treatment of Cardiovascular Disease

[0125] A vein segment is harvested from the leg and is stored in Ham's F12 medium. Gutless adenovirus suspended in CVDM is then injected into the isolated vein segment and incubated for 10 to 40 minutes depending on the desired level of transfection. The infection may be performed under pressure to enhance efficiency.

[0126] After the incubation, the vein segment is washed several times to eliminate all viral particles that have not entered the endothelial cells of the vein segment, and is then grafted into the desired treatment site. The thorough rinse avoids the spread of the viral vector to other organs of the body following in situ grafting, and any systemic immune response to the viral vector. EXAMPLE 7. In vivo treatment for Peripheral Vascular Disease

[0127] In this application, the vein in the leg is treated following evacuation of the clot. A catheter is inserted in the leg vein and both the proximal and distal balloons are inflated to isolate the vein segment to be transfected. The segment is evacuated of all blood, rinsed with physiologic saline. The segment is then filled with the CVDS described above, under pressure. The isolated vein segment is exposed to the CVDS for a period of 10 to 45 minutes, depending upon the desired transfection efficiency.

EXAMPLE 8. In vivo expression of TM by intravenous infusion of viral vectors

Material and methods

[0128] Infection with gutless TM virus: 3 male Wistar rats weighing approximately 300 grams were intravenously injected in the tail vein with a low dose of gutless TM virus (approximately 2x10 ¹⁰ viral particles) in a total volume of 500 ul of sucrose buffer. After three weeks, the animals were sacrificed and liver tissue and blood plasma was collected and immediately frozen in liquid nitrogen.

[0129] TM expression in the liver was determined by western blotting. Approximately 500mg of liver tissue was homogenized in 2 ml of RIPA buffer. Liver protein samples (20 μg) were separated on a 7.5% polyacrylamide/ SDS gel and transferred to nitrocellulose membrane. Primary antibody TM (c-17) (1 :2000, Santa Cruz) and secondary antibody Polyclonal Rabbit Anti-Goat Immunoglobulins/HRP (1 :4000, DakoCytomation) were used to detect the proteins.

[0130] Detection of rat Anti-TM antibodies in the plasma of TM infected rats: HEK 293 cells were cultured in a 6 well cluster. 3 wells were infected with 100 μl of TM gutless virus (approximately 4x 10 ⁹ virus particles) and 3 wells received no virus. After 24 hours, non-infected and TM infected cells were washed with PBS and lysed in 125μl RJPA buffer. Protein samples (16μl) were separated on a 7.5% polyacrylamide/ SDS gel and transferred to nitrocellulose membrane. Blots containing protein from both TM expressing cells and non- infected cells were incubated with primary antibody TM (c-17) (1 :2000, Santa Cruz) or plasma from TM infected rats (1:20, 1:100 and 1:1000 dilution). Detection of primary antibodies was performed using Polyclonal Rabbit Anti-Goat Immunoglobulins/HRP (1:4000, DakoCytomation) and Polyclonal Rabbit Anti-Rat Immunoglobulins/HRP (1 :4000, DakoCytomation), respectively. REPA buffer was prepared as described in Example 4. [0131] TM expression in the liver: No adverse effects of the injection of gutless TM virus could be detected. Animals displayed normal growth characteristics and did not suffer from excessive bleeding. Three weeks after injection, animals were sacrificed and no internal bleeding could be detected. Liver TM expression was evaluated using western-blot. TM expression was elevated two-fold above background levels, indicating modest over- expression of TM gutless virus in the liver three weeks after infection (Figure 8).

[0132] To detect TM antibodies in the plasma of rats infected with the gutless TM virus, four western blots were made. Each blot contains a protein sample from human cells expressing TM (positive control) and a sample from the same cells that do not produce TM (negative control). Blot 1 was probed with a commercial antibody against TM (Figure 9, blot 1), indicating the presence of human TM only in the positive control lane. Blots 2,3 and 4 were probed with plasma from animals infected with TM virus in the dilution 1:20, 1:100 and 1:1000, respectively. Although some immunoreactivity is observed, the plasma of rats did not lead to the specific detection of TM in the positive control lane. Therefore, the plasma of these rats do not contain detectable levels of rat IgG antibodies against human TM.

[0133] Conclusion: Intravenous administration of low dose gutless TM virus into rat tail vein resulted in modest expression of TM in the liver of the recipient rats three weeks after injection. The viral injection did not result in the production of IgG antibodies against TM. EXAMPLE 9. Adenovirus-Mediated in vivo Gene Transfer To Vena Cava

[0134] Inbred male Brown Norway rats (BN / rijHsd, Harlan, Netherlands) with an age of 11 weeks were used. Animals were housed in a light and temperature controlled environment and fed standard rodent chow and water ad libitum. Rats were anaesthetized with isoflurane (3% in O ₂ ). The vene cava with the branches was exposed by a mid-line incision. The vene cava was clamped just below the vene renalis of the left kidney. All accessible sidebranches of the vena cava in the region between the vena renalis and the bifurcation were also clamped. The virus particles were administered through an insulin syringe (29-gauge needle) with a volume of 290ul containing 2 x 10 ¹¹ virus particles. After injection of the viral solution, the syringe with needle was not removed from the vena cava but remained in place during the following incubation period of 20 minutes. Subsequently, the clamps on the sidebranches of the vene cava were removed. The transfected segment of vena cava was washed by making a puncture with a needle 25-gauge needle just below the clamp near the vena renalis. The expelled blood containing excess virus was absorbed with a cotton bud. After bleeding a volume of approximately 0.5 ml, the bleeding was stopped by applying a pressure on the puncture site with a cottonswab. Subsequently, the clamp near the vene renalis was released and the abdomen was sutured. For post- operative pain relief, the rats received buprenorphin (temgesic®) 10 μg/kg subcutaneously. The rats were allowed to recover with access to water and food ad libitum.

[0135] Two days after the transfection procedure, rats were anaesthetized with isoflurane (3% in O ₂ ). The vene cava was exposed by a mid-line incision and clamped just below the vena renalis of the left kidney. The abdomen was temporarily closed during the incubation time of 2 hours. Subsequently, the abdomen was reopened and blood was collected from the aorta. The vena cava was harvested from the bifurcation till above the clamp. The vene cava was opened longitudinally and the thrombus was removed and placed in saline for size evaluation. The results of the experiment were summarized in Table I. Table I. Vena cava thrombus in the experimental animals

EXAMPLE 10. Adenovirus-Mediated Gene Transfer To Kidney via Intravenous Infusion

[0136] This example describes the procedure for slowly infusing a recombinant adenovirus into the renal circulation. Male Sprague-Dawley rats (100-150 g) were injected intramuscularly with 20,000 units of penicillin, anesthetized with ketamine (70 mg/kg, ip) and xylazine (7 mg/kg, ip) and underwent surgical exposure of the right kidney, the aorta and the right renal blood vessels. The right renal blood flow was interrupted by clamping the aorta above and below the right renal artery and the superior mesenteric artery (SMA). This setting selectively excluded the right kidney without interrupting the blood circulation through the left kidney and allowed infusion of virus into the right kidney through the SMA. A 27-gauge winged infusion needle was inserted into the SMA and fixed in place with a microaneurism clamp. 1.5 ml of recombinant adenovirus in phosphate buffered saline (PBS) containing 5 units of heparin/ml were slowly infused into the right kidney with a Razel A-99 syringe pump at a flow rate of 0.1 ml/min. The right kidney was packed with ice during the infusion to minimize ischemic damage. Renal circulation was reestablished at the end of infusion. The abdominal cavity was closed with sutures. The animal was placed on a warm pad to recover from the anesthesia and was returned to its cage after recovery. EXAMPLE 11. Adenovirus-Mediated Gene Transfer to Kidney via Balloon Catheter

[0137] In this application, a catheter is inserted in a vein near or in the kidney. Both the proximal and distal balloons are inflated to isolate the vein segment to be transfected. The segment is evacuated of all blood, rinsed with physiologic saline. The segment is then filled with the CVDS described above, under pressure. The isolated vein segment is exposed to the CVDS for a period of 10 to 45 minutes, depending upon the desired transfection efficiency. EXAMPLE 12. In vivo Treatment With Virus Containing Stent

[0138] In this application, a virus-coated stent is placed at a treatment site in or near the kidney. Alternatively, the virus may be embedded in the stent and is releases gradually through a time-releasing mechanism well-known to one skilled in the art. EXAMPLE 13. Construction of gutless adenovirus vectors carrying the IDO gene

[0139] Rat and human IDO cDNA were amplified by RT-PCR using the following set of primers:

Forward primer (containing a Fsel restriction site):

5 '-TATTTATTGGCCGGCCGCGTTAAGATACATTGATGAG-S' (SEQ ID NO: 17) Reverse primer (containing a Sbfl restriction site):

5 '-TATTTATTCCTGCAGGTCGTAGGTCAAGGTAGTAGA-S ' (SEQ ID NO: 18).

[0140] The amplified rat IDO cDNA (SEQ ID NO: 19) and human IDO cDNA (SEQ ID NO: 20) were cloned into expression plasmids pAdTrackCMV-rIDO and pAdTrackCMV- hlDO, respectively.

[0141] Expression cassettes comprising a CMV promoter, IDO cDNA and poly- adenylation signal were constructed using PCR. PCR primers were equipped with additional restriction enzyme sites to facilitate cloning into the gutless backbone vector.

[0142] Forward primer (containing a Fsel restriction site): tatttattggccggcCGCGTTAAGATACATTGATGAG (SEQ ID NO: 17)

[0143] Reverse primer (containing a Sbfl restriction site): tatttattcctgcaggTCGTAGGTCAAGGTAGTAGA (SEQ ID NO: 18)

[0144] The resulting PCR fragments were cloned into pGEM-T-EASY for sequencing and cloning. Sequencing confirmed the presence of rat IDO expression cassette (Figure 10, SEQ ID NO:21) and human IDO expression cassette (Figure 11, SEQ ID NO:22).

[0145] The gutless backbone (SEQ ID NO:23, Figure 12) was cut with Sbfl and Fsel to release the TM expression cassette. The backbone was subsequently dephosphorylated to prevent vector self-ligation. Rat and human IDO expression cassettes were released from pGEM-T-Easy by digestion with Fsel and Sbfl and ligated into the Fsel and Sbfl sites of the gutless backbone. The resulting constructs prIDO-fϊnal (Figure 13, SEQ ED NO:24) and phlDO-final (Figure 14, SEQ ID NO:25) were cloned in E-coli DH5α. DNA midipreps were generated for the production of high quality plasmid DNA. Gutless adenovirus containing rat IDO or human IDO was produced using the procedure described in Example 3.

EXAMPLE 14. Perfusion of Kidney Transplant with gutless adenovirus vectors carrying the IDO gene [0146] The experiment was carried out in Fisher-Lewis kidney transplantation model. Gutless adenoviruses carrying the IDO gene (Ad.TIDO) or luciferase gene (Ad.TL) were surface-modified with cyclic arginine-glycine-aspartic acid (RGD) peptides through a bifunctional poly(ethyleneglycol) linker for integrin alpha(v)beta(3) specific delivery. The resulting RGD modified viruses were designated RGD-Ad.TIDO and Ad.TL. The transplanted kidneys were incubated with either RGD-AdTIDO (n=6) or RGD-AdTL (n=5) at 4°C for 20 min with saline. The transplanted animals were sacrificed at day 7. The transplanted kidneys were isolated and subjected to Western blot and immunohistological examination.

[0147] As shown in Figure 15, IDO expression was detected in the kidneys infected with RGD-AdTIDO but not in kidneys infected with RGD-AdTL. Figures 16A- 16D shows that, comparing to kidneys perfused with saline or control virus (RGD-AdTL), kidneys infected with RGD-AdTIDO showed reduced plasma creatinin levels (Figure 16A). Kidneys infected with RGD-AdTIDO also showed reduced tissue damage, as evidenced by the reduced ED-I staining (Figure 16B), reduced macrophage influx (Figure 16C, CD-8 staining for T-lymphocytes), and reduced fibrotic response (Figure 16D, staining for smooth muscle actin).

[0148] The above description is for the purpose of teaching the person of ordinary skill in the art how to practice the present invention, and it is not intended to detail all those obvious modifications and variations of it which will become apparent to the skilled worker upon reading the description. It is intended, however, that all such obvious modifications and variations be included within the scope of the present invention, which is defined by the following claims. The claims are intended to cover the claimed components and steps in any sequence which is effective to meet the objectives there intended, unless the context specifically indicates the contrary. SEQUENCE LISTING

<400> 1 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tactggtacc gcggccgcct 360 cgagtctaga actagtggat cccccgggct gcaggaattc tgatggctct caaaattcct 420 gcctccttta gggataaaag actttaagac tttttaacaa aaaagaaaaa gaaaaaaaaa 480 attcctgcct cctggtgtac acacacagaa gggttccctc cccttgaatg tgaccaggat 540 ctgtgaaaat aacgggatag ccgctcctgt gattaggtta tgtggtagac tagagcaaga 600 ttctcctgct ggttttgaag aagtcagctg ccatgttgtg agactgtcat gggctagggc 660 atgagccttt aaatatctgg gagcaacccc tggccagcag ccagtgagaa aacgggccct 720 cagtcctaca atcacaagga actaaattct gccaacaacc tgaaggaact ttgaagagga 780 tcatgagtcc cttgattcag cttgatgagc ccctgagcag aggatacagc taacttgtac 840 tagggaagta taaaaaacat gcatgggaat gatatatatc aactttaagg ataattgtca 900 tacttctggg aatgaaggga aagaaatggg gctttagttg tattatgatc tttaatttct 960 caaaaaaaat aagatcagaa gcaaatatgg caaaatgtta atacttttgt gggtacgtag 1020 gtattcagca tacccttttt tctgagttca aaatatttta taattaaaat gaaatgcagg 1080 ccaggcacag tggctcatgc ctataatacc agcactttgc gaggccgagg tgggaggatg 1140 gcttgaggcc agaccagcct ggccaacatg gcaaaacccc atctctactt aaaaaaaaaa 1200 aaactatata tatatatatg tgtgtgtgtg tgtatatata tatatgtata tatatttata 1260 tatgtgtgta tatatatata tgtatatata tttatatatg tgtgtgtata tatatatata 1320 cacacacaca catatataca tacatacata cacacacaca cacacacaat tagccaggca 1380 tggtggcgca cacctgtagt cccagctact tgggaggctg agacatgaga attgcttgaa 1440 cctgggaggc agagtagtta gtgagctgag atcataccac tgcactccag cctggtgaca 1500 gagtgagact ctgtcttaaa aaaaataaaa attaaaatta aatgcaaaag gtccaagtga 1560 attgaagagg aaaggggtat caaggaaggt tttgtggagg tgacgtttga gctgggtctt 1620 aaatgactta aacatgggat aagaagggag ggaataagga catttcaggt acgagaaata 1680 aggagcaaac agtggaaaca acctaacgtc tgtcaaccag tgaatggata acaaaaatgt 1740 aattcagatg gtatccaact tacgatggtt caacatgaga tttttctgac tttaggatag 1800 atttatcaaa gtagtaaatc cattttcaac ttatgatatt ttcaacttca gatgggttta 1860 tcaggacaca gttgaggaac acctgtctat ccatacaatt tggcaataaa aaggaaatga 1920 gtgcagatat actccacaac atgaatgaac cttgaaaaca ttaagtgaga gaagccagat 1980 acaaaaggcc acatattgta tgattctatt tatacaaaat gtccagaata ggcaaatctt 2040 atagacagca agtaggtaga tgatcagttt gctaggtgct gggggaaggg gaaatgggga 2100 gtgatggcta aggggattgg gtttctttgt ggggcaatga aaatgtttta aaattgagcg 2160 tgataatgat tgcacaatgc tgcatatata tataatctat agattatata tatataaaga 2220 gaggctgtta gacagtgata agtgatatat atatatatat acatagagag agagagagag 2280 agagagagag gctgttagtg ataagtgatc aggaaaataa aagtattgag gaggaatacg 2340 aagttgacgg tgtgaaaaca tgagatttta tataggatgg ccagggaagg ccttaatgag 2400 aaagtgactt atgagtaaaa acaagggatc ctaaacctta gcatgcatca gaatcactcg 2460 gaaacttgtt aaagcatagc ttgctgggcc tcatcacaga tattttgatt cggtaggttc 2520 ttgtctgata ttaatacttt tggtctaggg aaccacattt tgagaaccac tgagctaaag 2580 gaagtaaagg tttcccttag tttactagct ggtaacccta ggaaactgct tagcctctcg 2640 gtgctaagat acaaaatact ttagcacata ataacacatg gaaaatagtc tataaattat 2700 aaatattatt ttttatgtac caaatattac ataagacaaa atctaagcaa gatatatata 2760 tatatacata aaatataaga tatatatgta tatattatat atagataaat agagagagag 2820 agttatgttt agaaagaaaa tacttcaaac taaaaaaaga gaggtaggaa gtataccatt 2880 ccattattgg taaaaacaaa ttactaagta gtctttacaa aaaaccaatc tcactccttt 2940 agaacacaag cccaccatta aaactgatgc agaggaattt ctctccctgg cttaccttta 3000 ggatggtgca tactaagtta gaaaagtcat aaatgttata ttaaaagtaa atgtgaactt 3060 acttccacaa tcaagacatt ctagaagaaa aagagaaatg aaaatcagta caatgaataa 3120 aacggtattt ccaattataa gtcaaatcac atcataacaa ccctaaggaa ttatccaaac 3180 tcttgttttt agatgcttta ttatatcaaa ctctccttta aacaagtggc ccatctgctg 3240 ggatttggaa gcctgtaata ctgaaatttt catcataatg gaaattttaa aaacagaatt 3300 tgacccacct gtttttaaaa cactttcatt acttaacaag aggtctaatc ttgggcaagt 3360 cttgaaattt ctctggcctt agtttcccat gtgttaaatg aaacttgaag cagttggtct 3420 cttatagtct cctgactcta acattctaag aattatattt gtacaataac tcaaaaatca 3480 cataatttaa tttaccatat ggactccaaa atatattttc tcattaggct aaacttgatc 3540 tgcattttct ggatgtgtcc atattcttgg actacactaa aacatgatac caatgcttcc 3600 tctcaccata aaccctcact tcgctttcta catttaagaa ttttatagct ggaagagtcc 3660 ttaacagaaa ataccatcta ataattaccc ctcaaaatcg agaaagtcct atctgttctt 3720 atgctagtta taagaatgag gcagcatttc acataatggt tataaacact gccacaagaa 3780 gattcatgat gtgttgttta tctgtagctc tcatcatact ctgtcatata actatagcat 3840 taagatttta atgttctata tattcttcta agacagtgtt taccagagta aggcacaaaa 3900 gatccactgg tttgcaagaa agattagaac ttttaaattt tttacctcac cttgtttaat 3960 ctatattttt gtatgtattt tgtaacatat atattattat taccataaat catatataat 4020 ttaaaatgca tatattaggg gtaaatgctc aggaaacttt ttataaattg ggcatgcaaa 4080 tacaagtttg aagactcact gttctaggta ttaaaagtaa agttataacc aagtaaagct 4140 tccacctttt catgtctcaa agcagtttat tgttggaggt aagatctctt agaagcctaa 4200 acaggtccaa gtacagaatg aagtaaggct agcccataac ttgtggcaag caattcatac 4260 tatttctctc atgctgagct ctcctcagtg aagcagctac tatagacaac tgcagcctat 4320 tggtagccta ttttacaggc aggaaaaaaa ttacttttta ttcaaagtgg aactcaggac 4380 atggggagaa aatgaataca aaaaataggg tcaatccaaa ggcacacagc aaatgagtaa 4440 cacagttatg tttttttccc atttgtatga ggtcccagta aattctaagt aaactgcaaa 4500 tttaataata cactaaaaaa gccatgcaat tgttcaaatg aatcccagca tggtacaagg 4560 agtacagaca ctagagtcta aaaaacaaaa gaatgccatt attgagtttt tgaattatat 4620 caagtagtta catctctact taataaatga gaaaaacgag gataagaggc catttgataa 4680 aatgaaaata gccaagaagt ggtattagag acttgaatac aggtattcgg gtccaaagtt 4740 catctgctca aatactaact ggggaaaaga gggaaaaata tttatataca tatatatctg 4800 cacacaaaaa tacccccaaa agacaaaatg aggccaggca gggtggctca cacccgtaat 4860 cccggtactt tgggaggctg aggcaggtgg atacctgaga tcaggagttg gagatcagcc 4920 tggtcaacat ggtgaaaccc tgtctctact aaagataaaa aaattagcca ggcatggtgg 4980 cgtgcgcctg taatcccagc tacttgggag tctgaggcag gagaatcact tgaactggga 5040 aggggaggtt gcagtgagcc aagatcgtac tactgcactc cagcctgggc agcagagtga 5100 gactccatca caaaaataaa taaataaata aaatacaatg aaacagaaag ttcaaataat 5160 cccataatct taccaccaag aaataacttt cactcgttat acttattgat ttttccataa 5220 taaatgtact ttactgtgac tatcatgaaa agaaagttat tttagaaaca gagaactgtt 5280 tcagatcaaa tctatgtagt agaacagagc cattaggtgg gaaagacgag atcaaactaa 5340 atctcagaag gcctaaaagg ctaggtccat tccagcacta aaaactgacc agacaagtaa 5400 tggcttcaac agcttctaaa tatggacaaa gcatgctgaa agggaaggac aggtctaaca 5460 gtggtatatg aaatgaacag gaggggcaaa gctcatttct cctctgaagt tttccaaaga 5520 tgctgaggag gacattagtt tgacatgacc ctgatatggg acaagataat ttcacagaag 5580 ttttacatgt taaagttttc ttatagatac tcattcaagt aagcaatgaa cactaaaatc 5640 taaagaaaga aaagagcttt agagtcaggt ctgtattcaa attcaagctc taccacttac 5700 tggttctgtg actttgggca agtcttttaa ccttattaag tcttaatttc ctgatttgta 5760 aaatggggat atcgtctccc tcacaggatt gttgtgaaac ttttatgaga ttaatgcctt 5820 tatatttggc atagtgtaag taaacaataa ctggcagctt caaaaaaaaa aagcagtagc 5880 attccatcat ttattattgg ttactctcaa aaagtttttc aatgtactag aagataaata 5940 ttcaaatacc ttaatatctc cattattttc aggtaaacag catgctcctg aacaaccaat 6000 gggtcaacaa ataaattaaa agggaaatct aaaaacatct tgatattaaa ctacatggaa 6060 gcacaatata ccaaaaccaa tggttcacac taggagaatt ttaaggtaca agaaaactct 6120 ttgagatttc ttaaaataat agtatgtctg aatttattga gtgatttacc agaaactgtt 6180 gtaagagctc tacttgcatt atagcactta atcctcttaa ctctatggct gctattatca 6240 acctcaccct aatcacatat gggacacaga gaggttaagt aacttgccca aggtcagagt 6300 taggaagtac taagccatgc tttgaatcag ttgtcaggct ccggaactca cactttcagc 6360 cactacataa tactgctttg ctatctttta ggaaactatg tgagtctacc tcacatagac 6420 tcacataggt ttgttttttt ttttttttta aaggctatct tttcccccat caatgttttt 6480 tgaaggatcc caaattagag tcccacagag gcagacagca gtacttgaca atatggacat 6540 ttaaggttaa tgttggattc tactgtcttt ttactacatg acctagggaa cgataattaa 6600 cctagactgc ttccaagggt taaataaccc atttagttat actatgtaaa ttatctctta 6660 gtgattgatt gaaagcacac tgttactaat tgactcggta tgaagtgctt ttttttcttc 6720 cctttcaaga tacatacctt tccagttaaa gttgagagat catctccacc aattactttt 6780 atgtcccctg ttgactggtc attctagtta aaaaaaaaaa aaactatata tatatatatc 6840 tacacacaca tatgtatatg tatatcctta tgtacacaca caaacttcaa attaaatgag 6900 aactagaaga tttgagaagt tagctagcta atatccatag cattatgata ttctaaatga 6960 tatgaattat aagaattagg tttcctgaaa tgaatgacta gaaaactttc aagtagagat 7020 tagtaaaaat taaaaagtcc taatcggcca ttactgattt gatgttttta agagtcctaa 7080 aaaatgggtt acatccattt ttaagtgggt agtattataa cagccaccca tcttcaatca 7140 cagtgatttc tgaattgtga gggaagttat tagcatgaca ggtgtctggt tctggccctg 7200 tacgattccc atgagtcaag caaattgtaa gggctggtct atatcacacc caaccccaag 7260 gatatgtccc tcaaaagtct agcccaggcc ccgtcatctt cagcatcatc tgggaaacca 7320 ggtctgatta gtagtccttt aaggaatacc tcttaggctc ccattttact gctatcacag 7380 aatccaataa aacccttaca ggagattcaa tgggaaatgc tcaacaccca ctgtagttgg 7440 tggtgacaat gaccataatt tggctgtgct ggattcagga cagaaaattt gggtgaaaga 7500 gcaggtgaac aaaagagctt cgacttgccc tagcagagag caagccatac cataccacaa 7560 agccacagca attacaacgg tgcagtacca gcacagtaaa tgaacaaagt agagcccaga 7620 aacagaccca gaactatatg aggatttagt atacaataaa gatggtattt cgagtcagta 7680 gggaaaagat gaattattca ataaatgatg tttggccaac tagtaacGca tttgggaaaa 7740 aataaaagta tggtccctac ctcacagcat acacaaaaat aaattccaga cggattaaaa 7800 tctaaatgta aaaaataaag ccataagtgg actggaagaa aatagagaat tttttttaac 7860 atccgtagaa agggtaaaaa cccaggcatg acatgaacca aaactgaaga ggttctgtaa 7920 caaatacccc cttttatata ttgggctcca acaataagaa cccataggaa aatggagaat 7980 gaacacaaat agacaattta tagaagagaa ggttataagg tgtaaaatta tatctatctg 8040 agaaacaaac actaaaacaa tgtgattcta ctgttctccc acccatactg gcaaaactta 8100 agcctgataa tatgctgagg ggaaataagc actcttgttg gtgagagtat taattggcat 8160 agcttctttt gaaaatgaca tagcaatacc tgttaaaatt gcaaacatgc atgtcactta 8220 atccagtaat cccacttctg ggaatcaatg ctacaaaaac actgacaagt atacaaagat 8280 acattcaaga gtgttcactg ggccgggtgc ggtggcttca tgcctgtaat cccagggagg 8340 cagaggcaag acgatcgctt gaccccagga gttcaaggcc agcccgagaa acacagcaag 8400 accctgtctc tctttttttt atttaaaaaa taaatgttca ctgtatcagt tgttcacaaa 8460 aacaaaccaa catgtccatt aacagggaac catttaaatt aatcaagttc atctacacaa 8520 tgtaatacca tgcaactatt aaaaagcacc tgataatcca aagcacactg agacagaata 8580 atgctattaa aaacaccaag tagtggaaca ctgtgttgcc tatgacacca tttttattca 8640 acatttaaac aaatttgtaa cagcaattac atgagtagtg acaatggcgt ttatgagact 8700 tttcactttt atgtgcttct atttttgtta tgcttctata tatacatcca tttattatgg 8760 agtgttactt tcaaaaatca caaatgggcc agtattattt ggtgttgcaa ggtgagcata 8820 tgacttctga tatcaacctt tgcatattac ttctcaattt agggaaatta cagacatccc 8880 ttattctaac taacttaaaa cccagcattt caaacataca gaattgatgg ggaaaaaaaa 8940 gaaagaagaa agaaagaaaa ggcaacaagc ttcagatgac agtgactcac atcaaattat 9000 ttataaaatc tgttaaatag tgccatcttc tggagatacc tggtattaca gtccaactcc 9060 agttgatgtc tttacagaga caagaggaat aaaggaaaaa atattcaaga actgaaaagt 9120 atggagtcat ggaaaaattg ctgtgatcca aaggctacgg tgataggaca agaaacaaga 9180 gaactccaag cagtaagaca ctgctgttct attagcatcc aaacctccat actcctgttt 9240 gccccaaggc ttttttaaaa aatagagaca ggatctcact attttgctca ggctggtctt 9300 gaactcctgg actcaagcta tcctcctgcc tcggcctcct aaagtgccga gattacaggc 9360 ttgagtcacc atacctggct atttattttt tcttaactct cttgcctggc ctatagccac 9420 catggaagct aataaagaat attaatttaa gagtaatggt atagttcact acattggaat 9480 acaggtataa gtgcctacat tgtacatgaa tggcatacat ggatcaatta ccccacctgg 9540 gtggccaaag gaactgcgcg aacctccctc cttggctgtc tggaacaagc ttcccactag 9600 atccctttac tgagtgcctc cctcatcttt aattatggtt aagtctagga taacaggact 9660 ggcaaaggtg aggggaaagc ttcctccaga gttgctctac cctctcctct accgtcctat 9720 ctcctcactc ctctcagcca aggagtccaa tctgtcctga actcagagcg tcactgtcaa 9780 ctacataaaa ttgccagaga agctctttgg gactacaaac acataccctt aatgtcttta 9840 tttctatttt gtctacctct tcagtctagg tgaaaaaata ggaaggataa tagggaagaa 9900 ctttgtttat gcctacttat ccgcccctag gaattttgaa aacctctagg tagcaataag 9960 aactgcagca tggtatagaa aaagaggagg aaagctgtat agaaatgcat aataaatggg 10020 caggaaaaga actgcttgga acaaacaggg aggttgaact ataaggagag aaagcagaga 10080 ggctaatcaa caaggctggg ttcccaagag ggcatgatga gactattact aaggtaggaa 10140 ttactaaggg ctccatgtcc ccttagtggc ttagtactat gtagcttgct ttctgcagtg 10200 aacttcagac ccttctttta ggatcctaga atggactttt tttttttatc ggaaaacagt 10260 cattctctca acattcaagc aggccccaag tctaccacac tcaatcacat tttctcttca 10320 tatcataatc tctcaaccat tctctgtcct tttaactgtt tttctatacc ctgatcaaat 10380 gccaacaaaa gtgagaatgt tagaatcatg tatttttaga ggtagactgt atctcagata 10440 aaaaaaaagg gcagatattc cattttccaa aatatgtatg cagaaaaaat aagtatgaaa 10500 ggacatatgc tcaggtaaca agttaatttg tttacttgta ttttatgaat tccctaaaac 10560 ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac cccctcatta 10620 tcatattggc ttcaatccaa aataaggtat attattgatg atgttaatta acatgcatgg 10680 atccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc 10740 tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta 10800 tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag 10860 aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg 10920 tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg 10980 tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg 11040 cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga 11100 agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc 11160 tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt 11220 aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact 11280 ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg 11340 cctaactacg gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt 11400 accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt 11460 ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct 11520 ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg 11580 gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt 11640 aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt 11700 gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc 11760 gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg 11820 cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc 11880 gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg 11940 gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctgca 12000 gccatgagat tatcaaaaag gatcttcacc tagatccttt tcacgtagaa agccagtccg 12060 cagaaacggt gctgaccccg gatgaatgtc agctactggg ctatctggac aagggaaaac 12120 gcaagcgcaa agagaaagca ggtagcttgc agtgggctta catggcgata gctagactgg 12180 gcggttttat ggacagcaag cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt 12240 gggaagccct gcaaagtaaa ctggatggct ttcttgccgc caaggatctg atggcgcagg 12300 ggatcaagct ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga 12360 ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa 12420 cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt 12480 ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaagacga ggcagcgcgg 12540 ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa 12600 gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac 12660 cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt 12720 gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact 12780 cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg 12840 ccagccgaac tgttcgccag gctcaaggcg agcatgcccg acggcgagga tctcgtcgtg 12900 acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc 12960 atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt 13020 gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc 13080 gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgaatt 13140 ttgttaaaat ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat 13200 cccttataaa tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa 13260 gagtccacta ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg 13320 cgatggccca ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa 13380 agcactaaat cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc 13440 gaacgtggcg agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag 13500 tgtagcggtc acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg 13560 cgcgtccatt cgccattcag gatcgaatta attcttaatt aa 13602

<400> 2

Met Leu GIy VaI Leu VaI Leu GIy Ala Leu Ala Leu Ala GIy Leu GIy

1 5 10 15

Phe Pro Ala Pro Ala GIu Pro GIn Pro GIy GIy Ser GIn Cys VaI GIu

20 25 30

His Asp Cys Phe Ala Leu Tyr Pro GIy Pro Ala Thr Phe Leu Asn Ala

35 40 45

Ser GIn lie Cys Asp GIy Leu Arg GIy His Leu Met Thr VaI Arg Ser

50 55 60

Ser VaI Ala Ala Asp VaI He Ser Leu Leu Leu Asn GIy Asp GIy GIy

65 70 75 80

VaI GIy Arg Arg Arg Leu Trp He GIy Leu GIn Leu Pro Pro GIy Cys 85 90 95

GIy Asp Pro Lys Arg Leu GIy Pro Leu Arg GIy Phe GIn Trp VaI Thr 100 105 110

GIy Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 115 120 125

GIy Ala Pro Leu Cys GIy Pro Leu Cys VaI Ala VaI Ser Ala Ala GIu

130 135 140

Ala Thr VaI Pro Ser GIu Pro He Trp GIu GIu GIn GIn Cys GIu VaI

145 150 155 160

Lys Ala Asp GIy Phe Leu Cys GIu Phe His Phe Pro Ala Thr Cys Arg 165 170 175

Pro Leu Ala VaI GIu Pro GIy Ala Ala Ala Ala Ala VaI Ser He Thr 180 185 190

Tyr GIy Thr Pro Phe Ala Ala Arg GIy Ala Asp Phe GIn Ala Leu Pro 195 200 205

VaI GIy Ser Ser Ala Ala VaI Ala Pro Leu GIy Leu GIn Leu Met Cys

210 215 220

Thr Ala Pro Pro GIy Ala VaI GIn GIy His Trp Ala Arg GIu Ala Pro

225 230 235 240

GIy Ala Trp Asp Cys Ser VaI GIu Asn GIy GIy Cys GIu His Ala Cys 245 250 255 Asn Ala lie Pro GIy Ala Pro Arg Cys GIn Cys Pro Ala GIy Ala Ala 260 265 270 Leu GIn Ala Asp GIy Arg Ser Cys Thr Ala Ser Ala Thr GIn Ser Cys 275 280 285

Asn Asp Leu Cys GIu His Phe Cys VaI Pro Asn Pro Asp GIn Pro GIy 290 295 300

Ser Tyr Ser Cys Met Cys GIu Thr GIy Tyr Arg Leu Ala Ala Asp GIn 305 310 315 320 His Arg Cys GIu Asp VaI Asp Asp Cys He Leu GIu Pro Ser Pro Cys 325 330 335

Pro GIn Arg Cys VaI Asn Thr GIn GIy GIy Phe GIu Cys His Cys Tyr 340 345 350 Pro Asn Tyr Asp Leu VaI Asp GIy GIu Cys VaI GIu Pro VaI Asp Pro 355 360 365

Cys Phe Arg Ala Asn Cys GIu Tyr Gin Cys GIn Pro Leu Asn GIn Thr 370 375 380

Ser Tyr Leu Cys VaI Cys Ala GIu GIy Phe Ala Pro He Pro His GIu 385 390 395 400 Pro His Arg Cys GIn Met Phe Cys Asn GIn Thr Ala Cys Pro Ala Asp 405 410 415

Cys Asp Pro Asn Thr GIn Ala Ser Cys GIu Cys Pro GIu GIy Tyr He 420 425 430 Leu Asp Asp GIy Phe He Cys Thr Asp He Asp GIu Cys GIu Asn GIy 435 440 445

GIy Phe Cys Ser GIy VaI Cys His Asn Leu Pro GIy Thr Phe GIu Cys 450 455 460 lie Cys GIy Pro Asp Ser Ala Leu Ala Arg His He GIy Thr Asp Cys 465 470 475 480 Asp Ser GIy Lys VaI Asp GIy GIy Asp Ser GIy Ser GIy GIu Pro Pro 485 490 495

Pro Ser Pro Thr Pro GIy Ser Thr Leu Thr Pro Pro Ala VaI GIy Leu 500 505 510 VaI His Ser GIy Leu Leu He GIy He Ser He Ala Ser Leu Cys Leu 515 520 525

VaI VaI Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys GIn GIy 530 535 540

Ala Ala Arg Ala Lys Met GIu Tyr Lys Cys Ala Ala Pro Ser Lys GIu 545 550 555 560 VaI VaI Leu GIn His VaI Arg Thr GIu Arg Thr Pro GIn Arg Leu 565 570 575

<400> 3 atgcttgggg tcctggtcct tggcgcgctg gccctggccg gcctggggtt ccccgcaccc 60 gcagagccgc agccgggtgg cagccagtgc gtcgagcacg actgcttcgc gctctacccg 120 ggccccgcga ccttcctcaa tgccagtcag atctgcgacg gactgcgggg ccacctaatg 180 acagtgcgct cctcggtggc tgccgatgtc atttccttgc tactgaacgg cgacggcggc 240 gttggccgcc ggcgcctctg gatcggcctg cagctgccac ccggctgcgg cgaccccaag 300 cgcctcgggc ccctgcgcgg cttccagtgg gttacgggag acaacaacac cagctatagc 360 aggtgggcac ggctcgacct caatggggct cccctctgcg gcccgttgtg cgtcgctgtc 420 tccgctgctg aggccactgt gcccagcgag ccgatctggg aggagcagca gtgcgaagtg 480 aaggccgatg gcttcctctg cgagttccac ttcccagcca cctgcaggcc actggctgtg 540 gagcccggcg ccgcggctgc cgccgtctcg atcacctacg gcaccccgtt cgcggcccgc 600 ggagcggact tccaggcgct gccggtgggc agctccgccg cggtggctcc cctcggctta 660 cagctaatgt gcaccgcgcc gcccggagcg gtccaggggc actgggccag ggaggcgccg 720 ggcgcttggg actgcagcgt ggagaacggc ggctgcgagc acgcgtgcaa tgcgatccct 780 ggggctcccc gctgccagtg cccagccggc gccgccctgc aggcagacgg gcgctcctgc 840 accgcatccg cgacgcagtc ctgcaacgac ctctgcgagc acttctgcgt tcccaacccc 900 gaccagccgg gctcctactc gtgcatgtgc gagaccggct accggctggc ggccgaccaa 960 caccggtgcg aggacgtgga tgactgcata ctggagccca gtccgtgtcc gcagcgctgt 1020 gtcaacacac agggtggctt cgagtgccac tgctacccta actacgacct ggtggacggc 1080 gagtgtgtgg agcccgtgga cccgtgcttc agagccaact gcgagtacca gtgccagccc 1140 ctgaaccaaa ctagctacct ctgcgtctgc gccgagggct tcgcgcccat tccccacgag 1200 ccgcacaggt gccagatgtt ttgcaaccag actgcctgtc cagccgactg cgaccccaac 1260 acccaggcta gctgtgagtg ccctgaaggc tacatcctgg acgacggttt catctgcacg 1320 gacatcgacg agtgcgaaaa cggcggcttc tgctccgggg tgtgccacaa cctccccggt 1380 accttcgagt gcatctgcgg gcccgactcg gcccttgccc gccacattgg caccgactgt 1440 gactccggca aggtggacgg tggcgacagc ggctctggcg agcccccgcc cagcccgacg 1500 cccggctcca ccttgactcc tccggccgtg gggctcgtgc attcgggctt gctcataggc 1560 atctccatcg cgagcctgtg cctggtggtg gcgcttttgg cgctcctctg ccacctgcgc 1620 aagaagcagg gcgccgccag ggccaagatg gagtacaagt gcgcggcccc ttccaaggag 1680 gtagtgctgc agcacgtgcg gaccgagcgg acgccgcaga gactc 1725

<400> 4 tctagacgcg ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat 60 tagttcatag cccatgatat catatggagt tccgcgttac ataacttacg gtaaatggcc 120 cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca 180 tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg 240 cccacttggc agtacatcaa gtgtatcata tgccaagtac gcccccctat tgacgtcaat 300 gacggtaaat ggcccgcctg gcattatgcc cagtncatga ccttatggga ctttcctact 360 tggcagacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca 420 tcaatgggcg tggatagcgg tttgactcac ggggattttc caagtctcca ccccattgac 480 gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac 540 tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga 600 gctctctggc taactagaga acccctgctt actggcttat cgagatatc 649

<400> 5 ggcagcgcgc agcggcaaga agtgtctggg ctgggacgga caggagaggc tgtcgccatc 60 ggcgtcctgt gcccctctgc tccggcacgg ccctgtcgca gtgcccgcgc tttccccggc 120 gcctgcacgc ggcgcgcctg ggtaacatgc ttggggtcct ggtccttggc gcgctggccc 180 tggccggcct ggggttcccc gcacccgcag agccgcagcc gggtggcagc cagtgcgtcg 240 agcacgactg cttcgcgctc tacccgggcc ccgcgacctt cctcaatgcc agtcagatct 300 gcgacggact gcggggccac ctaatgacag tgcgctcctc ggtggctgcc gatgtcattt 360 ccttgctact gaacggcgac ggcggcgttg gccgccggcg cctctggatc ggcctgcagc 420 tgccacccgg ctgcggcgac cccaagcgcc tcgggcccct gcgcggcttc cagtgggtta 480 cgggagacaa caacaccagc tatagcaggt gggcacggct cgacctcaat ggggctcccc 540 tctgcggccc gttgtgcgtc gctgtctccg ctgctgaggc cactgtgccc agcgagccga 600 tctgggagga gcagcagtgc gaagtgaagg ccgatggctt cctctgcgag ttccacttcc 660 cagccacctg caggccactg gctgtggagc ccggcgccgc ggctgccgcc gtctcgatca 720 cctacggcac cccgttcgcg gcccgcggag cggacttcca ggcgctgccg gtgggcagct 780 ccgccgcggt ggctcccctc ggcttacagc taatgtgcac cgcgccgccc ggagcggtcc 840 aggggcactg ggccagggag gcgccgggcg cttgggactg cagcgtggag aacggcggct 900 gcgagcacgc gtgcaatgcg atccctgggg ctccccgctg ccagtgccca gccggcgccg 960 ccctgcaggc agacgggcgc tcctgcaccg catccgcgac gcagtcctgc aacgacctct 1020 gcgagcactt ctgcgttccc aaccccgacc agccgggctc ctactcgtgc atgtgcgaga 1080 ccggctaccg gctggcggcc gaccaacacc ggtgcgagga cgtggatgac tgcatactgg 1140 agcccagtcc gtgtccgcag cgctgtgtca acacacaggg tggcttcgag tgccactgct 1200 accctaacta cgacctggtg gacggcgagt gtgtggagcc cgtggacccg tgcttcagag 1260 ccaactgcga gtaccagtgc cagcccctga accaaactag ctacctctgc gtctgcgccg 1320 agggcttcgc gcccattccc cacgagccgc acaggtgcca gatgttttgc aaccagactg 1380 cctgtccagc cgactgcgac cccaacaccc aggctagctg tgagtgccct gaaggctaca 1440 tcctggacga cggtttcatc tgcacggaca tcgacgagtg cgaaaacggc ggcttctgct 1500 ccggggtgtg ccacaacctc cccggtacct tcgagtgcat ctgcgggccc gactcggccc 1560 ttgcccgcca cattggcacc gactgtgact ccggcaaggt ggacggtggc gacagcggct 1620 ctggcgagcc cccgcccagc ccgacgcccg gctccacctt gactcctccg gccgtggggc 1680 tcgtgcattc gggcttgctc ataggcatct ccatcgcgag cctgtgcctg gtggtggcgc 1740 ttttggcgct cctctgccac ctgcgcaaga agcagggcgc cgccagggcc aagatggagt 1800 acaagtgcgc ggccccttcc aaggaggtag tgctgcagca cgtgcggacc gagcggacgc 1860 cgcagagact ctgagcggcc tccgtccagg agcctggctc cgtccaggag cctgtgcctc 1920 ctcaccccca gctttgctac caaagcacct tagctggcat tacagctgga gaagaccctc 1980 cccgcacccc ccaagctgtt ttcttctatt ccatggctaa ctggcgaggg ggtgattaga 2040 gggaggagaa tgagcctcgg cctcttccgt gacgtcactg gaccactggg caatgatggc 2100 aattttgtaa cgaagacaca gactgcgatt tgtcccaggt cctcactacc gggcgcagga 2160 gggtgagcgt tattggtcgg cagccttctg ggcagacctt gacctcgtgg gctagggatg 2220 actaaaatat ttattttttt taagtattta ggtttttgtt tgtttccttt gttcttacct 2280 gtatgtctcc agtatccact ttgcacagct ctccggtctc tctctctcta caaactccca 2340 cttgtcatgt gacaggtaaa ctatcttggt gaattttttt ttcctagccc tctcacattt 2400 atgaagcaag ccccacttat tccccattct tcctagtttt ctcctcccag gaactgggcc 2460 aactcacctg agtcacccta cctgtgcctg accctacttc ttttgctctt agctgtctgc 2520 tcagacagaa cccctacatg aaacagaaac aaaaacacta aaaataaaaa tggccatttg 2580 ctttttcacc agatttgcta atttatcctg aaatttcaga ttcccagagc aaaataattt 2640 taaacaaagg ttgagatgta aaaggtatta aattgatgtt gctggactgt catagaaatt 2700 acacccaaag aggtatttat ctttactttt aaacagtgag cctgaatttt gttgctgttt 2760 tgatttgtac tgaaaaatgg taattgttgc taatcttctt atgcaatttc cttttttgtt 2820 attattactt atttttgaca gtgttgaaaa tgttcagaag gttgctctag attgagagaa 2880 gagacaaaca cctcccagga gacagttcaa gaaagcttca aactgcatga ttcatgccaa 2940 ttagcaattg actgtcactg ttccttgtca ctggtagacc aaaataaaac cagctctact 3000 ggtcttgtgg aattgggagc ttgggaatgg atcctggagg atgcccaatt agggcctagc 3060 cttaatcagg tcctcagaga atttctacca tttcagagag gccttttgga atgtggcccc 3120 tgaacaagaa ttggaagctg ccctgcccat gggagctggt tagaaatgca gaatcctagg 3180 ctccacccca tccagttcat gagaatctat atttaacaag atctgcaggg ggtgtgtctg 3240 ctcagtaatt tgaggacaac cattccagac tgcttccaat tttctggaat acatgaaata 3300 tagatcagtt ataagtagca ggccaagtca ggcccttatt ttcaagaaac tgaggaattt 3360 tctttgtgta gctttgctct ttggtagaaa aggctaggta cacagctcta gacactgcca 3420 cacagggtct gcaaggtctt tggttcagct aagctaggaa tgaaatcctg cttcagtgta 3480 tggaaataaa tgtatcatag aaatgtaact tttgtaagac aaaggttttc ctcttctatt 3540 ttgtaaactc aaaatatttg tacatagtta tttatttatt ggagataatc tagaacacag 3600 gcaaaatcct tgcttatgac atcacttgta caaaataaac aaataacaat gtgaaaaaaa 3660 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3693

