Title:
INDAZOLE KINASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/087565
Kind Code:
A1
Abstract:
The present invention relates to a kinase inhibitor, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention further relates to pharmaceutical compositions comprising the kinase inhibitor, as well as to using said compounds and compositions to inhibit cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGFRª┴, PDGFRª┬, and/or VEGFR2 kinase activity in cells or a subject, and/or to a use and method for preventing or treating disorders related to cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGFRª┴, PDGFRª┬, and/or VEGFR2 activity in a subject. (I)
Inventors:
LIU JING (CN)
LIU QINGSONG (CN)
LIU XUESONG (CN)
WANG BEILEI (CN)
CHEN CHENG (CN)
QI ZIPING (CN)
WANG WENCHAO (CN)
WANG JUNJIE (CN)
JIANG ZONGRU (CN)
WANG WENLIANG (CN)
QI SHUANG (CN)
WANG LI (CN)
LIU QINGSONG (CN)
LIU XUESONG (CN)
WANG BEILEI (CN)
CHEN CHENG (CN)
QI ZIPING (CN)
WANG WENCHAO (CN)
WANG JUNJIE (CN)
JIANG ZONGRU (CN)
WANG WENLIANG (CN)
QI SHUANG (CN)
WANG LI (CN)
Application Number:
PCT/CN2018/115025
Publication Date:
May 07, 2020
Filing Date:
November 12, 2018
Export Citation:
Assignee:
TARAPEUTICS SCIENCE INC (CN)
International Classes:
C07D231/56; A61K31/381; A61K31/427; C07D277/44; C07D277/46; C07D277/48
Domestic Patent References:
| WO2017027400A1 | 2017-02-16 |
Foreign References:
| CN102958927A | 2013-03-06 | |||
| CN103080093A | 2013-05-01 | |||
| CN101790526A | 2010-07-28 |
Other References:
"The Pharmacological Basis of Therapeutics", 1996, MCGRAW-HILL
See also references of EP 3878841A4
See also references of EP 3878841A4
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
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