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Title:
IN-VIVO RELEASE SUSTAINED RECOMBINANT COAGULATION FACTOR VIII AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/139416
Kind Code:
A1
Abstract:
The present invention provides an in-vivo release-sustained recombinant coagulation factor VIII in which a biocompatible polymer is conjugated to at least one sugar chain terminus, and a preparation method therefor. An in-vivo release-sustained recombinant coagulation factor VIII according to the present invention has a protein surface modified through a method more elaborate and safer than conventional glycoconjugation techniques and enjoys the advantage of decreasing in immunogenicity and increasing in in-vivo sustainability.

Inventors:
KANG KWAN YUB (KR)
KIM TAEYOON (KR)
RYU JAE HWAN (KR)
KIM YEON JUNG (KR)
KIM YONG JAE (KR)
Application Number:
KR2019/000479
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
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Assignee:
MOGAM INSTITUTE FOR BIOMEDICAL RES (KR)
International Classes:
C07K14/755; A61K47/54; A61K47/60; C07K19/00; C12N9/64
Domestic Patent References:
WO2014176125A12014-10-30
WO2014026954A12014-02-20
Foreign References:
JP2015155469A2015-08-27
US20160115219A12016-04-28
KR2017006633W2017-06-23
Other References:
KANNICHT C.: "Characterisation of the post-translational modifications of a novel, human cell line-derived recombinant human factor VIII", THROMB. RES., vol. 131, no. 1, 2013, pages 78 - 88, XP055268361, doi:10.1016/j.thromres.2012.09.011
"Function and 3D Structure of the N-Glycans on Glycoproteins", INT. J. MOL. SCI., vol. 13, 2012, pages 8398 - 8429
"Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins", J PHARM SCI., vol. 94, no. 8, 2005, pages 1626 - 35
"Production of therapeutic antibodies with controlled fucosylation", MABS, vol. 1, no. 3, 2009, pages 230 - 236
GILLIES ET AL., J. IMMUNOL. METH, vol. 125, 1989, pages 191 - 202
SAKANO ET AL., NATURE, vol. 286, 1980, pages 676 - 683
WATSON ET AL., NUCLEIC ACID RESEARCH, vol. 12, 1984, pages 5145 - 5164
J THROMB HAEMOST, vol. 15, no. 6, 2017, pages 1106 - 1114
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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