<400> 6 gtttaaacgg gccctctaga cgcgttgaca ttgattattg actagttatt aatagtaatc 60 aattacgggg tcattagttc atagcccatg atatcatatg gagttccgcg ttacataact 120 tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat 180 gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta 240 tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc 300 ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtnc atgaccttat 360 gggactttcc tacttggcag acatctacgt attagtcatc gctattacca tggtgatgcg 420 gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat tttccaagtc 480 tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa 540 aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg 600 tctatataag cagagctctc tggctaacta gagaacccct gcttactggc ttatcgagat 660 atctgcagaa ttcatctgtc gactgctacc ggcagcgcgc agcggcaaga agtgtctggg 720 ctgggacgga caggagaggc tgtcgccatc ggcgtcctgt gcccctctgc tccggcacgg 780 ccctgtcgca gtgcccgcgc tttccccggc gcctgcacgc ggcgcgcctg ggtaacatgc 840 ttggggtcct ggtccttggc gcgctggccc tggccggcct ggggttcccc gcacccgcag 900 agccgcagcc gggtggcagc cagtgcgtcg agcacgactg cttcgcgctc tacccgggcc 960 ccgcgacctt cctcaatgcc agtcagatct gcgacggact gcggggccac ctaatgacag 1020 tgcgctcctc ggtggctgcc gatgtcattt ccttgctact gaacggcgac ggcggcgttg 1080 gccgccggcg cctctggatc ggcctgcagc tgccacccgg ctgcggcgac cccaagcgcc 1140 tcgggcccct gcgcggcttc cagtgggtta cgggagacaa caacaccagc tatagcaggt 1200 gggcacggct cgacctcaat ggggctcccc tctgcggccc gttgtgcgtc gctgtctccg 1260 ctgctgaggc cactgtgccc agcgagccga tctgggagga gcagcagtgc gaagtgaagg 1320 ccgatggctt cctctgcgag ttccacttcc cagccacctg caggccactg gctgtggagc 1380 ccggcgccgc ggctgccgcc gtctcgatca cctacggcac cccgttcgcg gcccgcggag 1440 cggacttcca ggcgctgccg gtgggcagct ccgσcgcggt ggctcccctc ggcttacagc 1500 taatgtgcac cgcgccgccc ggagcggtcc aggggcactg ggccagggag gcgccgggcg 1560 cttgggactg cagcgtggag aacggcggct gcgagcacgc gtgcaatgcg atccctgggg 1620 ctccccgctg ccagtgccca gccggcgccg ccctgcaggc agacgggcgc tcctgcaccg 1680 catccgcgac gcagtcctgc aacgacctct gcgagcactt ctgcgttccc aaccccgacc 1740 agccgggctc ctactcgtgc atgtgcgaga ccggctaccg gctggcggcc gaccaacacc 1800 ggtgcgagga cgtggatgac tgcatactgg agcccagtcc gtgtccgcag cgctgtgtca 1860 acacacaggg tggcttcgag tgccactgct accctaacta cgacctggtg gacggcgagt 1920 gtgtggagcc cgtggacccg tgcttcagag ccaactgcga gtaccagtgc cagcccctga 1980 accaaactag ctacctctgc gtctgcgccg agggcttcgc gcccattccc cacgagccgc 2040 acaggtgcca gatgttttgc aaccagactg cctgtccagc cgactgcgac cccaacaccc 2100 aggctagctg tgagtgccct gaaggctaca tcctggacga cggtttcatc tgcacggaca 2160 tcgacgagtg cgaaaacggc ggcttctgct ccggggtgtg ccacaacctc cccggtacct 2220 tcgagtgcat ctgcgggccc gactcggccc ttgcccgcca cattggcacc gactgtgact 2280 ccggcaaggt ggacggtggc gacagcggct ctggcgagcc cccgcccagc ccgacgcccg 2340 gctccacctt gactcctccg gccgtggggc tcgtgcattc gggcttgctc ataggcatct 2400 ccatcgcgag cctgtgcctg gtggtggcgc ttttggcgct cctctgccac ctgcgcaaga 2460 agcagggcgc cgccagggcc aagatggagt acaagtgcgc ggccccttcc aaggaggtag 2520 tgctgcagca cgtgcggacc gagcggacgc cgcagagact ctgagcggcc tccgtccagg 2580 agcctggctc cgtccaggag cctgtgcctc ctcaccccca gctttgctac caaagcacct 2640 tagctggcat tacagctgga gaagaccctc cccgcacccc ccaagctgtt ttcttctatt 2700 ccatggctaa ctggcgaggg ggtgattaga gggaggagaa tgagcctcgg cctcttccgt 2760 gacgtcactg gaccactggg caatgatggc aattttgtaa cgaagacaca gactgcgatt 2820 tgtcccaggt cctcactacc gggcgcagga gggtgagcgt tattggtcgg cagccttctg 2880 ggcagacctt gacctcgtgg gctagggatg actaaaatat ttattttttt taagtattta 2940 ggtttttgtt tgtttccttt gttcttacct gtatgtctcc agtatccact ttgcacagct 3000 ctccggtctc tctctctcta caaactccca cttgtcatgt gacaggtaaa ctatcttggt 3060 gaattttttt ttcctagccc tctcacattt atgaagcaag ccccacttat tccccattct 3120 tcctagtttt ctcctcccag gaactgggcc aactcacctg agtcacccta cctgtgcctg 3180 accctacttc ttttgctctt agctgtctgc tcagacagaa cccctacatg aaacagaaac 3240 aaaaacacta aaaataaaaa tggccatttg ctttttcacc agatttgcta atttatcctg 3300 aaatttcaga ttcccagagc aaaataattt taaacaaagg ttgagatgta aaaggtatta 3360 aattgatgtt gctggactgt catagaaatt acacccaaag aggtatttat ctttactttt 3420 aaacagtgag cctgaatttt gttgctgttt tgatttgtac tgaaaaatgg taattgttgc 3480 taatcttctt atgcaatttc cttttttgtt attattactt atttttgaca gtgttgaaaa 3540 tgttcagaag gttgctctag attgagagaa gagacaaaca cctcccagga gacagttcaa 3600 gaaagcttca aactgcatga ttcatgccaa ttagcaattg actgtcactg ttccttgtca 3660 ctggtagacc aaaataaaac cagctctact ggtcttgtgg aattgggagc ttgggaatgg 3720 atcctggagg atgcccaatt agggcctagc cttaatcagg tcctcagaga atttctacca 3780 tttcagagag gccttttgga atgtggcccc tgaacaagaa ttggaagctg ccctgcccat 3840 gggagctggt tagaaatgca gaatcctagg ctccacccca tccagttcat gagaatctat 3900 atttaacaag atctgcaggg ggtgtgtctg ctcagtaatt tgaggacaac cattccagac 3960 tgcttccaat tttctggaat acatgaaata tagatcagtt ataagtagca ggccaagtca 4020 ggcccttatt ttcaagaaac tgaggaattt tctttgtgta gctttgctct ttggtagaaa 4080 aggctaggta cacagctcta gacactgcca cacagggtct gcaaggtctt tggttcagct 4140 aagctaggaa tgaaatcctg cttcagtgta tggaaataaa tgtatcatag aaatgtaact 4200 tttgtaagac aaaggttttc ctcttctatt ttgtaaactc aaaatatttg tacatagtta 4260 tttatttatt ggagataatc tagaacacag gcaaaatcct tgcttatgac atcacttgta 4320 caaaataaac aaataacaat gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4380 aaaggtagca gtcgacagat gaattccacc acactggact agtggatccg agctcggtac 4440 caagcttaag tttaaac 4457

<400> 7 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tactggtacc gcggccgcct 360 cgagtctaga actagtggat cccccaaacg ggccctctag acgcgttgac attgattatt 420 gactagttat taatagtaat caattacggg gtcattagtt catagcccat gatatcatat 480 ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc 540 ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca 600 ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta 660 tcatatgcca agtacgcccc cctattgacg tcaatgacgg taaatggccc gcctggcatt 720 atgcccagtn catgacctta tgggactttc ctacttggca gacatctacg tattagtcat 780 cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga 840 ctcacgggga ttttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc 900 aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg 960 gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaacccc 1020 tgcttactgg cttatcgaga tatctgcaga attcatctgt cgactgctac cggcagcgcg 1080 cagcggcaag aagtgtctgg gctgggacgg acaggagagg ctgtcgccat cggcgtcctg 1140 tgcccctctg ctccggcacg gccctgtcgc agtgcccgcg ctttccccgg cgcctgcacg 1200 cggcgcgcct gggtaacatg cttggggtcc tggtccttgg cgcgctggcc ctggccggcc 1260 tggggttccc cgcacccgca gagccgcagc cgggtggcag ccagtgcgtc gagcacgact 1320 gcttcgcgct ctacccgggc cccgcgacct tcctcaatgc cagtcagatc tgcgacggac 1380 tgcggggcca cctaatgaca gtgcgctcct cggtggctgc cgatgtcatt tccttgctac 1440 tgaacggcga cggcggcgtt ggccgccggc gcctctggat cggcctgcag ctgccacccg 1500 gctgcggcga ccccaagcgc ctcgggcccc tgcgcggctt ccagtgggtt acgggagaca 1560 acaacaccag ctatagcagg tgggcacggc tcgacctcaa tggggctccc ctctgcggcc 1620 cgttgtgcgt cgctgtctcc gctgctgagg ccactgtgcc cagcgagccg atctgggagg 1680 agcagcagtg cgaagtgaag gccgatggct tcctctgcga gttccacttc ccagccacct 1740 gcaggccact ggctgtggag cccggcgccg cggctgccgc cgtctcgatc acctacggca 1800 ccccgttcgc ggcccgcgga gcggacttcc aggcgctgcc ggtgggcagc tccgccgcgg 1860 tggctcccct cggcttacag ctaatgtgca ccgcgccgcc cggagcggtc caggggcact 1920 gggccaggga ggcgccgggc gcttgggact gcagcgtgga gaacggcggc tgcgagcacg 1980 cgtgcaatgc gatccctggg gctccccgct gccagtgccc agccggcgcc gccctgcagg 2040 cagacgggcg ctcctgcacc gcatccgcga cgcagtcctg caacgacctc tgcgagcact 2100 tctgcgttcc caaccccgac cagccgggct cctactcgtg catgtgcgag accggctacc 2160 ggctggcggc cgaccaacac cggtgcgagg acgtggatga ctgcatactg gagcccagtc 2220 cgtgtccgca gcgctgtgtc aacacacagg gtggcttcga gtgccactgc taccctaact 2280 acgacctggt ggacggcgag tgtgtggagc ccgtggaccc gtgcttcaga gccaactgcg 2340 agtaccagtg ccagcccctg aaccaaacta gctacctctg cgtctgcgcc gagggcttcg 2400 cgcccattcc ccacgagccg cacaggtgcc agatgttttg caaccagact gcctgtccag 2460 ccgactgcga ccccaacacc caggctagct gtgagtgccc tgaaggctac atcctggacg 2520 acggtttcat ctgcacggac atcgacgagt gcgaaaacgg cggcttctgc tccggggtgt 2580 gccacaacct ccccggtacc ttcgagtgca tctgcgggcc cgactcggcc cttgcccgcc 2640 acattggcac cgactgtgac tccggcaagg tggacggtgg cgacagcggc tctggcgagc 2700 ccccgcccag cccgacgccc ggctccacct tgactcctcc ggccgtgggg ctcgtgcatt 2760 cgggcttgct cataggcatc tccatcgcga gcctgtgcct ggtggtggcg cttttggcgc 2820 tcctctgcca cctgcgcaag aagcagggcg ccgccagggc caagatggag tacaagtgcg 2880 cggccccttc caaggaggta gtgctgcagc acgtgcggac cgagcggacg ccgcagagac 2940 tctgagcggc ctccgtccag gagcctggct ccgtccagga gcctgtgcct cctcaccccc 3000 agctttgcta ccaaagcacc ttagctggca ttacagctgg agaagaccct ccccgcaccc 3060 cccaagctgt tttcttctat tccatggcta actggcgagg gggtgattag agggaggaga 3120 atgagcctcg gcctcttccg tgacgtcact ggaccactgg gcaatgatgg caattttgta 3180 acgaagacac agactgcgat ttgtcccagg tcctcactac cgggcgcagg agggtgagcg 3240 ttattggtcg gcagccttct gggcagacct tgacctcgtg ggctagggat gactaaaata 3300 tttatttttt ttaagtattt aggtttttgt ttgtttcctt tgttcttacc tgtatgtctc 3360 cagtatccac tttgcacagc tctccggtct ctctctctct acaaactccc acttgtcatg 3420 tgacaggtaa actatcttgg tgaatttttt tttcctagcc ctctcacatt tatgaagcaa 3480 gccccactta ttccccattc ttcctagttt tctcctccca ggaactgggc caactcacct 3540 gagtcaccct acctgtgcct gaccctactt cttttgctct tagctgtctg ctcagacaga 3600 acccctacat gaaacagaaa caaaaacact aaaaataaaa atggccattt gctttttcac 3660 cagatttgct aatttatcct gaaatttcag attcccagag caaaataatt ttaaacaaag 3720 gttgagatgt aaaaggtatt aaattgatgt tgctggactg tcatagaaat tacacccaaa 3780 gaggtattta tctttacttt taaacagtga gcctgaattt tgttgctgtt ttgatttgta 3840 ctgaaaaatg gtaattgttg ctaatcttct tatgcaattt ccttttttgt tattattact 3900 tatttttgac agtgttgaaa atgttcagaa ggttgctcta gattgagaga agagacaaac 3960 acctcccagg agacagttca agaaagcttc aaactgcatg attcatgcca attagcaatt 4020 gactgtcact gttccttgtc actggtagac caaaataaaa ccagctctac tggtcttgtg 4080 gaattgggag cttgggaatg gatcctggag gatgcccaat tagggcctag ccttaatcag 4140 gtcctcagag aatttctacc atttcagaga ggccttttgg aatgtggccc ctgaacaaga 4200 attggaagct gccctgccca tgggagctgg ttagaaatgc agaatcctag gctccacccc 4260 atccagttca tgagaatcta tatttaacaa gatctgcagg gggtgtgtct gctcagtaat 4320 ttgaggacaa ccattccaga ctgcttccaa ttttctggaa tacatgaaat atagatcagt 4380 tataagtagc aggccaagtc aggcccttat tttcaagaaa ctgaggaatt ttctttgtgt 4440 agctttgctc tttggtagaa aaggctaggt acacagctct agacactgcc acacagggtc 4500 tgcaaggtct ttggttcagc taagctagga atgaaatcct gcttcagtgt atggaaataa 4560 atgtatcata gaaatgtaac ttttgtaaga caaaggtttt cctcttctat tttgtaaact 4620 caaaatattt gtacatagtt atttatttat tggagataat ctagaacaca ggcaaaatcc 4680 ttgcttatga catcacttgt acaaaataaa caaataacaa tgtgaaaaaa aaaaaaaaaa 4740 aaaaaaaaaa aaaaaaaaaa aaaaggtagc agtcgacaga tgaattccac cacactggac 4800 tagtggatcc gagctcggta ccaagcttaa gtttgggctg caggaattct gatggctctc 4860 aaaattcctg cctcctttag ggataaaaga ctttaagact ttttaacaaa aaagaaaaag 4920 aaaaaaaaaa ttcctgcctc ctggtgtaca cacacagaag ggttccctcc ccttgaatgt 4980 gaccaggatc tgtgaaaata acgggatagc cgctcctgtg attaggttat gtggtagact 5040 agagcaagat tctcctgctg gttttgaaga agtcagctgc catgttgtga gactgtcatg 5100 ggctagggca tgagccttta aatatctggg agcaacccct ggccagcagc cagtgagaaa 5160 acgggccctc agtcctacaa tcacaaggaa ctaaattctg ccaacaacct gaaggaactt 5220 tgaagaggat catgagtccc ttgattcagc ttgatgagcc cctgagcaga ggatacagct 5280 aacttgtact agggaagtat aaaaaacatg catgggaatg atatatatca actttaagga 5340 taattgtcat acttctggga atgaagggaa agaaatgggg ctttagttgt attatgatct 5400 ttaatttctc aaaaaaaata agatcagaag caaatatggc aaaatgttaa tacttttgtg 5460 ggtacgtagg tattcagcat accctttttt ctgagttcaa aatattttat aattaaaatg 5520 aaatgcaggc caggcacagt ggctcatgcc tataatacca gcactttgcg aggccgaggt 5580 gggaggatgg cttgaggcca gaccagcctg gccaacatgg caaaacccca tctctactta 5640 aaaaaaaaaa aactatatat atatatatgt gtgtgtgtgt gtatatatat atatgtatat 5700 atatttatat atgtgtgtat atatatatat gtatatatat ttatatatgt gtgtgtatat 5760 atatatatac acacacacac atatatacat acatacatac acacacacac acacacaatt 5820 agccaggcat ggtggcgcac acctgtagtc ccagctactt gggaggctga gacatgagaa 5880 ttgcttgaac ctgggaggca gagtagttag tgagctgaga tcataccact gcactccagc 5940 ctggtgacag agtgagactc tgtcttaaaa aaaataaaaa ttaaaattaa atgcaaaagg 6000 tccaagtgaa ttgaagagga aaggggtatc aaggaaggtt ttgtggaggt gacgtttgag 6060 ctgggtctta aatgacttaa acatgggata agaagggagg gaataaggac atttcaggta 6120 cgagaaataa ggagcaaaca gtggaaacaa cctaacgtct gtcaaccagt gaatggataa 6180 caaaaatgta attcagatgg tatccaactt acgatggttc aacatgagat ttttctgact 6240 ttaggataga tttatcaaag tagtaaatcc attttcaact tatgatattt tcaacttcag 6300 atgggtttat caggacacag ttgaggaaca cctgtctatc catacaattt ggcaataaaa 6360 aggaaatgag tgcagatata ctccacaaca tgaatgaacc ttgaaaacat taagtgagag 6420 aagccagata caaaaggcca catattgtat gattctattt atacaaaatg tccagaatag 6480 gcaaatctta tagacagcaa gtaggtagat gatcagtttg ctaggtgctg ggggaagggg 6540 aaatggggag tgatggctaa ggggattggg tttctttgtg gggcaatgaa aatgttttaa 6600 aattgagcgt gataatgatt gcacaatgct gcatatatat ataatctata gattatatat 6660 atataaagag aggctgttag acagtgataa gtgatatata tatatatata catagagaga 6720 gagagagaga gagagagagg ctgttagtga taagtgatca ggaaaataaa agtattgagg 6780 aggaatacga agttgacggt gtgaaaacat gagattttat ataggatggc cagggaaggc 6840 cttaatgaga aagtgactta tgagtaaaaa caagggatcc taaaccttag catgcatcag 6900 aatcactcgg aaacttgtta aagcatagct tgctgggcct catcacagat attttgattc 6960 ggtaggttct tgtctgatat taatactttt ggtctaggga accacatttt gagaaccact 7020 gagctaaagg aagtaaaggt ttcccttagt ttactagctg gtaacactgg cccaggaggc 7080 ctttctggtg acccctaagg aattatccaa actcttgttt ttagatgctt tattatatca 7140 aactctcctt taaacaagtg gcccatctgc tgggatttgg aagcctgtaa tactgaaatt 7200 ttcatcataa tggaaatttt aaaaacagaa tttgacccac ctgtttttaa aacactttca 7260 ttacttaaca agaggtctaa tcttgggcaa gtcttgaaat ttctctggcc ttagtttccc 7320 atgtgttaaa tgaaacttga agcagttggt ctcttatagt ctcctgactc taacattcta 7380 agaattatat ttgtacaata actcaaaaat cacataattt aatttaccat atggactcca 7440 aaatatattt tctcattagg ctaaacttga tctgcatttt ctggatgtgt ccatattctt 7500 ggactacact aaaacatgat accaatgctt cctctcacca taaaccctca cttcgctttc 7560 tacatttaag aattttatag ctggaagagt ccttaacaga aaataccatc taataattac 7620 ccctcaaaat cgagaaagtc ctatctgttc ttatgctagt tataagaatg aggcagcatt 7680 tcacataatg gttataaaca ctgccacaag aagattcatg atgtgttgtt tatctgtagc 7740 tctcatcata ctctgtcata taactatagc attaagattt taatgttcta tatattcttc 7800 taagacagtg tttaccagag taaggcacaa aagatccact ggtttgcaag aaagattaga 7860 acttttaaat tttttacctc accttgttta atctatattt ttgtatgtat tttgtaacat 7920 atatattatt attaccataa atcatatata atttaaaatg catatattag gggtaaatgc 7980 tcaggaaact ttttataaat tgggcatgca aatacaagtt tgaagactca ctgttctagg 8040 tattaaaagt aaagttataa ccaagtaaag cttccacctt ttcatgtctc aaagcagttt 8100 attgttggag gtaagatctc ttagaagcct aaacaggtcc aagtacagaa tgaagtaagg 8160 ctagcccata acttgtggca agcaattcat actatttctc tcatgctgag ctctcctcag 8220 tgaagcagct actatagaca actgcagcct attggtagcc tattttacag gcaggaaaaa 8280 aattactttt tattcaaagt ggaactcagg acatggggag aaaatgaata caaaaaatag 8340 ggtcaatcca aaggcacaca gcaaatgagt aacacagtta tgtttttttc ccatttgtat 8400 gaggtcccag taaattctaa gtaaactgca aatttaataa tacactaaaa aagccatgca 8460 attgttcaaa tgaatcccag catggtacaa ggagtacaga cactagagtc taaaaaacaa 8520 aagaatgcca ttattgagtt tttgaattat atcaagtagt tacatctcta cttaataaat 8580 gagaaaaacg aggataagag gccatttgat aaaatgaaaa tagccaagaa gtggtattag 8640 agacttgaat acaggtattc gggtccaaag ttcatctgct caaatactaa ctggggaaaa 8700 gagggaaaaa tatttatata catatatatc tgcacacaaa aataccccca aaagacaaaa 8760 tgaggccagg cagggtggct cacacccgta atcccggtac tttgggaggc tgaggcaggt 8820 ggatacctga gatcaggagt tggagatcag cctggtcaac atggtgaaac cctgtctcta 8880 ctaaagataa aaaaattagc caggcatggt ggcgtgcgcc tgtaatccca gctacttggg 8940 agtctgaggc aggagaatca cttgaactgg gaaggggagg ttgcagtgag ccaagatcgt 9000 actactgcac tccagcctgg gcagcagagt gagactccat cacaaaaata aataaataaa 9060 taaaatacaa tgaaacagaa agttcaaata atcccataat cttaccacca agaaataact 9120 ttcactcgtt atacttattg atttttccat aataaatgta ctttactgtg actatcatga 9180 aaagaaagtt attttagaaa cagagaactg tttcagatca aatctatgta gtagaacaga 9240 gccattaggt gggaaagacg agatcaaact aaatctcaga aggcctaaaa ggctaggtcc 9300 attccagcac taaaaactga ccagacaagt aatggcttca acagcttcta aatatggaca 9360 aagcatgctg aaagggaagg acaggtctaa cagtggtata tgaaatgaac aggaggggca 9420 aagctcattt Gtcctctgaa gttttccaaa gatgctgagg aggacattag tttgacatga 9480 ccctgatatg ggacaagata atttcacaga agttttacat gttaaagttt tcttatagat 9540 actcattcaa gtaagcaatg aacactaaaa tctaaagaaa gaaaagagct ttagagtcag 9600 gtctgtattc aaattcaagc tctaccactt actggttctg tgactttggg caagtctttt 9660 aaccttatta agtcttaatt tcctgatttg taaaatgggg atatcgtctc cctcacagga 9720 ttgttgtgaa acttttatga gattaatgcc tttatatttg gcatagtgta agtaaacaat 9780 aactggcagc ttcaaaaaaa aaaagcagta gcattccatc atttattatt ggttactctc 9840 aaaaagtttt tcaatgtact agaagataaa tattcaaata ccttaatatc tccattattt 9900 tcaggtaaac agcatgctcc tgaacaacca atgggtcaac aaataaatta aaagggaaat 9960 ctaaaaacat cttgatatta aactacatgg aagcacaata taccaaaacc aatggttcac 10020 actaggagaa ttttaaggta caagaaaact ctttgagatt tcttaaaata atagtatgtc 10080 tgaatttatt gagtgattta ccagaaactg ttgtaagagc tctacttgca ttatagcact 10140 taatcctctt aactctatgg ctgctattat caacctcacc ctaatcacat atgggacaca 10200 gagaggttaa gtaacttgcc caaggtcaga gttaggaagt actaagccat gctttgaatc 10260 agttgtcagg ctccggaact cacactttca gccactacat aatactgctt tgctatcttt 10320 taggaaacta tgtgagtcta cctcacatag actcacatag gtttgttttt tttttttttt 10380 taaaggctat cttttccccc atcaatgttt tttgaaggat cccaaattag agtcccacag 10440 aggcagacag cagtacttga caatatggac atttaaggtt aatgttggat tctactgtct 10500 ttttactaca tgacctaggg aacgataatt aacctagact gcttccaagg gttaaataac 10560 ccatttagtt atactatgta aattatctct tagtgattga ttgaaagcac actgttacta 10620 attgactcgg tatgaagtgc ttttttttct tccctttcaa gatacatacc tttccagtta 10680 aagttgagag atcatctcca ccaattactt ttatgtcccc tgttgactgg tcattctagt 10740 taaaaaaaaa aaaaactata tatatatata tctacacaca catatgtata tgtatatcct 10800 tatgtacaca cacaaacttc aaattaaatg agaactagaa gatttgagaa gttagctagc 10860 taatatccat agcattatga tattctaaat gatatgaatt ataagaatta ggtttcctga 10920 aatgaatgac tagaaaactt tcaagtagag attagtaaaa attaaaaagt cctaatcggc 10980 cattactgat ttgatgtttt taagagtcct aaaaaatggg ttacatccat ttttaagtgg 11040 gtagtattat aacagccacc catcttcaat cacagtgatt tctgaattgt gagggaagtt 11100 attagcatga caggtgtctg gttctggccc tgtacgattc ccatgagtca agcaaattgt 11160 aagggctggt ctatatcaca cccaacccca aggatatgtc cctcaaaagt ctagcccagg 11220 ccccgtcatc ttcagcatca tctgggaaac caggtctgat tagtagtcct ttaaggaata 11280 cctcttaggc tcccatttta ctgctatcac agaatccaat aaaaccctta caggagattc 11340 aatgggaaat gctcaacacc cactgtagtt ggtggtgaca atgaccataa tttggctgtg 11400 ctggattcag gacagaaaat ttgggtgaaa gagcaggtga acaaaagagc ttcgacttgc 11460 cctagcagag agcaagccat accataccac aaagccacag caattacaac ggtgcagtac 11520 cagcacagta aatgaacaaa gtagagccca gaaacagacc cagaactata tgaggattta 11580 gtatacaata aagatggtat ttcgagtcag tagggaaaag atgaattatt caataaatga 11640 tgtttggcca actagtaacc catttgggaa aaaataaaag tatggtccct acctcacagc 11700 atacacaaaa ataaattcca gacggattaa aatctaaatg taaaaaataa agccataagt 11760 ggactggaag aaaatagaga atttttttta acatccgtag aaagggtaaa aacccaggca 11820 tgacatgaac caaaactgaa gaggttctgt aacaaatacc cccttttata tattgggctc 11880 caacaataag aacccatagg aaaatggaga atgaacacaa atagacaatt tatagaagag 11940 aaggttataa ggtgtaaaat tatatctatc tgagaaacaa acactaaaac aatgtgattc 12000 tactgttctc ccacccatac tggcaaaact taagcctgat aatatgctga ggggaaataa 12060 gcactcttgt tggtgagagt attaattggc atagcttctt ttgaaaatga catagcaata 12120 cctgttaaaa ttgcaaacat gcatgtcact taatccagta atcccacttc tgggaatcaa 12180 tgctacaaaa acactgacaa gtatacaaag atacattcaa gagtgttcac tgggccgggt 12240 gcggtggctt catgcctgta atcccaggga ggcagaggca agacgatcgc ttgaccccag 12300 gagttcaagg ccagcccgag aaacacagca agaccctgtc tctctttttt ttatttaaaa 12360 aataaatgtt cactgtatca gttgttcaca aaaacaaacc aacatgtcca ttaacaggga 12420 accatttaaa ttaatcaagt tcatctacac aatgtaatac catgcaacta ttaaaaagca 12480 cctgataatc caaagcacac tgagacagaa taatgctatt aaaaacacca agtagtggaa 12540 cactgtgttg cctatgacac catttttatt caacatttaa acaaatttgt aacagcaatt 12600 acatgagtag tgacaatggc gtttatgaga cttttcactt ttatgtgctt ctatttttgt 12660 tatgcttcta tatatacatc catttattat ggagtgttac tttcaaaaat cacaaatggg 12720 ccagtattat ttggtgttgc aaggtgagca tatgacttct gatatcaacc tttgcatatt 12780 acttctcaat ttagggaaat tacagacatc ccttattcta actaacttaa aacccagcat 12840 ttcaaacata cagaattgat ggggaaaaaa aagaaagaag aaagaaagaa aaggcaacaa 12900 gcttcagatg acagtgactc acatcaaatt atttataaaa tctgttaaat agtgccatct 12960 tctggagata cctggtatta cagtccaact ccagttgatg tctttacaga gacaagagga 13020 ataaaggaaa aaatattcaa gaactgaaaa gtatggagtc atggaaaaat tgctgtgatc 13080 caaaggctac ggtgatagga caagaaacaa gagaactcca agcagtaaga cactgctgtt 13140 ctattagcat ccaaacctcc atactcctgt ttgccccaag gcttttttaa aaaatagaga 13200 caggatctca ctattttgct caggctggtc ttgaactcct ggactcaagc tatcctcctg 13260 cctcggcctc ctaaagtgcc gagattacag gcttgagtca ccatacctgg ctatttattt 13320 tttcttaact ctcttgcctg gcctatagcc accatggaag ctaataaaga atattaattt 13380 aagagtaatg gtatagttca ctacattgga atacaggtat aagtgcctac attgtacatg 13440 aatggcatac atggatcaat taccccacct gggtggccaa aggaactgcg cgaacctccc 13500 tccttggctg tctggaacaa gcttcccact agatcccttt actgagtgcc tccctcatct 13560 ttaattatgg ttaagtctag gataacagga ctggcaaagg tgaggggaaa gcttcctcca 13620 gagttgctct accctctcct ctaccgtcct atctcctcac tcctctcagc caaggagtcc 13680 aatctgtcct gaactcagag cgtcactgtc aactacataa aattgccaga gaagctcttt 13740 gggactacaa acacataccc ttaatgtctt tatttctatt ttgtctacct cttcagtcta 13800 ggtgaaaaaa taggaaggat aatagggaag aactttgttt atgcctactt atccgcccct 13860 aggaattttg aaaacctcta ggtagcaata agaactgcag catggtatag aaaaagagga 13920 ggaaagctgt atagaaatgc ataataaatg ggcaggaaaa gaactgcttg gaacaaacag 13980 ggaggttgaa ctataaggag agaaagcaga gaggctaatc aacaaggctg ggttcccaag 14040 agggcatgat gagactatta ctaaggtagg aattactaag ggctccatgt ccccttagtg 14100 gcttagtact atgtagcttg ctttctgcag tgaacttcag acccttcttt taggatccta 14160 gaatggactt ttttttttta tcggaaaaca gtcattctct caacattcaa gcaggcccca 14220 agtctaccac actcaatcac attttctctt catatcataa tctctcaacc attctctgtc 14280 cttttaactg tttttctata ccctgatcaa atgccaacaa aagtgagaat gttagaatca 14340 tgtattttta gaggtagact gtatctcaga taaaaaaaaa gggcagatat tccattttcc 14400 aaaatatgta tgcagaaaaa ataagtatga aaggacatat gctcaggtaa caagttaatt 14460 tgtttacttg tattttatga attccctaaa acctacgtca cccgccccgt tcccacgccc 14520 cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt 14580 atattattga tgatgttaat taacatgcat ggatccatat gcggtgtgaa ataccgcaca 14640 gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc actgactcgc 14700 tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt 14760 tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg 14820 ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg 14880 agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat 14940 accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta 15000 ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct 15060 gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc 15120 ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa 15180 gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg 15240 taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag 15300 tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt 15360 gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta 15420 cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc 15480 agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca 15540 cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa 15600 cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat 15660 ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct 15720 taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt 15780 tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat 15840 ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta 15900 atagtttgcg caacgttgtt gccattgctg cagccatgag attatcaaaa aggatcttca 15960 cctagatcct tttcacgtag aaagccagtc cgcagaaacg gtgctgaccc cggatgaatg 16020 tcagctactg ggctatctgg acaagggaaa acgcaagcgc aaagagaaag caggtagctt 16080 gcagtgggct tacatggcga tagctagact gggcggtttt atggacagca agcgaaccgg 16140 aattgccagc tggggcgccc tctggtaagg ttgggaagcc ctgcaaagta aactggatgg 16200 ctttcttgcc gccaaggatc tgatggcgca ggggatcaag ctctgatcaa gagacaggat 16260 gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg 16320 tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg 16380 tgttccggct gtcagcgcag 999 ^C 9 ^CCC 99 ttctttttgt caagaccgac ctgtccggtg 16440 ccctgaatga actgcaagac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc 16500 cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg 16560 aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca 16620 tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc 16680 aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg 16740 atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg 16800 cgagcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata 16860 tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg 16920 accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat 16980 gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct 17040 tctatcgcct tcttgacgag ttcttctgaa ttttgttaaa atttttgtta aatcagctca 17100 ttttttaacc aataggccga aatcggcaaa atcccttata aatcaaaaga atagaccgag 17160 atagggttga gtgttgttcc agtttggaac aagagtccac tattaaagaa cgtggactcc 17220 aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga accatcaccc 17280 taatcaagtt ttttggggtc gaggtgccgt aaagcactaa atcggaaccc taaagggagc 17340 ccccgattta gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa 17400 gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc 17460 acacccgccg cgcttaatgc gccgctacag ggcgcgtcca ttcgccattc aggatcgaat 17520 taattcttaa ttaa 17534

<400> 8 gtaacactgg cccaggaggc ctttctggtg acccc 35

<400> 9 tgaccgggtc ctccggaaag accactgggg att 33 <400> 10 tagttccttc tgcctggaat ac 22

