Title:
IN VIVO MEASUREMENT OF MITOCHONDRIAL FUNCTION
Document Type and Number:
WIPO Patent Application WO/2009/124114
Kind Code:
A3
Abstract:
Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.
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Inventors:
GORMAN JOSEPH H III (US)
GORMAN ROBERT C (US)
RANJI MAHSA (US)
GORMAN ROBERT C (US)
RANJI MAHSA (US)
Application Number:
PCT/US2009/039098
Publication Date:
June 24, 2010
Filing Date:
April 01, 2009
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
GORMAN JOSEPH H III (US)
GORMAN ROBERT C (US)
RANJI MAHSA (US)
GORMAN JOSEPH H III (US)
GORMAN ROBERT C (US)
RANJI MAHSA (US)
International Classes:
A61B6/00
Foreign References:
| US20050234315A1 | 2005-10-20 | |||
| US5916171A | 1999-06-29 | |||
| US20070179571A1 | 2007-08-02 |
Other References:
MAYEVSKY ET AL.: "Mitochondrial Dysfunction: Bench-to-Bedside Optical Monitoring of Tissue Vitality.", THE JOURNAL OF BIOMEDICAL OPTICAL SPECTROSCOPY (SPIE), vol. 6853, no. 68531B, 2 February 2008 (2008-02-02), BELLINGHAM, WA, USA., pages 1605 - 7422
Attorney, Agent or Firm:
CALDWELL, John, W. et al. (Cira Centre 12th Floor,2929 Arch Stree, Philadelphia PA, US)
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