Title:
IN-VIVO RAPID RECELLULARIZATION TISSUE ENGINEERED BLOOD VESSEL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/021869
Kind Code:
A1
Abstract:
Disclosed are an in-vivo rapid recellularization tissue engineered blood vessel and a preparation method therefor. The preparation method comprises: dissolving polyglycolic acid and polyethylene glycol in an organic solvent to prepare a spinning solution, and performing electrostatic spinning according to a certain proportion to prepare a tubular polymer composite support of a special tube wall structure, the fiber on the outer side of the tube wall support containing a higher proportion of polyethylene glycol; planting seed cells on the tubular polymer support of the special tube wall structure, and under certain culture conditions, simulating body arteriopalmus flow conditions and performing perfusion culture for 3 weeks to 3 months; and removing cell components from the tube wall of the obtained engineered blood vessel by using a decellularization method to give a tissue engineered blood vessel composed of an extracellular matrix of a bionic structure. The tissue engineered blood vessel of the present invention has the three-dimensional structure of a special bionic extracellular matrix, and can realize rapid recellularization after being implanted in the body, reconstruct new blood vessels in situ in the body, improve blood vessel performance, and meet the clinical "on-demand" requirement.
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Inventors:
QIU XUEFENG (CN)
GUO YING (CN)
GUO YING (CN)
Application Number:
PCT/CN2023/098423
Publication Date:
February 01, 2024
Filing Date:
June 05, 2023
Export Citation:
Assignee:
HUMATRIX MEDICAL TECH SUZHOU CO LTD (CN)
International Classes:
A61L27/38; A61L27/50
Foreign References:
| CN114949362A | 2022-08-30 | |||
| CN113694253A | 2021-11-26 | |||
| CN111714248A | 2020-09-29 | |||
| CN111603611A | 2020-09-01 | |||
| US20190321158A1 | 2019-10-24 | |||
| CN106267369A | 2017-01-04 | |||
| CN108434519A | 2018-08-24 | |||
| US20150031131A1 | 2015-01-29 | |||
| US20210060208A1 | 2021-03-04 |
Attorney, Agent or Firm:
WUHAN DONGYU PATENT AGENCY (CN)
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