<400> 11 caagtcacaa ggatggacta ca 22

<400> 12 tagttccttc tgcctggaat acttcctcat ctcacttgct ttcctgcctg gcagcttcct 60 acttgccctc tggaaccagc tctagggtca ccacatctct gcttctgagt gcctcctcag 120 acacagtctg tatttcctct tccaagctct catcacaaac attgtgctgt attatatgtt 180 tctgtgtggt cttccttcta tgaggaagcc ttggaaagca ggagacttat tttagtcttc 240 tttatgtttc ttttattccc aacacattat gtctgcccca tagacctttt caataaatga 300 ttattgagtt agtgactcct tttacatgct gacaaatgtg gctcttatta ctccccattt 360 cagtatcaca tatttgtaaa agtgaatcct tcttaatcgt tttacttttc tcctagtaaa 420 ttcctcatct atgcctgtct gctgctgttc tctgtgctgc tggcccttcg tttggatggc 480 atcatacagt ggagttactg ggctgtcttt gctccaatat ggctgtggaa gttaatggtc 540 attgttggag cctcagttgg aactggagtc tgggcacgaa atcctcaata tcggtaatac 600 tgctttatac aacccattgg tctctagcat gagggagcaa tatcttgact tttctcactt 660 ttgatgaagt aaggaccatt ttattttcta cctatctggg gtcttagaac tatagtataa 720 gctaacagat ctcttctgtg tttttgaaaa tttagtcttt ggtatgtatt ttcttacaaa 780 agcagtgcca tttgggggta agttgccagc cagctcacag atgcctatat aatccaaaat 840 gcacccaaaa tacagaactg gtatgccata ctagactaag cagcatgaaa ccaccctgtt 900 tttaggaaaa gacactcata ttatgtttgg tcatgaaaga tctttctcca atacagtttt 960 ggaactgggg ctccccttgt cccaccctcc tagtcccaga gctttaggac tattagcagt 1020 gtaggggagg tggcttgacc aggagaccat gagtccctga gacagcagct ggggaatgag 1080 gaaagtcaaa gattggatgc cgagaaggaa agcagagcct ttgggggcag gggagagggg 1140 taccctttac cgtttccaac tcttgccctc cctgctcttg gatgcctccg ctggcccaaa 1200 ttcctgggag ttgctcacgc cagcatgcaa cctgcttgtt gctgggacct gcgagagtct 1260 ttcccttctc tgccacagag actgtaacta cataaaggga aaaaggggga cttaagactg 1320 ggaggctatt atgaacctcc actgggaaaa tgaggagtac aggaattccc agaaggcagc 1380 tgctcatgtg ggaaaagtgt aaagttgaaa ctaccgcacc tttttttttt tttttttttt 1440 tttttttttt ttgagacaga gtttcgctct tgttgcccag gctggagtgc aatggtgtga 1500 tctcggccca ctgcagcctc cacatcccgg gttcaagtga ttctcctgcc tcggcctcct 1560 gagtagctgg gattacaggc acctgccacc atgcccagct aattttttgt atttttagta 1620 gagatagggt ttcaccatgc caggctagtt ttgaactcct gacatcaggt gatccacccg 1680 ccttggcctc ctgaagtgct gggattacag gtgtgagcca ccacgtccgg ccactacatc 1740 aactttttaa atttttgttt actaaatatg aaaatgattc agattgtgta aattacatat 1800 cacatacatg tctaagaact gtaaaacagt tacacagaga gccttggcag gtgagggaca 1860 ttcatgtata gctgtttcag agttcttaga ttttttttga aagattgatg acctgtgtgg 1920 ctgtatgtgt tttatttttt tatgagatat tttcagatat ctaatattaa ttgcttctca 1980 aagaatgcaa agttaaataa acatttaggt tctactaatt gatatttaga atatattcaa 2040 acttctcttt gttggtctta tttaagatgt tttgagcaag gaaaggaatt gtgtatgtgg 2100 ggttgaatgt aaggaatgta caggcgtggt cattctcatg ttaacattaa ccagtggaac 2160 atggttgggt cctacaggaa taacctctga tagcattttc tctatgatct aacttccggt 2220 gtatttgtca cccacaatac atgtatatca taaatgttca tctgtatttt gaataaacat 2280 tgtaggcctt tcagatgcat tatagagcct tttcctgatt agcggcctta ccattgctca 2340 attgtagatc tgttaaggtt attgtgcatg atacttagct aattaaactg attttgtttg 2400 agaacagttt taactcttgt tcttctttct ctttcatgtg caggtgttaa tttatcttaa 2460 tggaatagaa aggaaaatga aaatcattta tacgttttat ttgcatttaa aaatagcacc 2520 taacaatagt tactactatc ttgaaatata actggcactt gttcatagaa ctagagttat 2580 ttttataata ttgtgtgaag ggtggtttac atggtttctt gaaaaatgag gatcatgaga 2640 cttaaggggt atttgcctgg ttttagcagc agaagcaaat cagcttgaat aatcttggaa 2700 gtaactcttg ttgttgaatt taaagatgtg aacagaagtg tttatgtaca ttgtcaggga 2760 aataagaact ggctattact tttgagaata tccttatacg gttaaaacat taaattctgg 2820 tttggttgta atgttcattt tgtattatgt agtagttctt cgatgtttca gagattgcct 2880 accaaagctt aggtttaagt tagctttcta cctgatttcc ctttgctttt gtcaaatttt 2940 caagtaaaat tcaaagtata aatataagtt ggtatttgcc ctgaactgct tgcttatagt 3000 ggagattctg aactgagggt gttttcttct tctctccctt ttttagagca gaaggagaaa 3060 cgtgtgtgga gtttaaagcc atgttgattg cagtgggcat ccacttgctc ttgttgatgt 3120 ttgaagttct ggtctgtgac agaatcgaga gaggaagcca tttctggctc ctggtcttca 3180 tgccgctgtt ctttgtttcc ccggtgtctg ttgcagcttg cgtttggggc tttcgacatg 3240 acaggtcact agaggtgaga tttcatatat ttaagaatgt tttccacttt gggaggtcaa 3300 ggcaggtgga tcacttgagg tcaggagttt gagaccagcc tggccaacat ggtgaaaccc 3360 catctctact aataatacaa aaattagccg ggtgtggtgg catgcgccag taatcccagc 3420 ttctccggag gctgaggcgg gagaatctct tgaacccagg aggcggaggt tgcagtgagc 3480 caagattgaa ccattgcact ccagcctggg tgacagaatg aaactccgtc ttaaaaaaaa 3540 aaaaaaagaa tgttttcaaa agtaaaatat tttgctcagt tattcagatg tcaatttctt 3600 accctttgtt aggaagagct tgatcattac caactctaca tcatgagaca acaaggcaac 3660 aaaagatgat ggaaataaca atttttcttt cttcacttag aacactagct tttcacccag 3720 gacatcagcc ttctcccagc ttcacatcct gtatcaatca gacagaaaca gaactgatag 3780 gttagataca gatatatgta taaagagagt taaggaactg gctcacatta ctgtggggct 3840 ggcaagtctg aaatctccag ggcaggtgaa caggctggag acctaggagg agttgacact 3900 gcagtcctgg cacagaattt tttcctctcc aggaaaccac agtttttgct tttaaggcct 3960 tcacctgatt gcatgaggcc cacccatgct atggagggta gtctccttta ttcaaagtca 4020 gtaccttcac tgcaacagca agcttagtgt ttgattaaat aactgggtac tatagcccag 4080 ccaagttgac actcaaaact gaccatctcc ccacctcaga ccccatgatt tagcacctcc 4140 cctgctgtct ggttagctta tcctgatgtg cccctgtgtt tgtttattca ttcaataaac 4200 atttatcaag tatttactag atgccaagcc ctttttccct aagcatagag gatatgcaga 4260 tgaataaaat accaggacta gtaataatag taatgaaagt aattgcagat aacgtttatt 4320 gagcacttac tgtgtgccag gcattgtgcg aggcacatta catgtggtag ttttcttact 4380 aactaactct gtgaggtagg tccagagaag ataagtcatt tgttcatggc cacatgtgaa 4440 ggggcaggac caggattccg tttgagtcag cccgactcta aagcccgggc acataactac 4500 ataactgcat agaagctgag ggcccaaagc tgaatactga tgggttgagg ggagaactag 4560 aggctgtaga tgcctggttt tgagccgtgt ggatgaagag tgaagggaga agactgcagt 4620 tggcttagga agtaaacata gcagctgtag ggtgggtcag gcatataagc ctagacccca 4680 ggtatgggcg tgaggggaag gtatgtagac agagggacgg tgatggagca aggccctgtg 4740 ggactcaggg agaatgggac ctagagcacc aggaagggtt tggccttgaa caaggggagc 4800 tattccctga ttttcatgct ggtggaaagg ccacagcatg ggtatagtgg taggtaggag 4860 tgagccgtgg agggagagta tctgatggtc cactttcacc ctccctacaa ttcccagttt 4920 atatcaggga cttgagcatc catggatttt ggtatccaca gggggtcctg gaaccaatcc 4980 cccacagata ctgagggaca actatacaag gactaggact gcattgggcc tgaattacag 5040 aaagtaagtc tttcatatat tcacactcta ggcattcctg cccttggaag aaacaacata 5100 ccaggagctg agctccctcc tcctgtgatg caagaacagt acctatgttg gtgagggggt 5160 ggtctggagt aggctcatac agagatggga aggaggagtt gagggtctgc caggaagccc 5220 tgtgttggga gggaagggat ggcatttttg ggacacattg aagcctagag gcaggaaaca 5280 ctccatcagc tgagtggact gtggcgattc agatccgacg ggagcacaag gtggaaagga 5340 aggaactgtg ggagttgaga agagagggag cctctacaga gggattgggg caaatagggg 5400 ccacgtcctc agcccacaga gcatgtgctg aagtgcccca ggcaccccag tgcactcaca 5460 gggcaccagg ggatagtgga cattttgagg aaaacagtaa tacctgacat ttgttgggac 5520 accatacaaa ctactagctt gaaatagttt acaggtttat ttttaggcca cactgcattc 5580 ctttcagtga cgtcgtatct ttaagaagct gggttttcag cagttgctgt gaaaacaaaa 5640 aaggctaatg ctgtgtgaaa atccgggtga agaacaggta acgagtggga gcaccttgtc 5700 tgattccaag gcgtgggaaa tggtgagcta cctgacaggc acacgcatcc cactgggaat 5760 tagttttggt tatttaagaa taatattaac atttttcttt agatttatat gaattatttt 5820 ttctagtggc tacttagaaa tacttactaa gttagatgta attacttaaa tcagtgcaac 5880 tgttggcatt cccagccaca ttagggattt cttttggcct agaggtctat ggaggaatta 5940 ctaaattccc catgtaccta tgtactgaga acttttggga agctctgggc ctggtcccag 6000 atttcaattt tgtgggcaag aatgtacttt accagagtga ggagcagcct gcagggcgtt 6060 tgggctggag gcgggaggtt agtaaggggt tgctgaagtg gtaggcggat ggtgccgaag 6120 aaggcctcac taggcagtca tcatcaggat aggaagtggg cacgggattc aggagaaatc 6180 tggactttac agtggacagg atgtggtgac tgaacgtgac agtgtgggaa aaagaatgca 6240 gggtgattcc cgggctcatg gcttgagaaa tgagaccact gttgtgcctc caagtgacat 6300 gggaggctat agaaagtgac atgggaggct atagaaagtg acatgggagg ccatagaaag 6360 tgacatggga ggccatagaa agtgacatgg gaggccatag aaagtgacaa gggaggccat 6420 agaaagtgac atgggaggcc atagtgacat gggaggccat agaaagtgac atgggaggct 6480 atagaaagtg acatgggagg ccatagaaag tgacatggga ggccatagaa agtgacatgg 6540 gaggccatag tgacatggga ggccatagaa agtgacatgg gaggctatag aaagaggaga 6600 tacaaggttc taagtgcagg cgataatgat ctctatttgg gactggcttc atttgaggtg 6660 cctttaggag agccgagtgg cctatgcaca gctgggtctg ctatgcagca ggaaggctaa 6720 gttggagaca gatgtgagaa ctaaccatga aggaggtaat aatgcagacc aagggtctgg 6780 ttgaaatttc ttctccccca gtccagggtg cagcgggtga gtgaaaatat gtgtgtttgt 6840 gtgtctgtct tcctagtcgg gagagaagac tgagtttgtg gctctgcgga gcatcaccat 6900 ttaaggaggg ggaaaaggag acagaaggaa ttaccagaac actccagagg gctccaagac 6960 tgtatggtgg gatctagatg gccaggagga ggggagcaaa aaggaaagag tcatccacag 7020 tatcagtagg atgccagttg aagtgttttt gctgcctccc ggttatcggt gactttgatg 7080 aaagctgtct tctggtggtc atgggggtgg aggccagatc acaaggaagc tgggaatggt 7140 agatgagata gtaggggctt gcatattcat tactgtctcg cagagagaaa cctgaggcta 7200 agaggggtct tggatcaaag gatggggtgg gtttatctgg tttcggggct tttgttttta 7260 atgagaagga gtcatttctg tgctgctagg agggatcaat ggaataggtg gggttaaaga 7320 tacagtacgg aatctacagt tgatggcttg atgtgacaag gtcctcaagg agcctgaaag 7380 gaaggggtgg ggtccaaggg caaaaccgag gtatgagaag aaggatgcac aaggatggtt 7440 tcgagtagac agtattgttg gtagggacat gaaggaagtt tagtggtcta ttgcagctag 7500 cctgtgttcc cagtgaacct ggaaacaagg ttctcatctg tgctcaggcc tcaggccaga 7560 aagggcaagg cagcagaggg gcaaggcagc aggctgagcc ccatttcccc ttgccataat 7620 actgctgtgc ccctctggta ccgaaaatca ggagtttcca gtgcaatata atattataca 7680 agttacactg tattataatg tgtattgtct tttagtgtgt taaccaaatt actgcagtat 7740 taaatgcaaa ttatactttg tttaactgat tcttctcttc atttttagtt agaaatcctg 7800 tgttctgtca acattctcca gtttatattc attgccttaa gactggacaa gatcatccac 7860 tggccctggc ttgtatgtaa cttttaaaat ccttaaataa acttcttttt tattataaaa 7920 gtaattcata ttcactgtac aaagcttgga aaagacggac aagcagaagt aatagcctaa 7980 tagtcaccca taatcccacc atggggagat aacatggtta gtgtttttat gtctgtgttt 8040 tatacaaaca gtttggatat aactgtgtgc accattttgt atcctgattt ttttgtttta 8100 atgttgtatc ataaacattt tatcatgtta ataaaaggtc tttataaaca tgacttctaa 8160 agtttaattg atacaaaata ttcttcaagt gcatgtatca gaccatcctc ttatttctaa 8220 aatatggtat ttccattgtt gccagtgttg aatgatttta aatcatactg cagtatatat 8280 gtttatgcat taaaattttt gccttttgtt ttttggttgt tttcttagga aatagtccag 8340 aaatagtgtt actgagctag aggttgggaa ctatttgaga ttcctatata cgtatactgc 8400 actgccaact tgcttttcca aaagccatac ctggccaggc gcagtggctt acacttacag 8460 tcccagcact ttgggaggcc gaggtgagct gatcacttga gctcaggagt tcgagaccaa 8520 cctgtgcaat gtagcaagac cctgtctcaa aagaaaaaaa aaaaaagcca tacccattta 8580 cactcttgct ggtggtggca tctatgtcat gcttctaaac tgtgacttca gttactgggc 8640 atttggttga aattaactgt gaataaatgg gtagatggat gcagagatag aaagataagt 8700 ggcaaggtag aaattagaga acacagtata gattccacta ttaaatgcat ggaaaaaaga 8760 tggagactaa aggcagaaga gttccattgc cactgggagg taaggtcatg ctagtgtttt 8820 tgttcggttt tattttctct gttgtttgat gtataatttt gcatacaata tattttatgt 8880 attaaatata gctaccctta aaaagtgaaa agtatagtaa agaattggga gcagagaaga 8940 aatgaaggga acctaagtat actccatatt taaagatggg aataatcact tctgcccaaa 9000 gtctttgata aaacattcat aataaaaaat attcagtcac tcatcctaca acttcacagt 9060 gctgtatctg gagaatggtc attgggttca aaactgtttc tgttgtgacg tgaaggaaac 9120 atatctaaac aagaccaaat tttttcgtat aagatactgt cagggaaaaa aaagattagt 9180 aattttgaga gctttccaca aatgagaaga aagatttttt ctgcccttca tcctctgtag 9240 atcccagttg atgaagcagt ctgagtacat gtttcccata gtgagcaaga gaaaacaagg 9300 aagcctattg agatctaaca ttccacccat gaagggaact tcagtaaaaa ggagaatctc 9360 atcacagaat ggggaacggg gaagaaaggc tgtgcataga ctctgcagag aaacctacaa 9420 tcaagaactg gtcaggagaa gtaaaattcg tatgccaact caaatcatag atctaaaaga 9480 aaatgtaaaa ctatagatct gttaggaaat aacataggac agaatctttg gggtttgcaa 9540 ttaggcagag agtacttaga aatggcactg ttaatatggt ccatacgaga gagaaatcat 9600 aaatttggac ttcctcaaaa ttaaaatgaa atgaagacag gccacagact gggagaaaat 9660 atttgcaaag cacacatcaa aacactgact tgcacccaga acatacagag aactcttaaa 9720 aactcaaaac tgcaaaaaga aacacctaaa aattggcaaa agagttgaca atttgcgaag 9780 gggatataca catggcgaaa aagcacagga aaagatgctc aacgccatta caggttaggg 9840 aagacaaact acaaccagga tgagggcccg aaacacatgg cttcagaatg gtgaaactca 9900 gcaacactga cgaggccacg tgcctgggag gatgcagagg aactgggaca ctccagtgtt 9960 actggcggga aggcaggtgg tacgggcact gtagaaaatg gtttggccat ctctgatgca 10020 gttaaaagcg cacttcccgt gggacttggc tgccccactc ctgggtataa gatttacccc 10080 cagagaagtg aaagcgcgca gccttgtaga aacccacaca ccagtgtttg tagcagtctt 10140 gtttgcattt tggatagcgg ccttgtttgg ttttcacaaa ccaccctcag cggacagtca 10200 gataaactgt aggcatccat acaatggaat accactcaga tctgagaggg aacgacctgt 10260 ggatacaggg agggaacaac ttggatgaat ctcattagag acattatgtg gatggcggga 10320 agccagtctc aacaggttac ttgtctcgcg atgccatcta cataaagttc cagcagagac 10380 aaaagtacag tgagagaaca gatcagtgtt tgccggggct aatggtgggg acggtgtgat 10440 agtgaaggga cagcacggag agttttgcag ggtgacagac ctcttctgca tcctgccaac 10500 ggctgtgtga atctacttgt gtgaagactc agggaactca caccaaagga agacggtcac 10560 ttttcctact gtatgataga taattaataa aaagggagaa cggaggagtg tcgtcccagg 10620 aggcagggca ggagggcgaa gacgtgtcac aggggagcct ggccaagtgg cgcccccgga 10680 actcgtcctc tgggcttgtg tgtggatgag acaaggtcta cctggtacga cagggacata 10740 ctgggaatgc gcccttgccg tggaggcggg gacccggcag cgctacgtat ccagcatcaa 10800 cctgtatcca gcatcaaccc gccaagttca ctaacttggt aggggtgagg ttagggatcc 10860 ttaggagccc aggcagccag actttctggg gagcccattc ccatttgtgt tgccaaagta 10920 cccccagcag gttgtgggaa tgttgcctgt gaagagagtc tgttggggtg agatcttgtg 10980 tgtgtgcaca gggtgacagt tgtgtcccat ttcccgggaa gctgtgatgg cagcagaacc 11040 tagaggagcc tgagagagtg tgggagagtg ggcctctgga agagtagagg ctgcggagcc 11100 aggtgcaggg ctgtctgtca cccaaaggaa gagggactga tgactcactg agcgtgtgtg 11160 tcccctggtg gcagcaggcc ccatagtgaa cataccatac cttttctgtc ctgagcgatg 11220 ctcccagcag tcctgggaga tggaacggtc cttattcggc tcacaggaag gaccgcctta 11280 actggacaga cacagcaagg tgctaaagat gccttccatc agaggccagg ttggaagctc 11340 taaagagact tctcttgctg ttctctcacc cacccccagg ttgtgtgtgt cccgctgtgg 11400 attctcatgt cctttctgtg cctggtggtc ctctactaca ttgtgtggtc cgtcttgttc 11460 ttgcgctcta tggatgtgat tgcggacagc gcaggacaca cataaccatg gccctgagct 11520 ggatgaccat cgtcgtgccc cttcttacat ttgaggtaag cgttccacgg gaagcctctt 11580 cagcccctga agcttgcgct tcccctgaca ggattctgca cccctagaaa ggcagcctct 11640 gtccctcgag ctcacagtga gcccactcca ggagagggga gagaacacag ccatctccga 11700 gagggagctt cggtgaaagg agagcatcct tcctttctct tgggggcagc acgtggggct 11760 ggcagggaga agagtgcacc tttttagcca tggtgcctct gtatggctcc agtttccact 11820 ctggggaaag cagagtggga tgtcagattt gtgtattgga gtcacgtgga gaattctaga 11880 atgggagctg ttgactcctt agaacaaaca cccggaggag tttgccataa aactgctggc 11940 actgggaact tttcaagtgg ataggctatt gccgagctct gaagagggac ataaaagctc 12000 atttcgagct ttccccaggg ataggtggtt tcctgccttt ttctggcggt gctgatgttc 12060 cctcttgtgg gagctcacgc gggggtgggg tggtggggag gaactgccta atgaagtctg 12120 gcttccgσct ctgcccattt tcggtgctgg catcaaccgg gactatgtct ctttctttag 12180 attctgctgg ttcacaaact ggatggccac aacgccttct cctgcatccc gatctttgtc 12240 cccctttggc tctcgttgat cacgctgatg gcaaccacat ttggacagaa gggaggaaac 12300 cactgtatgt actcagcatt tcagaagtcc ttggtgtgtg tctggggggg gaccaggggg 12360 tggggggtgg cggatagaag tctaggaagg gatgagtccc cgagggcccc aatttagaag 12420 cttgtgtggg aaagtgaggg ctgaggaaat tctgggacct tctaagggaa gggcatgccg 12480 taactctggt gttctgctgg cctgcaccgg gacttttctc gcagtgcacg ctgccatttg 12540 aggtagaacc agacacggca ggcaacctct cagagatccc gttccctcct ctgcaaaatg 12600 gggatcaaga cagattcttc ccaggcccgg gagggtttga tggaaaatcc acatctccca 12660 cccaaacctg ggattcatcc taggtccctg ttggccgctc tgcctccccc atatccttgc 12720 tgccatcacc cgagtcttgc ctgtcttgcc ttgctaacac tctattcccc tccacctgct 12780 tgctgaggca gacacttcca aaacgatctc tgcagagggt gccttcctgg caaggctgtg 12840 ggctccatgg cacggaagcc cagagcattg cccttcggaa agccagtggg tttgggggca 12900 gggcctcact gcagcccagc agcccgggct gtgcttgctg tttgtgcctc tgccccctac 12960 cccgcacccg ggagcaggga gggcttgcac cgagctgaca ctccagtagc ctacagagag 13020 gagtagtggg actgggaaag tggctttaag gtggctccat gagttcaggc cccctcctgg 13080 ccaacccgtg catgactacc gccctcacgg attccagagg gtgacagaaa tcttgttctt 13140 gggtggcact gtcatccatg agtttatcct ggctggagaa gattagcgga agacaccgta 13200 gtctgcgcac cacagatatt ttgagactca ctggagcagt agttctcaaa tttgggcatc 13260 cagcagaatc ccaaaagggc caggaaaagg ggaccgctgg agcccaccct agcccgactc 13320 agtttctgga ggtctgggct ggggcccgag aatggcatcc ctaactaggc cccgtggacg 13380 ctgtccctgc cggtccggga accccactcc aagcaccaca gagctagcat ttgcacttct 13440 tccccatttt gggtactcaa gccctgttca ggctttgtga ctcaggagtc tggataaagt 13500 atgttatgac attgtaggag tgaaacttct tgttacggaa agaaagttaa caggaaggtc 13560 agttgagcct cgtgtgtgaa ataaaaaatt cttatttttc agggtggttt ggtatccgca 13620 aagatttctg tcagtttctg cttgaaatct tcccatttct acgagaatat ggaaacattt 13680 cctatgatct ccatcacgaa gataatgaag aaaccgaaga gaccccagtt ccggagcccc 13740 ctaaaatcgc acccatgttt cgaaagaagg ccagggtggt cattacccag agccctggga 13800 agtatgtgct cccacctccc aaattaaata tcgaaatgcc agattagatg ccacttccgg 13860 ggacagagct taagtggact gggacgcact ctctccgcct tcctctgccc cctcgttcac 13920 cccgcagacc agaaccagta ctggagctgg gtctccaggt acgtccatct catgccttgt 13980 ttgcatccag cgcctatcag ccactcacca cgacgggacg cggaagtggc aggtgacggg 14040 ggtgtgtgcc agcagatgcg gatgccagga agagtgtgag aacaggggtg ggattaccgt 14100 ctgtctggga ggggctccag gtacccctct tccccgtcag acccactggg agatggctgc 14160 ttgccaggcc cccagaagga acatctgtct atacggtgct gaaatcccaa tcaaaagtat 14220 tgtttagaaa tgtatttctc cacagggctg acctcctgca gctcgctgag cactcccagg 14280 tcctcagcac tcccaggtcg tggctggggc agtcagtagg aactgtaact atgtctctga 14340 tgcaccacgt gtttagacac agcacagtcc ttttttctgt tcctactgtg gaagtagttt 14400 ctctttgggc atgctgacag cagtttttca tagcctcacg gatgagccct ttctacggga 14460 gtgactccat gcttgtatac agagtattta tacaaatgtt ttagcatctt catatgcggt 14520 gttaacccct agttctgtac agcatattct gttcaagtat ttttttacaa gcttgtgctg 14580 taggcacatg ccttctgctg cagaagtgga cgcccgtggc acactccccc cccccccccg 14640 tggggtgcca cgccttcatg ggacattgcc acttctgccc tggaactcgt gcaggtacgt 14700 agtagctgct actgccacaa cggcaacacc aagcaagaga tggtccatgc ttttctgacg 14760 ttctcagaat agtggctagc ttcaaacctg acaagcgctg cttgaagccg gaacactaga 14820 gaatgttgct gagagcagaa acggccacgc gggtcacgac tatgcgtggg aaagtctcaa 14880 gcttccctcc tgccagcaac aagaaggctt tggagtaggc atgatgtttt cacgtgtgcg 14940 tgccgtttct ccaagcactg caggttccac cgtgtgtcag aggctgcaag tttaacatcc 15000 tcctgcctga aaacaaatag gtcctttgct gaaaagaggg taaaaaaaga gctttgatct 15060 tctcagccag gagaagaggg tggtgttttc acgcgggcaa ctgctcgccg gcctacatgg 15120 ggttaattca agtctgctgc gagcacgact ccgcccttgg cactggcctc cagcaagccc 15180 tgttctcttt ggggtacagg ggaacgggat ggtttagact ttcctgctca gtgtgtaaaa 15240 aatgtagcta aagccactat ttttgctctc cttaagctgt tcaataaacc ggttcctcat 15300 tttacacgtg catgatgtgt atcttctttg ctggatgggc caggaaactg gagtggtcct 15360 ctcagccagc ctcagaggaa agaaatctct agctggcaca ggcagccagt gagtgaggct 15420 ggcggctgca ggggcacagc ctttagaatg agtccttcag tgcacaggtc ccagggtata 15480 cggggtagtg ggaggaagga ggggacgcct cgcagatgcc actgttggct gggctacacc 15540 ttgccacact tgttactgct taggaggctt tctggagtgt tccttgggtg ctacgacaat 15600 ctgcagcaga cactgtcctt tcaccgctcc tggtcctcgt ttgctcccca gtgatgtcaa 15660 cagctgagga ctgctcacgc tgcaacaaaa ggctctgcag tcgctgtcta gcttgcccta 15720 gtcgtctcta gagttctgcc tgaactgaaa ctcaagtggg gttcagctca tgacttgtgg 15780 caattgacca ggaaattcac cagttgctgt ggctggaagg attttcagtc ctgtgggttg 15840 taaccagagg ccacaggtgg attctgcctt aggctcatga gatttccgac ttgctgttga 15900 agaaaatgcc ttgtgaagtg acaacagtag ctctgaccca actgccggtg cctcgctagt 15960 tcctatacgt cccactggat cctcacagcc ccgggaagca ggtgctacta ctcttatccc 16020 cgggaggaga cagaggccga gagaggttaa gtgacgtgcc caagtcacac agctcggcag 16080 cggccgggtt gagcatcagc agtctgtttg cagacccctc actgtcaccc cctgagccag 16140 tgcgccttgg gccctgcggt caggatgtct caagcgtgga ggcatcaccg gttcgtggca 16200 gtctctggaa ggtcactgag ctctgtgccc agaatcgagt cgggggagtc tgtgcagagg 16260 tggccctgtg tgtggggaca gtgtgtgaca cagacactgc tttggatgga cacctctccc 16320 gtgacctcct agcatccaat cccaaaggaa caactgttgc agagatggac cgctggacac 16380 aaacccacgt gcgtttctct ggagacactg gccaaggaaa acaaaacatg ctcgaaggcc 16440 aacagctgca tgccccaccg cgatgtgacc gcagacaccc ggggtgtaga agggtctctg 16500 cctggtgggg ggacacgtgc aggccgagga gaggcaggaa ggaggctgcc tccgactccc 16560 cactggactg catggcgacg gcgtgtggtg gggcagtcag ctaagccatt tgcctaaggg 16620 gctgtcgggc atctgcgtgc tggggaccga cagtgtgggt gtgttaggag gatctgtatg 16680 gagcacattg ctgcctctgg ctaggacagg gtggaaaggg tggcgtggct acagcctgac 16740 ccatgggcac cgtcctaccc tttgttctgt gcttccgagt gtcagtcatg tgctggggtc 16800 tgtgggccca tgactcagac ggtgagctct gaccttcctg agccagggct ttgctgtagt 16860 tgtgcctggc tcaggagctc taggacaagg ggaccgctcc aggtctgcat ctacggtgtg 16920 gcagggcccc tcggcactct tgtgcactag tgtcatcttt cccattgaaa tgactgtgag 16980 gaccagaatg tgcacatgca gatgggcagc tacttgtctg ccttggccct ttattacaca 17040 acttgctggg ggtggagatg ccaccccccg gcagtcagag cccctttatg atgtcatggg 17100 gctggttaca tgactgccaa ggggtgctgc tggccacact gcactagcaa gtttgccaga 17160 tggaggacaa gcgatcattg agtatggctc gctgtgaaga aagaaattcg agaggacagg 17220 atcatggctt ggaaagggtg cctttccctc cccagttgca gtcagagacc taccttcacc 17280 cagcagatcc ttcccctgcc tgggacgacc cggggtccac tgggagccct aacttgaggc 17340 tgctgacaga agaaatcgct ttccaacctc tggccgagga agcttcgttc agaaggccgc 17400 accctgacgg tgacgtcccg ccccagggag aagataatct cctctccctc ccctttccac 17460 agaaactgtg gagactggtc agcagcaacc agttttcgtc catctggtgg gatgacagtg 17520 gggcttgtag agtgatcaat caaaaactct ttgaaaagga gattctcaaa agggacgtcg 17580 cacacaaagt gtttgccaca acttcgataa agagcttctt ccgccagcta aacttgtatg 17640 gcttccgaaa acggcgtcaa tgcactttca ggaccttcac ccgcattttc tccgcaaaaa 17700 ggctggtctc catcttgaat aaggtaatga acgacaagcc tctggagggg ttaagtcggt 17760 gggctctggg gcctggtcgg gtggaagtcc caggactgcc tcctgggaag tgggcgacct 17820 caggcagggt gtggggccat cgctgtgggc ctgtgtcccc ctctgggtgg aggtgacatg 17880 aactaagagt gaatgtgggg agagggctga ggatggtgcg ggcccctctc gagtgtgtaa 17940 aatatcacag gtgccaagta gccgtatctg cgtgtcgtcc tccccggggc cagccatgtc 18000 atctggtggt tgctgtgtcc ccctgactcc acagcacatt accctgtgag gtgagcaggc 18060 caggggagtc tggtatttgt accactgtca ccctagctgg tgtctggaga ggtgctcaag 18120 tggaagcact gaagggcgcc tggcgcagga ggtgcagatg ctcctgctgc ccttggtagg 18180 tgggcccctg gtgtggaaga gccagtaccc agggcctcca acccagccgg ggtgcattct 18240 gttgccagct gacactgcat gggggaggcc cagaatcttc ttccctcctg gtctgcaact 18300 tcaaagaccc tttccgccgg ccatggacac cctaatctgc cattttgagg ctttttccaa 18360 gacggaaagg cccgccacaa cttggtaaac cttgacgatg tgaacgcgag tccccagctt 18420 cctttgggga ctgggacctt ttccagaaag gcctcctggg ccagtagagt tctcttgcac 18480 aggggcgtag atggttggta gttgtagtcc atccttgtga cttg 18524

<400> 13 ggcccaggag gcctttctgg aaaaggtccc agtccccaaa ggaagctggg gactcgcgtt 60 cacatcgtca aggtttacca agttgtggcg ggcctttccg tcttggaaaa agcctcaaaa 120 tggcagatta gggtgtccat ggccggcgga aagggtcttt gaagttgcag accaggaggg 180 aagaagattc tgggcctccc ccatgcagtg tcagctggca acagaatgca ccccggctgg 240 gttggaggcc ctgggtactg gctcttccac accaggggcc cacctaccaa gggcagcagg 300 agcatctgca cctcctgcgc caggcgccct tcagtgcttc cacttgagca cctctccaga 360 caccagctag ggtgacagtg gtacaaatac cagactcccc tggcctgctc acctcacagg 420 gtaatgtgct gtggagtcag ggggacacag caaccaccag atgacatggc tggccccggg 480 gaggacgaca cgcagatacg gctacttggc acctgtgata ttttacacac tcgagagggg 540 cccgcaccat cctcagccct ctccccacat tcactcttag ttcatgtcac ctccacccag 600 agggggacac aggcccacag cgatggcccc acaccctgcc tgaggtcgcc cacttcccag 660 gaggcagtcc tgggacttcc acccgaccag gccccagagc ccaccgactt aacccctcca 720 gaggcttgtc gttcattacc ttattcaaga tggagaccag cctttttgcg gagaaaatgc 780 gggtgaaggt cctgaaagtg cattgacgcc gttttcggaa gccatacaag tttagctggc 840 ggaagaagct ctttatcgaa gttgtggcaa acactttgtg tgcgacgtcc cttttgagaa 900 tctccttttc aaagagtttt tgattgatca ctctacaagc cccactgtca tcccaccaga 960 tggacgaaaa ctggttgctg ctgaccagtc tccacagttt ctgtggaaag gggagggaga 1020 ggagattatc ttctccctgg ggcgggacgt caccgtcagg gtgcggcctt ctgaacgaag 1080 cttcctcggc cagaggttgg aaagcgattt cttctgtcag cagcctcaag ttagggctcc 1140 cagtggaccc cgggtcgtcc caggcagggg aaggatctgc tgggtgaagg taggtctctg 1200 actgcaactg gggagggaaa ggcacccttt ccaagccatg atcctgtcct ctcgaatttc 1260 tttcttcaca gcgagccata ctcaatgatc gcttgtcctc catctggcaa acttgctagt 1320 gcagtgtggc cagcagcacc ccttggcagt catgtaacca gccccatgac atcataaagg 1380 ggctctgact gccggggggt ggcatctcca cccccagcaa gttgtgtaat aaagggccaa 1440 ggcagacaag tagctgccca tctgcatgtg cacattctgg tcctcacagt catttcaatg 1500 ggaaagatga cactagtgca caagagtgcc gaggggccct gccacaccgt agatgcagac 1560 ctggagcggt ccccttgtcc tagagctcct gagccaggca caactacagc aaagccctgg 1620 ctcaggaagg tcagagctca ccgtctgagt catgggccca cagaccccag cacatgactg 1680 acactcggaa gcacagaaca aagggtagga cggtgcccat gggtcaggct gtagccacgc 1740 caccctttcc accctgtcct agccagaggc agcaatgtgc tccatacaga tcctcctaac 1800 acacccacac tgtcggtccc cagcacgcag atgcccgaca gccccttagg caaatggctt 1860 agctgactgc cccaccacac gccgtcgcca tgcagtccag tggggagtcg gaggcagcct 1920 ccttcctgcc tctcctcggc ctgcacgtgt ccccccacca ggcagagacc cttctacacc 1980 ccgggtgtct gcggtcacat cgcggtgggg catgcagctg ttggccttcg agcatgtttt 2040 gttttccttg gccagtgtct ccagagaaac gcacgtgggt ttgtgtccag cggtccatct 2100 ctgcaacagt tgttcctttg ggattggatg ctaggaggtc acgggagagg tgtccatcca 2160 aagcagtgtc tgtgtcacac actgtcccca cacacagggc cacctctgca cagactcccc 2220 cgactcgatt ctgggcacag agctcagtga ccttccagag actgccacga accggtgatg 2280 cctccacgct tgagacatcc tgaccgcagg gcccaaggcg cactggctca gggggtgaca 2340 gtgaggggtc tgcaaacaga ctgctgatgc tcaacccggc cgctgccgag ctgtgtgact 2400 tgggcacgtc acttaacctc tctcggcctc tgtctcctCG cggggataag agtagtagca 2460 cctgcttccc ggggctgtga ggatccagtg ggacgtatag gaactagcga ggcaccggca 2520 gttgggtcag agctactgtt gtcacttcac aaggcatttt cttcaacagc aagtcggaaa 2580 tctcatgagc ctaaggcaga atccacctgt ggcctctggt tacaacccac aggactgaaa 2640 atccttccag ccacagcaac tggtgaattt cctggtcaat tgccacaagt catgagctga 2700 accccacttg agtttcagtt caggcagaac tctagagacg actagggcaa gctagacagc 2760 gactgcagag ccttttgttg cagcgtgagc agtcctcagc tgttgacatc actggggagc 2820 aaacgaggac caggagcggt gaaaggacag tgtctgctgc agattgtcgt agcacccaag 2880 gaacactcca gaaagcctcc taagcagtaa caagtgtggc aaggtgtagc ccagccaaca 2940 gtggcatctg cgaggcgtcc cctccttcct cccactaccc cgtataccct gggacctgtg 3000 cactgaagga ctcattctaa aggctgtgcc cctgcagccg ccagcctcac tcactggctg 3060 cctgtgccag ctagagattt ctttcctctg aggctggctg agaggaccac tccagtttcc 3120 tggcccatcc agcaaagaag atacacatca tgcacgtgta aaatgaggaa Gcggtttatt 3180 gaacagctta aggagagcaa aaatagtggc tttagctaca ttttttacac actgagcagg 3240 aaagtctaaa ccatcccgtt cccctgtacc ccaaagagaa cagggcttgc tggaggccag 3300 tgccaagggc ggagtcgtgc tcgcagcaga cttgaattaa ccccatgtag gccggcgagc 3360 agttgcccgc gtgaaaacac caccctcttc tcctggctga gaagatcaaa gctctttttt 3420 taccctcttt tcagcaaagg acctatttgt tttcaggcag gaggatgtta aacttgcagc 3480 ctctgacaca cggtggaacc tgcagtgctt ggagaaacgg cacgcacacg tgaaaacatc 3540 atgcctactc caaagccttc ttgttgctgg caggagggaa gcttgagact ttcccacgca 3600 tagtcgtgac ccgcgtggcc gtttctgctc tcagcaacat tctctagtgt tccggcttca 3660 agcagcgctt gtcaggtttg aagctagcca ctattctgag aacgtcagaa aagcatggac 3720 catctcttgc ttggtgttgc cgttgtggca gtagcagcta ctacgtacct gcacgagttc 3780 cagggcagaa gtggcaatgt cccatgaagg cgtggcaccc cacggggggg gggggggagt 3840 gtgccacggg cgtccacttc tgcagcagaa ggcatgtgcc tacagcacaa gcttgtaaaa 3900 aaatacttga acagaatatg ctgtacagaa ctaggggtta acaccgcata tgaagatgct 3960 aaaacatttg tataaatact ctgtatacaa gcatggagtc actcccgtag aaagggctca 4020 tccgtgaggc tatgaaaaac tgctgtcagc atgcccaaag agaaactact tccacagtag 4080 gaacagaaaa aaggactgtg ctgtgtctaa acacgtggtg catcagagac atagttacag 4140 ttcctactga ctgccccagc cacgacctgg gagtgctgag gacctgggag tgctcagcga 4200 gctgcaggag gtcagccctg tggagaaata catttctaaa caatactttt gattgggatt 4260 tcagcaccgt atagacagat gttccttctg ggggcctggc aagcagccat ctcccagtgg 4320 gtctgacggg gaagaggggt acctggagcc cctcccagac agacggtaat cccacccctg 4380 ttctcacact cttcctggca tccgcatctg ctggcacaca cccccgtcac ctgccacttc 4440 cgcgtcccgt cgtggtgagt ggctgatagg cgctggatgc aaacaaggca tgagatggac 4500 gtacctggag acccagctcc agtactggtt ctggtctgcg gggtgaacga gggggcagag 4560 gaaggcggag agagtgcgtc ccagtccact taagctctgt ccccggaagt ggcatctaat 4620 ctggcatttc gatatttaat ttgggaggtg ggagcacata cttcccaggg ctctgggtaa 4680 tgaccaccct ggccttcttt cgaaacatgg gtgcgatttt agggggctcc ggaactgggg 4740 tctcttcggt ttcttcatta tcttcgtgat ggagatcata ggaaatgttt ccatattctc 4800 gtagaaatgg gaagatttca agcagaaact gacagaaatc tttgcggata ccaaaccacc 4860 ctgaaaaata agaatttttt atttcacaca cgaggctcaa ctgaccttcc tgttaacttt 4920 ctttccgtaa caagaagttt cactcctaca atgtcataac atactttatc cagactcctg 4980 agtcacaaag cctgaacagg gcttgagtac ccaaaatggg gaagaagtgc aaatgctagc 5040 tctgtggtgc ttggagtggg gttcccggac cggcagggac agcgtccacg gggcctagtt 5100 agggatgcca ttctcgggcc ccagcccaga cctccagaaa ctgagtcggg ctagggtggg 5160 ctccagcggt ccccttttcc tggccctttt gggattctgc tggatgccca aatttgagaa 5220 ctactgctcc agtgagtctc aaaatatctg tggtgcgcag actacggtgt cttccgctaa 5280 tcttctccag ccaggataaa ctcatggatg acagtgccac ccaagaacaa gatttctgtc 5340 accctctgga atccgtgagg gcggtagtca tgcacgggtt ggccaggagg gggcctgaac 5400 tcatggagcc accttaaagc cactttccca gtcccactac tcctctctgt aggctactgg 5460 agtgtcagct cggtgcaagc cctccctgct cccgggtgcg gggtaggggg cagaggcaca 5520 aacagcaagc acagcccggg ctgctgggct gcagtgaggc cctgccccca aacccactgg 5580 ctttccgaag ggcaatgctc tgggcttccg tgccatggag cccacagcct tgccaggaag 5640 gcacGCtctg cagagatcgt tttggaagtg tctgcctcag caagcaggtg gaggggaata 5700 gagtgttagc aaggcaagac aggcaagact cgggtgatgg cagcaaggat atgggggagg 5760 cagagcggcc aacagggacc taggatgaat cccaggtttg ggtgggagat gtggattttc 5820 catcaaaccc tcccgggcct gggaagaatc tgtcttgatc cccattttgc agaggaggga 5880 acgggatctc tgagaggttg cctgccgtgt ctggttctac ctcaaatggc agcgtgcact 5940 gcgagaaaag tcccggtgca ggccagcaga acaccagagt tacggcatgc ccttccctta 6000 gaaggtccca gaatttcctc agccctcact ttcccacaca agcttctaaa ttggggccct 6060 cggggactca tcccttccta gacttctatc cgccaccccc caccccctgg tcccccccca 6120 gacacacacc aaggacttct gaaatgctga gtacatacag tggtttcctc ccttctgtcc 6180 aaatgtggtt gccatcagcg tgatcaacga gagccaaagg gggacaaaga tcgggatgca 6240 ggagaaggcg ttgtggccat ccagtttgtg aaccagcaga atctaaagaa agagacatag 6300 tcccggttga tgccagcacc gaaaatgggc agaggcggaa gccagacttc attaggcagt 6360 tcctccccac caccccaccc ccgcgtgagc tcccacaaga gggaacatca gcaccgccag 6420 aaaaaggcag gaaaccacct atccctgggg aaagctcgaa atgagctttt atgtccctct 6480 tcagagctcg gcaatagcct atccacttga aaagttccca gtgccagcag ttttatggca 6540 aactcctccg ggtgtttgtt ctaaggagtc aacagctccc attctagaat tctccacgtg 6600 actccaatac acaaatctga catcccactc tgctttcccc agagtggaaa ctggagccat 6660 acagaggcac catggctaaa aaggtgcact cttctccctg ccagccccac gtgctgcccc 6720 caagagaaag gaaggatgct ctcctttcac cgaagctccc tctcggagat ggctgtgttc 6780 tctcccctct cctggagtgg gctcactgtg agctcgaggg acagaggctg cctttctagg 6840 ggtgcagaat cctgtcaggg gaagcgcaag cttcaggggc tgaagaggct tcccgtggaa 6900 cgcttacctc aaatgtaaga aggggcacga cgatggtcat ccagctcagg gccatggtta 6960 tgtgtgtcct gcgctgtccg caatcacatc catagagcgc aagaacaaga cggaccacac 7020 aatgtagtag aggaccacca ggcacagaaa ggacatgaga atccacagcg ggacacacac 7080 aacctggggg tgggtgagag aacagcaaga gaagtctctt tagagcttcc aacctggcct 7140 ctgatggaag gcatctttag caccttgctg tgtctgtcca gttaaggcgg tccttcctgt 7200 gagccgaata aggaccgttc catctcccag gactgctggg agcatcgctc aggacagaaa 7260 aggtatggta tgttcactat ggggcctgct gccaccaggg gacacacacg ctcagtgagt 7320 catcagtccc tcttcctttg ggtgacagac agccctgcac ctggctccgc agcctctact 7380 cttccagagg cccactctcc cacactctct caggctcctc taggttctgc tgccatcaca 7440 gcttcccggg aaatgggaca caactgtcac cctgtgcaca cacacaagat ctcaccccaa 7500 cagactctct tcacaggcaa cattcccaca acctgctggg ggtactttgg caacacaaat 7560 gggaatgggc tccccagaaa gtctggctgc ctgggctcct aaggatccct aacctcaccc 7620 ctaccaagtt agtgaacttg gcgggttgat gctggataca ggttgatgct ggatacgtag 7680 cgctgccggg tgacc 7695

<400> 14 gggcgaattg ggcccgacgt cgcatgctcc cggccgccat ggcggccgcg ggaattcgat 60 atcactagtg aattcgcggc cggcgattgg gcccgacgtc gcatgctccc ggccgccatg 120 gcggccgcgg gaattcgatt ccttaattaa gtcgactggg acccaaactt tggagtcgtt 180 gacagatgtg acaggtgaag cctgggatga catcgccaaa aatgcaacgt ctcactcatt 240 gtcactactc ccagggctca gtcgtcactg gggaaaatct ccagaaggta gcgcgggcca 300 aggtgacagg tgtctgccaa gatctgcccg ccagactccc gggcggcgcg ctccctccct 360 gcaggccttc agcccgtcag catccccttc ctcggggccc tgctcactcc cagcctccat 420 ccccctgcca tctcctccgc cggtcgcgtg cggacacaag gatggggacc tcccagcgag 480 gagcgctctg ggcggggctc cggacgcatg cgcggccctc gtacggaagc ccggaaggag 540 gggcaggggg cggtggctca ggtttctccg ggcggcggcg gcggcggcgg cggcgacggc 600 gacggcgacg gcagcgggga cggcagcagt agcgggagca gcagcgtgga cgcggctggc 660 gctggcgcca tgaacccgct gtaaggcgca ggctgtgcag cacggggtgc gggggaggag 720 gaggaggacg ccgcggtgaa gttctccgcc atgaacctga ggggcctctt ccaggacttc 780 aacccgaggt gaggcggcgt cgttggcgcc cccgggagtc cgcgctgcgg gctcgggcgc 840 gggctggtgt tcggctccgg ggaggcacgg cgggcgagat gctgcagccc gaggacccgg 900 gcgcctgccc gagcctccct gcgggtgcaa gcggtcccca ggcaaaacag tcggcctcgg 960 cgcccgcccg cttcctcctc ccgtgcccgg tgctttcagc ccctgcccgg ccacggccgg 1020 aagggcccgg ccgcgagccc cgtcctgccc caagggaacc ccattctttt ctgcttgctg 1080 tccctcattg gtgtcccaac ttcttcgtct cggttccatc ctcttctgcg ccgctgcggg 1140 ccctccattc tccgcgtcag ggccgtctca ctcgacccaa cacccctacc cccaccccag 1200 ctgtttcctc cagttcctcg cagtccttgg ggttttcctt gggtttatgc ccatccctct 1260 cttgtttgct tctttgttga acggatacct gaaacactgt tgaatccttg gagtcagtgt 1320 cggggtatgg caatacctta tataatgcat ttctgggtga gcctgatcat tttccatact 1380 cattttctca tcagtcttca ctacaagttt atttgcagga agtagatatt gctgtccttc 1440 ttttccagat ggggaacacc cagtggacag tgtggagaaa acactggcta agcactcaag 1500 cgcctgtcct tgcacttgcc cgactgtttt gtaactgttc tttaccccag gctgtgagct 1560 ccctgaagct gagaccatct cctgctcatc tcagtgtccc cagcgcctcc cacccaccgt 1620 atctggcaca tagtaggcac atataaaatg tttgtggaac taaactgagc ccaaagactt 1680 ggattggaga cgaggccata tgtaactggg tgattctctg cccttctttg gcccttctgt 1740 aaaatgagga gttggcctaa ctgatctctt aaatgcacta ctctccgaaa ggagtatccg 1800 tttcccttat ttgccagttg ggaagacgtg ctcagtaaat atttgtgtgc tgtaacctat 1860 gttaggtgct ttagatgctg gcggtctcag catggggtga agaagggctt gtacacttaa 1920 gatgccttac agtactgtgc agtgctgtac tgcgggggcc aactctgggg acctatgcct 1980 tggctgcttg ttgaggatga aaggaagttt taggggagta tttgtatgtt gagggtgcag 2040 tctccctagg gatggtgaca ttttaacttg tgagtcattg tgactttgta tgtgccctta 2100 ttccactttg agttcatgtt ctggttagga gtgccagtgt ctctaacacg gtgcagacat 2160 tatcattgtt ggcttcgaag gcatagagga ggtaacagaa ctaactgcag tcccttcctc 2220 tgctgcatca gggggttaag attggtctgc agggtagtag ggttggtgct gtggctggac 2280 aagccctgta tgtcttctat ttggagatgg tgataagaaa gttaagtaaa aactgaattg 2340 ttttgtgccc ttgggcaact cacttatcta ttgttttatc tgtagaatga gtataatctc 2400 tcagtggggt agggaggcca attaaggatt gattacaaag tgccttacaa atagaaagct 2460 acagtgactt gtttgcaagg tgacagagaa ttcagaagcc tcaagaaact gccttaagtg 2520 atcaaacagg ctaacggagt tgccaaagca aaatagtgct gcactgatac tacctttaac 2580 cgttttttcc tttagccctt ttccccccaa aaaaattagt atatgaaatt acagtgaaat 2640 acctggtatc taagcagatt tatagtaatt ctcaacatat tcatcaatct cttaattcta 2700 cctgcattaa aatgtatttc tacctgaaaa gtttaaaggt cttttatact gtgccatttt 2760 cctgattcat tgttgccaga ggtagtgagt tccttaattt tacagatatt tcaagaggac 2820 attggccagg tattattggt aaatcagatt tgttttttta gctggtagtg tttcacctct 2880 cctgagcact cctagttttt gacagtgtgc tttagtctcc ttccatgctg aggaaggcct 2940 tctctatagg agaaagaaaa ctgaggggtg tacacaggaa gttaccttat gctggggact 3000 caaaccttga tgctactgct ttgctccctg cctctatttt tgaaccaatt caacatctcc 3060 ctcctacccc aggaccttgt cacacactgt tctctttacc aggaatgttt ccctctcttt 3120 tcctctcctc cagacctagt gaactcctat ttatcctcac ttggcacttg ctaagggaag 3180 cattcctgac ttccctgacc agatttactg ctccctgttt ctacagttcc tgtagtattt 3240 actactcctc catcatagtg catatttgta cccttgtgtc tgtctggatg cttatttgat 3300 taatacctgc ctcccccact aaactttaag ctccatgggg tcaaggccgt gactgtgtca 3360 gtatcgtagc ctgcatactt ggaatagtac ctggctcaat aaatatttgt ggagtaaata 3420 actgaataac tctccagagc ctataagata aatctagagc tgctgctttc aatcactgct 3480 ttcctggtgg tctgtggcct ggttctcttt cttctcacac tcttcccacc ttcagagtgc 3540 agccattgct ttggagagat gggagagaac atggcactaa ggcagaatat ggσtatattt 3600 actttgaaga gcatgtcttt gtcatagaaa tagtcactgt catggtttgg tgggtcccaa 3660 ggcatgggtc atggctccag atcccctttc cagccttttg gatcttggta agtctgaacc 3720 cactgctgcg ttggcaaggc tctggaaact atagtgacag agaatgattc acaagtgtca 3780 acactcagat gtacagggct gccagctgac ccactctacc tatttccatc tggcactgaa 3840 ctggttgatc atgaacttct tttcataatt gctttttagt tatgcaggtt aagacatgcc 3900 gaaacagatg taccggaccc acaaacaagt ccttccttga atgcctgagg cttcctaaca 3960 gtgaaagagc cctgttctta gagtaggcaa actgattctg aggcattgta ggtggtaggg 4020 atctggtagt aggtagcatt aggtgggctc ccggcactca ccatggagcc ttgaaatttt 4080 ctgctacttt gggggagttg ctggttcaga gaaggccctt ccaccctggt agccatgtgg 4140 cactggaagg ctgtgaaaac tctgctgggc cttcttagtc atctgttgtg agctcctgat 4200 gggagtgtgg tgtatccctc aggtgtgcta gactggaaca aaggctgaga agtgttgctc 4260 tgggggttcc aacttgtggg catggggtac tgatgagatc agtagtgttt ggagacttct 4320 gtatgctcca tcttcagaag acattctgga gtccatataa gttatcttgt ctcttgtttg 4380 aagcaggaaa aaggaatgcg attgctggta atatagttca ctaaagtcag ctacctggcc 4440 tctaacagtt atttgcaaag tatattataa cattgattcc tcaaacatct agattcctat 4500 ctcgtgccaa gtgatgtact aggtgctcta agtacaaaaa taaaggaata tagtcctcct 4560 ctcaatgcgt aagcctagtg gaagaagcag aaatgaaagg gaaataagaa ttcaatagag 4620 tatgaggcat tacagtgaaa gaaaccaaat gtcttagaag tacaaatggc agagctacta 4680 attctgtctc gagcaggcag ggaagagtct atagtggaaa tgacttttga gctagatttt 4740 gaattgagct agtcttttga gccagacttt tgagctagaa ttgtagggtt gtcatcagac 4800 cagagagtag gaagggtacc ttgtgaggaa gagagagaga gatcagattg ttactgtgtc 4860 tatgtagaaa aggaagacat aagaaactcc attttgatct gtactaagaa aaattgtttc 4920 tgctttgaga tgctgttaac ctgtaacttt agtcccaacc ctgtgctcac agaaacctgt 4980 gctgtaatga atcaaggttt aatggattta gggctgtgca ggatgtacct tgttaacaat 5040 atgtttgcag gcagtatgct tggtaaaagt catcgccatt ctccattctc gattaaccag 5100 ggacacagtg cactgcggaa ggccgcaggg acatctgccc aagaaagcct gggtattgtc 5160 caaggtttcc ccccactgag acagcctgag atatggcctt gtgggaaagg aaagacctta 5220 ccacccccca gcccgacacc cgtaaagtgt ctgtgctgag gaggagtagt gaaagagcgg 5280 ggcctctttg cagttgagat aagaggaagg cttctgtctc ctgctcatcc ctgggaatgg 5340 aatgtctctg tgtaaagctg accattccca ttcgttctat tctgagatag gagaaaacca 5400 ccctgtggct ggaggcgaag tatgctggca gcaatactgc tctgttactc tttgctacac 5460 tgagttgttt gggtaaagag aaacataaat ctagcctgcg tgcacatcca ggcacagtac 5520 ctttccttga acttattcat gatacagatt cctttgctca cgtttccctg ctgaccttct 5580 ccccacctgt tgccctgcta cactcccctc gctaagatag taaaaataat gatcagtaaa 5640 tactgaggta actcagaggc tagcgctggt gcgggtcctc cgtatgctga gtgccggtcc 5700 cctgggccca ctgttctttc tctatacttt gtttctgtgt cttatttctt ttctcagtct 5760 cgtcccacct gacgagaaat acccacaggt gtggaggggc tggccccttt cagtatctca 5820 gaagggacaa agtacacaaa ggcatggggt catgatagtg cctggtatgt tcaggtagtg 5880 aagaggtcca tgtggtatga gcactgcaga tgatatgtgt cgtatgaatt aaaaatacat 5940 agttactgca aatagttttt acaggttatt gtttttaaga aagcagtatc taatgcacga 6000 gtgtactgtc agtactgtca atgaactact taccactcaa gtgactgctt acgcgtcgaa 6060 tcactagtga attcgcggcc gcctgcaggt cgaccatatg ggagagctcc caacgcgttg 6120 gatgcatagc ttgagtattc tatagtgtca cctaaatagc ttggcgtaat catggtcata 6180 gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag 6240 cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg 6300 ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca 6360 acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc 6420 gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg 6480 gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa 6540 ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga 6600 cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag 6660 ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct 6720 taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg 6780 ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc 6840 ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt 6900 aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta 6960 tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac 7020 agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc 7080 ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat 7140 tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc 7200 tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt 7260 cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta 7320 aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct 7380 atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg 7440 cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga 7500 tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt 7560 atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt 7620 taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt 7680 tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat 7740 gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc 7800 cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc 7860 cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat 7920 gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag 7980 aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt 8040 accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc 8100 ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa 8160 gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg 8220 aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa 8280 taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgatg cggtgtgaaa 8340 taccgcacag atgcgtaagg agaaaatacc gcatcaggaa attgtaagcg ttaatatttt 8400 gttaaaattc gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat 8460 cggcaaaatc ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt 8520 ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt 8580 ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag 8640 gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg 8700 aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc 8760 gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc 8820 gctacagggc gcgtccattc gccattcagg ctgcgcaact gttgggaagg gcgatcggtg 8880 cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag gcgattaagt 8940 tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag tgaattgtaa 9000 tacgactcac tata 9014

