Title:
IN VIVO STEALTH NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2016/088384
Kind Code:
A1
Abstract:
Provided is a molecular imprint polymer that is capable of acquiring stealth properties through a new mechanism. The molecular imprint polymer according to the present invention, which has a plasma protein recognition site carrying a plasma protein molecularly imprinted thereon and contains a constituent derived from a biocompatible monomer, is an in vivo stealth nanoparticle to be used in intravascular delivery. As the plasma protein, albumin is preferred. When carrying a drug thereon, the in vivo stealth nanoparticle according to the present invention is usable as a drug for drug delivery system.
More Like This:
Inventors:
TAKEUCHI TOSHIFUMI (JP)
KITAYAMA YUKIYA (JP)
KITAYAMA YUKIYA (JP)
Application Number:
PCT/JP2015/006041
Publication Date:
June 09, 2016
Filing Date:
December 04, 2015
Export Citation:
Assignee:
NAT UNIV CORP UNIV KOBE (JP)
International Classes:
A61K47/32; A61K9/51; B82Y5/00; C08F2/44; C08F220/36; C08F220/60
Foreign References:
| JP2001501931A | 2001-02-13 |
Other References:
CUNLIFFE DAVID ET AL.: "Molecularly imprinted drug delivery systems", ADVANCED DRUG DELIVERY REVIEWS, vol. 57, 13 October 2005 (2005-10-13), pages 1836 - 1853, XP005173266
CURCIO MANUELA ET AL.: "Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices", JOURNAL OF FUNCTIONAL BIOMATERIALS, vol. 3, 29 March 2012 (2012-03-29), pages 269 - 282, XP055452201
QING-QING GAI ET AL.: "The preparation of bovine serum albumin surface-imprinted superparamagnetic polymer with the assistance of basic functional monomer and its application for protein separation", JOURNAL OF CHROMATOGRAPHY A, vol. 1218, 4 April 2011 (2011-04-04), pages 3489 - 3495, XP028206778, DOI: doi:10.1016/j.chroma.2011.03.069
MUGE ANDAC ET AL.: "Molecularly imprinted poly(hydroxyethyl methacrylate)based cryogel for albumin depletion from human serum", COLLOIDS AND SURFACES B:BIOINTERFACES, vol. 109, 17 April 2013 (2013-04-17), pages 259 - 265, XP028553673, DOI: doi:10.1016/j.colsurfb.2013.03.054
TAKIMOTO KYOHEI ET AL.: "Synthesis of Monodispersed Submillimeter-Sized Moleculary imprinted Particles Selective for Human Serum Albmin Using Inverse Suspension Polymerizatino in Water-in-Oil Emulsion Prepared Using Microfluidics", LANGMUIR, vol. 31, 8 April 2015 (2015-04-08), pages 4981 - 4987, XP055452208
CURCIO MANUELA ET AL.: "Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices", JOURNAL OF FUNCTIONAL BIOMATERIALS, vol. 3, 29 March 2012 (2012-03-29), pages 269 - 282, XP055452201
QING-QING GAI ET AL.: "The preparation of bovine serum albumin surface-imprinted superparamagnetic polymer with the assistance of basic functional monomer and its application for protein separation", JOURNAL OF CHROMATOGRAPHY A, vol. 1218, 4 April 2011 (2011-04-04), pages 3489 - 3495, XP028206778, DOI: doi:10.1016/j.chroma.2011.03.069
MUGE ANDAC ET AL.: "Molecularly imprinted poly(hydroxyethyl methacrylate)based cryogel for albumin depletion from human serum", COLLOIDS AND SURFACES B:BIOINTERFACES, vol. 109, 17 April 2013 (2013-04-17), pages 259 - 265, XP028553673, DOI: doi:10.1016/j.colsurfb.2013.03.054
TAKIMOTO KYOHEI ET AL.: "Synthesis of Monodispersed Submillimeter-Sized Moleculary imprinted Particles Selective for Human Serum Albmin Using Inverse Suspension Polymerizatino in Water-in-Oil Emulsion Prepared Using Microfluidics", LANGMUIR, vol. 31, 8 April 2015 (2015-04-08), pages 4981 - 4987, XP055452208
Attorney, Agent or Firm:
CREIA IP ATTORNEYS (JP)
Patent business corporation クレイア patent firm (JP)
Patent business corporation クレイア patent firm (JP)
Download PDF:
Previous Patent: VARIABLE DISPLACEMENT PUMP
Next Patent: DIFFUSION SHEET, LAMINATED PRISM SHEET, AND LAMINATED OPTICAL SHEET
Next Patent: DIFFUSION SHEET, LAMINATED PRISM SHEET, AND LAMINATED OPTICAL SHEET