<400> 15 ggccgcggga attcgattcc ttaattaagt cgactgggac ccaaactttg gagtcgttga 60 cagatgtgac aggtgaagcc tgggatgaca tcgccaaaaa tgcaacgtct cactcattgt 120 cactactccc agggctcagt cgtcactggg gaaaatctcc agaaggtagc gcgggccaag 180 gtgacaggtg tctgccaaga tctgcccgcc agactcccgg gcggcgcgct ccctccctgc 240 aggccttcag cccgtcagca tccccttcct cggggccctg ctcactccca gcctccatcc 300 ccctgccatc tcctccgccg gtcgcgtgcg gacacaagga tggggacctc ccagcgagga 360 gcgctctggg cggggctccg gacgcatgcg cggccctcgt acggaagccc ggaaggaggg 420 gcagggggcg gtggctcagg tttctccggg cggcggcggc ggcggcggcg gcgacggcga 480 cggcgacggc agcggggacg gcagcagtag cgggagcagc agcgtggacg cggctggcgc 540 tggcgccatg aacccgctgt aaggcgcagg ctgtgcagca cggggtgcgg gggaggagga 600 ggaggacgcc gcggtgaagt tctccgccat gaacctgagg ggcctcttcc aggacttcaa 660 cccgaggtga ggcggcgtcg ttggcgcccc cgggagtccg cgctgcgggc tcgggcgcgg 720 gctggtgttc ggctccgggg aggcacggcg ggcgagatgc tgcagcccga ggacccgggc 780 gcctgcccga gcctccctgc gggtgcaagc ggtccccagg caaaacagtc ggcctcggcg 840 cccgcccgct tcctcctccc gtgcccggtg ctttcagccc ctgcccggcc acggccggaa 900 gggcccggcc gcgagccccg tcctgcccca agggaacccc attcttttct gcttgctgtc 960 cctcattggt gtcccaactt cttcgtctcg gttccatcct cttctgcgcc gctgcgggcc 1020 ctccattctc cgcgtcaggg ccgtctcact cgacccaaca cccctacccc caccccagct 1080 gtttcctcca gttcctcgca gtccttgggg ttttccttgg gtttatgccc atccctctct 1140 tgtttgcttc tttgttgaac ggatacctga aacactgttg aatccttgga gtcagtgtcg 1200 gggtatggca ataccttata taatgcattt ctgggtgagc ctgatcattt tccatactca 1260 ttttctcatc agtcttcact acaagtttat ttgcaggaag tagatattgc tgtccttctt 1320 ttccagatgg ggaacacGca gtggacagtg tggagaaaac actggctaag cactcaagcg 1380 cctgtccttg cacttgcccg actgttttgt aactgttctt taccccaggc tgtgagctcc 1440 ctgaagctga gaccatctcc tgctcatctc agtgtcccca gcgcctccca cccaccgtat 1500 ctggcacata gtaggcacat ataaaatgtt tgtggaacta aactgagccc aaagacttgg 1560 attggagacg aggccatatg taactgggtg attctctgcc cttctttggc ccttctgtaa 1620 aatgaggagt tggcctaact gatctcttaa atgcactact ctccgaaagg agtatccgtt 1680 tcccttattt gccagttggg aagacgtgct cagtaaatat ttgtgtgctg taacctatgt 1740 taggtgcttt agatgctggc ggtctcagca tggggtgaag aagggcttgt acacttaaga 1800 tgccttacag tactgtgcag tgctgtactg cgggggccaa ctctggggac ctatgccttg 1860 gctgcttgtt gaggatgaaa ggaagtttta ggggagtatt tgtatgttga gggtgcagtc 1920 tccctaggga tggtgacatt ttaacttgtg agtcattgtg actttgtatg tgcccttatt 1980 ccactttgag ttcatgttct ggttaggagt gccagtgtct ctaacacggt gcagacatta 2040 tcattgttgg cttcgaaggc atagaggagg taacagaact aactgcagtc ccttcctctg 2100 ctgcatcagg gggttaagat tggtctgcag ggtagtaggg ttggtgctgt ggctggacaa 2160 gccctgtatg tcttctattt ggagatggtg ataagaaagt taagtaaaaa ctgaattgtt 2220 ttgtgccctt gggcaactca cttatctatt gttttatctg tagaatgagt ataatctctc 2280 agtggggtag ggaggccaat taaggattga ttacaaagtg ccttacaaat agaaagctac 2340 agtgacttgt ttgcaaggtg acagagaatt cagaagcctc aagaaactgc cttaagtgat 2400 caaacaggct aacggagttg ccaaagcaaa atagtgctgc actgatacta cctttaaccg 2460 ttttttcctt tagccctttt ccccccaaaa aaattagtat atgaaattac agtgaaatac 2520 ctggtatcta agcagattta tagtaattct caacatattc atcaatctct taattctacc 2580 tgcattaaaa tgtatttcta cctgaaaagt ttaaaggtct tttatactgt gccattttcc 2640 tgattcattg ttgccagagg tagtgagttc cttaatttta cagatatttc aagaggacat 2700 tggccaggta ttattggtaa atcagatttg tttttttagc tggtagtgtt tcacctctcc 2760 tgagcactcG tagtttttga cagtgtgctt tagtctcctt ccatgctgag gaaggccttc 2820 tctataggag aaagaaaact gaggggtgta cacaggaagt taccttatgc tggggactca 2880 aaccttgatg ctactgcttt gctccctgcc tctatttttg aaccaattca acatctccct 2940 cctaccccag gaccttgtca cacactgttc tctttaccag gaatgtttcc ctctcttttc 3000 ctctcctcca gacctagtga actcctattt atcctcactt ggcacttgct aagggaagca 3060 ttcctgactt ccctgaccag atttactgct ccctgtttct acagttcctg tagtatttac 3120 tactcctcca tcatagtgca tatttgtacc cttgtgtctg tctggatgct tatttgatta 3180 atacctgcct cccccactaa actttaagct ccatggggtc aaggccgtga ctgtgtcagt 3240 atcgtagcct gcatacttgg aatagtacct ggctcaataa atatttgtgg agtaaataac 3300 tgaataactc tccagagcct ataagataaa tctagagctg ctgctttcaa tcactgcttt 3360 cctggtggtc tgtggcctgg ttctctttct tctcacactc ttcccacctt cagagtgcag 3420 ccattgcttt ggagagatgg gagagaacat ggcactaagg cagaatatgg ctatatttac 3480 tttgaagagc atgtctttgt catagaaata gtcactgtca tggtttggtg ggtcccaagg 3540 catgggtcat ggctccagat cccctttcca gccttttgga tcttggtaag tctgaaccca 3600 ctgctgcgtt ggcaaggctc tggaaactat agtgacagag aatgattcac aagtgtcaac 3660 actcagatgt acagggctgc cagctgaccc actctaccta tttccatctg gcactgaact 3720 ggttgatcat gaacttcttt tcataattgc tttttagtta tgcaggttaa gacatgccga 3780 aacagatgta ccggacccac aaacaagtcc ttccttgaat gcctgaggct tcctaacagt 3840 gaaagagccc tgttcttaga gtaggcaaac tgattctgag gcattgtagg tggtagggat 3900 ctggtagtag gtagcattag gtgggctccc ggcactcacc atggagcctt gaaattttct 3960 gctactttgg gggagttgct ggttcagaga aggcccttcc accctggtag ccatgtggca 4020 ctggaaggct gtgaaaactc tgctgggcct tcttagtcat ctgttgtgag ctcctgatgg 4080 gagtgtggtg tatccctcag gtgtgctaga ctggaacaaa ggctgagaag tgttgctctg 4140 ggggttccaa cttgtgggca tggggtactg atgagatcag tagtgtttgg agacttctgt 4200 atgctccatc ttcagaagac attctggagt ccatataagt tatcttgtct cttgtttgaa 4260 gcaggaaaaa ggaatgcgat tgctggtaat atagttcact aaagtcagct acctggcctc 4320 taacagttat ttgcaaagta tattataaca ttgattcctc aaacatctag attcctatct 4380 cgtgccaagt gatgtactag gtgctctaag tacaaaaata aaggaatata gtcctcctct 4440 caatgcgtaa gcctagtgga agaagcagaa atgaaaggga aataagaatt caatagagta 4500 tgaggcatta cagtgaaaga aaccaaatgt cttagaagta caaatggcag agctactaat 4560 tctgtctcga gcaggcaggg aagagtctat agtggaaatg acttttgagc tagattttga 4620 attgagctag tcttttgagc cagacttttg agctagaatt gtagggttgt catcagacca 4680 gagagtagga agggtacctt gtgaggaaga gagagagaga tcagattgtt actgtgtcta 4740 tgtagaaaag gaagacataa gaaactccat tttgatctgt actaagaaaa attgtttctg 4800 ctttgagatg ctgttaacct gtaactttag tcccaaccct gtgctcacag aaacctgtgc 4860 tgtaatgaat caaggtttaa tggatttagg gctgtgcagg atgtaccttg ttaacaatat 4920 gtttgcaggc agtatgcttg gtaaaagtca tcgccattct ccattctcga ttaaccaggg 4980 acacagtgca ctgcggaagg ccgcagggac atctgcccaa gaaagcctgg gtattgtcca 5040 aggtttcccc ccactgagac agcctgagat atggccttgt gggaaaggaa agaccttacc 5100 accccccagc ccgacacccg taaagtgtct gtgctgagga ggagtagtga aagagcgggg 5160 cctctttgca gttgagataa gaggaaggct tctgtctcct gctcatccct gggaatggaa 5220 tgtctctgtg taaagctgac cattcccatt cgttctattc tgagatagga gaaaaccacc 5280 ctgtggctgg aggcgaagta tgctggcagc aatactgctc tgttactctt tgctacactg 5340 agttgtttgg gtaaagagaa acataaatct agcctgcgtg cacatccagg cacagtacct 5400 ttccttgaac ttattcatga tacagattcc tttgctcacg tttccctgct gaccttctcc 5460 ccacctgttg ccctgctaca ctcccctcgc taagatagta aaaataatga tcagtaaata 5520 ctgaggtaac tcagaggcta gcgctggtgc gggtcctccg tatgctgagt gccggtcccc 5580 tgggcccact gttctttctc tatactttgt ttctgtgtct tatttctttt ctcagtctcg 5640 tcccacctga cgagaaatac ccacaggtgt ggaggggctg gcccctttca gtatctcaga 5700 agggacaaag tacacaaagg catggggtca tgatagtgcc tggtatgttc aggtagtgaa 5760 gaggtccatg tggtatgagc actgcagatg atatgtgtcg tatgaattaa aaatacatag 5820 ttactgcaaa tagtttttac aggttattgt ttttaagaaa gcagtatcta atgcacgagt 5880 gtactgtcag tactgtcaat gaactactta ccactcaagt gactgcttac gcgtcgaatc 5940 actagtgaat tcgc 5954

<400> 16 gtacggaagc ccggaaggag gggcaggggg cggtggctca ggtttctccg ggcggcggcg 60 gcggcggcgg cggcgacggc gacggcgacg gcagcgggga cggcagcagt agcgggagca 120 gcagcgtgga cgcggctggc gctggcgcca tgaacccgct gtaaggcgca ggctgtgcag 180 cacggggtgc gggggaggag gaggaggacg ccgcggtgaa gttctccgcc atgaacctga 240 ggggcctctt ccaggacttc aacccgaggt gaggcggcgt cgttggcgcc cccgggagtc 300 cgcgctgcgg gctcgggcgc gggctggtgt tcggctccgg ggaggcacgg cgggcgagat 360 gctgcagccc gaggacccgg gcgcctgccc gagcctccct gcgggtgcaa gcggtcccca 420 ggcaaaacag tcggcctcgg cgcccgcccg cttcctcctc ccgtgcccgg tgctttcagc 480 ccctgcccgg ccacggccgg aagggcccgg ccgcgagccc cgtcctgccc caagggaacc 540 ccattctttt ctgcttgctg tccctcattg gtgtcccaac ttcttcgtct cggttccatc 600 ctcttctgcg ccgctgcggg ccctccattc tccgcgtcag ggccgtctca ctcgacccaa 660 cacccctacc cccaccccag ctgtttcctc cagttcctcg cagtccttgg ggttttcctt 720 gggtttatgc ccatccctct cttgtttgct tctttgttga acggatacct gaaacactgt 780 tgaatccttg gagtcagtgt cggggtatgg caatacctta tataatgcat ttctgggtga 840 gcctgatcat tttccatact cattttctca tcagtcttca ctacaagttt atttgcagga 900 agtagatatt gctgtccttc ttttccagat ggggaacacc cagtggacag tgtggagaaa 960 acactggcta agcactcaag cgcctgtcct tgcacttgcc cgactgtttt gtaactgttc 1020 tttaccccag gctgtgagct ccctgaagct gagaccatct cctgctcatc tcagtgtccc 1080 cagcgcctcc cacccaccgt atctggcaca tagtaggcac atataaaatg tttgtggaac 1140 taaactgagc ccaaagactt ggattggaga cgaggccata tgtaactggg tgattctctg 1200 cccttctttg gcccttctgt aaaatgagga gttggcctaa ctgatctctt aaatgcacta 1260 ctctccgaaa ggagtatccg tttcccttat ttgccagttg ggaagacgtg ctcagtaaat 1320 atttgtgtgc tgtaacctat gttaggtgct ttagatgctg gcggtctcag catggggtga 1380 agaagggctt gtacacttaa gatgccttac agtactgtgc agtgctgtac tgcgggggcc 1440 aactctgggg acctatgcct tggctgcttg ttgaggatga aaggaagttt taggggagta 1500 tttgtatgtt gagggtgcag tctccctagg gatggtgaca ttttaacttg tgagtcattg 1560 tgactttgta tgtgccctta ttccactttg agttcatgtt ctggttagga gtgccagtgt 1620 ctctaacacg gtgcagacat tatcattgtt ggcttcgaag gcatagagga ggtaacagaa 1680 ctaactgcag tcccttcctc tgctgcatca gggggttaag attggtctgc agggtagtag 1740 ggttggtgct gtggctggac aagccctgta tgtcttctat ttggagatgg tgataagaaa 1800 gttaagtaaa aactgaattg ttttgtgccc ttgggcaact cacttatcta ttgttttatc 1860 tgtagaatga gtataatctc tcagtggggt agggaggcca attaaggatt gattacaaag 1920 tgccttacaa atagaaagct acagtgactt gtttgcaagg tgacagagaa ttcagaagcc 1980 tcaagaaact gccttaagtg atcaaacagg ctaacggagt tgccaaagca aaatagtgct 2040 gcactgatac tacctttaac cgttttttcc tttagccctt ttccccccaa aaaaattagt 2100 atatgaaatt acagtgaaat acctggtatc taagcagatt tatagtaatt ctcaacatat 2160 tcatcaatct cttaattcta cctgcattaa aatgtatttc tacctgaaaa gtttaaaggt 2220 cttttatact gtgccatttt cctgattcat tgttgccaga ggtagtgagt tccttaattt 2280 tacagatatt tcaagaggac attggccagg tattattggt aaatcagatt tgttttttta 2340 gctggtagtg tttcacctct cctgagcact cctagttttt gacagtgtgc tttagtctcc 2400 ttccatgctg aggaaggcct tctctatagg agaaagaaaa ctgaggggtg tacacaggaa 2460 gttaccttat gctggggact caaaccttga tgctactgct ttgctcGctg cctctatttt 2520 tgaaccaatt caacatctcc ctcctacccc aggaccttgt cacacactgt tctctttacc 2580 aggaatgttt ccctctcttt tcctctcctc cagacctagt gaactcctat ttatcctcac 2640 ttggcacttg ctaagggaag cattcctgac ttccctgacc agatttactg ctccctgttt 2700 ctacagttcc tgtagtattt actactcctc catcatagtg catatttgta cccttgtgtc 2760 tgtctggatg cttatttgat taatacctgc ctcccccact aaactttaag ctccatgggg 2820 tcaaggccgt gactgtgtca gtatcgtagc ctgcatactt ggaatagtac ctggctcaat 2880 aaatatttgt ggagtaaata actgaataac tctccagagc ctataagata aatctagagc 2940 tgctgctttc aatcactgct ttcctggtgg tctgtggcct ggttctcttt cttctcacac 3000 tcttcccacc ttcagagtgc agccattgct ttggagagat gggagagaac atggcactaa 3060 ggcagaatat ggctatattt actttgaaga gcatgtcttt gtcatagaaa tagtcactgt 3120 catggtttgg tgggtcccaa ggcatgggtc atggctccag atcccctttc cagccttttg 3180 gatcttggta agtctgaacG cactgctgcg ttggcaaggc tctggaaact atagtgacag 3240 agaatgattc acaagtgtca acactcagat gtacagggct gccagctgac ccactctacc 3300 tatttccatc tggcactgaa ctggttgatc atgaacttct tttcataatt gctttttagt 3360 tatgcaggtt aagacatgcc gaaacagatg taccggaccc acaaacaagt ccttccttga 3420 atgcctgagg cttcctaaca gtgaaagagc cctgttctta gagtaggcaa actgattctg 3480 aggcattgta ggtggtaggg atctggtagt aggtagcatt aggtgggctc ccggcactca 3540 ccatggagcc ttgaaatttt ctgctacttt gggggagttg ctggttcaga gaaggccctt 3600 ccaccctggt agccatgtgg cactggaagg ctgtgaaaac tctgctgggc cttcttagtc 3660 atctgttgtg agctcctgat gggagtgtgg tgtatcGctc aggtgtgcta gactggaaca 3720 aaggctgaga agtgttgctc tgggggttcc aacttgtggg catggggtac tgatgagatc 3780 agtagtgttt ggagacttct gtatgctcca tcttcagaag acattctgga gtccatataa 3840 gttatcttgt ctcttgtttg aagcaggaaa aaggaatgcg attgctggta atatagttca 3900 ctaaagtcag ctacctggcc tctaacagtt atttgcaaag tatattataa cattgattcc 3960 tcaaacatct agattcctat ctcgtgccaa gtgatgtact aggtgctcta agtacaaaaa 4020 taaaggaata tagtcctcct ctcaatgcgt aagcctagtg gaagaagcag aaatgaaagg 4080 gaaataagaa ttcaatagag tatgaggcat tacagtgaaa gaaaccaaat gtcttagaag 4140 tacaaatggc agagctacta attctgtctc gagcaggcag ggaagagtct atagtggaaa 4200 tgacttttga gctagatttt gaattgagct agtcttttga gccagacttt tgagctagaa 4260 ttgtagggtt gtcatcagac cagagagtag gaagggtacc ttgtgaggaa gagagagaga 4320 gatcagattg ttactgtgtc tatgtagaaa aggaagacat aagaaactcc attttgatct 4380 gtactaagaa aaattgtttc tgctttgaga tgctgttaac ctgtaacttt agtcccaacc 4440 ctgtgctcac agaaacctgt gctgtaatga atcaaggttt aatggattta gggctgtgca 4500 ggatgtacct tgttaacaat atgtttgcag gcagtatgct tggtaaaagt catcgccatt 4560 ctccattctc gattaaccag ggacacagtg cactgcggaa ggccgcaggg acatctgccc 4620 aagaaagcct gggtattgtc caaggtttcc ccccactgag acagcctgag atatggcctt 4680 gtgggaaagg aaagacctta ccacccccca gcccgacacc cgtaaagtgt ctgtgctgag 4740 gaggagtagt gaaagagcgg ggcctctttg cagttgagat aagaggaagg cttctgtctc 4800 ctgctcatcc ctgggaatgg aatgtctctg tgtaaagctg accattccca ttcgttctat 4860 tctgagatag gagaaaacca ccctgtggct ggaggcgaag tatgctggca gcaatactgc 4920 tctgttactc tttgctacac tgagttgttt gggtaaagag aaacataaat ctagcctgcg 4980 tgcacatcca ggcacagtac ctttccttga acttattcat gatacagatt cctttgctca 5040 cgtttccctg ctgaccttct ccccacctgt tgccctgcta cactcccctc gctaagatag 5100 taaaaataat gatcagtaaa tactgaggta actcagaggc tagcgctggt gcgggtcctc 5160 cgtatgctga gtgccggtcc cctgggccca ctgttctttc tctatacttt gtttctgtgt 5220 cttatttctt ttctcagtct cgtcccacct gacgagaaat acccacaggt gtggaggggc 5280 tggccccttt cagtatctca gaagggacaa agtacacaaa ggcatggggt catgatagtg 5340 cctggtatgt tcaggtagtg aagaggtcca tgtggtatga gcactgcaga tgatatgtgt 5400 cgtatgaatt aaaaatacat agttactgca aatagttttt acaggttatt gtttttaaga 5460 aagcagtatc taatgcacga gtgtactgtc agtactgtca atgaactact taccactcaa 5520 gtgactgctt acgcgtcgaa tcactagtga attcgcggcc gcctcgagtc tagaactagt 5580 ggatccccca aacgggccct ctagacgcgt tgacattgat tattgactag ttattaatag 5640 taatcaatta cggggtcatt agttcatagc ccatgatatc atatggagtt ccgcgttaca 5700 taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca 5760 ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg 5820 gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg 5880 cccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtncatgac 5940 cttatgggac tttcctactt ggcagacatc tacgtattag tcatcgctat taccatggtg 6000 atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggattttcc 6060 aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 6120 tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg 6180 ggaggtctat ataagcagag ctctctggct aactagagaa cccctgctta ctggcttatc 6240 gagatatctg cagaattcat ctgtcgactg ctaccggcag cgcgcagcgg caagaagtgt 6300 ctgggctggg acggacagga gaggctgtcg ccatcggcgt cctgtgcccc tctgctccgg 6360 cacggccctg tcgcagtgcc cgcgctttcc ccggcgcctg cacgcggcgc gcctgggtaa 6420 catgcttggg gtcctggtcc ttggcgcgct ggccctggcc ggcctggggt tccccgcacc 6480 cgcagagccg cagccgggtg gcagccagtg cgtcgagcac gactgcttcg cgctctaccc 6540 gggccccgcg accttcctca atgccagtca gatctgcgac ggactgcggg gccacctaat 6600 gacagtgcgc tcctcggtgg ctgccgatgt catttccttg ctactgaacg gcgacggcgg 6660 cgttggccgc cggcgcctct ggatcggcct gcagctgcca cccggctgcg gcgaccccaa 6720 gcgcctcggg cccctgcgcg gcttccagtg ggttacggga gacaacaaca ccagctatag 6780 caggtgggca cggctcgacc tcaatggggc tcccctctgc ggcccgttgt gcgtcgctgt 6840 ctccgctgct gaggccactg tgcccagcga gccgatctgg gaggagcagc agtgcgaagt 6900 gaaggccgat ggcttcctct gcgagttcca cttcccagcc acctgcaggc cactggctgt 6960 ggagcccggc gccgcggctg ccgccgtctc gatcacctac ggcaccccgt tcgcggcccg 7020 cggagcggac ttccaggcgc tgccggtggg cagctccgcc gcggtggctc ccctcggctt 7080 acagctaatg tgcaccgcgc cgcccggagc ggtccagggg cactgggcca gggaggcgcc 7140 gggcgcttgg gactgcagcg tggagaacgg cggctgcgag cacgcgtgca atgcgatccc 7200 tggggctccc cgctgccagt gcccagccgg cgccgccctg caggcagacg ggcgctcctg 7260 caccgcatcc gcgacgcagt cctgcaacga cctctgcgag cacttctgcg ttcccaaccc 7320 cgaccagccg ggctcctact cgtgcatgtg cgagaccggc taccggctgg cggccgacca 7380 acaccggtgc gaggacgtgg atgactgcat actggagccc agtccgtgtc cgcagcgctg 7440 tgtcaacaca cagggtggct tcgagtgcca ctgctaccct aactacgacc tggtggacgg 7500 cgagtgtgtg gagcccgtgg acccgtgctt cagagccaac tgcgagtacc agtgccagcc 7560 cctgaaccaa actagctacc tctgcgtctg cgccgagggc ttcgcgccca ttccccacga 7620 gccgcacagg tgccagatgt tttgcaacca gactgcctgt ccagccgact gcgaccccaa 7680 cacccaggct agctgtgagt gccctgaagg ctacatcctg gacgacggtt tcatctgcac 7740 ggacatcgac gagtgcgaaa acggcggctt ctgctccggg gtgtgccaca acctccccgg 7800 taccttcgag tgcatctgcg ggcccgactc ggcccttgcc cgccacattg gcaccgactg 7860 tgactccggc aaggtggacg gtggcgacag cggctctggc gagcccccgc ccagcccgac 7920 gcccggctcc accttgactc ctccggccgt ggggctcgtg cattcgggct tgctcatagg 7980 catctccatc gcgagcctgt gcctggtggt ggcgcttttg gcgctcctct gccacctgcg 8040 caagaagcag ggcgccgcca gggccaagat ggagtacaag tgcgcggccc cttccaagga 8100 ggtagtgctg cagcacgtgc ggaccgagcg gacgccgcag agactctgag cggcctccgt 8160 ccaggagcct ggctccgtcc aggagcctgt gcctcctcac ccccagcttt gctaccaaag 8220 caccttagct ggcattacag ctggagaaga ccctccccgc accccccaag ctgttttctt 8280 ctattccatg gctaactggc gagggggtga ttagagggag gagaatgagc ctcggcctct 8340 tccgtgacgt cactggacca ctgggcaatg atggcaattt tgtaacgaag acacagactg 8400 cgatttgtcc caggtcctca ctaccgggcg caggagggtg agcgttattg gtcggcagcc 8460 ttctgggcag accttgacct cgtgggctag ggatgactaa aatatttatt ttttttaagt 8520 atttaggttt ttgtttgttt cctttgttct tacctgtatg tctccagtat ccactttgca 8580 cagctctccg gtctctctct ctctacaaac tcccacttgt catgtgacag gtaaactatc 8640 ttggtgaatt tttttttcct agccctctca catttatgaa gcaagcccca cttattcccc 8700 attcttccta gttttctcct CGcaggaact gggccaactc acctgagtca ccctacctgt 8760 gcctgaccct acttcttttg ctcttagctg tctgctcaga cagaacccct acatgaaaca 8820 gaaacaaaaa cactaaaaat aaaaatggcc atttgctttt tcaccagatt tgctaattta 8880 tcctgaaatt tcagattccc agagcaaaat aattttaaac aaaggttgag atgtaaaagg 8940 tattaaattg atgttgctgg actgtcatag aaattacacc caaagaggta tttatcttta 9000 cttttaaaca gtgagcctga attttgttgc tgttttgatt tgtactgaaa aatggtaatt 9060 gttgctaatc ttcttatgca atttcctttt ttgttattat tacttatttt tgacagtgtt 9120 gaaaatgttc agaaggttgc tctagattga gagaagagac aaacacctcc caggagacag 9180 ttcaagaaag cttcaaactg catgattcat gccaattagc aattgactgt cactgttcct 9240 tgtcactggt agaccaaaat aaaaccagct ctactggtct tgtggaattg ggagcttggg 9300 aatggatcct ggaggatgcc caattagggc ctagccttaa tcaggtcctc agagaatttc 9360 taccatttca gagaggcctt ttggaatgtg gcccctgaac aagaattgga agctgccctg 9420 cccatgggag ctggttagaa atgcagaatc ctaggctcca ccccatccag ttcatgagaa 9480 tctatattta acaagatctg cagggggtgt gtctgctcag taatttgagg acaaccattc 9540 cagactgctt ccaattttct ggaatacatg aaatatagat cagttataag tagcaggcca 9600 agtcaggccc ttattttcaa gaaactgagg aattttcttt gtgtagcttt gctctttggt 9660 agaaaaggct aggtacacag ctctagacac tgccacacag ggtctgcaag gtctttggtt 9720 cagctaagct aggaatgaaa tcctgcttca gtgtatggaa ataaatgtat catagaaatg 9780 taacttttgt aagacaaagg ttttcctctt ctattttgta aactcaaaat atttgtacat 9840 agttatttat ttattggaga taatctagaa cacaggcaaa atccttgctt atgacatcac 9900 ttgtacaaaa taaacaaata acaatgtgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 9960 aaaaaaaagg tagcagtcga cagatgaatt ccaccacact ggactagtgg atccgagctc 10020 ggtaccaagc ttaagtttgg gctgcaggaa ttctgatggc tctcaaaatt cctgcctcct 10080 ttagggataa aagactttaa gactttttaa caaaaaagaa aaagaaaaaa aaaattcctg 10140 cctcctggtg tacacacaca gaagggttcc ctccccttga atgtgaccag gatctgtgaa 10200 aataacggga tagccgctcc tgtgattagg ttatgtggta gactagagca agattctcct 10260 gctggttttg aagaagtcag ctgccatgtt gtgagactgt catgggctag ggcatgagcc 10320 tttaaatatc tgggagcaac ccctggccag cagccagtga gaaaacgggc cctcagtcct 10380 acaatcacaa ggaactaaat tctgccaaca acctgaagga actttgaaga ggatcatgag 10440 tcccttgatt cagcttgatg agcccctgag cagaggatac agctaacttg tactagggaa 10500 gtataaaaaa catgcatggg aatgatatat atcaacttta aggataattg tcatacttct 10560 gggaatgaag ggaaagaaat ggggctttag ttgtattatg atctttaatt tctcaaaaaa 10620 aataagatca gaagcaaata tggcaaaatg ttaatacttt tgtgggtacg taggtattca 10680 gcataccctt ttttctgagt tcaaaatatt ttataattaa aatgaaatgc aggccaggca 10740 cagtggctca tgcctataat accagcactt tgcgaggccg aggtgggagg atggcttgag 10800 gccagaccag cctggccaac atggcaaaac cccatctcta cttaaaaaaa aaaaaactat 10860 atatatatat atgtgtgtgt gtgtgtatat atatatatgt atatatattt atatatgtgt 10920 gtatatatat atatgtatat atatttatat atgtgtgtgt atatatatat atacacacac 10980 acacatatat acatacatac atacacacac acacacacac aattagccag gcatggtggc 11040 gcacacctgt agtcccagct acttgggagg ctgagacatg agaattgctt gaacctggga 11100 ggcagagtag ttagtgagct gagatcatac cactgcactc cagcctggtg acagagtgag 11160 actctgtctt aaaaaaaata aaaattaaaa ttaaatgcaa aaggtccaag tgaattgaag 11220 aggaaagggg tatcaaggaa ggttttgtgg aggtgacgtt tgagctgggt cttaaatgac 11280 ttaaacatgg gataagaagg gagggaataa ggacatttca ggtacgagaa ataaggagca 11340 aacagtggaa acaacctaac gtctgtcaac cagtgaatgg ataacaaaaa tgtaattcag 11400 atggtatcca acttacgatg gttcaacatg agatttttct gactttagga tagatttatc 11460 aaagtagtaa atccattttc aacttatgat attttcaact tcagatgggt ttatcaggac 11520 acagttgagg aacacctgtc tatccataca atttggcaat aaaaaggaaa tgagtgcaga 11580 tatactccac aacatgaatg aaccttgaaa acattaagtg agagaagcca gatacaaaag 11640 gccacatatt gtatgattct atttatacaa aatgtccaga ataggcaaat cttatagaca 11700 gcaagtaggt agatgatcag tttgctaggt gctgggggaa ggggaaatgg ggagtgatgg 11760 ctaaggggat tgggtttctt tgtggggcaa tgaaaatgtt ttaaaattga gcgtgataat 11820 gattgcacaa tgctgcatat atatataatc tatagattat atatatataa agagaggctg 11880 ttagacagtg ataagtgata tatatatata tatacataga gagagagaga gagagagaga 11940 gaggctgtta gtgataagtg atcaggaaaa taaaagtatt gaggaggaat acgaagttga 12000 cggtgtgaaa acatgagatt ttatatagga tggccaggga aggccttaat gagaaagtga 12060 cttatgagta aaaacaaggg atcctaaacc ttagcatgca tcagaatcac tcggaaactt 12120 gttaaagcat agcttgctgg gcctcatcac agatattttg attcggtagg ttcttgtctg 12180 atattaatac ttttggtcta gggaaccaca ttttgagaac cactgagcta aaggaagtaa 12240 aggtttccct tagtttacta gctggtaaca ctggcccagg aggcctttct ggaaaaggtc 12300 ccagtcccca aaggaagctg gggactcgcg ttcacatcgt caaggtttac caagttgtgg 12360 cgggcctttc cgtcttggaa aaagcctcaa aatggcagat tagggtgtcc atggccggcg 12420 gaaagggtct ttgaagttgc agaccaggag ggaagaagat tctgggcctc ccccatgcag 12480 tgtcagctgg caacagaatg caccccggct gggttggagg ccctgggtac tggctcttcc 12540 acaccagggg cccacctacc aagggcagca ggagcatctg cacctcctgc gccaggcgcc 12600 cttcagtgct tccacttgag cacctctcca gacaccagct agggtgacag tggtacaaat 12660 accagactcc cctggcctgc tcacctcaca gggtaatgtg ctgtggagtc agggggacac 12720 agcaaccacc agatgacatg gctggccccg gggaggacga cacgcagata cggctacttg 12780 gcacctgtga tattttacac actcgagagg ggcccgcacc atcctcagcc ctctccccac 12840 attcactctt agttcatgtc acctccaccc agagggggac acaggcccac agcgatggcc 12900 ccacaccctg cctgaggtcg cccacttccc aggaggcagt cctgggactt ccacccgacc 12960 aggccccaga gcccaccgac ttaacccctc cagaggcttg tcgttcatta ccttattcaa 13020 gatggagacc agcctttttg cggagaaaat gcgggtgaag gtcctgaaag tgcattgacg 13080 ccgttttcgg aagccataca agtttagctg gcggaagaag ctctttatcg aagttgtggc 13140 aaacactttg tgtgcgacgt cccttttgag aatctccttt tcaaagagtt tttgattgat 13200 cactctacaa gccccactgt catcccacca gatggacgaa aactggttgc tgctgaccag 13260 tctccacagt ttctgtggaa aggggaggga gaggagatta tcttctccct ggggcgggac 13320 gtcaccgtca gggtgcggcc ttctgaacga agcttcctcg gccagaggtt ggaaagcgat 13380 ttcttctgtc agcagcctca agttagggct cccagtggac cccgggtcgt cccaggcagg 13440 ggaaggatct gctgggtgaa ggtaggtctc tgactgcaac tggggaggga aaggcaccct 13500 ttccaagcca tgatcctgtc ctctcgaatt tctttcttca cagcgagcca tactcaatga 13560 tcgcttgtcc tccatctggc aaacttgcta gtgcagtgtg gccagcagca ccccttggca 13620 gtcatgtaac cagccccatg acatcataaa ggggctctga ctgccggggg gtggcatctc 13680 cacccccagc aagttgtgta ataaagggcc aaggcagaca agtagctgcc catctgcatg 13740 tgcacattct ggtcctcaca gtcatttcaa tgggaaagat gacactagtg cacaagagtg 13800 ccgaggggcc Gtgccacacc gtagatgcag acctggagcg gtccccttgt cctagagctc 13860 ctgagccagg cacaactaca gcaaagccct ggctcaggaa ggtcagagct caccgtctga 13920 gtcatgggcc cacagacccc agcacatgac tgacactcgg aagcacagaa caaagggtag 13980 gacggtgccc atgggtcagg ctgtagccac gccacccttt ccaccctgtc ctagccagag 14040 gcagcaatgt gctccataca gatcctccta acacacccac actgtcggtc cccagcacgc 14100 agatgcccga cagcccctta ggcaaatggc ttagctgact gcGCcaccac acgccgtcgc 14160 catgcagtcc agtggggagt cggaggcagc ctccttcctg cctctcctcg gcctgcacgt 14220 gtccccccac caggcagaga cccttctaca ccccgggtgt ctgcggtcac atcgcggtgg 14280 ggcatgcagc tgttggcctt cgagcatgtt ttgttttcct tggccagtgt ctccagagaa 14340 acgcacgtgg gtttgtgtcc agcggtccat ctctgcaaca gttgttcctt tgggattgga 14400 tgctaggagg tcacgggaga ggtgtccatc caaagcagtg tctgtgtcac acactgtccc 14460 cacacacagg gccacctctg cacagactcc cccgactcga ttctgggcac agagctcagt 14520 gaccttccag agactgccac gaaccggtga tgcctccacg cttgagacat cctgaccgca 14580 gggcccaagg cgcactggct cagggggtga cagtgagggg tctgcaaaca gactgctgat 14640 gctcaacccg gccgctgccg agctgtgtga cttgggcacg tcacttaacc tctctcggcc 14700 tctgtctcct cccggggata agagtagtag cacctgcttc ccggggctgt gaggatccag 14760 tgggacgtat aggaactagc gaggcaccgg cagttgggtc agagctactg ttgtcacttc 14820 acaaggcatt ttcttcaaca gcaagtcgga aatctcatga gcctaaggca gaatccacct 14880 gtggcctctg gttacaaccc acaggactga aaatccttcc agccacagca actggtgaat 14940 ttcctggtca attgccacaa gtcatgagct gaaccccact tgagtttcag ttcaggcaga 15000 actctagaga cgactagggc aagctagaca gcgactgcag agccttttgt tgcagcgtga 15060 gcagtcctca gctgttgaca tcactgggga gcaaacgagg accaggagcg gtgaaaggac 15120 agtgtctgct gcagattgtc gtagcaccca aggaacactc cagaaagcct cctaagcagt 15180 aacaagtgtg gcaaggtgta gcccagccaa cagtggcatc tgcgaggcgt cccctccttc 15240 ctcccactac cccgtatacc ctgggacctg tgcactgaag gactcattct aaaggctgtg 15300 cccctgcagc cgccagcctc actcactggc tgcctgtgcc agctagagat ttctttcctc 15360 tgaggctggc tgagaggacc actccagttt cctggcccat ccagcaaaga agatacacat 15420 catgcacgtg taaaatgagg aaccggttta ttgaacagct taaggagagc aaaaatagtg 15480 gctttagcta cattttttac acactgagca ggaaagtcta aaccatcccg ttcccctgta 15540 ccccaaagag aacagggctt gctggaggcc agtgccaagg gcggagtcgt gctcgcagca 15600 gacttgaatt aacGccatgt aggccggcga gcagttgccc gcgtgaaaac accaccctct 15660 tctcctggct gagaagatca aagctctttt tttaccctct tttcagcaaa ggacctattt 15720 gttttcaggc aggaggatgt taaacttgca gcctctgaca cacggtggaa cctgcagtgc 15780 ttggagaaac ggcacgcaca cgtgaaaaca tcatgcctac tccaaagcct tcttgttgct 15840 ggcaggaggg aagcttgaga ctttcccacg catagtcgtg acccgcgtgg ccgtttctgc 15900 tctcagcaac attctctagt gttccggctt caagcagcgc ttgtcaggtt tgaagctagc 15960 cactattctg agaacgtcag aaaagcatgg accatctctt gcttggtgtt gccgttgtgg 16020 cagtagcagc tactacgtac ctgcacgagt tccagggcag aagtggcaat gtcccatgaa 16080 ggcgtggcac cccacggggg ggggggggga gtgtgccacg ggcgtccact tctgcagcag 16140 aaggcatgtg cctacagcac aagcttgtaa aaaaatactt gaacagaata tgctgtacag 16200 aactaggggt taacaccgca tatgaagatg ctaaaacatt tgtataaata ctctgtatac 16260 aagcatggag tcactcccgt agaaagggct catccgtgag gctatgaaaa actgctgtca 16320 gcatgcccaa agagaaacta cttccacagt aggaacagaa aaaaggactg tgctgtgtct 16380 aaacacgtgg tgcatcagag acatagttac agttcctact gactgcccca gccacgacct 16440 gggagtgctg aggacctggg agtgctcagc gagctgcagg aggtcagccc tgtggagaaa 16500 tacatttcta aacaatactt ttgattggga tttcagcacc gtatagacag atgttccttc 16560 tgggggcctg gcaagcagcc atctcccagt gggtctgacg gggaagaggg gtacctggag 16620 cccctcccag acagacggta atcccacccc tgttctcaca ctcttcctgg catccgcatc 16680 tgctggcaca cacccccgtc acctgccact tccgcgtccc gtcgtggtga gtggctgata 16740 ggcgctggat gcaaacaagg catgagatgg acgtacctgg agacccagct ccagtactgg 16800 ttctggtctg cggggtgaac gagggggcag aggaaggcgg agagagtgcg tcccagtcca 16860 cttaagctct gtcGccggaa gtggcatcta atctggcatt tcgatattta atttgggagg 16920 tgggagcaca tacttcccag ggctctgggt aatgaccacc ctggccttct ttcgaaacat 16980 gggtgcgatt ttagggggct ccggaactgg ggtctcttcg gtttcttcat tatcttcgtg 17040 atggagatca taggaaatgt ttccatattc tcgtagaaat gggaagattt caagcagaaa 17100 ctgacagaaa tctttgcgga taccaaacca ccctgaaaaa taagaatttt ttatttcaca 17160 cacgaggctc aactgacctt cctgttaact ttctttccgt aacaagaagt ttcactccta 17220 caatgtcata acatacttta tccagactcc tgagtcacaa agcctgaaca gggcttgagt 17280 acccaaaatg gggaagaagt gcaaatgcta gctctgtggt gcttggagtg gggttcccgg 17340 accggcaggg acagcgtcca cggggcctag ttagggatgc cattctcggg ccccagccca 17400 gacctccaga aactgagtcg ggctagggtg ggctccagcg gtcccctttt cctggccctt 17460 ttgggattct gctggatgcc caaatttgag aactactgct ccagtgagtc tcaaaatatc 17520 tgtggtgcgc agactacggt gtcttccgct aatcttctcc agccaggata aactcatgga 17580 tgacagtgcc acccaagaac aagatttctg tcaccctctg gaatccgtga gggcggtagt 17640 catgcacggg ttggccagga gggggcctga actcatggag ccaccttaaa gccactttcc 17700 cagtcccact actcctctct gtaggctact ggagtgtcag ctcggtgcaa gccctccctg 17760 ctcccgggtg cggggtaggg ggcagaggca caaacagcaa gcacagcccg ggctgctggg 17820 ctgcagtgag gccctgcccc caaacccact ggctttccga agggcaatgc tctgggcttc 17880 cgtgccatgg agcccacagc cttgccagga aggcaccctc tgcagagatc gttttggaag 17940 tgtctgcctc agcaagcagg tggaggggaa tagagtgtta gcaaggcaag acaggcaaga 18000 ctcgggtgat ggcagcaagg atatggggga ggcagagcgg ccaacaggga cctaggatga 18060 atcccaggtt tgggtgggag atgtggattt tccatcaaac cctcccgggc ctgggaagaa 18120 tctgtcttga tccccatttt gcagaggagg gaacgggatc tctgagaggt tgcctgccgt 18180 gtctggttct acctcaaatg gcagcgtgca ctgcgagaaa agtcccggtg caggccagca 18240 gaacaccaga gttacggcat gcccttccct tagaaggtcc cagaatttcc tcagccctca 18300 ctttcccaca caagcttcta aattggggcc ctcggggact catcccttcc tagacttcta 18360 tccgccaccc cccaccccct ggtccccccc cagacacaca ccaaggactt ctgaaatgct 18420 gagtacatac agtggtttcc tcccttctgt ccaaatgtgg ttgccatcag cgtgatcaac 18480 gagagccaaa gggggacaaa gatcgggatg caggagaagg cgttgtggcc atccagtttg 18540 tgaaccagca gaatctaaag aaagagacat agtcccggtt gatgccagca ccgaaaatgg 18600 gcagaggcgg aagccagact tcattaggca gttcctcccc accaccccac ccccgcgtga 18660 gctcccacaa gagggaacat cagcaccgcc agaaaaaggc aggaaaccac ctatccctgg 18720 ggaaagctcg aaatgagctt ttatgtccct cttcagagct cggcaatagc ctatccactt 18780 gaaaagttcc cagtgccagc agttttatgg caaactcctc cgggtgtttg ttctaaggag 18840 tcaacagctc ccattctaga attctccacg tgactccaat acacaaatct gacatcccac 18900 tctgctttcc ccagagtgga aactggagcc atacagaggc accatggcta aaaaggtgca 18960 ctcttctccc tgccagcccc acgtgctgcc cccaagagaa aggaaggatg ctctcctttc 19020 accgaagctc cctctcggag atggctgtgt tctctcccct ctcctggagt gggctcactg 19080 tgagctcgag ggacagaggc tgcctttcta ggggtgcaga atcctgtcag gggaagcgca 19140 agcttcaggg gctgaagagg cttcccgtgg aacgcttacc tcaaatgtaa gaaggggcac 19200 gacgatggtc atccagctca gggccatggt tatgtgtgtc ctgcgctgtc cgcaatcaca 19260 tccatagagc gcaagaacaa gacggaccac acaatgtagt agaggaccac caggcacaga 19320 aaggacatga gaatccacag cgggacacac acaacctggg ggtgggtgag agaacagcaa 19380 gagaagtctc tttagagctt ccaacctggc ctctgatgga aggcatcttt agcaccttgc 19440 tgtgtctgtc cagttaaggc ggtccttcct gtgagccgaa taaggaccgt tccatctccc 19500 aggactgctg ggagcatcgc tcaggacaga aaaggtatgg tatgttcact atggggcctg 19560 ctgccaccag gggacacaca cgctcagtga gtcatcagtc cctcttcctt tgggtgacag 19620 acagccctgc acctggctcc gcagcctcta ctcttccaga ggcccactct cccacactct 19680 ctcaggctcc tctaggttct gctgccatca cagcttcccg ggaaatggga cacaactgtc 19740 accctgtgca cacacacaag atctcacccc aacagactct cttcacaggc aacattccca 19800 caacctgctg ggggtacttt ggcaacacaa atgggaatgg gctccccaga aagtctggct 19860 gcctgggctc ctaaggatcc ctaacctcac ccctaccaag ttagtgaact tggcgggttg 19920 atgctggata caggttgatg ctggatacgt agcgctgccg ggtcgtgacc cctaaggaat 19980 tatccaaact cttgttttta gatgctttat tatatcaaac tctcctttaa acaagtggcc 20040 catctgctgg gatttggaag Gctgtaatac tgaaattttc atcataatgg aaattttaaa 20100 aacagaattt gacccacctg tttttaaaac actttcatta cttaacaaga ggtctaatct 20160 tgggcaagtc ttgaaatttc tctggcctta gtttcccatg tgttaaatga aacttgaagc 20220 agttggtctc ttatagtctc ctgactctaa cattctaaga attatatttg tacaataact 20280 caaaaatcac ataatttaat ttaccatatg gactccaaaa tatattttct cattaggcta 20340 aacttgatct gcattttctg gatgtgtcca tattcttgga ctacactaaa acatgatacc 20400 aatgcttcct ctcaccataa accctcactt cgctttctac atttaagaat tttatagctg 20460 gaagagtcct taacagaaaa taccatctaa taattacccc tcaaaatcga gaaagtccta 20520 tctgttctta tgctagttat aagaatgagg cagcatttca cataatggtt ataaacactg 20580 ccacaagaag attcatgatg tgttgtttat ctgtagctct catcatactc tgtcatataa 20640 ctatagcatt aagattttaa tgttctatat attcttctaa gacagtgttt accagagtaa 20700 ggcacaaaag atccactggt ttgcaagaaa gattagaact tttaaatttt ttacctcacc 20760 ttgtttaatc tatatttttg tatgtatttt gtaacatata tattattatt accataaatc 20820 atatataatt taaaatgcat atattagggg taaatgctca ggaaactttt tataaattgg 20880 gcatgcaaat acaagtttga agactcactg ttctaggtat taaaagtaaa gttataacca 20940 agtaaagctt ccaccttttc atgtctcaaa gcagtttatt gttggaggta agatctctta 21000 gaagcctaaa caggtccaag tacagaatga agtaaggcta gcccataact tgtggcaagc 21060 aattcatact atttctctca tgctgagctc tcctcagtga agcagctact atagacaact 21120 gcagcctatt ggtagcctat tttacaggca ggaaaaaaat tactttttat tcaaagtgga 21180 actcaggaca tggggagaaa atgaatacaa aaaatagggt caatccaaag gcacacagca 21240 aatgagtaac acagttatgt ttttttccca tttgtatgag gtcccagtaa attctaagta 21300 aactgcaaat ttaataatac actaaaaaag ccatgcaatt gttcaaatga atcccagcat 21360 ggtacaagga gtacagacac tagagtctaa aaaacaaaag aatgccatta ttgagttttt 21420 gaattatatc aagtagttac atctctactt aataaatgag aaaaacgagg ataagaggcc 21480 atttgataaa atgaaaatag ccaagaagtg gtattagaga cttgaataca ggtattcggg 21540 tccaaagttc atctgctcaa atactaactg gggaaaagag ggaaaaatat ttatatacat 21600 atatatctgc acacaaaaat acccccaaaa gacaaaatga ggccaggcag ggtggctcac 21660 acccgtaatc ccggtacttt gggaggctga ggcaggtgga tacctgagat caggagttgg 21720 agatcagcct ggtcaacatg gtgaaaccct gtctctacta aagataaaaa aattagccag 21780 gcatggtggc gtgcgcctgt aatcccagct acttgggagt ctgaggcagg agaatcactt 21840 gaactgggaa ggggaggttg cagtgagcca agatcgtact actgcactcc agcctgggca 21900 gcagagtgag actccatcac aaaaataaat aaataaataa aatacaatga aacagaaagt 21960 tcaaataatc ccataatctt accaccaaga aataactttc actcgttata cttattgatt 22020 tttccataat aaatgtactt tactgtgact atcatgaaaa gaaagttatt ttagaaacag 22080 agaactgttt cagatcaaat ctatgtagta gaacagagcc attaggtggg aaagacgaga 22140 tcaaactaaa tctcagaagg cctaaaaggc taggtccatt ccagcactaa aaactgacca 22200 gacaagtaat ggcttcaaca gcttctaaat atggacaaag catgctgaaa gggaaggaca 22260 ggtctaacag tggtatatga aatgaacagg aggggcaaag ctcatttctc ctctgaagtt 22320 ttccaaagat gctgaggagg acattagttt gacatgaccc tgatatggga caagataatt 22380 tcacagaagt tttacatgtt aaagttttct tatagatact cattcaagta agcaatgaac 22440 actaaaatct aaagaaagaa aagagcttta gagtcaggtc tgtattcaaa ttcaagctct 22500 accacttact ggttctgtga ctttgggcaa gtcttttaac cttattaagt cttaatttcc 22560 tgatttgtaa aatggggata tcgtctccct cacaggattg ttgtgaaact tttatgagat 22620 taatgccttt atatttggca tagtgtaagt aaacaataac tggcagcttc aaaaaaaaaa 22680 agcagtagca ttccatcatt tattattggt tactctcaaa aagtttttca atgtactaga 22740 agataaatat tcaaatacct taatatctcc attattttca ggtaaacagc atgctcctga 22800 acaaccaatg ggtcaacaaa taaattaaaa gggaaatcta aaaacatctt gatattaaac 22860 tacatggaag cacaatatac caaaaccaat ggttcacact aggagaattt taaggtacaa 22920 gaaaactctt tgagatttct taaaataata gtatgtctga atttattgag tgatttacca 22980 gaaactgttg taagagctct acttgcatta tagcacttaa tcctcttaac tctatggctg 23040 ctattatcaa cctcacccta atcacatatg ggacacagag aggttaagta acttgcccaa 23100 ggtcagagtt aggaagtact aagccatgct ttgaatcagt tgtcaggctc cggaactcac 23160 actttcagcc actacataat actgctttgc tatcttttag gaaactatgt gagtctacct 23220 cacatagact cacataggtt tgtttttttt ttttttttaa aggctatctt ttcccccatc 23280 aatgtttttt gaaggatccc aaattagagt cccacagagg cagacagcag tacttgacaa 23340 tatggacatt taaggttaat gttggattct actgtctttt tactacatga cctagggaac 23400 gataattaac ctagactgct tccaagggtt aaataaccca tttagttata ctatgtaaat 23460 tatctcttag tgattgattg aaagcacact gttactaatt gactcggtat gaagtgcttt 23520 tttttcttcc ctttcaagat acataccttt ccagttaaag ttgagagatc atctccacca 23580 attactttta tgtcccctgt tgactggtca ttctagttaa aaaaaaaaaa aactatatat 23640 atatatatct acacacacat atgtatatgt atatccttat gtacacacac aaacttcaaa 23700 ttaaatgaga actagaagat ttgagaagtt agctagctaa tatccatagc attatgatat 23760 tctaaatgat atgaattata agaattaggt ttcctgaaat gaatgactag aaaactttca 23820 agtagagatt agtaaaaatt aaaaagtcct aatcggccat tactgatttg atgtttttaa 23880 gagtcctaaa aaatgggtta catccatttt taagtgggta gtattataac agccacccat 23940 cttcaatcac agtgatttct gaattgtgag ggaagttatt agcatgacag gtgtctggtt 24000 ctggccctgt acgattccca tgagtcaagc aaattgtaag ggctggtcta tatcacaccc 24060 aaccccaagg atatgtccct caaaagtcta gcccaggccc cgtcatcttc agcatcatct 24120 gggaaaccag gtctgattag tagtccttta aggaatacct cttaggctcc cattttactg 24180 ctatcacaga atccaataaa acccttacag gagattcaat gggaaatgct caacacccac 24240 tgtagttggt ggtgacaatg accataattt ggctgtgctg gattcaggac agaaaatttg 24300 ggtgaaagag caggtgaaca aaagagcttc gacttgccct agcagagagc aagccatacc 24360 ataccacaaa gccacagcaa ttacaacggt gcagtaccag cacagtaaat gaacaaagta 24420 gagcccagaa acagacccag aactatatga ggatttagta tacaataaag atggtatttc 24480 gagtcagtag ggaaaagatg aattattcaa taaatgatgt ttggccaact agtaacccat 24540 ttgggaaaaa ataaaagtat ggtccctacc tcacagcata cacaaaaata aattccagac 24600 ggattaaaat ctaaatgtaa aaaataaagc cataagtgga ctggaagaaa atagagaatt 24660 ttttttaaca tccgtagaaa gggtaaaaac ccaggcatga catgaaccaa aactgaagag 24720 gttctgtaac aaataccccc ttttatatat tgggctccaa caataagaac ccataggaaa 24780 atggagaatg aacacaaata gacaatttat agaagagaag gttataaggt gtaaaattat 24840 atctatctga gaaacaaaca ctaaaacaat gtgattctac tgttctccca cccatactgg 24900 caaaacttaa gcctgataat atgctgaggg gaaataagca ctcttgttgg tgagagtatt 24960 aattggcata gcttcttttg aaaatgacat agcaatacct gttaaaattg caaacatgca 25020 tgtcacttaa tccagtaatc ccacttctgg gaatcaatgc tacaaaaaca ctgacaagta 25080 tacaaagata cattcaagag tgttcactgg gccgggtgcg gtggcttcat gcctgtaatc 25140 ccagggaggc agaggcaaga cgatcgcttg accccaggag ttcaaggcca gcccgagaaa 25200 cacagcaaga ccctgtctct ctttttttta tttaaaaaat aaatgttcac tgtatcagtt 25260 gttcacaaaa acaaaccaac atgtccatta acagggaacc atttaaatta atcaagttca 25320 tctacacaat gtaataccat gcaactatta aaaagcacct gataatccaa agcacactga 25380 gacagaataa tgctattaaa aacaccaagt agtggaacac tgtgttgcct atgacaccat 25440 ttttattcaa catttaaaca aatttgtaac agcaattaca tgagtagtga caatggcgtt 25500 tatgagactt ttcactttta tgtgcttcta tttttgttat gcttctatat atacatccat 25560 ttattatgga gtgttacttt caaaaatcac aaatgggcca gtattatttg gtgttgcaag 25620 gtgagcatat gacttctgat atcaaccttt gcatattact tctcaattta gggaaattac 25680 agacatccct tattctaact aacttaaaac ccagcatttc aaacatacag aattgatggg 25740 gaaaaaaaag aaagaagaaa gaaagaaaag gcaacaagct tcagatgaca gtgactcaca 25800 tcaaattatt tataaaatct gttaaatagt gccatcttct ggagatacct ggtattacag 25860 tccaactcca gttgatgtct ttacagagac aagaggaata aaggaaaaaa tattcaagaa 25920 ctgaaaagta tggagtcatg gaaaaattgc tgtgatccaa aggctacggt gataggacaa 25980 gaaacaagag aactccaagc agtaagacac tgctgttcta ttagcatcca aacctccata 26040 ctcctgtttg ccccaaggct tttttaaaaa atagagacag gatctcacta ttttgctcag 26100 gctggtcttg aactcctgga ctcaagctat cctcctgcct cggcctccta aagtgccgag 26160 attacaggct tgagtcacca tacctggcta tttatttttt cttaactctc ttgcctggcc 26220 tatagccacc atggaagcta ataaagaata ttaatttaag agtaatggta tagttcacta 26280 cattggaata caggtataag tgcctacatt gtacatgaat ggcatacatg gatcaattac 26340 cccacctggg tggccaaagg aactgcgcga acctccctcc ttggctgtct ggaacaagct 26400 tcccactaga tccctttact gagtgcctcc ctcatcttta attatggtta agtctaggat 26460 aacaggactg gcaaaggtga ggggaaagct tcctccagag ttgctctacc ctctcctcta 26520 ccgtcctatc tcctcactcc tctcagccaa ggagtccaat ctgtcctgaa ctcagagcgt 26580 cactgtcaac tacataaaat tgccagagaa gctctttggg actacaaaca cataccctta 26640 atgtctttat ttctattttg tctacctctt cagtctaggt gaaaaaatag gaaggataat 26700 agggaagaac tttgtttatg cctacttatc cgcccctagg aattttgaaa acctctaggt 26760 agcaataaga actgcagcat ggtatagaaa aagaggagga aagctgtata gaaatgcata 26820 ataaatgggc aggaaaagaa ctgcttggaa caaacaggga ggttgaacta taaggagaga 26880 aagcagagag gctaatcaac aaggctgggt tcccaagagg gcatgatgag actattacta 26940 aggtaggaat tactaagggc tccatgtccc cttagtggct tagtactatg tagcttgctt 27000 tctgcagtga acttcagacc cttcttttag gatcctagaa tggacttttt ttttttatcg 27060 gaaaacagtc attctctcaa cattcaagca ggccccaagt ctaccacact caatcacatt 27120 ttctcttcat atcataatct ctcaaccatt ctctgtcctt ttaactgttt ttctataccc 27180 tgatcaaatg ccaacaaaag tgagaatgtt agaatcatgt atttttagag gtagactgta 27240 tctcagataa aaaaaaaggg cagatattcc attttccaaa atatgtatgc agaaaaaata 27300 agtatgaaag gacatatgct caggtaacaa gttaatttgt ttacttgtat tttatgaatt 27360 ccctaaaacc tacgtcaccc gccccgttcc cacgccccgc gccacgtcac aaactccacc 27420 ccctcattat catattggct tcaatccaaa ataaggtata ttattgatga tgttaattaa 27480 catgcatgga tccatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc 27540 atcaggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg 27600 cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac 27660 gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg 27720 ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca 27780 agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc 27840 tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc 27900 ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag 27960 gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc 28020 ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca 28080 gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg 28140 aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg 28200 aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct 28260 ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa 28320 gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa 28380 gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa 28440 tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc 28500 ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga 28560 ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca 28620 atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc 28680 ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat 28740 tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc 28800 attgctgcag ccatgagatt atcaaaaagg atcttcacct agatcctttt cacgtagaaa 28860 gccagtccgc agaaacggtg ctgaccccgg atgaatgtca gctactgggc tatctggaca 28920 agggaaaacg caagcgcaaa gagaaagcag gtagcttgca gtgggcttac atggcgatag 28980 ctagactggg cggttttatg gacagcaagc gaaccggaat tgccagctgg ggcgccctct 29040 ggtaaggttg ggaagccctg caaagtaaac tggatggctt tcttgccgcc aaggatctga 29100 tggcgcaggg gatcaagctc tgatcaagag acaggatgag gatcgtttcg catgattgaa 29160 caagatggat tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac 29220 tgggcacaac agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg 29280 cgcccggttc tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaagacgag 29340 gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt 29400 gtcactgaag cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg 29460 tcatctcacc ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg 29520 catacgcttg atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga 29580 gcacgtactc ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag 29640 gggctcgcgc cagccgaact gttcgccagg ctcaaggcga gcatgcccga cggcgaggat 29700 ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt 29760 tctggattca tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg 29820 gctacccgtg atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt 29880 tacggtatcg ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc 29940 ttctgaattt tgttaaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat 30000 cggcaaaatc ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt 30060 ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt 30120 ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag 30180 gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg 30240 aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc 30300 gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc 30360 gctacagggc gcgtccattc gccattcagg atcgaattaa ttcttaatta acatcatcaa 30420 taatatacct tattttggat tgaagccaat atgataatga gggggtggag tttgtgacgt 30480 ggcgcggggc gtgggaacgg ggcgggtgac gtagtagtgt ggcggaagtg tgatgttgca 30540 agtgtggcgg aacacatgta agcgacggat gtggcaaaag tgacgttttt ggtgtgcgcc 30600 ggtgtacaca ggaagtgaca attttcgcgc ggttttaggc ggatgttgta gtaaatttgg 30660 gcgtaaccga gtaagatttg gccattttcg cgggaaaact gaataagagg aagtgaaatc 30720 tgaataattt tgtgttactc atagcgcgta atactg 30756

<400> 17 tatttattgg ccggccgcgt taagatacat tgatgag 37

<400> 18 tatttattcc tgcaggtcgt aggtcaaggt agtaga 36

<400> 19 atgcctcaca gtcaaatatc tcctgcagaa ggctctagaa ggatccttga agaataccac 60 atagatgaag atgtgggctt tgctctacca catccactgg aggagctgcc tgatacgtac 120 agaccttgga tccttgtggc tagaaatctg cctaagctga ttgagaatgg gaagctccga 180 gaagaagtcg agaagctgcc cacactgcgc accgaagaac tgaggggaca caggttacag 240 cgcctggcac atttggccct ggggtacatc accatggcgt atgtgtggaa ccgaggggat 300 gatgatattc gaaaggtgct gccccgcaat cttgccgttc cctactgcga gctctcggag 360 aagctggggc tgcctcccat tctgtcttac gcagactgcg tcctggcaaa ctggaagaaa 420 aaggacccca atgggcccat gacatacgag aacatggaca ttctgttctc gtttcctggt 480 ggggactgcg ataaaggctt cttcctggtc tctctaatgg tggaaatcgc agcttctcct 540 gcaatcaaag caattcctac tgtatccagt gcagtagagc atcaagaccc gaaagcactg 600 gagaaggcac tgtgtagtat agctgccagt ctggagaaag ccaaggaaat ttttaagagg 660 atgcgtgact tcgtggatcc agacaccttt ttccacgttc ttcgcatata tttgtctggt 720 tggaagggca accctaagct gccggagggt ctgctgtacg agggcgtctg ggacaccccc 780 aaaaaatttt cagggggcag tgcaggccag agcagcatct ttcagagtct tgatgtcctt 840 ctgggaataa agcatgacgt tggtgaagga tctgctgcag aattcctcca ggaaatgaga 900 gagtacatgc ctccagccca ccggaacttc ctctcctcct tagagtcagc tcccccagtc 960 cgtgagtttg tcattttaag acgcaatgaa gacttgaagg aggcttataa tgagtgtgtg 1020 aatggcctgg tctccctcag aatgttccac ctctcgatag tagatactta cattgtgaag 1080 ccttcgaagc agaagcccat gggtggccac aagtcagaag agccctcaaa cacggaaaac 1140 agagggactg ggggtactga cgtcatgaat ttcctgagga gtgtgaaaga tacaaccaag 1200 aaagcccttc tgagttggcc ttag 1224

<400> 20 atggcacacg ctatggaaaa ctcctggaca atcagtaaag agtaccatat tgatgaagaa 60 gtgggctttg ctctgccaaa tccacaggaa aatctacctg atttttataa tgactggatg 120 ttcattgcta aacatctgcc tgatctcata gagtctggcc agcttcgaga aagagttgag 180 aagttaaaca tgctcagcat tgatcatctc acagaccaca agtcacagcg ccttgcacgt 240 ctagttctgg gatgcatcac catggcatat gtgtggggca aaggtcatgg agatgtccgt 300 aaggtcttgc caagaaatat tgctgttcct tactgccaac tctccaagaa actggaactg 360 cctcctattt tggtttatgc agactgtgtc ttggcaaact ggaagaaaaa ggatcctaat 420 aagcccctga cttatgagaa catggacgtt ttgttctcat ttcgtgatgg agactgcagt 480 aaaggattct tcctggtctc tctattggtg gaaatagcag ctgcttctgc aatcaaagta 540 attcctactg tattcaaggc aatgcaaatg caagaacggg acactttgct aaaggcgctg 600 ttggaaatag cttcttgctt ggagaaagcc cttcaagtgt ttcaccaaat ccacgatcat 660 gtgaacccaa aagcattttt cagtgttctt cgcatatatt tgtctggctg gaaaggcaac 720 ccccagctat cagacggtct ggtgtatgaa gggttctggg aagacccaaa ggagtttgca 780 gggggcagtg caggccaaag cagcgtcttt cagtgctttg acgtcctgct gggcatccag 840 cagactgctg gtggaggaca tgctgctcag ttcctccagg acatgagaag atatatgcca 900 ccagctcaca ggaacttcct gtgctcatta gagtcaaatc cctcagtccg tgagtttgtc 960 ctttcaaaag gtgatgctgg cctgcgggaa gcttatgacg cctgtgtgaa agctctggtc 1020 tccctgagga gctaccatct gcaaatcgtg actaagtaca tcctgattcc tgcaagccag 1080 cagccaaagg agaataagac ctctgaagac ccttcaaaac tggaagccaa aggaactgga 1140 ggcactgatt taatgaattt cctgaagact gtaagaagta caactgagaa atcccttttg 1200 aaggaaggtt 1212

<400> 21 tatttattcc tgcaggtcgt aggtcaaggt agtagagttt gcgggcagga cggggcgacc 60 atcaatgctg gagcccatca cattctgacg caccccggcc catgggggca tgcgcgttgt 120 caaatatgag ctcacaatgc ttccatcaaa cgagttggtg ctcatggcgg cggcggctgc 180 tgcaaaacag atacaaaact acataagacc cccaccttat atattctttc ccacccttan 240 nntaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgttg 300 gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg 360 tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta 420 cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt 480 gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac 540 tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt 600 tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac 660 cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt 720 cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat 780 ataagcagag ctggtttagt gaaccgtcag atccgctaga gatctggtac cgtcgacgcg 840 gccgcgggaa ttcgattatg cctcacagtc aaatatctcc tgcagaaggc tctagaagga 900 tccttgaaga ataccacata gatgaagatg tgggctttgc tctaccacat ccactggagg 960 agctgcctga tacgtacaga ccttggatcc ttgtggctag aaatctgcct aagctgattg 1020 agaatgggaa gctccgagaa gaagtcgaga agctgcccac actgcgcacc gaagaactga 1080 ggggacacag gttacagcgc ctggcacatt tggccctggg gtacatcacc atggcgtatg 1140 tgtggaaccg aggggatgat gatattcgaa aggtgctgcc ccgcaatctt gccgttccct 1200 actgcgagct ctcggagaag ctggggctgc ctcccattct gtcttacgca gactgcgtcc 1260 tggcaaactg gaagaaaaag gaccccaatg ggcccatgac atacgagaac atggacattc 1320 tgttctcgtt tcctggtggg gactgcgata aaggcttctt cctggtctct ctaatggtgg 1380 aaatcgcagc ttctcctgca atcaaagcaa ttcctactgt atccagtgca gtagagcatc 1440 aagacccgaa agcactggag aaggcactgt gtagtatagc tgccagtctg gagaaagcca 1500 aggaaatttt taagaggatg cgtgacttcg tggatccaga cacctttttc cacgttcttc 1560 gcatatattt gtctggttgg aagggcaacc ctaagctgcc ggagggtctg ctgtacgagg 1620 gcgtctggga cacccccaaa aaattttcag ggggcagtgc aggccagagc agcatctttc 1680 agagtcttga tgtccttctg ggaataaagc atgacgttgg tgaaggatct gctgcagaat 1740 tcctccagga aatgagagag tacatgcctc cagcccaccg gaacttcctc tcctccttag 1800 agtcagctcc cccagtccgt gagtttgtca ttttaagacg caatgaagac ttgaaggagg 1860 cttataatga gtgtgtgaat ggcctggtct ccctcagaat gttccacctc tcgatagtag 1920 atacttacat tgtgaagcct tcgaagcaga agcccatggg tggccacaag tcagaagagc 1980 cctcaaacac ggaaaacaga gggactgggg gtactgacgt catgaatttc ctgaggagtg 2040 tgaaagatac aaccaagaaa gcccttctga gttggcctta gaatcactag ataagatatc 2100 cgatcnntgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag 2160 tccggactca gatccaccgg atctagntaa ctgatcataa tcagccatac cacatttgta 2220 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 2280 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 2340 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 2400 aaactcatca atgtatctta acgcggccgg ccaataaata 2440

<400> 22 tatttattcc tgcaggtcgt aggtcaaggt agtagagttt gcgggcagga cggggcgacc 60 atcaatgctg gagcccatca cattctgacg caccccggcc catgggggca tgcgcgttgt 120 caaatatgag ctcacaatgc ttccatcaaa cgagttggtg ctcatggcgg cggcggctgc 180 tgcaaaacag atacaaaact acataagacc cccaccttat atattctttc ccacccttan 240 nntaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta 300 cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt 360 caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg 420 tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta 480 cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga 540 ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg 600 tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc 660 caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact 720 ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt 780 gggaggtcta tataagcaga gctggtttag tgaaccgtca gatccgctag agatctccag 840 aggagcagac tacaagaatg gcacacgcta tggaaaactc ctggacaatc agtaaagagt 900 accatattga tgaagaagtg ggctttgctc tgccaaatcc acaggaaaat ctacctgatt 960 tttataatga ctggatgttc attgctaaac atctgcctga tctcatagag tctggccagc 1020 ttcgagaaag agttgagaag ttaaacatgc tcagcattga tcatctcaca gaccacaagt 1080 cacagcgcct tgcacgtcta gttctgggat gcatcaccat ggcatatgtg tggggcaaag 1140 gtcatggaga tgtccgtaag gtcttgccaa gaaatattgc tgttccttac tgccaactct 1200 ccaagaaact ggaactgcct cctattttgg tttatgcaga ctgtgtcttg gcaaactgga 1260 agaaaaagga tcctaataag cccctgactt atgagaacat ggacgttttg ttctcatttc 1320 gtgatggaga ctgcagtaaa ggattcttcc tggtctctct attggtggaa atagcagctg 1380 cttctgcaat caaagtaatt cctactgtat tcaaggcaat gcaaatgcaa gaacgggaca 1440 ctttgctaaa ggcgctgttg gaaatagctt cttgcttgga gaaagccctt caagtgtttc 1500 accaaatcca cgatcatgtg aacccaaaag catttttcag tgttcttcgc atatatttgt 1560 ctggctggaa aggcaacccc cagctatcag acggtctggt gtatgaaggg ttctgggaag 1620 acccaaagga gtttgcaggg ggcagtgcag gccaaagcag cgtctttcag tgctttgacg 1680 tcctgctggg catccagcag actgctggtg gaggacatgc tgctcagttc ctccaggaca 1740 tgagaagata tatgccacca gctcacagga acttcctgtg ctcattagag tcaaatccct 1800 cagtccgtga gtttgtcctt tcaaaaggtg atgctggcct gcgggaagct tatgacgcct 1860 gtgtgaaagc tctggtctcc ctgaggagct accatctgca aatcgtgact aagtacatcc 1920 tgattcctgc aagccagcag ccaaaggaga ataagacctc tgaagaccct tcaaaactgg 1980 aagccaaagg aactggaggc actgatttaa tgaatttcct gaagactgta agaagtacaa 2040 ctgagaaatc ccttttgaag gaaggttaat gtaacccaac aagagcactc gagcctaagc 2100 ttctagataa gatatccgat ccaccggatc tagataactg atcataatca gccataccac 2160 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 2220 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 2280 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 2340 tttgtccaaa ctcatcaatg tatcttaacg cggccggcca ataaata 2387

<400> 23 gtacggaagc ccggaaggag gggcaggggg cggtggctca ggtttctccg ggcggcggcg 60 gcggcggcgg cggcgacggc gacggcgacg gcagcgggga cggcagcagt agcgggagca 120 gcagcgtgga cgcggctggc gctggcgcca tgaacccgct gtaaggcgca ggctgtgcag 180 cacggggtgc gggggaggag gaggaggacg ccgcggtgaa gttctccgcc atgaacctga 240 ggggcctctt ccaggacttc aacccgaggt gaggcggcgt cgttggcgcc cccgggagtc 300 cgcgctgcgg gctcgggcgc gggctggtgt tcggctccgg ggaggcacgg cgggcgagat 360 gctgcagccc gaggacccgg gcgcctgccc gagcctccct gcgggtgcaa gcggtcccca 420 ggcaaaacag tcggcctcgg cgcccgcccg cttcctcctc ccgtgcccgg tgctttcagc 480 ccctgcccgg ccacggccgg aagggcccgg ccgcgagccc cgtcctgccc caagggaacc 540 ccattctttt ctgcttgctg tccctcattg gtgtcccaac ttcttcgtct cggttccatc 600 ctcttctgcg ccgctgcggg ccctccattc tccgcgtcag ggccgtctca ctcgacccaa 660 cacccctacc cccaccccag ctgtttcctc cagttcctcg cagtccttgg ggttttcctt 720 gggtttatgc ccatccctct cttgtttgct tctttgttga acggatacct gaaacactgt 780 tgaatccttg gagtcagtgt cggggtatgg caatacctta tataatgcat ttctgggtga 840 gcctgatcat tttccatact cattttctca tcagtcttca ctacaagttt atttgcagga 900 agtagatatt gctgtccttc ttttccagat ggggaacacc cagtggacag tgtggagaaa 960 acactggcta agcactcaag cgcctgtcct tgcacttgcc cgactgtttt gtaactgttc 1020 tttaccccag gctgtgagct ccctgaagct gagaccatct cctgctcatc tcagtgtccc 1080 cagcgcctcc cacccaccgt atctggcaca tagtaggcac atataaaatg tttgtggaac 1140 taaactgagc ccaaagactt ggattggaga cgaggccata tgtaactggg tgattctctg 1200 cccttctttg gcccttctgt aaaatgagga gttggcctaa ctgatctctt aaatgcacta 1260 ctctccgaaa ggagtatccg tttcccttat ttgccagttg ggaagacgtg ctcagtaaat 1320 atttgtgtgc tgtaacctat gttaggtgct ttagatgctg gcggtctcag catggggtga 1380 agaagggctt gtacacttaa gatgccttac agtactgtgc agtgctgtac tgcgggggcc 1440 aactctgggg acctatgcct tggctgcttg ttgaggatga aaggaagttt taggggagta 1500 tttgtatgtt gagggtgcag tctccctagg gatggtgaca ttttaacttg tgagtcattg 1560 tgactttgta tgtgccctta ttccactttg agttcatgtt ctggttagga gtgccagtgt 1620 ctctaacacg gtgcagacat tatcattgtt ggcttcgaag gcatagagga ggtaacagaa 1680 ctaactgcag tcccttcctc tgctgcatca gggggttaag attggtctgc agggtagtag 1740 ggttggtgct gtggctggac aagccctgta tgtcttctat ttggagatgg tgataagaaa 1800 gttaagtaaa aactgaattg ttttgtgccc ttgggcaact cacttatcta ttgttttatc 1860 tgtagaatga gtataatctc tcagtggggt agggaggcca attaaggatt gattacaaag 1920 tgccttacaa atagaaagct acagtgactt gtttgcaagg tgacagagaa ttcagaagcc 1980 tcaagaaact gccttaagtg atcaaacagg ctaacggagt tgccaaagca aaatagtgct 2040 gcactgatac tacctttaac cgttttttcc tttagccctt ttccccccaa aaaaattagt 2100 atatgaaatt acagtgaaat acctggtatc taagcagatt tatagtaatt ctcaacatat 2160 tcatcaatct cttaattcta cctgcattaa aatgtatttc tacctgaaaa gtttaaaggt 2220 cttttatact gtgccatttt cctgattcat tgttgccaga ggtagtgagt tccttaattt 2280 tacagatatt tcaagaggac attggccagg tattattggt aaatcagatt tgttttttta 2340 gctggtagtg tttcacctct cctgagcact cctagttttt gacagtgtgc tttagtctcc 2400 ttccatgctg aggaaggcct tctctatagg agaaagaaaa ctgaggggtg tacacaggaa 2460 gttaccttat gctggggact caaaccttga tgctactgct ttgctccctg cctctatttt 2520 tgaaccaatt caacatctcc ctcctacccc aggaccttgt cacacactgt tctctttacc 2580 aggaatgttt ccctctcttt tcctctcctc cagacctagt gaactcctat ttatcctcac 2640 ttggcacttg ctaagggaag cattcctgac ttccctgacc agatttactg ctccctgttt 2700 ctacagttcc tgtagtattt actactcctc catcatagtg catatttgta cccttgtgtc 2760 tgtctggatg cttatttgat taatacctgc ctcccccact aaactttaag ctccatgggg 2820 tcaaggccgt gactgtgtca gtatcgtagc ctgcatactt ggaatagtac ctggctcaat 2880 aaatatttgt ggagtaaata actgaataac tctccagagc ctataagata aatctagagc 2940 tgctgctttc aatcactgct ttcctggtgg tctgtggcct ggttctcttt cttctcacac 3000 tcttcccacc ttcagagtgc agccattgct ttggagagat gggagagaac atggcactaa 3060 ggcagaatat ggctatattt actttgaaga gcatgtcttt gtcatagaaa tagtcactgt 3120 catggtttgg tgggtcccaa ggcatgggtc atggctccag atcccctttc cagccttttg 3180 gatcttggta agtctgaacc cactgctgcg ttggcaaggc tctggaaact atagtgacag 3240 agaatgattc acaagtgtca acactcagat gtacagggct gccagctgac ccactctacc 3300 tatttccatc tggcactgaa ctggttgatc atgaacttct tttcataatt gctttttagt 3360 tatgcaggtt aagacatgcc gaaacagatg taccggaccc acaaacaagt ccttccttga 3420 atgcctgagg cttcctaaca gtgaaagagc cctgttctta gagtaggcaa actgattctg 3480 aggcattgta ggtggtaggg atctggtagt aggtagcatt aggtgggctc ccggcactca 3540 ccatggagcc ttgaaatttt ctgctacttt gggggagttg ctggttcaga gaaggccctt 3600 ccaccctggt agccatgtgg cactggaagg ctgtgaaaac tctgctgggc cttcttagtc 3660 atctgttgtg agctcctgat gggagtgtgg tgtatccctc aggtgtgcta gactggaaca 3720 aaggctgaga agtgttgctc tgggggttcc aacttgtggg catggggtac tgatgagatc 3780 agtagtgttt ggagacttct gtatgctcca tcttcagaag acattctgga gtccatataa 3840 gttatcttgt ctcttgtttg aagcaggaaa aaggaatgcg attgctggta atatagttca 3900 ctaaagtcag ctacctggcc tctaacagtt atttgcaaag tatattataa cattgattcc 3960 tcaaacatct agattcctat ctcgtgccaa gtgatgtact aggtgctcta agtacaaaaa 4020 taaaggaata tagtcctcct ctcaatgcgt aagcctagtg gaagaagcag aaatgaaagg 4080 gaaataagaa ttcaatagag tatgaggcat tacagtgaaa gaaaccaaat gtcttagaag 4140 tacaaatggc agagctacta attctgtctc gagcaggcag ggaagagtct atagtggaaa 4200 tgacttttga gctagatttt gaattgagct agtcttttga gccagacttt tgagctagaa 4260 ttgtagggtt gtcatcagac cagagagtag gaagggtacc ttgtgaggaa gagagagaga 4320 gatcagattg ttactgtgtc tatgtagaaa aggaagacat aagaaactcc attttgatct 4380 gtactaagaa aaattgtttc tgctttgaga tgctgttaac ctgtaacttt agtcccaacc 4440 ctgtgctcac agaaacctgt gctgtaatga atcaaggttt aatggattta gggctgtgca 4500 ggatgtacct tgttaacaat atgtttgcag gcagtatgct tggtaaaagt catcgccatt 4560 ctccattctc gattaaccag ggacacagtg cactgcggaa ggccgcaggg acatctgccc 4620 aagaaagcct gggtattgtc caaggtttcc ccccactgag acagcctgag atatggcctt 4680 gtgggaaagg aaagacctta ccacccccca gcccgacacc cgtaaagtgt ctgtgctgag 4740 gaggagtagt gaaagagcgg ggcctctttg cagttgagat aagaggaagg cttctgtctc 4800 ctgctcatcc ctgggaatgg aatgtctctg tgtaaagctg accattccca ttcgttctat 4860 tctgagatag gagaaaacca ccctgtggct ggaggcgaag tatgctggca gcaatactgc 4920 tctgttactc tttgctacac tgagttgttt gggtaaagag aaacataaat ctagcctgcg 4980 tgcacatcca ggcacagtac ctttccttga acttattcat gatacagatt cctttgctca 5040 cgtttccctg ctgaccttct ccccacctgt tgccctgcta cactcGcctc gctaagatag 5100 taaaaataat gatcagtaaa tactgaggta actcagaggc tagcgctggt gcgggtcctc 5160 cgtatgctga gtgccggtcc cctgggccca ctgttctttc tctatacttt gtttctgtgt 5220 cttatttctt ttctcagtct cgtcccacct gacgagaaat acccacaggt gtggaggggc 5280 tggccccttt cagtatctca gaagggacaa agtacacaaa ggcatggggt catgatagtg 5340 cctggtatgt tcaggtagtg aagaggtcca tgtggtatga gcactgcaga tgatatgtgt 5400 cgtatgaatt aaaaatacat agttactgca aatagttttt acaggttatt gtttttaaga 5460 aagcagtatc taatgcacga gtgtactgtc agtactgtca atgaactact taccactcaa 5520 gtgactgctt acgcgtcgaa tcactagtga attcgcggcc gcctcgagtc tagaactagt 5580 ggatccccca aacgggccct ctagacgcgt tgacattgat tattgactag ttattaatag 5640 taatcaatta cggggtcatt agttcatagc ccatgatatc atatggagtt ccgcgttaca 5700 taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca 5760 ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg 5820 gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg 5880 cccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtncatgac 5940 cttatgggac tttcctactt ggcagacatc tacgtattag tcatcgctat taccatggtg 6000 atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggattttcc 6060 aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 6120 tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg 6180 ggaggtctat ataagcagag ctctctggct aactagagaa cccctgctta ctggcttatc 6240 gagatatctg cagaattcat ctgtcgactg ctaccggcag cgcgcagcgg caagaagtgt 6300 ctgggctggg acggacagga gaggctgtcg ccatcggcgt cctgtgcccc tctgctccgg 6360 cacggccctg tcgcagtgcc cgcgctttcc ccggcgcctg cacgcggcgc gcctgggtaa 6420 catgcttggg gtcctggtcc ttggcgcgct ggccctggcc ggcctggggt tccccgcacc 6480 cgcagagccg cagccgggtg gcagccagtg cgtcgagcac gactgcttcg cgctctaccc 6540 gggccccgcg accttcctca atgccagtca gatctgcgac ggactgcggg gccacctaat 6600 gacagtgcgc tcctcggtgg ctgccgatgt catttccttg ctactgaacg gcgacggcgg 6660 cgttggccgc cggcgcctct ggatcggcct gcagctgcca cccggctgcg gcgaccccaa 6720 gcgcctcggg cccctgcgcg gcttccagtg ggttacggga gacaacaaca ccagctatag 6780 caggtgggca cggctcgacc tcaatggggc tcccctctgc ggcccgttgt gcgtcgctgt 6840 ctccgctgct gaggccactg tgcccagcga gccgatctgg gaggagcagc agtgcgaagt 6900 gaaggccgat ggcttcctct gcgagttcca cttcccagcc acctgcaggc cactggctgt 6960 ggagcccggc gccgcggctg ccgccgtctc gatcacctac ggcaccccgt tcgcggcccg 7020 cggagcggac ttccaggcgc tgccggtggg cagctccgcc gcggtggctc ccctcggctt 7080 acagctaatg tgcaccgcgc cgcccggagc ggtccagggg cactgggcca gggaggcgcc 7140 gggcgcttgg gactgcagcg tggagaacgg cggctgcgag cacgcgtgca atgcgatccc 7200 tggggctccc cgctgccagt gcccagccgg cgccgccctg caggcagacg ggcgctcctg 7260 caccgcatcc gcgacgcagt cctgcaacga cctctgcgag cacttctgcg ttcccaaccc 7320 cgaccagccg ggctcctact cgtgcatgtg cgagaccggc taccggctgg cggccgacca 7380 acaccggtgc gaggacgtgg atgactgcat actggagccc agtccgtgtc cgcagcgctg 7440 tgtcaacaca cagggtggct tcgagtgcca ctgctaccct aactacgacc tggtggacgg 7500 cgagtgtgtg gagcccgtgg acccgtgctt cagagccaac tgcgagtacc agtgccagcc 7560 cctgaaccaa actagctacc tctgcgtctg cgccgagggc ttcgcgccca ttccccacga 7620 gccgcacagg tgccagatgt tttgcaacca gactgcctgt ccagccgact gcgaccccaa 7680 cacccaggct agctgtgagt gccctgaagg ctacatcctg gacgacggtt tcatctgcac 7740 ggacatcgac gagtgcgaaa acggcggctt ctgctccggg gtgtgccaca acctccccgg 7800 taccttcgag tgcatctgcg ggcccgactc ggcccttgcc cgccacattg gcaccgactg 7860 tgactccggc aaggtggacg gtggcgacag cggctctggc gagcccccgc ccagcccgac 7920 gcccggctcc accttgactc ctccggccgt ggggctcgtg cattcgggct tgctcatagg 7980 catctccatc gcgagcctgt gcctggtggt ggcgcttttg gcgctcctct gccacctgcg 8040 caagaagcag ggcgccgcca gggccaagat ggagtacaag tgcgcggccc cttccaagga 8100 ggtagtgctg cagcacgtgc ggaccgagcg gacgccgcag agactctgag cggcctccgt 8160 ccaggagcct ggctccgtcc aggagcctgt gcctcctcac ccccagcttt gctaccaaag 8220 caccttagct ggcattacag ctggagaaga ccctccccgc accccccaag ctgttttctt 8280 ctattccatg gctaactggc gagggggtga ttagagggag gagaatgagc ctcggcctct 8340 tccgtgacgt cactggacca ctgggcaatg atggcaattt tgtaacgaag acacagactg 8400 cgatttgtcc caggtcctca ctaccgggcg caggagggtg agcgttattg gtcggcagcc 8460 ttctgggcag accttgacct cgtgggctag ggatgactaa aatatttatt ttttttaagt 8520 atttaggttt ttgtttgttt cctttgttct tacctgtatg tctccagtat ccactttgca 8580 cagctctccg gtctctctct ctctacaaac tcccacttgt catgtgacag gtaaactatc 8640 ttggtgaatt tttttttcct agccctctca catttatgaa gcaagcccca cttattcccc 8700 attcttccta gttttctcct cccaggaact gggccaactc acctgagtca ccctacctgt 8760 gcctgaccct acttcttttg Gtcttagctg tctgctcaga cagaacccct acatgaaaca 8820 gaaacaaaaa cactaaaaat aaaaatggcc atttgctttt tcaccagatt tgctaattta 8880 tcctgaaatt tcagattccc agagcaaaat aattttaaac aaaggttgag atgtaaaagg 8940 tattaaattg atgttgctgg actgtcatag aaattacacc caaagaggta tttatcttta 9000 cttttaaaca gtgagcctga attttgttgc tgttttgatt tgtactgaaa aatggtaatt 9060 gttgctaatc ttcttatgca atttcctttt ttgttattat tacttatttt tgacagtgtt 9120 gaaaatgttc agaaggttgc tctagattga gagaagagac aaacacctcc caggagacag 9180 ttcaagaaag cttcaaactg catgattcat gccaattagc aattgactgt cactgttcct 9240 tgtcactggt agaccaaaat aaaaccagct ctactggtct tgtggaattg ggagcttggg 9300 aatggatcct ggaggatgcc caattagggc ctagccttaa tcaggtcctc agagaatttc 9360 taccatttca gagaggcctt ttggaatgtg gcccctgaac aagaattgga agctgccctg 9420 cccatgggag ctggttagaa atgcagaatc ctaggctcca ccccatccag ttcatgagaa 9480 tctatattta acaagatctg cagggggtgt gtctgctcag taatttgagg acaaccattc 9540 cagactgctt ccaattttct ggaatacatg aaatatagat cagttataag tagcaggcca 9600 agtcaggccc ttattttcaa gaaactgagg aattttcttt gtgtagcttt gctctttggt 9660 agaaaaggct aggtacacag ctctagacac tgccacacag ggtctgcaag gtctttggtt 9720 cagctaagct aggaatgaaa tcctgcttca gtgtatggaa ataaatgtat catagaaatg 9780 taacttttgt aagacaaagg ttttcctctt ctattttgta aactcaaaat atttgtacat 9840 agttatttat ttattggaga taatctagaa cacaggcaaa atccttgctt atgacatcac 9900 ttgtacaaaa taaacaaata acaatgtgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 9960 aaaaaaaagg tagcagtcga cagatgaatt ccaccacact ggactagtgg atccgagctc 10020 ggtaccaagc ttaagtttgg gctgcaggaa ttctgatggc tctcaaaatt cctgcctcct 10080 ttagggataa aagactttaa gactttttaa caaaaaagaa aaagaaaaaa aaaattcctg 10140 cctcctggtg tacacacaca gaagggttcc ctccccttga atgtgaccag gatctgtgaa 10200 aataacggga tagccgctcc tgtgattagg ttatgtggta gactagagca agattctcct 10260 gctggttttg aagaagtcag ctgccatgtt gtgagactgt catgggctag ggcatgagcc 10320 tttaaatatc tgggagcaac ccctggccag cagccagtga gaaaacgggc cctcagtcct 10380 acaatcacaa ggaactaaat tctgccaaca acctgaagga actttgaaga ggatcatgag 10440 tcccttgatt cagcttgatg agcccctgag cagaggatac agctaacttg tactagggaa 10500 gtataaaaaa catgcatggg aatgatatat atcaacttta aggataattg tcatacttct 10560 gggaatgaag ggaaagaaat ggggctttag ttgtattatg atctttaatt tctcaaaaaa 10620 aataagatca gaagcaaata tggcaaaatg ttaatacttt tgtgggtacg taggtattca 10680 gcataccctt ttttctgagt tcaaaatatt ttataattaa aatgaaatgc aggccaggca 10740 cagtggctca tgcctataat accagcactt tgcgaggccg aggtgggagg atggcttgag 10800 gccagaccag cctggccaac atggcaaaac cccatctcta cttaaaaaaa aaaaaactat 10860 atatatatat atgtgtgtgt gtgtgtatat atatatatgt atatatattt atatatgtgt 10920 gtatatatat atatgtatat atatttatat atgtgtgtgt atatatatat atacacacac 10980 acacatatat acatacatac atacacacac acacacacac aattagccag gcatggtggc 11040 gcacacctgt agtcccagct acttgggagg ctgagacatg agaattgctt gaacctggga 11100 ggcagagtag ttagtgagct gagatcatac cactgcactc cagcctggtg acagagtgag 11160 actctgtctt aaaaaaaata aaaattaaaa ttaaatgcaa aaggtccaag tgaattgaag 11220 aggaaagggg tatcaaggaa ggttttgtgg aggtgacgtt tgagctgggt cttaaatgac 11280 ttaaacatgg gataagaagg gagggaataa ggacatttca ggtacgagaa ataaggagca 11340 aacagtggaa acaacctaac gtctgtcaac cagtgaatgg ataacaaaaa tgtaattcag 11400 atggtatcca acttacgatg gttcaacatg agatttttct gactttagga tagatttatc 11460 aaagtagtaa atccattttc aacttatgat attttcaact tcagatgggt ttatcaggac 11520 acagttgagg aacacctgtc tatccataca atttggcaat aaaaaggaaa tgagtgcaga 11580 tatactccac aacatgaatg aaccttgaaa acattaagtg agagaagcca gatacaaaag 11640 gccacatatt gtatgattct atttatacaa aatgtccaga ataggcaaat cttatagaca 11700 gcaagtaggt agatgatcag tttgctaggt gctgggggaa ggggaaatgg ggagtgatgg 11760 ctaaggggat tgggtttctt tgtggggcaa tgaaaatgtt ttaaaattga gcgtgataat 11820 gattgcacaa tgctgcatat atatataatc tatagattat atatatataa agagaggctg 11880 ttagacagtg ataagtgata tatatatata tatacataga gagagagaga gagagagaga 11940 gaggctgtta gtgataagtg atcaggaaaa taaaagtatt gaggaggaat acgaagttga 12000 cggtgtgaaa acatgagatt ttatatagga tggccaggga aggccttaat gagaaagtga 12060 cttatgagta aaaacaaggg atcctaaacc ttagcatgca tcagaatcac tcggaaactt 12120 gttaaagcat agcttgctgg gcctcatcac agatattttg attcggtagg ttcttgtctg 12180 atattaatac ttttggtcta gggaaccaca ttttgagaac cactgagcta aaggaagtaa 12240 aggtttccct tagtttacta gctggtaaca ctggcccagg aggcctttct ggaaaaggtc 12300 ccagtcccca aaggaagctg gggactcgcg ttcacatcgt caaggtttac caagttgtgg 12360 cgggcctttc cgtcttggaa aaagcctcaa aatggcagat tagggtgtcc atggccggcg 12420 gaaagggtct ttgaagttgc agaccaggag ggaagaagat tctgggcctc ccccatgcag 12480 tgtcagctgg caacagaatg caccccggct gggttggagg ccctgggtac tggctcttcc 12540 acaccagggg cccacctacc aagggcagca ggagcatctg cacctcctgc gccaggcgcc 12600 cttcagtgct tccacttgag cacctctcca gacaccagct agggtgacag tggtacaaat 12660 accagactcc cctggcctgc tcacctcaca gggtaatgtg ctgtggagtc agggggacac 12720 agcaaccacc agatgacatg gctggccccg gggaggacga cacgcagata cggctacttg 12780 gcacctgtga tattttacac actcgagagg ggcccgcacc atcctcagcc ctctccccac 12840 attcactctt agttcatgtc acctccaccc agagggggac acaggcccac agcgatggcc 12900 ccacaccctg cctgaggtcg cccacttccc aggaggcagt cctgggactt ccacccgacc 12960 aggccccaga gcccaccgac ttaacccctc cagaggcttg tcgttcatta ccttattcaa 13020 gatggagacc agcctttttg cggagaaaat gcgggtgaag gtcctgaaag tgcattgacg 13080 ccgttttcgg aagccataca agtttagctg gcggaagaag ctctttatcg aagttgtggc 13140 aaacactttg tgtgcgacgt cccttttgag aatctccttt tcaaagagtt tttgattgat 13200 cactctacaa gccccactgt catcccacca gatggacgaa aactggttgc tgctgaccag 13260 tctccacagt ttctgtggaa aggggaggga gaggagatta tcttctccct ggggcgggac 13320 gtcaccgtca gggtgcggcc ttctgaacga agcttcctcg gccagaggtt ggaaagcgat 13380 ttcttctgtc agcagcctca agttagggct cccagtggac cccgggtcgt cccaggcagg 13440 ggaaggatct gctgggtgaa ggtaggtctc tgactgcaac tggggaggga aaggcaccct 13500 ttccaagcca tgatcctgtc ctctcgaatt tctttcttca cagcgagcca tactcaatga 13560 tcgcttgtcc tccatctggc aaacttgcta gtgcagtgtg gccagcagca ccccttggca 13620 gtcatgtaac cagccccatg acatcataaa ggggctctga ctgccggggg gtggcatctc 13680 cacccccagc aagttgtgta ataaagggcc aaggcagaca agtagctgcc catctgcatg 13740 tgcacattct ggtcctcaca gtcatttcaa tgggaaagat gacactagtg cacaagagtg 13800 ccgaggggcc ctgccacacc gtagatgcag acctggagcg gtccccttgt cctagagctc 13860 ctgagccagg cacaactaca gcaaagccct ggctcaggaa ggtcagagct caccgtctga 13920 gtcatgggcc cacagacccc agcacatgac tgacactcgg aagcacagaa caaagggtag 13980 gacggtgccc atgggtcagg ctgtagccac gccacccttt ccaccctgtc ctagccagag 14040 gcagcaatgt gctccataca gatcctccta acacacccac actgtcggtc cccagcacgc 14100 agatgcccga cagcccctta ggcaaatggc ttagctgact gccccaccac acgccgtcgc 14160 catgcagtcc agtggggagt cggaggcagc ctccttcctg cctctcctcg gcctgcacgt 14220 gtccccccac caggcagaga cccttctaca ccccgggtgt ctgcggtcac atcgcggtgg 14280 ggcatgcagc tgttggcctt cgagcatgtt ttgttttcct tggccagtgt ctccagagaa 14340 acgcacgtgg gtttgtgtcc agcggtccat ctctgcaaca gttgttcctt tgggattgga 14400 tgctaggagg tcacgggaga ggtgtccatc caaagcagtg tctgtgtcac acactgtccc 14460 cacacacagg gccacctctg cacagactcc cccgactcga ttctgggcac agagctcagt 14520 gaccttccag agactgccac gaaccggtga tgcctccacg cttgagacat cctgaccgca 14580 gggcccaagg cgcactggct cagggggtga cagtgagggg tctgcaaaca gactgctgat 14640 gctcaacccg gccgctgccg agctgtgtga cttgggcacg tcacttaacc tctctcggcc 14700 tctgtctcct cccggggata agagtagtag cacctgcttc ccggggctgt gaggatccag 14760 tgggacgtat aggaactagc gaggcaccgg cagttgggtc agagctactg ttgtcacttc 14820 acaaggcatt ttcttcaaca gcaagtcgga aatctcatga gcctaaggca gaatccacct 14880 gtggcctctg gttacaaccc acaggactga aaatccttcc agccacagca actggtgaat 14940 ttcctggtca attgccacaa gtcatgagct gaaccccact tgagtttcag ttcaggcaga 15000 actctagaga cgactagggc aagctagaca gcgactgcag agccttttgt tgcagcgtga 15060 gcagtcctca gctgttgaca tcactgggga gcaaacgagg accaggagcg gtgaaaggac 15120 agtgtctgct gcagattgtc gtagcaccca aggaacactc cagaaagcct cctaagcagt 15180 aacaagtgtg gcaaggtgta gcccagccaa cagtggcatc tgcgaggcgt cccctccttc 15240 ctcccactac cccgtatacc ctgggacctg tgcactgaag gactcattct aaaggctgtg 15300 cccctgcagc cgccagcctc actcactggc tgcctgtgcc agctagagat ttctttcctc 15360 tgaggctggc tgagaggacc actccagttt cctggcccat ccagcaaaga agatacacat 15420 catgcacgtg taaaatgagg aaccggttta ttgaacagct taaggagagc aaaaatagtg 15480 gctttagcta cattttttac acactgagca ggaaagtcta aaccatcccg ttcccctgta 15540 ccccaaagag aacagggctt gctggaggcc agtgccaagg gcggagtcgt gctcgcagca 15600 gacttgaatt aaccccatgt aggccggcga gcagttgccc gcgtgaaaac accaccctct 15660 tctcctggct gagaagatca aagctctttt tttaccctct tttcagcaaa ggacctattt 15720 gttttcaggc aggaggatgt taaacttgca gcctctgaca cacggtggaa cctgcagtgc 15780 ttggagaaac ggcacgcaca cgtgaaaaca tcatgcctac tccaaagcct tcttgttgct 15840 ggcaggaggg aagcttgaga ctttcccacg catagtcgtg acccgcgtgg ccgtttctgc 15900 tctcagcaac attctctagt gttccggctt caagcagcgc ttgtcaggtt tgaagctagc 15960 cactattctg agaacgtcag aaaagcatgg accatctctt gcttggtgtt gccgttgtgg 16020 cagtagcagc tactacgtac ctgcacgagt tccagggcag aagtggcaat gtcccatgaa 16080 ggcgtggcac cccacggggg ggggggggga gtgtgccacg ggcgtccact tctgcagcag 16140 aaggcatgtg cctacagcac aagcttgtaa aaaaatactt gaacagaata tgctgtacag 16200 aactaggggt taacaccgca tatgaagatg ctaaaacatt tgtataaata ctctgtatac 16260 aagcatggag tcactcccgt agaaagggct catccgtgag gctatgaaaa actgctgtca 16320 gcatgcccaa agagaaacta cttccacagt aggaacagaa aaaaggactg tgctgtgtct 16380 aaacacgtgg tgcatcagag acatagttac agttcctact gactgcccca gccacgacct 16440 gggagtgctg aggacctggg agtgctcagc gagctgcagg aggtcagccc tgtggagaaa 16500 tacatttcta aacaatactt ttgattggga tttcagcacc gtatagacag atgttccttc 16560 tgggggcctg gcaagcagcc atctcccagt gggtctgacg gggaagaggg gtacctggag 16620 cccctcccag acagacggta atcccacccc tgttctcaca ctcttcctgg catccgcatc 16680 tgctggcaca cacccccgtc acctgccact tccgcgtccc gtcgtggtga gtggctgata 16740 ggcgctggat gcaaacaagg catgagatgg acgtacctgg agacccagct ccagtactgg 16800 ttctggtctg cggggtgaac gagggggcag aggaaggcgg agagagtgcg tcccagtcca 16860 cttaagctct gtccccggaa gtggcatcta atctggcatt tcgatattta atttgggagg 16920 tgggagcaca tacttcccag ggctctgggt aatgaccacc ctggccttct ttcgaaacat 16980 gggtgcgatt ttagggggct ccggaactgg ggtctcttcg gtttcttcat tatcttcgtg 17040 atggagatca taggaaatgt ttccatattc tcgtagaaat gggaagattt caagcagaaa 17100 ctgacagaaa tctttgcgga taccaaacca ccctgaaaaa taagaatttt ttatttcaca 17160 cacgaggctc aactgacctt cctgttaact ttctttccgt aacaagaagt ttcactccta 17220 caatgtcata acatacttta tccagactcc tgagtcacaa agcctgaaca gggcttgagt 17280 acccaaaatg gggaagaagt gcaaatgcta gctctgtggt gcttggagtg gggttcccgg 17340 accggcaggg acagcgtcca cggggcctag ttagggatgc cattctcggg ccccagccca 17400 gacctccaga aactgagtcg ggctagggtg ggctccagcg gtcccctttt cctggccctt 17460 ttgggattct gctggatgcc caaatttgag aactactgct ccagtgagtc tcaaaatatc 17520 tgtggtgcgc agactacggt gtcttccgct aatcttctcc agccaggata aactcatgga 17580 tgacagtgcc acccaagaac aagatttctg tcaccctctg gaatccgtga gggcggtagt 17640 catgcacggg ttggccagga gggggcctga actcatggag ccaccttaaa gccactttcc 17700 cagtcccact actcctctct gtaggctact ggagtgtcag ctcggtgcaa gccctccctg 17760 ctcccgggtg cggggtaggg ggcagaggca caaacagcaa gcacagcccg ggctgctggg 17820 ctgcagtgag gccctgcccc caaacccact ggctttccga agggcaatgc tctgggcttc 17880 cgtgccatgg agcccacagc cttgccagga aggcaccctc tgcagagatc gttttggaag 17940 tgtctgcctc agcaagcagg tggaggggaa tagagtgtta gcaaggcaag acaggcaaga 18000 ctcgggtgat ggcagcaagg atatggggga ggcagagcgg ccaacaggga cctaggatga 18060 atcccaggtt tgggtgggag atgtggattt tccatcaaac cctcccgggc ctgggaagaa 18120 tctgtcttga tccccatttt gcagaggagg gaacgggatc tctgagaggt tgcctgccgt 18180 gtctggttct acctcaaatg gcagcgtgca ctgcgagaaa agtcccggtg caggccagca 18240 gaacaccaga gttacggcat gcccttccct tagaaggtcc cagaatttcc tcagccctca 18300 ctttcccaca caagcttcta aattggggcc ctcggggact catcccttcc tagacttcta 18360 tccgccaccc cccaccccct ggtccccccc cagacacaca ccaaggactt ctgaaatgct 18420 gagtacatac agtggtttcc tcccttctgt ccaaatgtgg ttgccatcag cgtgatcaac 18480 gagagccaaa gggggacaaa gatcgggatg caggagaagg cgttgtggcc atccagtttg 18540 tgaaccagca gaatctaaag aaagagacat agtcccggtt gatgccagca ccgaaaatgg 18600 gcagaggcgg aagccagact tcattaggca gttcctcccc accaccccac ccccgcgtga 18660 gctcccacaa gagggaacat cagcaccgcc agaaaaaggc aggaaaccac ctatccctgg 18720 ggaaagctcg aaatgagctt ttatgtccct cttcagagct cggcaatagc ctatccactt 18780 gaaaagttcc cagtgccagc agttttatgg caaactcctc cgggtgtttg ttctaaggag 18840 tcaacagctc ccattctaga attctccacg tgactccaat acacaaatct gacatcccac 18900 tctgctttcc ccagagtgga aactggagcc atacagaggc accatggcta aaaaggtgca 18960 ctcttctccc tgccagcccc acgtgctgcc cccaagagaa aggaaggatg ctctcctttc 19020 accgaagctc cctctcggag atggctgtgt tctctcccct ctcctggagt gggctcactg 19080 tgagctcgag ggacagaggc tgcctttcta ggggtgcaga atcctgtcag gggaagcgca 19140 agcttcaggg gctgaagagg cttcccgtgg aacgcttacc tcaaatgtaa gaaggggcac 19200 gacgatggtc atccagctca gggccatggt tatgtgtgtc ctgcgctgtc cgcaatcaca 19260 tccatagagc gcaagaacaa gacggaccac acaatgtagt agaggaccac caggcacaga 19320 aaggacatga gaatccacag cgggacacac acaacctggg ggtgggtgag agaacagcaa 19380 gagaagtctc tttagagctt ccaacctggc ctctgatgga aggcatcttt agcaccttgc 19440 tgtgtctgtc cagttaaggc ggtccttcct gtgagccgaa taaggaccgt tccatctccc 19500 aggactgctg ggagcatcgc tcaggacaga aaaggtatgg tatgttcact atggggcctg 19560 ctgccaccag gggacacaca cgctcagtga gtcatcagtc cctcttcctt tgggtgacag 19620 acagccctgc acctggctcc gcagcctcta ctcttccaga ggcccactct cccacactct 19680 ctcaggctcc tctaggttct gctgccatca cagcttcccg ggaaatggga cacaactgtc 19740 accctgtgca cacacacaag atctcacccc aacagactct cttcacaggc aacattccca 19800 caacctgctg ggggtacttt ggcaacacaa atgggaatgg gctccccaga aagtctggct 19860 gcctgggctc ctaaggatcc ctaacctcac ccctaccaag ttagtgaact tggcgggttg 19920 atgctggata caggttgatg ctggatacgt agcgctgccg ggtcgtgacc cctaaggaat 19980 tatccaaact cttgttttta gatgctttat tatatcaaac tctcctttaa acaagtggcc 20040 catctgctgg gatttggaag cctgtaatac tgaaattttc atcataatgg aaattttaaa 20100 aacagaattt gacccacctg tttttaaaac actttcatta cttaacaaga ggtctaatct 20160 tgggcaagtc ttgaaatttc tctggcctta gtttcccatg tgttaaatga aacttgaagc 20220 agttggtctc ttatagtctc ctgactctaa cattctaaga attatatttg tacaataact 20280 caaaaatcac ataatttaat ttaccatatg gactccaaaa tatattttct cattaggcta 20340 aacttgatct gcattttctg gatgtgtcca tattcttgga ctacactaaa acatgatacc 20400 aatgcttcct ctcaccataa accctcactt cgctttctac atttaagaat tttatagctg 20460 gaagagtcct taacagaaaa taccatctaa taattacccc tcaaaatcga gaaagtccta 20520 tctgttctta tgctagttat aagaatgagg cagcatttca cataatggtt ataaacactg 20580 ccacaagaag attcatgatg tgttgtttat ctgtagctct catcatactc tgtcatataa 20640 ctatagcatt aagattttaa tgttctatat attcttctaa gacagtgttt accagagtaa 20700 ggcacaaaag atccactggt ttgcaagaaa gattagaact tttaaatttt ttacctcacc 20760 ttgtttaatc tatatttttg tatgtatttt gtaacatata tattattatt accataaatc 20820 atatataatt taaaatgcat atattagggg taaatgctca ggaaactttt tataaattgg 20880 gcatgcaaat acaagtttga agactcactg ttctaggtat taaaagtaaa gttataacca 20940 agtaaagctt ccaccttttc atgtctcaaa gcagtttatt gttggaggta agatctctta 21000 gaagcctaaa caggtccaag tacagaatga agtaaggcta gcccataact tgtggcaagc 21060 aattcatact atttctctca tgctgagctc tcctcagtga agcagctact atagacaact 21120 gcagcctatt ggtagcctat tttacaggca ggaaaaaaat tactttttat tcaaagtgga 21180 actcaggaca tggggagaaa atgaatacaa aaaatagggt caatccaaag gcacacagca 21240 aatgagtaac acagttatgt ttttttccca tttgtatgag gtcccagtaa attctaagta 21300 aactgcaaat ttaataatac actaaaaaag ccatgcaatt gttcaaatga atcccagcat 21360 ggtacaagga gtacagacac tagagtctaa aaaacaaaag aatgccatta ttgagttttt 21420 gaattatatc aagtagttac atctctactt aataaatgag aaaaacgagg ataagaggcc 21480 atttgataaa atgaaaatag ccaagaagtg gtattagaga cttgaataca ggtattcggg 21540 tccaaagttc atctgctcaa atactaactg gggaaaagag ggaaaaatat ttatatacat 21600 atatatctgc acacaaaaat acccccaaaa gacaaaatga ggccaggcag ggtggctcac 21660 acccgtaatc ccggtacttt gggaggctga ggcaggtgga tacctgagat caggagttgg 21720 agatcagcct ggtcaacatg gtgaaaccct gtctctacta aagataaaaa aattagccag 21780 gcatggtggc gtgcgcctgt aatcccagct acttgggagt ctgaggcagg agaatcactt 21840 gaactgggaa ggggaggttg cagtgagcca agatcgtact actgcactcc agcctgggca 21900 gcagagtgag actccatcac aaaaataaat aaataaataa aatacaatga aacagaaagt 21960 tcaaataatc ccataatctt accaccaaga aataactttc actcgttata cttattgatt 22020 tttccataat aaatgtactt tactgtgact atcatgaaaa gaaagttatt ttagaaacag 22080 agaactgttt cagatcaaat ctatgtagta gaacagagcc attaggtggg aaagacgaga 22140 tcaaactaaa tctcagaagg cctaaaaggc taggtccatt ccagcactaa aaactgacca 22200 gacaagtaat ggcttcaaca gcttctaaat atggacaaag catgctgaaa gggaaggaca 22260 ggtctaacag tggtatatga aatgaacagg aggggcaaag ctcatttctc ctctgaagtt 22320 ttccaaagat gctgaggagg acattagttt gacatgaccc tgatatggga caagataatt 22380 tcacagaagt tttacatgtt aaagttttct tatagatact cattcaagta agcaatgaac 22440 actaaaatct aaagaaagaa aagagcttta gagtcaggtc tgtattcaaa ttcaagctct 22500 accacttact ggttctgtga ctttgggcaa gtcttttaac cttattaagt cttaatttcc 22560 tgatttgtaa aatggggata tcgtctccct cacaggattg ttgtgaaact tttatgagat 22620 taatgccttt atatttggca tagtgtaagt aaacaataac tggcagcttc aaaaaaaaaa 22680 agcagtagca ttccatcatt tattattggt tactctcaaa aagtttttca atgtactaga 22740 agataaatat tcaaatacct taatatctcc attattttca ggtaaacagc atgctcctga 22800 acaaccaatg ggtcaacaaa taaattaaaa gggaaatcta aaaacatctt gatattaaac 22860 tacatggaag cacaatatac caaaaccaat ggttcacact aggagaattt taaggtacaa 22920 gaaaactctt tgagatttct taaaataata gtatgtctga atttattgag tgatttacca 22980 gaaactgttg taagagctct acttgcatta tagcacttaa tcctcttaac tctatggctg 23040 ctattatcaa cctcacccta atcacatatg ggacacagag aggttaagta acttgcccaa 23100 ggtcagagtt aggaagtact aagccatgct ttgaatcagt tgtcaggctc cggaactcac 23160 actttcagcc actacataat actgctttgc tatcttttag gaaactatgt gagtctacct 23220 cacatagact cacataggtt tgtttttttt ttttttttaa aggctatctt ttcccccatc 23280 aatgtttttt gaaggatccc aaattagagt cccacagagg cagacagcag tacttgacaa 23340 tatggacatt taaggttaat gttggattct actgtctttt tactacatga cctagggaac 23400 gataattaac ctagactgct tccaagggtt aaataaccca tttagttata ctatgtaaat 23460 tatctcttag tgattgattg aaagcacact gttactaatt gactcggtat gaagtgcttt 23520 tttttCttCG ctttcaagat acataccttt ccagttaaag ttgagagatc atctccacca 23580 attactttta tgtcccctgt tgactggtca ttctagttaa aaaaaaaaaa aactatatat 23640 atatatatct acacacacat atgtatatgt atatccttat gtacacacac aaacttcaaa 23700 ttaaatgaga actagaagat ttgagaagtt agctagctaa tatccatagc attatgatat 23760 tctaaatgat atgaattata agaattaggt ttcctgaaat gaatgactag aaaactttca 23820 agtagagatt agtaaaaatt aaaaagtcct aatcggccat tactgatttg atgtttttaa 23880 gagtcctaaa aaatgggtta catccatttt taagtgggta gtattataac agccacccat 23940 cttcaatcac agtgatttct gaattgtgag ggaagttatt agcatgacag gtgtctggtt 24000 ctggccctgt acgattccca tgagtcaagc aaattgtaag ggctggtcta tatcacaccc 24060 aaccccaagg atatgtccct caaaagtcta gcccaggccc cgtcatcttc agcatcatct 24120 gggaaaccag gtctgattag tagtccttta aggaatacct cttaggctcc cattttactg 24180 ctatcacaga atccaataaa acccttacag gagattcaat gggaaatgct caacacccac 24240 tgtagttggt ggtgacaatg accataattt ggctgtgctg gattcaggac agaaaatttg 24300 ggtgaaagag caggtgaaca aaagagcttc gacttgccct agcagagagc aagccatacc 24360 ataccacaaa gccacagcaa ttacaacggt gcagtaccag cacagtaaat gaacaaagta 24420 gagcccagaa acagacccag aactatatga ggatttagta tacaataaag atggtatttc 24480 gagtcagtag ggaaaagatg aattattcaa taaatgatgt ttggccaact agtaacccat 24540 ttgggaaaaa ataaaagtat ggtccctacc tcacagcata cacaaaaata aattccagac 24600 ggattaaaat ctaaatgtaa aaaataaagc cataagtgga ctggaagaaa atagagaatt 24660 ttttttaaca tccgtagaaa gggtaaaaac ccaggcatga catgaaccaa aactgaagag 24720 gttctgtaac aaataccccc ttttatatat tgggctccaa caataagaac ccataggaaa 24780 atggagaatg aacacaaata gacaatttat agaagagaag gttataaggt gtaaaattat 24840 atctatctga gaaacaaaca ctaaaacaat gtgattctac tgttctccca cccatactgg 24900 caaaacttaa gcctgataat atgctgaggg gaaataagca ctcttgttgg tgagagtatt 24960 aattggcata gcttcttttg aaaatgacat agcaatacct gttaaaattg caaacatgca 25020 tgtcacttaa tccagtaatc ccacttctgg gaatcaatgc tacaaaaaca ctgacaagta 25080 tacaaagata cattcaagag tgttcactgg gccgggtgcg gtggcttcat gcctgtaatc 25140 ccagggaggc agaggcaaga cgatcgcttg accccaggag ttcaaggcca gcccgagaaa 25200 cacagcaaga ccctgtctct ctttttttta tttaaaaaat aaatgttcac tgtatcagtt 25260 gttcacaaaa acaaaccaac atgtccatta acagggaacc atttaaatta atcaagttca 25320 tctacacaat gtaataccat gcaactatta aaaagcacct gataatccaa agcacactga 25380 gacagaataa tgctattaaa aacaccaagt agtggaacac tgtgttgcct atgacaccat 25440 ttttattcaa catttaaaca aatttgtaac agcaattaca tgagtagtga caatggcgtt 25500 tatgagactt ttcactttta tgtgcttcta tttttgttat gcttctatat atacatccat 25560 ttattatgga gtgttacttt caaaaatcac aaatgggcca gtattatttg gtgttgcaag 25620 gtgagcatat gacttctgat atcaaccttt gcatattact tctcaattta gggaaattac 25680 agacatccct tattctaact aacttaaaac ccagcatttc aaacatacag aattgatggg 25740 gaaaaaaaag aaagaagaaa gaaagaaaag gcaacaagct tcagatgaca gtgactcaca 25800 tcaaattatt tataaaatct gttaaatagt gccatcttct ggagatacct ggtattacag 25860 tccaactcca gttgatgtct ttacagagac aagaggaata aaggaaaaaa tattcaagaa 25920 ctgaaaagta tggagtcatg gaaaaattgc tgtgatccaa aggctacggt gataggacaa 25980 gaaacaagag aactccaagc agtaagacac tgctgttcta ttagcatcca aacctccata 26040 ctcctgtttg ccccaaggct tttttaaaaa atagagacag gatctcacta ttttgctcag 26100 gctggtcttg aactcctgga ctcaagctat cctcctgcct cggcctccta aagtgccgag 26160 attacaggct tgagtcacca tacctggcta tttatttttt cttaactctc ttgcctggcc 26220 tatagccacc atggaagcta ataaagaata ttaatttaag agtaatggta tagttcacta 26280 cattggaata caggtataag tgcctacatt gtacatgaat ggcatacatg gatcaattac 26340 cccacctggg tggccaaagg aactgcgcga acctccctcc ttggctgtct ggaacaagct 26400 tcccactaga tccctttact gagtgcctcc ctcatcttta attatggtta agtctaggat 26460 aacaggactg gcaaaggtga ggggaaagct tcctccagag ttgctctacc ctctcctcta 26520 ccgtcctatc tcctcactcc tctcagccaa ggagtccaat ctgtcctgaa ctcagagcgt 26580 cactgtcaac tacataaaat tgccagagaa gctctttggg actacaaaca cataccctta 26640 atgtctttat ttctattttg tctacctctt cagtctaggt gaaaaaatag gaaggataat 26700 agggaagaac tttgtttatg cctacttatc cgcccctagg aattttgaaa acctctaggt 26760 agcaataaga actgcagcat ggtatagaaa aagaggagga aagctgtata gaaatgcata 26820 ataaatgggc aggaaaagaa ctgcttggaa caaacaggga ggttgaacta taaggagaga 26880 aagcagagag gctaatcaac aaggctgggt tcccaagagg gcatgatgag actattacta 26940 aggtaggaat tactaagggc tccatgtccc cttagtggct tagtactatg tagcttgctt 27000 tctgcagtga acttcagacc cttcttttag gatcctagaa tggacttttt ttttttatcg 27060 gaaaacagtc attctctcaa cattcaagca ggccccaagt ctaccacact caatcacatt 27120 ttctcttcat atcataatct ctcaaccatt ctctgtcctt ttaactgttt ttctataccc 27180 tgatcaaatg ccaacaaaag tgagaatgtt agaatcatgt atttttagag gtagactgta 27240 tctcagataa aaaaaaaggg cagatattcc attttccaaa atatgtatgc agaaaaaata 27300 agtatgaaag gacatatgct caggtaacaa gttaatttgt ttacttgtat tttatgaatt 27360 ccctaaaacc tacgtcaccc gccccgttcc cacgccccgc gccacgtcac aaactccacc 27420 ccctcattat catattggct tcaatccaaa ataaggtata ttattgatga tgttaattaa 27480 catgcatgga tccatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc 27540 atcaggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg 27600 cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac 27660 gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg 27720 ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca 27780 agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc 27840 tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc 27900 ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag 27960 gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc 28020 ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca 28080 gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg 28140 aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg 28200 aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct 28260 ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa 28320 gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa 28380 gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa 28440 tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc 28500 ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga 28560 ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca 28620 atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc 28680 ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat 28740 tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc 28800 attgctgcag ccatgagatt atcaaaaagg atcttcacct agatcctttt cacgtagaaa 28860 gccagtccgc agaaacggtg ctgaccccgg atgaatgtca gctactgggc tatctggaca 28920 agggaaaacg caagcgcaaa gagaaagcag gtagcttgca gtgggcttac atggcgatag 28980 ctagactggg cggttttatg gacagcaagc gaaccggaat tgccagctgg ggcgccctct 29040 ggtaaggttg ggaagccctg caaagtaaac tggatggctt tcttgccgcc aaggatctga 29100 tggcgcaggg gatcaagctc tgatcaagag acaggatgag gatcgtttcg catgattgaa 29160 caagatggat tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac 29220 tgggcacaac agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg 29280 cgcccggttc tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaagacgag 29340 gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt 29400 gtcactgaag cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg 29460 tcatctcacc ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg 29520 catacgcttg atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga 29580 gcacgtactc ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag 29640 gggctcgcgc cagccgaact gttcgccagg ctcaaggcga gcatgcccga cggcgaggat 29700 ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt 29760 tctggattca tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg 29820 gctacccgtg atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt 29880 tacggtatcg ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc 29940 ttctgaattt tgttaaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat 30000 cggcaaaatc ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt 30060 ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt 30120 ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag 30180 gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg 30240 aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc 30300 gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc 30360 gctacagggc gcgtccattc gccattcagg atcgaattaa ttcttaatta acatcatcaa 30420 taatatacct tattttggat tgaagccaat atgataatga gggggtggag tttgtgacgt 30480 ggcgcggggc gtgggaacgg ggcgggtgac gtagtagtgt ggcggaagtg tgatgttgca 30540 agtgtggcgg aacacatgta agcgacggat gtggcaaaag tgacgttttt ggtgtgcgcc 30600 ggtgtacaca ggaagtgaca attttcgcgc ggttttaggc ggatgttgta gtaaatttgg 30660 gcgtaaccga gtaagatttg gccattttcg cgggaaaact gaataagagg aagtgaaatc 30720 tgaataattt tgtgttactc atagcgcgta atactg 30756

<400> 24 gtacggaagc ccggaaggag gggcaggggg cggtggctca ggtttctccg ggcggcggcg 60 gcggcggcgg cggcgacggc gacggcgacg gcagcgggga cggcagcagt agcgggagca 120 gcagcgtgga cgcggctggc gctggcgcca tgaacccgct gtaaggcgca ggctgtgcag 180 cacggggtgc gggggaggag gaggaggacg ccgcggtgaa gttctccgcc atgaacctga 240 ggggcctctt ccaggacttc aacccgaggt gaggcggcgt cgttggcgcc cccgggagtc 300 cgcgctgcgg gctcgggcgc gggctggtgt tcggctccgg ggaggcacgg cgggcgagat 360 gctgcagccc gaggacccgg gcgcctgccc gagcctccct gcgggtgcaa gcggtcccca 420 ggcaaaacag tcggcctcgg cgcccgcccg cttcctcctc ccgtgcccgg tgctttcagc 480 ccctgcccgg ccacggccgg aagggcccgg ccgcgagccc cgtcctgccc caagggaacc 540 ccattctttt ctgcttgctg tccctcattg gtgtcccaac ttcttcgtct cggttccatc 600 ctcttctgcg ccgctgcggg ccctccattc tccgcgtcag ggccgtctca ctcgacccaa 660 cacccctacc cccaccccag ctgtttcctc cagttcctcg cagtccttgg ggttttcctt 720 gggtttatgc ccatccctct cttgtttgct tctttgttga acggatacct gaaacactgt 780 tgaatccttg gagtcagtgt cggggtatgg caatacctta tataatgcat ttctgggtga 840 gcctgatcat tttccatact cattttctca tcagtcttca ctacaagttt atttgcagga 900 agtagatatt gctgtccttc ttttccagat ggggaacacc cagtggacag tgtggagaaa 960 acactggcta agcactcaag cgcctgtcct tgcacttgcc cgactgtttt gtaactgttc 1020 tttaccccag gctgtgagct ccctgaagct gagaccatct cctgctcatc tcagtgtccc 1080 cagcgcctcc cacccaccgt atctggcaca tagtaggcac atataaaatg tttgtggaac 1140 taaactgagc ccaaagactt ggattggaga cgaggccata tgtaactggg tgattctctg 1200 cccttctttg gcccttctgt aaaatgagga gttggcctaa ctgatctctt aaatgcacta 1260 ctctccgaaa ggagtatccg tttcccttat ttgccagttg ggaagacgtg ctcagtaaat 1320 atttgtgtgc tgtaacctat gttaggtgct ttagatgctg gcggtctcag catggggtga 1380 agaagggctt gtacacttaa gatgccttac agtactgtgc agtgctgtac tgcgggggcc 1440 aactctgggg acctatgcct tggctgcttg ttgaggatga aaggaagttt taggggagta 1500 tttgtatgtt gagggtgcag tctccctagg gatggtgaca ttttaacttg tgagtcattg 1560 tgactttgta tgtgccctta ttccactttg agttcatgtt ctggttagga gtgccagtgt 1620 ctctaacacg gtgcagacat tatcattgtt ggcttcgaag gcatagagga ggtaacagaa 1680 ctaactgcag tcccttcctc tgctgcatca gggggttaag attggtctgc agggtagtag 1740 ggttggtgct gtggctggac aagccctgta tgtcttctat ttggagatgg tgataagaaa 1800 gttaagtaaa aactgaattg ttttgtgccc ttgggcaact cacttatcta ttgttttatc 1860 tgtagaatga gtataatctc tcagtggggt agggaggcca attaaggatt gattacaaag 1920 tgccttacaa atagaaagct acagtgactt gtttgcaagg tgacagagaa ttcagaagcc 1980 tcaagaaact gccttaagtg atcaaacagg ctaacggagt tgccaaagca aaatagtgct 2040 gcactgatac tacctttaac cgttttttcc tttagccctt ttccccccaa aaaaattagt 2100 atatgaaatt acagtgaaat acctggtatc taagcagatt tatagtaatt ctcaacatat 2160 tcatcaatct cttaattcta cctgcattaa aatgtatttc tacctgaaaa gtttaaaggt 2220 cttttatact gtgccatttt cctgattcat tgttgccaga ggtagtgagt tccttaattt 2280 tacagatatt tcaagaggac attggccagg tattattggt aaatcagatt tgttttttta 2340 gctggtagtg tttcacctct cctgagcact cctagttttt gacagtgtgc tttagtctcc 2400 ttccatgctg aggaaggcct tctctatagg agaaagaaaa ctgaggggtg tacacaggaa 2460 gttaccttat gctggggact caaaccttga tgctactgct ttgctccctg cctctatttt 2520 tgaaccaatt caacatctcc ctcctacccc aggaccttgt cacacactgt tctctttacc 2580 aggaatgttt ccctctcttt tcctctcctc cagacctagt gaactcctat ttatcctcac 2640 ttggcacttg ctaagggaag cattcctgac ttccctgacc agatttactg ctccctgttt 2700 ctacagttcc tgtagtattt actactcctc catcatagtg catatttgta cccttgtgtc 2760 tgtctggatg cttatttgat taatacctgc ctcccccact aaactttaag ctccatgggg 2820 tcaaggccgt gactgtgtca gtatcgtagc ctgcatactt ggaatagtac ctggctcaat 2880 aaatatttgt ggagtaaata actgaataac tctccagagc ctataagata aatctagagc 2940 tgctgctttc aatcactgct ttcctggtgg tctgtggcct ggttctcttt cttctcacac 3000 tcttcccacc ttcagagtgc agccattgct ttggagagat gggagagaac atggcactaa 3060 ggcagaatat ggctatattt actttgaaga gcatgtcttt gtcatagaaa tagtcactgt 3120 catggtttgg tgggtcccaa ggcatgggtc atggctccag atcccctttc cagccttttg 3180 gatcttggta agtctgaacc cactgctgcg ttggcaaggc tctggaaact atagtgacag 3240 agaatgattc acaagtgtca acactcagat gtacagggct gccagctgac ccactctacc 3300 tatttccatc tggcactgaa ctggttgatc atgaacttct tttcataatt gctttttagt 3360 tatgcaggtt aagacatgcc gaaacagatg taccggaccc acaaacaagt ccttccttga 3420 atgcctgagg cttcctaaca gtgaaagagc cctgttctta gagtaggcaa actgattctg 3480 aggcattgta ggtggtaggg atctggtagt aggtagcatt aggtgggctc ccggcactca 3540 ccatggagcc ttgaaatttt ctgctacttt gggggagttg ctggttcaga gaaggccctt 3600 ccaccctggt agccatgtgg cactggaagg ctgtgaaaac tctgctgggc cttcttagtc 3660 atctgttgtg agctcctgat gggagtgtgg tgtatccctc aggtgtgcta gactggaaca 3720 aaggctgaga agtgttgctc tgggggttcc aacttgtggg catggggtac tgatgagatc 3780 agtagtgttt ggagacttct gtatgctcca tcttcagaag acattctgga gtccatataa 3840 gttatcttgt ctcttgtttg aagcaggaaa aaggaatgcg attgctggta atatagttca 3900 ctaaagtcag ctacctggcc tctaacagtt atttgcaaag tatattataa cattgattcc 3960 tcaaacatct agattcctat ctcgtgccaa gtgatgtact aggtgctcta agtacaaaaa 4020 taaaggaata tagtcctcct ctcaatgcgt aagcctagtg gaagaagcag aaatgaaagg 4080 gaaataagaa ttcaatagag tatgaggcat tacagtgaaa gaaaccaaat gtcttagaag 4140 tacaaatggc agagctacta attctgtctc gagcaggcag ggaagagtct atagtggaaa 4200 tgacttttga gctagatttt gaattgagct agtcttttga gccagacttt tgagctagaa 4260 ttgtagggtt gtcatcagac cagagagtag gaagggtacc ttgtgaggaa gagagagaga 4320 gatcagattg ttactgtgtc tatgtagaaa aggaagacat aagaaactcc attttgatct 4380 gtactaagaa aaattgtttc tgctttgaga tgctgttaac ctgtaacttt agtcccaacc 4440 ctgtgctcac agaaacctgt gctgtaatga atcaaggttt aatggattta gggctgtgca 4500 ggatgtacct tgttaacaat atgtttgcag gcagtatgct tggtaaaagt catcgccatt 4560 ctccattctc gattaaccag ggacacagtg cactgcggaa ggccgcaggg acatctgccc 4620 aagaaagcct gggtattgtc caaggtttcc ccccactgag acagcctgag atatggcctt 4680 gtgggaaagg aaagacctta ccacccccca gcccgacacc cgtaaagtgt ctgtgctgag 4740 gaggagtagt gaaagagcgg ggcctctttg cagttgagat aagaggaagg cttctgtctc 4800 ctgctcatcc ctgggaatgg aatgtctctg tgtaaagctg accattccca ttcgttctat 4860 tctgagatag gagaaaacca ccctgtggct ggaggcgaag tatgctggca gcaatactgc 4920 tctgttactc tttgctacac tgagttgttt gggtaaagag aaacataaat ctagcctgcg 4980 tgcacatcca ggcacagtac ctttccttga acttattcat gatacagatt cctttgctca 5040 cgtttccctg ctgaccttct ccccacctgt tgccctgcta cactcccctc gctaagatag 5100 taaaaataat gatcagtaaa tactgaggta actcagaggc tagcgctggt gcgggtcctc 5160 cgtatgctga gtgccggtcc cctgggccca ctgttctttc tctatacttt gtttctgtgt 5220 cttatttctt ttctcagtct cgtcccacct gacgagaaat acccacaggt gtggaggggc 5280 tggccccttt cagtatctca gaagggacaa agtacacaaa ggcatggggt catgatagtg 5340 cctggtatgt tcaggtagtg aagaggtcca tgtggtatga gcactgcaga tgatatgtgt 5400 cgtatgaatt aaaaatacat agttactgca aatagttttt acaggttatt gtttttaaga 5460 aagcagtatc taatgcacga gtgtactgtc agtactgtca atgaactact taccactcaa 5520 gtgactgctt acgcgtcgaa tcactagtga attcgcggcc gcctcgagtc tagaactagt 5580 ggatccccca aacgggccct ctagacgcgt tgacattgat tattgactag ttattaatag 5640 taatcaatta cggggtcatt agttcatagc ccatgatatc atatggagtt ccgcgttaca 5700 taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca 5760 ataatgacgt atgttccσat agtaacgcca atagggactt tccattgacg tcaatgggtg 5820 gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg 5880 cccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtncatgac 5940 cttatgggac tttcctactt ggcagacatc tacgtattag tcatcgctat taccatggtg 6000 atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggattttcc 6060 aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 6120 tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg 6180 ggaggtctat ataagcagag ctctctggct aactagagaa cccctgctta ctggcttatc 6240 gagatatctg cagaattcat ctgtcgactg ctaccggcag cgcgcagcgg caagaagtgt 6300 ctgggctggg acggacagga gaggctgtcg ccatcggcgt cctgtgcccc tctgctccgg 6360 cacggccctg tcgcagtgcc cgcgctttcc ccggcgcctg cacgcggcgc gcctgggtaa 6420 catgcttggg gtcctggtcc ttggcgcgct ggccctggcc ggccgcgtta agatacattg 6480 atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt 6540 gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca 6600 attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt 6660 aaaacctcta caaatgtggt atggctgatt atgatcagtt anctagatcc ggtggatctg 6720 agtccggact tgtacagctc gtccatgccg agagtgatcc cggcggcggt cacgaactcc 6780 anngatcgga tatcttatct agtgattcta aggccaactc agaagggctt tcttggttgt 6840 atctttcaca ctcctcagga aattcatgac gtcagtaccc ccagtccctc tgttttccgt 6900 gtttgagggc tcttctgact tgtggccacc catgggcttc tgcttcgaag gcttcacaat 6960 gtaagtatct actatcgaga ggtggaacat tctgagggag accaggccat tcacacactc 7020 attataagcc tccttcaagt cttcattgcg tcttaaaatg acaaactcac ggactggggg 7080 agctgactct aaggaggaga ggaagttccg gtgggctgga ggcatgtact ctctcatttc 7140 ctggaggaat tctgcagcag atccttcacc aacgtcatgc tttattccca gaaggacatc 7200 aagactctga aagatgctgc tctggcctgc actgccccct gaaaattttt tgggggtgtc 7260 ccagacgccc tcgtacagca gaccctccgg cagcttaggg ttgcccttcc aaccagacaa 7320 atatatgcga agaacgtgga aaaaggtgtc tggatccacg aagtcacgca tcctcttaaa 7380 aatttccttg gctttctcca gactggcagc tatactacac agtgccttct ccagtgcttt 7440 cgggtcttga tgctctactg cactggatac agtaggaatt gctttgattg caggagaagc 7500 tgcgatttcc accattagag agaccaggaa gaagccttta tcgcagtccc caccaggaaa 7560 cgagaacaga atgtccatgt tctcgtatgt catgggccca ttggggtcct ttttcttcca 7620 gtttgccagg acgcagtctg cgtaagacag aatgggaggc agccccagct tctccgagag 7680 ctcgcagtag ggaacggcaa gattgcgggg cagcaccttt cgaatatcat catcccctcg 7740 gttccacaca tacgccatgg tgatgtaccc cagggccaaa tgtgccaggc gctgtaacct 7800 gtgtcccctc agttcttcgg tgcgcagtgt gggcagcttc tcgacttctt ctcggagctt 7860 cccattctca atcagcttag gcagatttct agccacaagg atccaaggtc tgtacgtatc 7920 aggcagctcc tccagtggat gtggtagagc aaagcccaca tcttcatcta tgtggtattc 7980 ttcaaggatc cttctagagc cttctgcagg agatatttga ctgtgaggca taatcgaatt 8040 cccgcggccg cgtcgacggt accagatctc tagcggatct gacggttcac taaaccagct 8100 ctgcttatat agacctccca ccgtacacgc ctaccgccca tttgcgtcaa tggggcggag 8160 ttgttacgac attttggaaa gtcccgttga ttttggtgcc aaaacaaact cccattgacg 8220 tcaatggggt ggagacttgg aaatccccgt gagtcaaacc gctatccacg cccattgatg 8280 tactgccaaa accgcatcac catggtaata gcgatgacta atacgtagat gtactgccaa 8340 gtaggaaagt cccataaggt catgtactgg gcataatgcc aggcgggcca tttaccgtca 8400 ttgacgtcaa tagggggcgt acttggcata tgatacactt gatgtactgc caagtgggca 8460 gtttaccgta aatactccac ccattgacgt caatggaaag tccctattgg cgttactatg 8520 ggaacatacg tcattattga cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg 8580 ccatttacca acgcggaact ccatatatgg gctatgaact aatgaccccg taattgatta 8640 ctattannnt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct 8700 gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct 8760 catatttgac aacgcgcatg cccccatggg ^cc 9999tgcg tcagaatgtg atgggctcca 8820 gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac gacctgcagg 8880 cagacgggcg ctcctgcacc gcatccgcga cgcagtcctg caacgacctc tgcgagcact 8940 tctgcgttcc caaccccgac cagccgggct cctactcgtg catgtgcgag accggctacc 9000 ggctggcggc cgaccaacac cggtgcgagg acgtggatga ctgcatactg gagcccagtc 9060 cgtgtccgca gcgctgtgtc aacacacagg gtggcttcga gtgccactgc taccctaact 9120 acgacctggt ggacggcgag tgtgtggagc ccgtggaccc gtgcttcaga gccaactgcg 9180 agtaccagtg ccagcccctg aaccaaacta gctacctctg cgtctgcgcc gagggcttcg 9240 cgcccattcc ccacgagccg cacaggtgcc agatgttttg caaccagact gcctgtccag 9300 ccgactgcga ccccaacacc caggctagct gtgagtgccc tgaaggctac atcctggacg 9360 acggtttcat ctgcacggac atcgacgagt gcgaaaacgg cggcttctgc tccggggtgt 9420 gccacaacct ccccggtacc ttcgagtgca tctgcgggcc cgactcggcc cttgcccgcc 9480 acattggcac cgactgtgac tccggcaagg tggacggtgg cgacagcggc tctggcgagc 9540 ccccgcccag cccgacgccc ggctccacct tgactcctcc ggccgtgggg ctcgtgcatt 9600 cgggcttgct cataggcatc tccatcgcga gcctgtgcct ggtggtggcg cttttggcgc 9660 tcctctgcca cctgcgcaag aagcagggcg ccgccagggc caagatggag tacaagtgcg 9720 cggccccttc caaggaggta gtgctgcagc acgtgcggac cgagcggacg ccgcagagac 9780 tctgagcggc ctccgtccag gagcctggct ccgtccagga gcctgtgcct cctcaccccc 9840 agctttgcta ccaaagcacc ttagctggca ttacagctgg agaagaccct ccccgcaccc 9900 cccaagctgt tttcttctat tccatggcta actggcgagg gggtgattag agggaggaga 9960 atgagcctcg gcctcttccg tgacgtcact ggaccactgg gcaatgatgg caattttgta 10020 acgaagacac agactgcgat ttgtcccagg tcctcactac cgggcgcagg agggtgagcg 10080 ttattggtcg gcagccttct gggcagacct tgacctcgtg ggctagggat gactaaaata 10140 tttatttttt ttaagtattt aggtttttgt ttgtttcctt tgttcttacc tgtatgtctc 10200 cagtatccac tttgcacagc tctccggtct ctctctctct acaaactccc acttgtcatg 10260 tgacaggtaa actatcttgg tgaatttttt tttcctagcc ctctcacatt tatgaagcaa 10320 gccccactta ttccccattc ttcctagttt tctcctccca ggaactgggc caactcacct 10380 gagtcaccct acctgtgcct gaccctactt cttttgctct tagctgtctg ctcagacaga 10440 acccctacat gaaacagaaa caaaaacact aaaaataaaa atggccattt gctttttcac 10500 cagatttgct aatttatcct gaaatttcag attcccagag caaaataatt ttaaacaaag 10560 gttgagatgt aaaaggtatt aaattgatgt tgctggactg tcatagaaat tacacccaaa 10620 gaggtattta tctttacttt taaacagtga gcctgaattt tgttgctgtt ttgatttgta 10680 ctgaaaaatg gtaattgttg ctaatcttct tatgcaattt ccttttttgt tattattact 10740 tatttttgac agtgttgaaa atgttcagaa ggttgctcta gattgagaga agagacaaac 10800 acctcccagg agacagttca agaaagcttc aaactgcatg attcatgcca attagcaatt 10860 gactgtcact gttccttgtc actggtagac caaaataaaa ccagctctac tggtcttgtg 10920 gaattgggag cttgggaatg gatcctggag gatgcccaat tagggcctag ccttaatcag 10980 gtcctcagag aatttctacc atttcagaga ggccttttgg aatgtggccc ctgaacaaga 11040 attggaagct gccctgccca tgggagctgg ttagaaatgc agaatcctag gctccacccc 11100 atccagttca tgagaatcta tatttaacaa gatctgcagg gggtgtgtct gctcagtaat 11160 ttgaggacaa ccattccaga ctgcttccaa ttttctggaa tacatgaaat atagatcagt 11220 tataagtagc aggccaagtc aggcccttat tttcaagaaa ctgaggaatt ttctttgtgt 11280 agctttgctc tttggtagaa aaggctaggt acacagctct agacactgcc acacagggtc 11340 tgcaaggtct ttggttcagc taagctagga atgaaatcct gcttcagtgt atggaaataa 11400 atgtatcata gaaatgtaac ttttgtaaga caaaggtttt cctcttctat tttgtaaact 11460 caaaatattt gtacatagtt atttatttat tggagataat ctagaacaca ggcaaaatcc 11520 ttgcttatga catcacttgt acaaaataaa caaataacaa tgtgaaaaaa aaaaaaaaaa 11580 aaaaaaaaaa aaaaaaaaaa aaaaggtagc agtcgacaga tgaattccac cacactggac 11640 tagtggatcc gagctcggta ccaagcttaa gtttgggctg caggaattct gatggctctc 11700 aaaattcctg cctcctttag ggataaaaga ctttaagact ttttaacaaa aaagaaaaag 11760 aaaaaaaaaa ttcctgcctc ctggtgtaca cacacagaag ggttccctcc ccttgaatgt 11820 gaccaggatc tgtgaaaata acgggatagc cgctcctgtg attaggttat gtggtagact 11880 agagcaagat tctcctgctg gttttgaaga agtcagctgc catgttgtga gactgtcatg 11940 ggctagggca tgagccttta aatatctggg agcaacccct ggccagcagc cagtgagaaa 12000 acgggccctc agtcctacaa tcacaaggaa ctaaattctg ccaacaacct gaaggaactt 12060 tgaagaggat catgagtccc ttgattcagc ttgatgagcc cctgagcaga ggatacagct 12120 aacttgtact agggaagtat aaaaaacatg catgggaatg atatatatca actttaagga 12180 taattgtcat acttctggga atgaagggaa agaaatgggg ctttagttgt attatgatct 12240 ttaatttctc aaaaaaaata agatcagaag caaatatggc aaaatgttaa tacttttgtg 12300 ggtacgtagg tattcagcat accctttttt ctgagttcaa aatattttat aattaaaatg 12360 aaatgcaggc caggcacagt ggctcatgcc tataatacca gcactttgcg aggccgaggt 12420 gggaggatgg cttgaggcca gaccagcctg gccaacatgg caaaacccca tctctactta 12480 aaaaaaaaaa aactatatat atatatatgt gtgtgtgtgt gtatatatat atatgtatat 12540 atatttatat atgtgtgtat atatatatat gtatatatat ttatatatgt gtgtgtatat 12600 atatatatac acacacacac atatatacat acatacatac acacacacac acacacaatt 12660 agccaggcat ggtggcgcac acctgtagtc ccagctactt gggaggctga gacatgagaa 12720 ttgcttgaac ctgggaggca gagtagttag tgagctgaga tcataccact gcactccagc 12780 ctggtgacag agtgagactc tgtcttaaaa aaaataaaaa ttaaaattaa atgcaaaagg 12840 tccaagtgaa ttgaagagga aaggggtatc aaggaaggtt ttgtggaggt gacgtttgag 12900 ctgggtctta aatgacttaa acatgggata agaagggagg gaataaggac atttcaggta 12960 cgagaaataa ggagcaaaca gtggaaacaa cctaacgtct gtcaaccagt gaatggataa 13020 caaaaatgta attcagatgg tatccaactt acgatggttc aacatgagat ttttctgact 13080 ttaggataga tttatcaaag tagtaaatcc attttcaact tatgatattt tcaacttcag 13140 atgggtttat caggacacag ttgaggaaca cctgtctatc catacaattt ggcaataaaa 13200 aggaaatgag tgcagatata ctccacaaca tgaatgaacc ttgaaaacat taagtgagag 13260 aagccagata caaaaggcca catattgtat gattctattt atacaaaatg tccagaatag 13320 gcaaatctta tagacagcaa gtaggtagat gatcagtttg ctaggtgctg ggggaagggg 13380 aaatggggag tgatggctaa ggggattggg tttctttgtg gggcaatgaa aatgttttaa 13440 aattgagcgt gataatgatt gcacaatgct gcatatatat ataatctata gattatatat 13500 atataaagag aggctgttag acagtgataa gtgatatata tatatatata catagagaga 13560 gagagagaga gagagagagg ctgttagtga taagtgatca ggaaaataaa agtattgagg 13620 aggaatacga agttgacggt gtgaaaacat gagattttat ataggatggc cagggaaggc 13680 cttaatgaga aagtgactta tgagtaaaaa caagggatcc taaaccttag catgcatcag 13740 aatcactcgg aaacttgtta aagcatagct tgctgggcct catcacagat attttgattc 13800 ggtaggttct tgtctgatat taatactttt ggtctaggga accacatttt gagaaccact 13860 gagctaaagg aagtaaaggt ttcccttagt ttactagctg gtaacactgg cccaggaggc 13920 ctttctggaa aaggtcccag tccccaaagg aagctgggga ctcgcgttca catcgtcaag 13980 gtttaccaag ttgtggcggg cctttccgtc ttggaaaaag cctcaaaatg gcagattagg 14040 gtgtccatgg ccggcggaaa gggtctttga agttgcagac caggagggaa gaagattctg 14100 ggcctccccc atgcagtgtc agctggcaac agaatgcacc ccggctgggt tggaggccct 14160 gggtactggc tcttccacac caggggcGca cctaccaagg gcagcaggag catctgcacc 14220 tcctgcgcca ggcgcccttc agtgcttcca cttgagcacc tctccagaca ccagctaggg 14280 tgacagtggt acaaatacca gactcccctg gcctgctcac ctcacagggt aatgtgctgt 14340 ggagtcaggg ggacacagca accaccagat gacatggctg gccccgggga ggacgacacg 14400 cagatacggc tacttggcac ctgtgatatt ttacacactc gagaggggcc cgcaccatcc 14460 tcagccctct ccccacattc actcttagtt catgtcacct ccacccagag ggggacacag 14520 gcccacagcg atggccccac accctgcctg aggtcgccca cttcccagga ggcagtcctg 14580 ggacttccac ccgaccaggc cccagagccc accgacttaa cccctccaga ggcttgtcgt 14640 tcattacctt attcaagatg gagaccagcc tttttgcgga gaaaatgcgg gtgaaggtcc 14700 tgaaagtgca ttgacgccgt tttcggaagc catacaagtt tagctggcgg aagaagctct 14760 ttatcgaagt tgtggcaaac actttgtgtg cgacgtccct tttgagaatc tccttttcaa 14820 agagtttttg attgatcact ctacaagccc cactgtcatc ccaccagatg gacgaaaact 14880 ggttgctgct gaccagtctc cacagtttct gtggaaaggg gagggagagg agattatctt 14940 ctccctgggg cgggacgtca ccgtcagggt gcggccttct gaacgaagct tcctcggcca 15000 gaggttggaa agcgatttct tctgtcagca gcctcaagtt agggctccca gtggaccccg 15060 ggtcgtccca ggcaggggaa ggatctgctg ggtgaaggta ggtctctgac tgcaactggg 15120 gagggaaagg caccctttcc aagccatgat cctgtcctct cgaatttctt tcttcacagc 15180 gagccatact caatgatcgc ttgtcctcca tctggcaaac ttgctagtgc agtgtggcca 15240 gcagcacccc ttggcagtca tgtaaccagc cccatgacat cataaagggg ctctgactgc 15300 cggggggtgg catctccacc cccagcaagt tgtgtaataa agggccaagg cagacaagta 15360 gctgcccatc tgcatgtgca cattctggtc ctcacagtca tttcaatggg aaagatgaca 15420 ctagtgcaca agagtgσcga ggggccctgc cacaccgtag atgcagacct ggagcggtcc 15480 ccttgtccta gagctcctga gccaggcaca actacagcaa agccctggct caggaaggtc 15540 agagctcacc gtctgagtca tgggcccaca gaccccagca catgactgac actcggaagc 15600 acagaacaaa gggtaggacg gtgcccatgg gtcaggctgt agccacgcca ccctttccac 15660 cctgtcctag ccagaggcag caatgtgctc catacagatc ctcctaacac acccacactg 15720 tcggtcccca gcacgcagat gcccgacagc cccttaggca aatggcttag ctgactgccc 15780 caccacacgc cgtcgccatg cagtccagtg gggagtcgga ggcagcctcc ttcctgcctc 15840 tcctcggcct gcacgtgtcc ccccaccagg cagagaccct tctacacccc gggtgtctgc 15900 ggtcacatcg cggtggggca tgcagctgtt ggccttcgag catgttttgt tttccttggc 15960 cagtgtctcc agagaaacgc acgtgggttt gtgtccagcg gtccatctct gcaacagttg 16020 ttcctttggg attggatgct aggaggtcac gggagaggtg tccatccaaa gcagtgtctg 16080 tgtcacacac tgtccccaca cacagggcca cctctgcaca gactcccccg actcgattct 16140 gggcacagag ctcagtgacc ttccagagac tgccacgaac cggtgatgcc tccacgcttg 16200 agacatcctg accgcagggc ccaaggcgca ctggctcagg gggtgacagt gaggggtctg 16260 caaacagact gctgatgctc aacccggccg ctgccgagct gtgtgacttg ggcacgtcac 16320 ttaacctctc tcggcctctg tctcctcccg gggataagag tagtagcacc tgcttcccgg 16380 ggctgtgagg atccagtggg acgtatagga actagcgagg caccggcagt tgggtcagag 16440 ctactgttgt cacttcacaa ggcattttct tcaacagcaa gtcggaaatc tcatgagcct 16500 aaggcagaat ccacctgtgg cctctggtta caacccacag gactgaaaat ccttccagcc 16560 acagcaactg gtgaatttcc tggtcaattg ccacaagtca tgagctgaac cccacttgag 16620 tttcagttca ggcagaactc tagagacgac tagggcaagc tagacagcga ctgcagagcc 16680 ttttgttgca gcgtgagcag tcctcagctg ttgacatcac tggggagcaa acgaggacca 16740 ggagcggtga aaggacagtg tctgctgcag attgtcgtag cacccaagga acactccaga 16800 aagcctccta agcagtaaca agtgtggcaa ggtgtagccc agccaacagt ggcatctgcg 16860 aggcgtcccc tccttcctcc cactaccccg tataccctgg gacctgtgca ctgaaggact 16920 cattctaaag gctgtgcccc tgcagccgcc agcctcactc actggctgcc tgtgccagct 16980 agagatttct ttcctctgag gctggctgag aggaccactc cagtttcctg gcccatccag 17040 caaagaagat acacatcatg cacgtgtaaa atgaggaacc ggtttattga acagcttaag 17100 gagagcaaaa atagtggctt tagctacatt ttttacacac tgagcaggaa agtctaaacc 17160 atcccgttcc cctgtacccc aaagagaaca gggcttgctg gaggccagtg ccaagggcgg 17220 agtcgtgctc gcagcagact tgaattaacc ccatgtaggc cggcgagcag ttgcccgcgt 17280 gaaaacacca ccctcttctc ctggctgaga agatcaaagc tcttttttta ccctcttttc 17340 agcaaaggac ctatttgttt tcaggcagga ggatgttaaa cttgcagcct ctgacacacg 17400 gtggaacctg cagtgcttgg agaaacggca cgcacacgtg aaaacatcat gcctactcca 17460 aagccttctt gttgctggca ggagggaagc ttgagacttt cccacgcata gtcgtgaccc 17520 gcgtggccgt ttctgctctc agcaacattc tctagtgttc cggcttcaag cagcgcttgt 17580 caggtttgaa gctagccact attctgagaa cgtcagaaaa gcatggacca tctcttgctt 17640 ggtgttgccg ttgtggcagt agcagctact acgtacctgc acgagttcca gggcagaagt 17700 ggcaatgtcc catgaaggcg tggcacccca cggggggggg gggggagtgt gccacgggcg 17760 tccacttctg cagcagaagg catgtgccta cagcacaagc ttgtaaaaaa atacttgaac 17820 agaatatgct gtacagaact aggggttaac accgcatatg aagatgctaa aacatttgta 17880 taaatactct gtatacaagc atggagtcac tcccgtagaa agggctcatc cgtgaggcta 17940 tgaaaaactg ctgtcagcat gcccaaagag aaactacttc cacagtagga acagaaaaaa 18000 ggactgtgct gtgtctaaac acgtggtgca tcagagacat agttacagtt cctactgact 18060 gccccagcca cgacctggga gtgctgagga cctgggagtg ctcagcgagc tgcaggaggt 18120 cagccctgtg gagaaataca tttctaaaca atacttttga ttgggatttc agcaccgtat 18180 agacagatgt tccttctggg ggcctggcaa gcagccatct cccagtgggt ctgacgggga 18240 agaggggtac ctggagcccc tcccagacag acggtaatcc cacccctgtt ctcacactct 18300 tcctggcatc cgcatctgct ggcacacacc cccgtcacct gccacttccg cgtcccgtcg 18360 tggtgagtgg ctgataggcg ctggatgcaa acaaggcatg agatggacgt acctggagac 18420 ccagctccag tactggttct ggtctgcggg gtgaacgagg gggcagagga aggcggagag 18480 agtgcgtccc agtccactta agctctgtcc ccggaagtgg catctaatct ggcatttcga 18540 tatttaattt gggaggtggg agcacatact tcccagggct ctgggtaatg accaccctgg 18600 ccttctttcg aaacatgggt gcgattttag ggggctccgg aactggggtc tcttcggttt 18660 cttcattatc ttcgtgatgg agatcatagg aaatgtttcc atattctcgt agaaatggga 18720 agatttcaag cagaaactga cagaaatctt tgcggatacc aaaccaccct gaaaaataag 18780 aattttttat ttcacacacg aggctcaact gaccttcctg ttaactttct ttccgtaaca 18840 agaagtttca ctcctacaat gtcataacat actttatcca gactcctgag tcacaaagcc 18900 tgaacagggc ttgagtaccc aaaatgggga agaagtgcaa atgctagctc tgtggtgctt 18960 ggagtggggt tcccggaccg gcagggacag cgtccacggg gcctagttag ggatgccatt 19020 ctcgggccGC agcccagacc tccagaaact gagtcgggct agggtgggct ccagcggtcc 19080 ccttttcctg gcccttttgg gattctgctg gatgcccaaa tttgagaact actgctccag 19140 tgagtctcaa aatatctgtg gtgcgcagac tacggtgtct tccgctaatc ttctccagcc 19200 aggataaact catggatgac agtgccaccc aagaacaaga tttctgtcac cctctggaat 19260 ccgtgagggc ggtagtcatg cacgggttgg ccaggagggg gcctgaactc atggagccac 19320 cttaaagcca ctttcccagt cccactactc ctctctgtag gctactggag tgtcagctcg 19380 gtgcaagccc tccctgctcc cgggtgcggg gtagggggca gaggcacaaa cagcaagcac 19440 agcccgggct gctgggctgc agtgaggccc tgcccccaaa cccactggct ttccgaaggg 19500 caatgctctg ggcttccgtg ccatggagcc cacagccttg ccaggaaggc accctctgca 19560 gagatcgttt tggaagtgtc tgcctcagca agcaggtgga ggggaataga gtgttagcaa 19620 ggcaagacag gcaagactcg ggtgatggca gcaaggatat gggggaggca gagcggccaa 19680 cagggaccta ggatgaatcc caggtttggg tgggagatgt ggattttcca tcaaaccctc 19740 ccgggcctgg gaagaatctg tcttgatccc cattttgcag aggagggaac gggatctctg 19800 agaggttgcc tgccgtgtct ggttctacct caaatggcag cgtgcactgc gagaaaagtc 19860 ccggtgcagg ccagcagaac accagagtta cggcatgccc ttcccttaga aggtcccaga 19920 atttcctcag ccctcacttt cccacacaag cttctaaatt ggggccctcg gggactcatc 19980 ccttcctaga cttctatccg ccacccccca ccccctggtc cccccccaga cacacaccaa 20040 ggacttctga aatgctgagt acatacagtg gtttcctccc ttctgtccaa atgtggttgc 20100 catcagcgtg atcaacgaga gccaaagggg gacaaagatc gggatgcagg agaaggcgtt 20160 gtggccatcc agtttgtgaa ccagcagaat ctaaagaaag agacatagtc ccggttgatg 20220 ccagcaccga aaatgggcag aggcggaagc cagacttcat taggcagttc ctccccacca 20280 ccccaccccc gcgtgagctc ccacaagagg gaacatcagc acσgccagaa aaaggcagga 20340 aaccacctat ccctggggaa agctcgaaat gagcttttat gtccctcttc agagctcggc 20400 aatagcctat ccacttgaaa agttcccagt gccagcagtt ttatggcaaa ctcctccggg 20460 tgtttgttct aaggagtcaa cagctcccat tctagaattc tccacgtgac tccaatacac 20520 aaatctgaca tcccactctg ctttccccag agtggaaact ggagccatac agaggcacca 20580 tggctaaaaa ggtgcactct tctccctgcc agccccacgt gctgccccca agagaaagga 20640 aggatgctct cctttcaccg aagctccctc tcggagatgg ctgtgttctc tcccctctcc 20700 tggagtgggc tcactgtgag ctcgagggac agaggctgcc tttctagggg tgcagaatcc 20760 tgtcagggga agcgcaagct tcaggggctg aagaggcttc ccgtggaacg cttacctcaa 20820 atgtaagaag gggcacgacg atggtcatcc agctcagggc catggttatg tgtgtcctgc 20880 gctgtccgca atcacatcca tagagcgcaa gaacaagacg gaccacacaa tgtagtagag 20940 gaccaccagg cacagaaagg acatgagaat ccacagcggg acacacacaa cctgggggtg 21000 ggtgagagaa cagcaagaga agtctcttta gagcttccaa cctggcctct gatggaaggc 21060 atctttagca ccttgctgtg tctgtccagt taaggcggtc cttcctgtga gccgaataag 21120 gaccgttcca tctcccagga ctgctgggag catcgctcag gacagaaaag gtatggtatg 21180 ttcactatgg ggcctgctgc caccagggga cacacacgct cagtgagtca tcagtccctc 21240 ttcctttggg tgacagacag ccctgcacct ggctccgcag cctctactct tccagaggcc 21300 cactctccca cactctctca ggctcctcta ggttctgctg ccatcacagc ttcccgggaa 21360 atgggacaca actgtcaccc tgtgcacaca cacaagatct caccccaaca gactctcttc 21420 acaggcaaca ttcccacaac ctgctggggg tactttggca acacaaatgg gaatgggctc 21480 cccagaaagt ctggctgcct gggctcctaa ggatccctaa cctcacccct accaagttag 21540 tgaacttggc gggttgatgc tggatacagg ttgatgctgg atacgtagcg ctgccgggtc 21600 gtgaccccta aggaattatc caaactcttg tttttagatg ctttattata tcaaactctc 21660 ctttaaacaa gtggcccatc tgctgggatt tggaagcctg taatactgaa attttcatca 21720 taatggaaat tttaaaaaca gaatttgacc cacctgtttt taaaacactt tcattactta 21780 acaagaggtc taatcttggg caagtcttga aatttctctg gccttagttt cccatgtgtt 21840 aaatgaaact tgaagcagtt ggtctcttat agtctcctga ctctaacatt ctaagaatta 21900 tatttgtaca ataactcaaa aatcacataa tttaatttac catatggact ccaaaatata 21960 ttttctcatt aggctaaact tgatctgcat tttctggatg tgtccatatt cttggactac 22020 actaaaacat gataccaatg cttcctctca ccataaaccc tcacttcgct ttctacattt 22080 aagaatttta tagctggaag agtccttaac agaaaatacc atctaataat tacccctcaa 22140 aatcgagaaa gtcctatctg ttcttatgct agttataaga atgaggcagc atttcacata 22200 atggttataa acactgccac aagaagattc atgatgtgtt gtttatctgt agctctcatc 22260 atactctgtc atataactat agcattaaga ttttaatgtt ctatatattc ttctaagaca 22320 gtgtttacca gagtaaggca caaaagatcc actggtttgc aagaaagatt agaactttta 22380 aattttttac ctcaccttgt ttaatctata tttttgtatg tattttgtaa catatatatt 22440 attattacca taaatcatat ataatttaaa atgcatatat taggggtaaa tgctcaggaa 22500 actttttata aattgggcat gcaaatacaa gtttgaagac tcactgttct aggtattaaa 22560 agtaaagtta taaccaagta aagcttccac cttttcatgt ctcaaagcag tttattgttg 22620 gaggtaagat ctcttagaag cctaaacagg tccaagtaca gaatgaagta aggctagccc 22680 ataacttgtg gcaagcaatt catactattt ctctcatgct gagctctcct cagtgaagca 22740 gctactatag acaactgcag cctattggta gcctatttta caggcaggaa aaaaattact 22800 ttttattcaa agtggaactc aggacatggg gagaaaatga atacaaaaaa tagggtcaat 22860 ccaaaggcac acagcaaatg agtaacacag ttatgttttt ttcccatttg tatgaggtcc 22920 cagtaaattc taagtaaact gcaaatttaa taatacacta aaaaagccat gcaattgttc 22980 aaatgaatcc cagcatggta caaggagtac agacactaga gtctaaaaaa caaaagaatg 23040 ccattattga gtttttgaat tatatcaagt agttacatct ctacttaata aatgagaaaa 23100 acgaggataa gaggccattt gataaaatga aaatagccaa gaagtggtat tagagacttg 23160 aatacaggta ttcgggtcca aagttcatct gctcaaatac taactgggga aaagagggaa 23220 aaatatttat atacatatat atctgcacac aaaaataccc ccaaaagaca aaatgaggcc 23280 aggcagggtg gctcacaccc gtaatcccgg tactttggga ggctgaggca ggtggatacc 23340 tgagatcagg agttggagat cagcctggtc aacatggtga aaccctgtct ctactaaaga 23400 taaaaaaatt agccaggcat ggtggcgtgc gcctgtaatc ccagctactt gggagtctga 23460 ggcaggagaa tcacttgaac tgggaagggg aggttgcagt gagccaagat cgtactactg 23520 cactccagcc tgggcagcag agtgagactc catcacaaaa ataaataaat aaataaaata 23580 caatgaaaca gaaagttcaa ataatcccat aatcttacca ccaagaaata actttcactc 23640 gttatactta ttgatttttc cataataaat gtactttact gtgactatca tgaaaagaaa 23700 gttattttag aaacagagaa ctgtttcaga tcaaatctat gtagtagaac agagccatta 23760 ggtgggaaag acgagatcaa actaaatctc agaaggccta aaaggctagg tccattccag 23820 cactaaaaac tgaccagaca agtaatggct tcaacagctt ctaaatatgg acaaagcatg 23880 ctgaaaggga aggacaggtc taacagtggt atatgaaatg aaσaggaggg gcaaagctca 23940 tttctcctct gaagttttcc aaagatgctg aggaggacat tagtttgaca tgaccctgat 24000 atgggacaag ataatttcac agaagtttta catgttaaag ttttcttata gatactcatt 24060 caagtaagca atgaacacta aaatctaaag aaagaaaaga gctttagagt caggtctgta 24120 ttcaaattca agctctacca cttactggtt ctgtgacttt gggcaagtct tttaacctta 24180 ttaagtctta atttcctgat ttgtaaaatg gggatatcgt ctccctcaca ggattgttgt 24240 gaaactttta tgagattaat gcctttatat ttggcatagt gtaagtaaac aataactggc 24300 agcttcaaaa aaaaaaagca gtagcattcc atcatttatt attggttact ctcaaaaagt 24360 ttttcaatgt actagaagat aaatattcaa ataccttaat atctccatta ttttcaggta 24420 aacagcatgc tcctgaacaa ccaatgggtc aacaaataaa ttaaaaggga aatctaaaaa 24480 catcttgata ttaaactaca tggaagcaca atataccaaa accaatggtt cacactagga 24540 gaattttaag gtacaagaaa actctttgag atttcttaaa ataatagtat gtctgaattt 24600 attgagtgat ttaccagaaa ctgttgtaag agctctactt gcattatagc acttaatcct 24660 cttaactcta tggctgctat tatcaacctc accctaatca catatgggac acagagaggt 24720 taagtaactt gcccaaggtc agagttagga agtactaagc catgctttga atcagttgtc 24780 aggctccgga actcacactt tcagccacta cataatactg ctttgctatc ttttaggaaa 24840 ctatgtgagt ctacctcaca tagactcaca taggtttgtt tttttttttt ttttaaaggc 24900 tatcttttcc cccatcaatg ttttttgaag gatcccaaat tagagtccca cagaggcaga 24960 cagcagtact tgacaatatg gacatttaag gttaatgttg gattctactg tctttttact 25020 acatgaccta gggaacgata attaacctag actgcttcca agggttaaat aacccattta 25080 gttatactat gtaaattatc tcttagtgat tgattgaaag cacactgtta ctaattgact 25140 cggtatgaag tgcttttttt tcttcccttt caagatacat acctttccag ttaaagttga 25200 gagatcatct ccaccaatta cttttatgtc ccctgttgac tggtcattct agttaaaaaa 25260 aaaaaaaact atatatatat atatctacac acacatatgt atatgtatat ccttatgtac 25320 acacacaaac ttcaaattaa atgagaacta gaagatttga gaagttagct agctaatatc 25380 catagcatta tgatattcta aatgatatga attataagaa ttaggtttcc tgaaatgaat 25440 gactagaaaa ctttcaagta gagattagta aaaattaaaa agtcctaatc ggccattact 25500 gatttgatgt ttttaagagt cctaaaaaat gggttacatc catttttaag tgggtagtat 25560 tataacagcc acccatcttc aatcacagtg atttctgaat tgtgagggaa gttattagca 25620 tgacaggtgt ctggttctgg ccctgtacga ttcccatgag tcaagcaaat tgtaagggct 25680 ggtctatatc acacccaacc ccaaggatat gtccctcaaa agtctagccc aggccccgtc 25740 atcttcagca tcatctggga aaccaggtct gattagtagt cctttaagga atacctctta 25800 ggctcccatt ttactgctat cacagaatcc aataaaaccc ttacaggaga ttcaatggga 25860 aatgctcaac acccactgta gttggtggtg acaatgacca taatttggct gtgctggatt 25920 caggacagaa aatttgggtg aaagagcagg tgaacaaaag agcttcgact tgccctagca 25980 gagagcaagc cataccatac cacaaagcca cagcaattac aacggtgcag taccagcaca 26040 gtaaatgaac aaagtagagc ccagaaacag acccagaact atatgaggat ttagtataca 26100 ataaagatgg tatttcgagt cagtagggaa aagatgaatt attcaataaa tgatgtttgg 26160 ccaactagta acccatttgg gaaaaaataa aagtatggtc cctacctcac agcatacaca 26220 aaaataaatt ccagacggat taaaatctaa atgtaaaaaa taaagccata agtggactgg 26280 aagaaaatag agaatttttt ttaacatccg tagaaagggt aaaaacccag gcatgacatg 26340 aaccaaaact gaagaggttc tgtaacaaat accccctttt atatattggg ctccaacaat 26400 aagaacccat aggaaaatgg agaatgaaca caaatagaca atttatagaa gagaaggtta 26460 taaggtgtaa aattatatct atctgagaaa caaacactaa aacaatgtga ttctactgtt 26520 ctcccaccca tactggcaaa acttaagcct gataatatgc tgaggggaaa taagcactct 26580 tgttggtgag agtattaatt ggcatagctt cttttgaaaa tgacatagca atacctgtta 26640 aaattgcaaa catgcatgtc acttaatcca gtaatcccac ttctgggaat caatgctaca 26700 aaaacactga caagtataca aagatacatt caagagtgtt cactgggccg ggtgcggtgg 26760 cttcatgcct gtaatcccag ggaggcagag gcaagacgat cgcttgaccc caggagttca 26820 aggccagccc gagaaacaca gcaagaccct gtctctcttt tttttattta aaaaataaat 26880 gttcactgta tcagttgttc acaaaaacaa accaacatgt ccattaacag ggaaccattt 26940 aaattaatca agttcatcta cacaatgtaa taccatgcaa ctattaaaaa gcacctgata 27000 atccaaagca cactgagaca gaataatgct attaaaaaca ccaagtagtg gaacactgtg 27060 ttgcctatga caccattttt attcaacatt taaacaaatt tgtaacagca attacatgag 27120 tagtgacaat ggcgtttatg agacttttca cttttatgtg cttctatttt tgttatgctt 27180 ctatatatac atccatttat tatggagtgt tactttcaaa aatcacaaat gggccagtat 27240 tatttggtgt tgcaaggtga gcatatgact tctgatatca acctttgcat attacttctc 27300 aatttaggga aattacagac atcccttatt ctaactaact taaaacccag catttcaaac 27360 atacagaatt gatggggaaa aaaaagaaag aagaaagaaa gaaaaggcaa caagcttcag 27420 atgacagtga ctcacatcaa attatttata aaatctgtta aatagtgcca tcttctggag 27480 atacctggta ttacagtcca actccagttg atgtctttac agagacaaga ggaataaagg 27540 aaaaaatatt caagaactga aaagtatgga gtcatggaaa aattgctgtg atccaaaggc 27600 tacggtgata ggacaagaaa caagagaact ccaagcagta agacactgct gttctattag 27660 catccaaacc tccatactcc tgtttgcccc aaggcttttt taaaaaatag agacaggatc 27720 tcactatttt gctcaggctg gtcttgaact cctggactca agctatcctc ctgcctcggc 27780 ctcctaaagt gccgagatta caggcttgag tcaccatacc tggctattta ttttttctta 27840 actctcttgc ctggcctata gccaccatgg aagctaataa agaatattaa tttaagagta 27900 atggtatagt tcactacatt ggaatacagg tataagtgcc tacattgtac atgaatggca 27960 tacatggatc aattacccca cctgggtggc caaaggaact gcgcgaacct ccctccttgg 28020 ctgtctggaa caagcttccc actagatccc tttactgagt gcctccctca tctttaatta 28080 tggttaagtc taggataaca ggactggcaa aggtgagggg aaagcttcct ccagagttgc 28140 tctaccctct cctctaccgt cctatctcct cactcctctc agccaaggag tccaatctgt 28200 cctgaactca gagcgtcact gtcaactaca taaaattgcc agagaagctc tttgggacta 28260 caaacacata cccttaatgt ctttatttct attttgtcta cctcttcagt ctaggtgaaa 28320 aaataggaag gataataggg aagaactttg tttatgccta cttatccgcc cctaggaatt 28380 ttgaaaacct ctaggtagca ataagaactg cagcatggta tagaaaaaga ggaggaaagc 28440 tgtatagaaa tgcataataa atgggcagga aaagaactgc ttggaacaaa cagggaggtt 28500 gaactataag gagagaaagc agagaggcta atcaacaagg ctgggttccc aagagggcat 28560 gatgagacta ttactaaggt aggaattact aagggctcca tgtcccctta gtggcttagt 28620 actatgtagc ttgctttctg cagtgaactt cagacccttc ttttaggatc ctagaatgga 28680 cttttttttt ttatcggaaa acagtcattc tctcaacatt caagcaggcc ccaagtctac 28740 cacactcaat cacattttct cttcatatca taatctctca accattctct gtccttttaa 28800 ctgtttttct ataccctgat caaatgccaa caaaagtgag aatgttagaa tcatgtattt 28860 ttagaggtag actgtatctc agataaaaaa aaagggcaga tattccattt tccaaaatat 28920 gtatgcagaa aaaataagta tgaaaggaca tatgctcagg taacaagtta atttgtttac 28980 ttgtatttta tgaattccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca 29040 cgtcacaaac tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat 29100 tgatgatgtt aattaacatg catggatcca tatgcggtgt gaaataccgc acagatgcgt 29160 aaggagaaaa taccgcatca ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc 29220 ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac 29280 agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa 29340 ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca 29400 caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc 29460 gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata 29520 cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta 29580 tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca 29640 gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga 29700 cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg 29760 tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga cagtatttgg 29820 tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg 29880 caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag 29940 aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa 30000 cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat 30060 ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc 30120 tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc 30180 atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc 30240 tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc 30300 aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc 30360 catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt 30420 gcgcaacgtt gttgccattg ctgcagccat gagattatca aaaaggatct tcacctagat 30480 ccttttcacg tagaaagcca gtccgcagaa acggtgctga ccccggatga atgtcagcta 30540 ctgggctatc tggacaaggg aaaacgcaag cgcaaagaga aagcaggtag cttgcagtgg 30600 gcttacatgg cgatagctag actgggcggt tttatggaca gcaagcgaac cggaattgcc 30660 agctggggcg ccctctggta aggttgggaa gccctgcaaa gtaaactgga tggctttctt 30720 gccgccaagg atctgatggc gcaggggatc aagctctgat caagagacag gatgaggatc 30780 gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag 30840 gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg 30900 gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa 30960 tgaactgcaa gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc 31020 agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc 31080 ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga 31140 tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa 31200 acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct 31260 ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgagcat 31320 gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt 31380 ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta 31440 tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga 31500 ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg 31560 ccttcttgac gagttcttct gaattttgtt aaaatttttg ttaaatcagc tcatttttta 31620 accaataggc cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt 31680 tgagtgttgt tccagtttgg aacaagagtc cactattaaa gaacgtggac tccaacgtca 31740 aagggcgaaa aaccgtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa 31800 gttttttggg gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg agcccccgat 31860 ttagagcttg acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag 31920 gagcgggcgc tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc accacacccg 31980 ccgcgcttaa tgcgccgcta cagggcgcgt ccattcgcca ttcaggatcg aattaattct 32040 taattaacat catcaataat ataccttatt ttggattgaa gccaatatga taatgagggg 32100 gtggagtttg tgacgtggcg cggggcgtgg gaacggggcg ggtgacgtag tagtgtggcg 32160 gaagtgtgat gttgcaagtg tggcggaaca catgtaagcg acggatgtgg caaaagtgac 32220 gtttttggtg tgcgccggtg tacacaggaa gtgacaattt tcgcgcggtt ttaggcggat 32280 gttgtagtaa atttgggcgt aaccgagtaa gatttggcca ttttcgcggg aaaactgaat 32340 aagaggaagt gaaatctgaa taattttgtg ttactcatag cgcgtaatac tg 32392

<400> 25 gtacggaagc ccggaaggag gggcaggggg cggtggctca ggtttctccg ggcggcggcg 60 gcggcggcgg cggcgacggc gacggcgacg gcagcgggga cggcagcagt agcgggagca 120 gcagcgtgga cgcggctggc gctggcgcca tgaacccgct gtaaggcgca ggctgtgcag 180 cacggggtgc gggggaggag gaggaggacg ccgcggtgaa gttctccgcc atgaacctga 240 ggggcctctt Gcaggacttc aacccgaggt gaggcggcgt cgttggcgcc cccgggagtc 300 cgcgctgcgg gctcgggcgc gggctggtgt tcggctccgg ggaggcacgg cgggcgagat 360 gctgcagccc gaggacccgg gcgcctgccc gagcctccct gcgggtgcaa gcggtcccca 420 ggcaaaacag tcggcctcgg cgcccgcccg cttcctcctc ccgtgcccgg tgctttcagc 480 ccctgcccgg ccacggccgg aagggcccgg ccgcgagccc cgtcctgccc caagggaacc 540 ccattctttt ctgcttgctg tccctcattg gtgtcccaac ttcttcgtct cggttccatc 600 ctcttctgcg ccgctgcggg ccctccattc tccgcgtcag ggccgtctca ctcgacccaa 660 cacccctacc cccaccccag ctgtttcctc cagttcctcg cagtccttgg ggttttcctt 720 gggtttatgc ccatccctct cttgtttgct tctttgttga acggatacct gaaacactgt 780 tgaatccttg gagtcagtgt cggggtatgg caatacctta tataatgcat ttctgggtga 840 gcctgatcat tttccatact cattttctca tcagtcttca ctacaagttt atttgcagga 900 agtagatatt gctgtccttc ttttccagat ggggaacacc cagtggacag tgtggagaaa 960 acactggcta agcactcaag cgcctgtcct tgcacttgcc cgactgtttt gtaactgttc 1020 tttaccccag gctgtgagct ccctgaagct gagaccatct cctgctcatc tcagtgtccc 1080 cagcgcctcc cacccaccgt atctggcaca tagtaggcac atataaaatg tttgtggaac 1140 taaactgagc ccaaagactt ggattggaga cgaggccata tgtaactggg tgattctctg 1200 cccttctttg gcccttctgt aaaatgagga gttggcctaa ctgatctctt aaatgcacta 1260 ctctccgaaa ggagtatccg tttcccttat ttgccagttg ggaagacgtg ctcagtaaat 1320 atttgtgtgc tgtaacctat gttaggtgct ttagatgctg gcggtctcag catggggtga 1380 agaagggctt gtacacttaa gatgccttac agtactgtgc agtgctgtac tgcgggggcc 1440 aactctgggg acctatgcct tggctgcttg ttgaggatga aaggaagttt taggggagta 1500 tttgtatgtt gagggtgcag tctccctagg gatggtgaca ttttaacttg tgagtcattg 1560 tgactttgta tgtgccctta ttccactttg agttcatgtt ctggttagga gtgccagtgt 1620 ctctaacacg gtgcagacat tatcattgtt ggcttcgaag gcatagagga ggtaacagaa 1680 ctaactgcag tcccttcctc tgctgcatca gggggttaag attggtctgc agggtagtag 1740 ggttggtgct gtggctggac aagccctgta tgtcttctat ttggagatgg tgataagaaa 1800 gttaagtaaa aactgaattg ttttgtgccc ttgggcaact cacttatcta ttgttttatc 1860 tgtagaatga gtataatctc tcagtggggt agggaggcca attaaggatt gattacaaag 1920 tgccttacaa atagaaagct acagtgactt gtttgcaagg tgacagagaa ttcagaagcc 1980 tcaagaaact gccttaagtg atcaaacagg ctaacggagt tgccaaagca aaatagtgct 2040 gcactgatac tacctttaac cgttttttcc tttagccctt ttccccccaa aaaaattagt 2100 atatgaaatt acagtgaaat acctggtatc taagcagatt tatagtaatt ctcaacatat 2160 tcatcaatct cttaattcta cctgcattaa aatgtatttc tacctgaaaa gtttaaaggt 2220 cttttatact gtgccatttt cctgattcat tgttgccaga ggtagtgagt tccttaattt 2280 tacagatatt tcaagaggac attggccagg tattattggt aaatcagatt tgttttttta 2340 gctggtagtg tttcacctct cctgagcact cctagttttt gacagtgtgc tttagtctcc 2400 ttccatgctg aggaaggcct tctctatagg agaaagaaaa ctgaggggtg tacacaggaa 2460 gttaccttat gctggggact caaaccttga tgctactgct ttgctccctg cctctatttt 2520 tgaaccaatt caacatctcc ctcctacccc aggaccttgt cacacactgt tctctttacc 2580 aggaatgttt ccctctcttt tcctctcctc cagacctagt gaactcctat ttatcctcac 2640 ttggcacttg ctaagggaag cattcctgac ttccctgacc agatttactg ctccctgttt 2700 ctacagttcc tgtagtattt actactcctc catcatagtg catatttgta cccttgtgtc 2760 tgtctggatg cttatttgat taatacctgc ctcccccact aaactttaag ctccatgggg 2820 tcaaggccgt gactgtgtca gtatcgtagc ctgcatactt ggaatagtac ctggctcaat 2880 aaatatttgt ggagtaaata actgaataac tctccagagc ctataagata aatctagagc 2940 tgctgctttc aatcactgct ttcctggtgg tctgtggcct ggttctcttt cttctcacac 3000 tcttcccacc ttcagagtgc agccattgct ttggagagat gggagagaac atggcactaa 3060 ggcagaatat ggctatattt actttgaaga gcatgtcttt gtcatagaaa tagtcactgt 3120 catggtttgg tgggtcccaa ggcatgggtc atggctccag atcccctttc cagccttttg 3180 gatcttggta agtctgaacc cactgctgcg ttggcaaggc tctggaaact atagtgacag 3240 agaatgattc acaagtgtca acactcagat gtacagggct gccagctgac ccactctacc 3300 tatttccatc tggcactgaa ctggttgatc atgaacttct tttcataatt gctttttagt 3360 tatgcaggtt aagacatgcc gaaacagatg taccggaccc acaaacaagt ccttccttga 3420 atgcctgagg cttcctaaca gtgaaagagc cctgttctta gagtaggcaa actgattctg 3480 aggcattgta ggtggtaggg atctggtagt aggtagcatt aggtgggctc ccggcactca 3540 ccatggagcc ttgaaatttt ctgctacttt gggggagttg ctggttcaga gaaggccctt 3600 ccaccctggt agccatgtgg cactggaagg ctgtgaaaac tctgctgggc cttcttagtc 3660 atctgttgtg agctcctgat gggagtgtgg tgtatccctc aggtgtgcta gactggaaca 3720 aaggctgaga agtgttgctc tgggggttcc aacttgtggg catggggtac tgatgagatc 3780 agtagtgttt ggagacttct gtatgctcca tcttcagaag acattctgga gtccatataa 3840 gttatcttgt ctcttgtttg aagcaggaaa aaggaatgcg attgctggta atatagttca 3900 ctaaagtcag ctacctggcc tctaacagtt atttgcaaag tatattataa cattgattcc 3960 tcaaacatct agattcctat ctcgtgccaa gtgatgtact aggtgctcta agtacaaaaa 4020 taaaggaata tagtcctcct ctcaatgcgt aagcctagtg gaagaagcag aaatgaaagg 4080 gaaataagaa ttcaatagag tatgaggcat tacagtgaaa gaaaccaaat gtcttagaag 4140 tacaaatggc agagctacta attctgtctc gagcaggcag ggaagagtct atagtggaaa 4200 tgacttttga gctagatttt gaattgagct agtcttttga gccagacttt tgagctagaa 4260 ttgtagggtt gtcatcagac cagagagtag gaagggtacc ttgtgaggaa gagagagaga 4320 gatcagattg ttactgtgtc tatgtagaaa aggaagacat aagaaactcc attttgatct 4380 gtactaagaa aaattgtttc tgctttgaga tgctgttaac ctgtaacttt agtcccaacc 4440 ctgtgctcac agaaacctgt gctgtaatga atcaaggttt aatggattta gggctgtgca 4500 ggatgtacct tgttaacaat atgtttgcag gcagtatgct tggtaaaagt catcgccatt 4560 ctccattctc gattaaccag ggacacagtg cactgcggaa ggccgcaggg acatctgccc 4620 aagaaagcct gggtattgtc caaggtttcc ccccactgag acagcctgag atatggcctt 4680 gtgggaaagg aaagacctta ccacccccca gcccgacacc cgtaaagtgt ctgtgctgag 4740 gaggagtagt gaaagagcgg ggcctctttg cagttgagat aagaggaagg cttctgtctc 4800 ctgctcatcc ctgggaatgg aatgtctctg tgtaaagctg accattccca ttcgttctat 4860 tctgagatag gagaaaacca ccctgtggct ggaggcgaag tatgctggca gcaatactgc 4920 tctgttactc tttgctacac tgagttgttt gggtaaagag aaacataaat ctagcctgcg 4980 tgcacatcca ggcacagtac ctttccttga acttattcat gatacagatt cctttgctca 5040 cgtttccctg ctgaccttct ccccacctgt tgccctgcta cactcccctc gctaagatag 5100 taaaaataat gatcagtaaa tactgaggta actcagaggc tagcgctggt gcgggtcctc 5160 cgtatgctga gtgccggtcc cctgggccca ctgttctttc tctatacttt gtttctgtgt 5220 cttatttctt ttctcagtct cgtcccacct gacgagaaat acccacaggt gtggaggggc 5280 tggccccttt cagtatctca gaagggacaa agtacacaaa ggcatggggt catgatagtg 5340 cctggtatgt tcaggtagtg aagaggtcca tgtggtatga gcactgcaga tgatatgtgt 5400 cgtatgaatt aaaaatacat agttactgca aatagttttt acaggttatt gtttttaaga 5460 aagcagtatc taatgcacga gtgtactgtc agtactgtca atgaactact taccactcaa 5520 gtgactgctt acgcgtcgaa tcactagtga attcgcggcc gcctcgagtc tagaactagt 5580 ggatccccca aacgggccct ctagacgcgt tgacattgat tattgactag ttattaatag 5640 taatcaatta cggggtcatt agttcatagc ccatgatatc atatggagtt ccgcgttaca 5700 taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca 5760 ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg 5820 gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg 5880 cccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtncatgac 5940 cttatgggac tttcctactt ggcagacatc tacgtattag tcatcgctat taccatggtg 6000 atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggattttcc 6060 aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 6120 tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg 6180 ggaggtctat ataagcagag ctctctggct aactagagaa cccctgctta ctggcttatc 6240 gagatatctg cagaattcat ctgtcgactg ctaccggcag cgcgcagcgg caagaagtgt 6300 ctgggctggg acggacagga gaggctgtcg ccatcggcgt cctgtgcccc tctgctccgg 6360 cacggccctg tcgcagtgcc cgcgctttcc Gcggcgcctg cacgcggcgc gcctgggtaa 6420 catgcttggg gtcctggtcc ttggcgcgct ggccctggcc ggccgcgtta agatacattg 6480 atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt 6540 gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca 6600 attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt 6660 aaaacctcta caaatgtggt atggctgatt atgatcagtt atctagatcc ggtggatcgg 6720 atatcttatc tagaagctta ggctcgagtg ctcttgttgg gttacattaa ccttccttca 6780 aaagggattt ctcagttgta cttcttacag tcttcaggaa attcattaaa tcagtgcctc 6840 cagttccttt ggcttccagt tttgaagggt cttcagaggt cttattctcc tttggctgct 6900 ggcttgcagg aatcaggatg tacttagtca cgatttgcag atggtagctc ctcagggaga 6960 ccagagcttt cacacaggcg tcataagctt cccgcaggcc agcatcacct tttgaaagga 7020 caaactcacg gactgaggga tttgactcta atgagcacag gaagttcctg tgagctggtg 7080 gcatatatct tctcatgtcc tggaggaact gagcagcatg tcctccacca gcagtctgct 7140 ggatgcccag caggacgtca aagcactgaa agacgctgct ttggcctgca ctgccccctg 7200 caaactcctt tgggtcttcc cagaaccctt catacaccag accgtctgat agctgggggt 7260 tgcctttcca gccagacaaa tatatgcgaa gaacactgaa aaatgctttt gggttcacat 7320 gatcgtggat ttggtgaaac acttgaaggg ctttctccaa gcaagaagct atttccaaca 7380 gcgcctttag caaagtgtcc cgttcttgca tttgcattgc cttgaataca gtaggaatta 7440 ctttgattgc agaagcagct gctatttcca ccaatagaga gaccaggaag aatcctttac 7500 tgcagtctcc atcacgaaat gagaacaaaa cgtccatgtt ctcataagtc aggggcttat 7560 taggatcctt tttcttccag tttgccaaga cacagtctgc ataaaccaaa ataggaggca 7620 gttccagttt cttggagagt tggcagtaag gaacagcaat atttcttggc aagaccttac 7680 ggacatctcc atgacctttg ccccacacat atgccatggt gatgcatccc agaactagac 7740 gtgcaaggcg ctgtgacttg tggtctgtga gatgatcaat gctgagcatg tttaacttct 7800 caactctttc tcgaagctgg ccagactcta tgagatcagg cagatgttta gcaatgaaca 7860 tccagtcatt ataaaaatca ggtagatttt cctgtggatt tggcagagca aagcccactt 7920 cttcatcaat atggtactct ttactgattg tccaggagtt ttccatagcg tgtgccattc 7980 ttgtagtctg ctcctctgga gatctctagc ggatctgacg gttcactaaa ccagctctgc 8040 ttatatagac ctcccaccgt acacgcctac cgcccatttg cgtcaatggg gcggagttgt 8100 tacgacattt tggaaagtcc cgttgatttt ggtgccaaaa caaactccca ttgacgtcaa 8160 tggggtggag acttggaaat ccccgtgagt caaaccgcta tccacgccca ttgatgtact 8220 gccaaaaccg catcaccatg gtaatagcga tgactaatac gtagatgtac tgccaagtag 8280 gaaagtccca taaggtcatg tactgggcat aatgccaggc gggccattta ccgtcattga 8340 cgtcaatagg gggcgtactt ggcatatgat acacttgatg tactgccaag tgggcagttt 8400 accgtaaata ctccacccat tgacgtcaat ggaaagtccc tattggcgtt actatgggaa 8460 catacgtcat tattgacgtc aatgggcggg ggtcgttggg cggtcagcca ggcgggccat 8520 ttaccgtaag ttatgtaacg cggaactcca tatatgggct atgaactaat gaccccgtaa 8580 ttgattacta ttannntaag ggtgggaaag aatatataag gtgggggtct tatgtagttt 8640 tgtatctgtt ttgcagcagc cgccgccgcc atgagcacca actcgtttga tggaagcatt 8700 gtgagctcat atttgacaac gcgcatgccc ccatgggccg gggtgcgtca gaatgtgatg 8760 ggctccagca ttgatggtcg ccccgtcctg cccgcaaact ctactacctt gacctacgac 8820 ctgcaggcag acgggcgctc ctgcaccgca tccgcgacgc agtcctgcaa cgacctctgc 8880 gagcacttct gcgttcccaa ccccgaccag ccgggctcct actcgtgcat gtgcgagacc 8940 ggctaccggc tggcggccga ccaacaccgg tgcgaggacg tggatgactg catactggag 9000 cccagtccgt gtccgcagcg ctgtgtcaac acacagggtg gcttcgagtg ccactgctac 9060 cctaactacg acctggtgga cggcgagtgt gtggagcccg tggacccgtg cttcagagcc 9120 aactgcgagt accagtgcca gcccctgaac caaactagct acctctgcgt ctgcgccgag 9180 ggcttcgcgc ccattcccca cgagccgcac aggtgccaga tgttttgcaa ccagactgcc 9240 tgtccagccg actgcgaccc caacacccag gctagctgtg agtgccctga aggctacatc 9300 ctggacgacg gtttcatctg cacggacatc gacgagtgcg aaaacggcgg cttctgctcc 9360 ggggtgtgcc acaacctccc cggtaccttc gagtgcatct gcgggcccga ctcggccctt 9420 gcccgccaca ttggcaccga ctgtgactcc ggcaaggtgg acggtggcga cagcggctct 9480 ggcgagcccc cgcccagccc gacgcccggc tccaccttga ctcctccggc cgtggggctc 9540 gtgcattcgg gcttgctcat aggcatctcc atcgcgagcc tgtgcctggt ggtggcgctt 9600 ttggcgctcc tctgccacct gcgcaagaag cagggcgccg ccagggccaa gatggagtac 9660 aagtgcgcgg ccccttccaa ggaggtagtg Gtgcagcacg tgcggaccga gcggacgccg 9720 cagagactct gagcggcctc cgtccaggag cctggctccg tccaggagcc tgtgcctcct 9780 cacccccagc tttgctacca aagcacctta gctggcatta cagctggaga agaccctccc 9840 cgcacccccc aagctgtttt cttctattcc atggctaact ggcgaggggg tgattagagg 9900 gaggagaatg agcctcggcc tcttccgtga cgtcactgga ccactgggca atgatggcaa 9960 ttttgtaacg aagacacaga ctgcgatttg tcccaggtcc tcactaccgg gcgcaggagg 10020 gtgagcgtta ttggtcggca gccttctggg cagaccttga cctcgtgggc tagggatgac 10080 taaaatattt atttttttta agtatttagg tttttgtttg tttcctttgt tcttacctgt 10140 atgtctccag tatccacttt gcacagctct ccggtctctc tctctctaca aactcccact 10200 tgtcatgtga caggtaaact atcttggtga attttttttt cctagccctc tcacatttat 10260 gaagcaagcc ccacttattc cccattcttc ctagttttct cctcccagga actgggccaa 10320 ctcacctgag tcaccctacc tgtgcctgac cctacttctt ttgctcttag ctgtctgctc 10380 agacagaacc cctacatgaa acagaaacaa aaacactaaa aataaaaatg gccatttgct 10440 ttttcaccag atttgctaat ttatcctgaa atttcagatt cccagagcaa aataatttta 10500 aacaaaggtt gagatgtaaa aggtattaaa ttgatgttgc tggactgtca tagaaattac 10560 acccaaagag gtatttatct ttacttttaa acagtgagcc tgaattttgt tgctgttttg 10620 atttgtactg aaaaatggta attgttgcta atcttcttat gcaatttcct tttttgttat 10680 tattacttat ttttgacagt gttgaaaatg ttcagaaggt tgctctagat tgagagaaga 10740 gacaaacacc tcccaggaga cagttcaaga aagcttcaaa ctgcatgatt catgccaatt 10800 agcaattgac tgtcactgtt ccttgtcact ggtagaccaa aataaaacca gctctactgg 10860 tcttgtggaa ttgggagctt gggaatggat cctggaggat gcccaattag ggcctagcct 10920 taatcaggtc ctcagagaat ttctaccatt tcagagaggc cttttggaat gtggcccctg 10980 aacaagaatt ggaagctgcc ctgcccatgg gagctggtta gaaatgcaga atcctaggct 11040 ccaccccatc cagttcatga gaatctatat ttaacaagat ctgcaggggg tgtgtctgct 11100 cagtaatttg aggacaacca ttccagactg cttccaattt tctggaatac atgaaatata 11160 gatcagttat aagtagcagg ccaagtcagg cccttatttt caagaaactg aggaattttc 11220 tttgtgtagc tttgctcttt ggtagaaaag gctaggtaca cagctctaga cactgccaca 11280 cagggtctgc aaggtctttg gttcagctaa gctaggaatg aaatcctgct tcagtgtatg 11340 gaaataaatg tatcatagaa atgtaacttt tgtaagacaa aggttttcct cttctatttt 11400 gtaaactcaa aatatttgta catagttatt tatttattgg agataatcta gaacacaggc 11460 aaaatccttg cttatgacat cacttgtaca aaataaacaa ataacaatgt gaaaaaaaaa 11520 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aggtagcagt cgacagatga attccaccac 11580 actggactag tggatccgag ctcggtacca agcttaagtt tgggctgcag gaattctgat 11640 ggctctcaaa attcctgcct cctttaggga taaaagactt taagactttt taacaaaaaa 11700 gaaaaagaaa aaaaaaattc ctgcctcctg gtgtacacac acagaagggt tccctcccct 11760 tgaatgtgac caggatctgt gaaaataacg ggatagccgc tcctgtgatt aggttatgtg 11820 gtagactaga gcaagattct cctgctggtt ttgaagaagt cagctgccat gttgtgagac 11880 tgtcatgggc tagggcatga gcctttaaat atctgggagc aacccctggc cagcagccag 11940 tgagaaaacg ggccctcagt cctacaatca caaggaacta aattctgcca acaacctgaa 12000 ggaactttga agaggatcat gagtcccttg attcagcttg atgagcccct gagcagagga 12060 tacagctaac ttgtactagg gaagtataaa aaacatgcat gggaatgata tatatcaact 12120 ttaaggataa ttgtcatact tctgggaatg aagggaaaga aatggggctt tagttgtatt 12180 atgatcttta atttctcaaa aaaaataaga tcagaagcaa atatggcaaa atgttaatac 12240 ttttgtgggt acgtaggtat tcagcatacc cttttttctg agttcaaaat attttataat 12300 taaaatgaaa tgcaggccag gcacagtggc tcatgcctat aataccagca ctttgcgagg 12360 ccgaggtggg aggatggctt gaggccagac cagcctggcG aacatggcaa aaccccatct 12420 ctacttaaaa aaaaaaaaac tatatatata tatatgtgtg tgtgtgtgta tatatatata 12480 tgtatatata tttatatatg tgtgtatata tatatatgta tatatattta tatatgtgtg 12540 tgtatatata tatatacaca cacacacata tatacataca tacatacaca cacacacaca 12600 cacaattagc caggcatggt ggcgcacacc tgtagtccca gctacttggg aggctgagac 12660 atgagaattg cttgaacctg ggaggcagag tagttagtga gctgagatca taccactgca 12720 ctccagcctg gtgacagagt gagactctgt cttaaaaaaa ataaaaatta aaattaaatg 12780 caaaaggtcc aagtgaattg aagaggaaag gggtatcaag gaaggttttg tggaggtgac 12840 gtttgagctg ggtcttaaat gacttaaaca tgggataaga agggagggaa taaggacatt 12900 tcaggtacga gaaataagga gcaaacagtg gaaacaacct aacgtctgtc aaccagtgaa 12960 tggataacaa aaatgtaatt cagatggtat ccaacttacg atggttcaac atgagatttt 13020 tctgacttta ggatagattt atcaaagtag taaatccatt ttcaacttat gatattttca 13080 acttcagatg ggtttatcag gacacagttg aggaacacct gtctatccat acaatttggc 13140 aataaaaagg aaatgagtgc agatatactc cacaacatga atgaaccttg aaaacattaa 13200 gtgagagaag ccagatacaa aaggccacat attgtatgat tctatttata caaaatgtcc 13260 agaataggca aatcttatag acagcaagta ggtagatgat cagtttgcta ggtgctgggg 13320 gaaggggaaa tggggagtga tggctaaggg gattgggttt ctttgtgggg caatgaaaat 13380 gttttaaaat tgagcgtgat aatgattgca caatgctgca tatatatata atctatagat 13440 tatatatata taaagagagg ctgttagaca gtgataagtg atatatatat atatatacat 13500 agagagagag agagagagag agagaggctg ttagtgataa gtgatcagga aaataaaagt 13560 attgaggagg aatacgaagt tgacggtgtg aaaacatgag attttatata ggatggccag 13620 ggaaggcctt aatgagaaag tgacttatga gtaaaaacaa gggatcctaa accttagcat 13680 gcatcagaat cactcggaaa cttgttaaag catagcttgc tgggcctcat cacagatatt 13740 ttgattcggt aggttcttgt ctgatattaa tacttttggt ctagggaacc acattttgag 13800 aaccactgag ctaaaggaag taaaggtttc ccttagttta ctagctggta acactggccc 13860 aggaggcctt tctggaaaag gtcccagtcc ccaaaggaag ctggggactc gcgttcacat 13920 cgtcaaggtt taccaagttg tggcgggcct ttccgtcttg gaaaaagcct caaaatggca 13980 gattagggtg tccatggccg gcggaaaggg tctttgaagt tgcagaccag gagggaagaa 14040 gattctgggc ctcccccatg cagtgtcagc tggcaacaga atgcaccccg gctgggttgg 14100 aggccctggg tactggctct tccacaccag gggcccacct accaagggca gcaggagcat 14160 ctgcacctcc tgcgccaggc gcccttcagt gcttccactt gagcacctct ccagacacca 14220 gctagggtga cagtggtaca aataccagac tcccctggcc tgctcacctc acagggtaat 14280 gtgctgtgga gtcaggggga cacagcaacc accagatgac atggctggcc ccggggagga 14340 cgacacgcag atacggctac ttggcacctg tgatatttta cacactcgag aggggcccgc 14400 accatcctca gccctctccc cacattcact cttagttcat gtcacctcca cccagagggg 14460 gacacaggcc cacagcgatg gccccacacc ctgcctgagg tcgcccactt cccaggaggc 14520 agtcctggga cttccacccg accaggcccc agagcccacc gacttaaccc ctccagaggc 14580 ttgtcgttca ttaccttatt caagatggag accagccttt ttgcggagaa aatgcgggtg 14640 aaggtcctga aagtgcattg acgccgtttt cggaagccat acaagtttag ctggcggaag 14700 aagctcttta tcgaagttgt ggcaaacact ttgtgtgcga cgtccctttt gagaatctcc 14760 ttttcaaaga gtttttgatt gatcactcta caagccccac tgtcatccca ccagatggac 14820 gaaaactggt tgctgctgac cagtctccac agtttctgtg gaaaggggag ggagaggaga 14880 ttatcttctc cctggggcgg gacgtcaccg tcagggtgcg gccttctgaa cgaagcttcc 14940 tcggccagag gttggaaagc gatttcttct gtcagcagcc tcaagttagg gctcccagtg 15000 gaccccgggt cgtcccaggc aggggaagga tctgctgggt gaaggtaggt ctctgactgc 15060 aactggggag ggaaaggcac cctttccaag ccatgatcct gtcctctcga atttctttct 15120 tcacagcgag ccatactcaa tgatcgcttg tcctccatct ggcaaacttg ctagtgcagt 15180 gtggccagca gcaccccttg gcagtcatgt aaccagcccc atgacatcat aaaggggctc 15240 tgactgccgg ggggtggcat ctccaccccc agcaagttgt gtaataaagg gccaaggcag 15300 acaagtagct gcccatctgc atgtgcacat tctggtcctc acagtcattt caatgggaaa 15360 gatgacacta gtgcacaaga gtgccgaggg gccctgccac accgtagatg cagacctgga 15420 gcggtcccct tgtcctagag ctcctgagcc aggcacaact acagcaaagc cctggctcag 15480 gaaggtcaga gctcaccgtc tgagtcatgg gcccacagac cccagcacat gactgacact 15540 cggaagcaca gaacaaaggg taggacggtg cccatgggtc aggctgtagc cacgccaccc 15600 tttccaccct gtcctagcca gaggcagcaa tgtgctccat acagatcctc ctaacacacc 15660 cacactgtcg gtccccagca cgcagatgcc cgacagcccc ttaggcaaat ggcttagctg 15720 actgccccac cacacgccgt cgccatgcag tccagtgggg agtcggaggc agcctccttc 15780 ctgcctctcc tcggcctgca cgtgtccccc caccaggcag agacccttct acaccccggg 15840 tgtctgcggt cacatcgcgg tggggcatgc agctgttggc cttcgagcat gttttgtttt 15900 ccttggccag tgtctccaga gaaacgcacg tgggtttgtg tccagcggtc catctctgca 15960 acagttgttc ctttgggatt ggatgctagg aggtcacggg agaggtgtcc atccaaagca 16020 gtgtctgtgt cacacactgt ccccacacac agggccacct ctgcacagac tcccccgact 16080 cgattctggg cacagagctc agtgaccttc cagagactgc cacgaaccgg tgatgcctcc 16140 acgcttgaga catcctgacc gcagggccca aggcgcactg gctcaggggg tgacagtgag 16200 gggtctgcaa acagactgct gatgctcaac ccggccgctg ccgagctgtg tgacttgggc 16260 acgtcactta acctctctcg gcctctgtct cctcccgggg ataagagtag tagcacctgc 16320 ttcccggggc tgtgaggatc cagtgggacg tataggaact agcgaggcac cggcagttgg 16380 gtcagagcta ctgttgtcac ttcacaaggc attttcttca acagcaagtc ggaaatctca 16440 tgagcctaag gcagaatcca cctgtggcct ctggttacaa cccacaggac tgaaaatcct 16500 tccagccaca gcaactggtg aatttcctgg tcaattgcca caagtcatga gctgaacccc 16560 acttgagttt cagttcaggc agaactctag agacgactag ggcaagctag acagcgactg 16620 cagagccttt tgttgcagcg tgagcagtcc tcagctgttg acatcactgg ggagcaaacg 16680 aggaccagga gcggtgaaag gacagtgtct gctgcagatt gtcgtagcac ccaaggaaca 16740 ctccagaaag cctcctaagc agtaacaagt gtggcaaggt gtagcccagc caacagtggc 16800 atctgcgagg cgtcccctcc ttcctcccac taccccgtat accctgggac ctgtgcactg 16860 aaggactcat tctaaaggct gtgcccctgc agccgccagc ctcactcact ggctgcctgt 16920 gccagctaga gatttctttc ctctgaggct ggctgagagg accactccag tttcctggcc 16980 catccagcaa agaagataca catcatgcac gtgtaaaatg aggaaccggt ttattgaaca 17040 gcttaaggag agcaaaaata gtggctttag ctacattttt tacacactga gcaggaaagt 17100 ctaaaccatc ccgttcccct gtaccccaaa gagaacaggg cttgctggag gccagtgcca 17160 agggcggagt cgtgctcgca gcagacttga attaacccca tgtaggccgg cgagcagttg 17220 cccgcgtgaa aacaccaccc tcttctcctg gctgagaaga tcaaagctct ttttttaccc 17280 tcttttcagc aaaggaccta tttgttttca ggcaggagga tgttaaactt gcagcctctg 17340 acacacggtg gaacctgcag tgcttggaga aacggcacgc acacgtgaaa acatcatgcc 17400 tactccaaag ccttcttgtt gctggcagga gggaagcttg agactttccc acgcatagtc 17460 gtgacccgcg tggccgtttc tgctctcagc aacattctct agtgttccgg cttcaagcag 17520 cgcttgtcag gtttgaagct agccactatt ctgagaacgt cagaaaagca tggaccatct 17580 cttgcttggt gttgccgttg tggcagtagc agctactacg tacctgcacg agttccaggg 17640 cagaagtggc aatgtcccat gaaggcgtgg caccccacgg gggggggggg ggagtgtgcc 17700 acgggcgtcc acttctgcag cagaaggcat gtgcctacag cacaagcttg taaaaaaata 17760 cttgaacaga atatgctgta cagaactagg ggttaacacc gcatatgaag atgctaaaac 17820 atttgtataa atactctgta tacaagcatg gagtcactcc cgtagaaagg gctcatccgt 17880 gaggctatga aaaactgctg tcagcatgcc caaagagaaa ctacttccac agtaggaaca 17940 gaaaaaagga ctgtgctgtg tctaaacacg tggtgcatca gagacatagt tacagttcct 18000 actgactgcc ccagccacga cctgggagtg ctgaggacct gggagtgctc agcgagctgc 18060 aggaggtcag ccctgtggag aaatacattt ctaaacaata cttttgattg ggatttcagc 18120 accgtataga cagatgttcc ttctgggggc ctggcaagca gccatctccc agtgggtctg 18180 acggggaaga ggggtacctg gagcccctcc cagacagacg gtaatcccac ccctgttctc 18240 acactcttcc tggcatccgc atctgctggc acacaccccc gtcacctgcc acttccgcgt 18300 cccgtcgtgg tgagtggctg ataggcgctg gatgcaaaca aggcatgaga tggacgtacc 18360 tggagaccca gctccagtac tggttctggt ctgcggggtg aacgaggggg cagaggaagg 18420 cggagagagt gcgtcccagt ccacttaagc tctgtccccg gaagtggcat ctaatctggc 18480 atttcgatat ttaatttggg aggtgggagc acatacttcc cagggctctg ggtaatgacc 18540 accctggcct tctttcgaaa catgggtgcg attttagggg gctccggaac tggggtctct 18600 tcggtttctt cattatcttc gtgatggaga tcataggaaa tgtttccata ttctcgtaga 18660 aatgggaaga tttcaagcag aaactgacag aaatctttgc ggataccaaa ccaccctgaa 18720 aaataagaat tttttatttc acacacgagg ctcaactgac cttcctgtta actttctttc 18780 cgtaacaaga agtttcactc ctacaatgtc ataacatact ttatccagac tcctgagtca 18840 caaagcctga acagggcttg agtacccaaa atggggaaga agtgcaaatg ctagctctgt 18900 ggtgcttgga gtggggttcc cggaccggca gggacagcgt ccacggggcc tagttaggga 18960 tgccattctc gggccccagc ccagacctcc agaaactgag tcgggctagg gtgggctcca 19020 gcggtcccct tttcctggcc cttttgggat tctgctggat gcccaaattt gagaactact 19080 gctccagtga gtctcaaaat atctgtggtg cgcagactac ggtgtcttcc gctaatcttc 19140 tccagccagg ataaactcat ggatgacagt gccacccaag aacaagattt ctgtcaccct 19200 ctggaatccg tgagggcggt agtcatgcac gggttggcca ggagggggcc tgaactcatg 19260 gagccacctt aaagccactt tcccagtccc actactcctc tctgtaggct actggagtgt 19320 cagctcggtg caagccctcc ctgctcccgg gtgcggggta gggggcagag gcacaaacag 19380 caagcacagc ccgggctgct gggctgcagt gaggccctgc ccccaaaccc actggctttc 19440 cgaagggcaa tgctctgggc ttccgtgcca tggagcccac agccttgcca ggaaggcacc 19500 ctctgcagag atcgttttgg aagtgtctgc ctcagcaagc aggtggaggg gaatagagtg 19560 ttagcaaggc aagacaggca agactcgggt gatggcagca aggatatggg ggaggcagag 19620 cggccaacag ggacctagga tgaatcccag gtttgggtgg gagatgtgga ttttccatca 19680 aaccctcccg ggcctgggaa gaatctgtct tgatccccat tttgcagagg agggaacggg 19740 atctctgaga ggttgcctgc cgtgtctggt tctacctcaa atggcagcgt gcactgcgag 19800 aaaagtcccg gtgcaggcca gcagaacacc agagttacgg catgcccttc ccttagaagg 19860 tcccagaatt tcctcagccc tcactttccc acacaagctt ctaaattggg gccctcgggg 19920 actcatccct tcctagactt ctatccgcca ccccccaccG cctggtcccc ccccagacac 19980 acaccaagga cttctgaaat gctgagtaca tacagtggtt tcctcccttc tgtccaaatg 20040 tggttgccat cagcgtgatc aacgagagcc aaagggggac aaagatcggg atgcaggaga 20100 aggcgttgtg gccatccagt ttgtgaacca gcagaatcta aagaaagaga catagtcccg 20160 gttgatgcca gcaccgaaaa tgggcagagg cggaagccag acttcattag gcagttcctc 20220 cccaccaccc cacccccgcg tgagctccca caagagggaa catcagcacc gccagaaaaa 20280 ggcaggaaac cacctatccc tggggaaagc tcgaaatgag cttttatgtc cctcttcaga 20340 gctcggcaat agcctatcca cttgaaaagt tcccagtgcc agcagtttta tggcaaactc 20400 ctccgggtgt ttgttctaag gagtcaacag ctcccattct agaattctcc acgtgactcc 20460 aatacacaaa tctgacatcc cactctgctt tccccagagt ggaaactgga gccatacaga 20520 ggcaccatgg ctaaaaaggt gcactcttct ccctgccagc cccacgtgct gcccccaaga 20580 gaaaggaagg atgctctcct ttcaccgaag ctccctctcg gagatggctg tgttctctcc 20640 cctctcctgg agtgggctca ctgtgagctc gagggacaga ggctgccttt ctaggggtgc 20700 agaatcctgt caggggaagc gcaagcttca ggggctgaag aggcttcccg tggaacgctt 20760 acctcaaatg taagaagggg cacgacgatg gtcatccagc tcagggccat ggttatgtgt 20820 gtcctgcgct gtccgcaatc acatccatag agcgcaagaa caagacggac cacacaatgt 20880 agtagaggac caccaggcac agaaaggaca tgagaatcca cagcgggaca cacacaacct 20940 gggggtgggt gagagaacag caagagaagt ctctttagag cttccaacct ggcctctgat 21000 ggaaggcatc tttagcacct tgctgtgtct gtccagttaa ggcggtcctt cctgtgagcc 21060 gaataaggac cgttccatct cccaggactg ctgggagcat cgctcaggac agaaaaggta 21120 tggtatgttc actatggggc ctgctgccac caggggacac acacgctcag tgagtcatca 21180 gtccctcttc ctttgggtga cagacagccc tgcacctggc tccgcagcct ctactcttcc 21240 agaggcccac tctcccacac tctctcaggc tcctctaggt tctgctgcca tcacagcttc 21300 ccgggaaatg ggacacaact gtcaccctgt gcacacacac aagatctcac cccaacagac 21360 tctcttcaca ggcaacattc ccacaacctg ctgggggtac tttggcaaca caaatgggaa 21420 tgggctcccc agaaagtctg gctgcctggg ctcctaagga tccctaacct cacccctacc 21480 aagttagtga acttggcggg ttgatgctgg atacaggttg atgctggata cgtagcgctg 21540 ccgggtcgtg acccctaagg aattatccaa actcttgttt ttagatgctt tattatatca 21600 aactctcctt taaacaagtg gcccatctgc tgggatttgg aagcctgtaa tactgaaatt 21660 ttcatcataa tggaaatttt aaaaacagaa tttgacccac ctgtttttaa aacactttca 21720 ttacttaaca agaggtctaa tcttgggcaa gtcttgaaat ttctctggcc ttagtttccc 21780 atgtgttaaa tgaaacttga agcagttggt ctcttatagt ctcctgactc taacattcta 21840 agaattatat ttgtacaata actcaaaaat cacataattt aatttaccat atggactcca 21900 aaatatattt tctcattagg ctaaacttga tctgcatttt ctggatgtgt ccatattctt 21960 ggactacact aaaacatgat accaatgctt cctctcacca taaaccctca cttcgctttc 22020 tacatttaag aattttatag ctggaagagt ccttaacaga aaataccatc taataattac 22080 ccctcaaaat cgagaaagtc ctatctgttc ttatgctagt tataagaatg aggcagcatt 22140 tcacataatg gttataaaca ctgccacaag aagattcatg atgtgttgtt tatctgtagc 22200 tctcatcata ctctgtcata taactatagc attaagattt taatgttcta tatattcttc 22260 taagacagtg tttaccagag taaggcacaa aagatccact ggtttgcaag aaagattaga 22320 acttttaaat tttttacctc accttgttta atctatattt ttgtatgtat tttgtaacat 22380 atatattatt attaccataa atcatatata atttaaaatg catatattag gggtaaatgc 22440 tcaggaaact ttttataaat tgggcatgca aatacaagtt tgaagactca ctgttctagg 22500 tattaaaagt aaagttataa ccaagtaaag cttccacctt ttcatgtctc aaagcagttt 22560 attgttggag gtaagatctc ttagaagcct aaacaggtcc aagtacagaa tgaagtaagg 22620 ctagcccata acttgtggca agcaattcat actatttctc tcatgctgag ctctcctcag 22680 tgaagcagct actatagaca actgcagcct attggtagcc tattttacag gcaggaaaaa 22740 aattactttt tattcaaagt ggaactcagg acatggggag aaaatgaata caaaaaatag 22800 ggtcaatcca aaggcacaca gcaaatgagt aacacagtta tgtttttttc ccatttgtat 22860 gaggtcccag taaattctaa gtaaactgca aatttaataa tacactaaaa aagccatgca 22920 attgttcaaa tgaatcccag catggtacaa ggagtacaga cactagagtc taaaaaacaa 22980 aagaatgcca ttattgagtt tttgaattat atcaagtagt tacatctcta cttaataaat 23040 gagaaaaacg aggataagag gccatttgat aaaatgaaaa tagccaagaa gtggtattag 23100 agacttgaat acaggtattc gggtccaaag ttcatctgct caaatactaa ctggggaaaa 23160 gagggaaaaa tatttatata catatatatc tgcacacaaa aataccccca aaagacaaaa 23220 tgaggccagg cagggtggct cacacccgta atcccggtac tttgggaggc tgaggcaggt 23280 ggatacctga gatcaggagt tggagatcag cctggtcaac atggtgaaac cctgtctcta 23340 ctaaagataa aaaaattagc caggcatggt ggcgtgcgcc tgtaatccca gctacttggg 23400 agtctgaggc aggagaatca cttgaactgg gaaggggagg ttgcagtgag ccaagatcgt 23460 actactgcac tccagcctgg gcagcagagt gagactccat cacaaaaata aataaataaa 23520 taaaatacaa tgaaacagaa agttcaaata atcccataat cttaccacca agaaataact 23580 ttcactcgtt atacttattg atttttccat aataaatgta ctttactgtg actatcatga 23640 aaagaaagtt attttagaaa cagagaactg tttcagatca aatctatgta gtagaacaga 23700 gccattaggt gggaaagacg agatcaaact aaatctcaga aggcctaaaa ggctaggtcc 23760 attccagcac taaaaactga ccagacaagt aatggcttca acagcttcta aatatggaca 23820 aagcatgctg aaagggaagg acaggtctaa cagtggtata tgaaatgaac aggaggggca 23880 aagctcattt ctcctctgaa gttttccaaa gatgctgagg aggacattag tttgacatga 23940 ccctgatatg ggacaagata atttcacaga agttttacat gttaaagttt tcttatagat 24000 actcattcaa gtaagcaatg aacactaaaa tctaaagaaa gaaaagagct ttagagtcag 24060 gtctgtattc aaattcaagc tctaccactt actggttctg tgactttggg caagtctttt 24120 aaccttatta agtcttaatt tcctgatttg taaaatgggg atatcgtctc cctcacagga 24180 ttgttgtgaa acttttatga gattaatgcc tttatatttg gcatagtgta agtaaacaat 24240 aactggcagc ttcaaaaaaa aaaagcagta gcattccatc atttattatt ggttactctc 24300 aaaaagtttt tcaatgtact agaagataaa tattcaaata ccttaatatc tccattattt 24360 tcaggtaaac agcatgctcc tgaacaacca atgggtcaac aaataaatta aaagggaaat 24420 ctaaaaacat cttgatatta aactacatgg aagcacaata taccaaaacc aatggttcac 24480 actaggagaa ttttaaggta caagaaaact ctttgagatt tcttaaaata atagtatgtc 24540 tgaatttatt gagtgattta ccagaaactg ttgtaagagc tctacttgca ttatagcact 24600 taatcctctt aactctatgg ctgctattat caacctcacc ctaatcacat atgggacaca 24660 gagaggttaa gtaacttgcc caaggtcaga gttaggaagt actaagccat gctttgaatc 24720 agttgtcagg ctccggaact cacactttca gccactacat aatactgctt tgctatcttt 24780 taggaaacta tgtgagtcta cctcacatag actcacatag gtttgttttt tttttttttt 24840 taaaggctat cttttccccc atcaatgttt tttgaaggat cccaaattag agtcccacag 24900 aggcagacag cagtacttga caatatggac atttaaggtt aatgttggat tctactgtct 24960 ttttactaca tgacctaggg aacgataatt aacctagact gcttccaagg gttaaataac 25020 ccatttagtt atactatgta aattatctct tagtgattga ttgaaagcac actgttacta 25080 attgactcgg tatgaagtgc ttttttttct tccctttcaa gatacatacc tttccagtta 25140 aagttgagag atcatctcca ccaattactt ttatgtcccc tgttgactgg tcattctagt 25200 taaaaaaaaa aaaaactata tatatatata tctacacaca catatgtata tgtatatcct 25260 tatgtacaca cacaaacttc aaattaaatg agaactagaa gatttgagaa gttagctagc 25320 taatatccat agcattatga tattctaaat gatatgaatt ataagaatta ggtttcctga 25380 aatgaatgac tagaaaactt tcaagtagag attagtaaaa attaaaaagt cctaatcggc 25440 cattactgat ttgatgtttt taagagtcct aaaaaatggg ttacatccat ttttaagtgg 25500 gtagtattat aacagccacc catcttcaat cacagtgatt tctgaattgt gagggaagtt 25560 attagcatga caggtgtctg gttctggccc tgtacgattc ccatgagtca agcaaattgt 25620 aagggctggt ctatatcaca cccaacccca aggatatgtc cctcaaaagt ctagcccagg 25680 ccccgtcatc ttcagcatca tctgggaaac caggtctgat tagtagtcct ttaaggaata 25740 cctcttaggc tcccatttta ctgctatcac agaatccaat aaaaccctta caggagattc 25800 aatgggaaat gctcaacacc cactgtagtt ggtggtgaca atgaccataa tttggctgtg 25860 ctggattcag gacagaaaat ttgggtgaaa gagcaggtga acaaaagagc ttcgacttgc 25920 cctagcagag agcaagccat accataccac aaagccacag caattacaac ggtgcagtac 25980 cagcacagta aatgaacaaa gtagagccca gaaacagacc cagaactata tgaggattta 26040 gtatacaata aagatggtat ttcgagtcag tagggaaaag atgaattatt caataaatga 26100 tgtttggcca actagtaacc catttgggaa aaaataaaag tatggtccct acctcacagc 26160 atacacaaaa ataaattcca gacggattaa aatctaaatg taaaaaataa agccataagt 26220 ggactggaag aaaatagaga atttttttta acatccgtag aaagggtaaa aacccaggca 26280 tgacatgaac caaaactgaa gaggttctgt aacaaatacc cccttttata tattgggctc 26340 caacaataag aacccatagg aaaatggaga atgaacacaa atagacaatt tatagaagag 26400 aaggttataa ggtgtaaaat tatatctatc tgagaaacaa acactaaaac aatgtgattc 26460 tactgttctc ccacccatac tggcaaaact taagcctgat aatatgctga ggggaaataa 26520 gcactcttgt tggtgagagt attaattggc atagcttctt ttgaaaatga catagcaata 26580 cctgttaaaa ttgcaaacat gcatgtcact taatccagta atcccacttc tgggaatcaa 26640 tgctacaaaa acactgacaa gtatacaaag atacattcaa gagtgttcac tgggccgggt 26700 gcggtggctt catgcctgta atcccaggga ggcagaggca agacgatcgc ttgaccccag 26760 gagttcaagg ccagcccgag aaacacagca agaccctgtc tctctttttt ttatttaaaa 26820 aataaatgtt cactgtatca gttgttcaca aaaacaaacc aacatgtcca ttaacaggga 26880 accatttaaa ttaatcaagt tcatctacac aatgtaatac catgcaacta ttaaaaagca 26940 cctgataatc caaagcacac tgagacagaa taatgctatt aaaaacacca agtagtggaa 27000 cactgtgttg cctatgacac catttttatt caacatttaa acaaatttgt aacagcaatt 27060 acatgagtag tgacaatggc gtttatgaga cttttcactt ttatgtgctt ctatttttgt 27120 tatgcttcta tatatacatc catttattat ggagtgttac tttcaaaaat cacaaatggg 27180 ccagtattat ttggtgttgc aaggtgagca tatgacttct gatatcaacc tttgcatatt 27240 acttctcaat ttagggaaat tacagacatc ccttattcta actaacttaa aacccagcat 27300 ttcaaacata cagaattgat ggggaaaaaa aagaaagaag aaagaaagaa aaggcaacaa 27360 gcttcagatg acagtgactc acatcaaatt atttataaaa tctgttaaat agtgccatct 27420 tctggagata cctggtatta cagtccaact ccagttgatg tctttacaga gacaagagga 27480 ataaaggaaa aaatattcaa gaactgaaaa gtatggagtc atggaaaaat tgctgtgatc 27540 caaaggctac ggtgatagga caagaaacaa gagaactcca agcagtaaga cactgctgtt 27600 ctattagcat ccaaacctcc atactcctgt ttgccccaag gcttttttaa aaaatagaga 27660 caggatctca ctattttgct caggctggtc ttgaactcct ggactcaagc tatcctcctg 27720 cctcggcctc ctaaagtgcc gagattacag gcttgagtca ccatacctgg ctatttattt 27780 tttcttaact ctcttgcctg gcctatagcc accatggaag ctaataaaga atattaattt 27840 aagagtaatg gtatagttca ctacattgga atacaggtat aagtgcctac attgtacatg 27900 aatggcatac atggatcaat taccccacct gggtggccaa aggaactgcg cgaacctccc 27960 tccttggctg tctggaacaa gcttcccact agatcccttt actgagtgcc tccctcatct 28020 ttaattatgg ttaagtctag gataacagga ctggcaaagg tgaggggaaa gcttcctcca 28080 gagttgctct accctctcct ctaccgtcct atctcctcac tcctctcagc caaggagtcc 28140 aatctgtcct gaactcagag cgtcactgtc aactacataa aattgccaga gaagctcttt 28200 gggactacaa acacataccc ttaatgtctt tatttctatt ttgtctacct cttcagtcta 28260 ggtgaaaaaa taggaaggat aatagggaag aactttgttt atgcctactt atccgcccct 28320 aggaattttg aaaacctcta ggtagcaata agaactgcag catggtatag aaaaagagga 28380 ggaaagctgt atagaaatgc ataataaatg ggcaggaaaa gaactgcttg gaacaaacag 28440 ggaggttgaa ctataaggag agaaagcaga gaggctaatc aacaaggctg ggttcccaag 28500 agggcatgat gagactatta ctaaggtagg aattactaag ggctccatgt ccccttagtg 28560 gcttagtact atgtagcttg ctttctgcag tgaacttcag acccttcttt taggatccta 28620 gaatggactt ttttttttta tcggaaaaca gtcattctct caacattcaa gcaggcccca 28680 agtctaccac actcaatcac attttctctt catatcataa tctctcaacc attctctgtc 28740 cttttaactg tttttctata ccctgatcaa atgccaacaa aagtgagaat gttagaatca 28800 tgtattttta gaggtagact gtatctcaga taaaaaaaaa gggcagatat tccattttcc 28860 aaaatatgta tgcagaaaaa ataagtatga aaggacatat gctcaggtaa caagttaatt 28920 tgtttacttg tattttatga attccctaaa acctacgtca cccgccccgt tcccacgccc 28980 cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt 29040 atattattga tgatgttaat taacatgcat ggatccatat gcggtgtgaa ataccgcaca 29100 gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc actgactcgc 29160 tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt 29220 tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg 29280 ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg 29340 agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat 29400 accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta 29460 ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct 29520 gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc 29580 ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcG aacccggtaa 29640 gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg 29700 taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag 29760 tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt 29820 gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta 29880 cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc 29940 agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca 30000 cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa 30060 cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat 30120 ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct 30180 taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt 30240 tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat 30300 ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta 30360 atagtttgcg caacgttgtt gccattgctg cagccatgag attatcaaaa aggatcttca 30420 cctagatcct tttcacgtag aaagccagtc cgcagaaacg gtgctgaccc cggatgaatg 30480 tcagctactg ggctatctgg acaagggaaa acgcaagcgc aaagagaaag caggtagctt 30540 gcagtgggct tacatggcga tagctagact gggcggtttt atggacagca agcgaaccgg 30600 aattgccagc tggggcgccc tctggtaagg ttgggaagcc ctgcaaagta aactggatgg 30660 ctttcttgcc gccaaggatc tgatggcgca ggggatcaag ctctgatcaa gagacaggat 30720 gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg 30780 tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg 30840 tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg 30900 ccctgaatga actgcaagac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc 30960 cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg 31020 aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca 31080 tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc 31140 aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg 31200 atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg 31260 cgagcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata 31320 tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg 31380 accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat 31440 gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct 31500 tctatcgcct tcttgacgag ttcttctgaa ttttgttaaa atttttgtta aatcagctca 31560 ttttttaacc aataggccga aatcggcaaa atcccttata aatcaaaaga atagaccgag 31620 atagggttga gtgttgttcc agtttggaac aagagtccac tattaaagaa cgtggactcc 31680 aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga accatcaccc 31740 taatcaagtt ttttggggtc gaggtgccgt aaagcactaa atcggaaccc taaagggagc 31800 ccccgattta gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa 31860 gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc 31920 acacccgccg cgcttaatgc gccgctacag ggcgcgtcca ttcgccattc aggatcgaat 31980 taattcttaa ttaacatcat caataatata ccttattttg gattgaagcc aatatgataa 32040 tgagggggtg gagtttgtga cgtggcgcgg ggcgtgggaa cggggcgggt gacgtagtag 32100 tgtggcggaa gtgtgatgtt gcaagtgtgg cggaacacat gtaagcgacg gatgtggcaa 32160 aagtgacgtt tttggtgtgc gccggtgtac acaggaagtg acaattttcg cgcggtttta 32220 ggcggatgtt gtagtaaatt tgggcgtaac cgagtaagat ttggccattt tcgcgggaaa 32280 actgaataag aggaagtgaa atctgaataa ttttgtgtta ctcatagcgc gtaatactg 32339