Title:
INDEX OF LOCAL SEVERITY OF ATOPIC DERMATITIS IN SKIN AND THERAPEUTIC EFFECT THEREON
Document Type and Number:
WIPO Patent Application WO/2017/188101
Kind Code:
A1
Abstract:
Provided is an objective and convenient index for judging full recovery from atopic dermatitis and severity thereof. The present invention provides a diagnosis assisting method for determining a treatment policy for an atopic dermatitis subject under the treatment, said method comprising: measuring the expression value of SCCA-1 in skin horny cells of the subject; i) when the SCCA-1 expression value is not statistically significantly higher than the level of those who do not suffer from atopic dermatitis, then determining that the continuation of the treatment for the disease becomes unnecessary thanks to the treatment; and, in the case where the continuation of the treatment is determined as still necessary, ii) ranking the severity of atopic dermatitis of the subject using the SCCA-1 expression value as an index and determining an adequate treatment method for atopic dermatitis to be given to the subject depending on the rank.
Inventors:
TANAKA CHIKA (JP)
MIZUMOTO CHIEKO (JP)
ONODERA TOMOKO (JP)
AIBA SETSUYA (JP)
KIKUCHI KATSUKO (JP)
YAMASAKI KENSHI (JP)
OZAWA MAKI (JP)
MIZUMOTO CHIEKO (JP)
ONODERA TOMOKO (JP)
AIBA SETSUYA (JP)
KIKUCHI KATSUKO (JP)
YAMASAKI KENSHI (JP)
OZAWA MAKI (JP)
Application Number:
PCT/JP2017/015792
Publication Date:
November 02, 2017
Filing Date:
April 19, 2017
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
C12Q1/04; G01N33/53; G01N33/543
Domestic Patent References:
| WO2006098523A1 | 2006-09-21 | |||
| WO2007046463A1 | 2007-04-26 |
Foreign References:
| JP2009115813A | 2009-05-28 | |||
| JP2012177601A | 2012-09-13 |
Other References:
YUKO MATSUMOTO ET AL.: "Nyuyoji no Atopy-sei Hifuen to SCCA1 Oyobi S 100A8 /A9 no Kanrensei", JAPANESE JOURNAL OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY, vol. 25, no. 3, 20 August 2011 (2011-08-20), pages 545, XP009513082, ISSN: 0914-2649, DOI: 10.3388/jspaci.25.531
YUKO MATSUMOTO ET AL.: "Nyuyoji Atopi-sei Hifuen o Taisho to shita Tei Shigekisei Skincare no Koka to Kakusochu no SCCA1 Tanpakushitsu no Hendo", THE ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC DERMATOLOGY PROGRAM . SHOROKUSHU, vol. 36, 2012, pages 112, XP009516414
KENJI IDEHARA: "Allergy Shikkan no Transcriptome Kaiseki II Shinki Allergy Shikkan Marker to shite no Henpei Johi Saibo Gan Kogen (SCCA) no Dotei", CLINICAL TESTING, vol. 49, no. 7, 15 July 2005 (2005-07-15), pages 769 - 772, XP009516413, ISSN: 0485-1420
TAKASHI ABE: "Skincare Keshohin no Kenkyu Kaihatsu Doko (2007 Nen", FRAGRANCE JOURNAL, vol. 36, no. 4, 15 April 2008 (2008-04-15), pages 78 - 83, XP009516412, ISSN: 0288-9803
SHOICHIRO OTA, KENJI IDEHARA: "III. Atopy-sei Hifuen no Atarashii Biomarker = [III. New Biomarkers for Atopic Dermatitis]", ALLERGOLOGY & IMMUNOLOGY, vol. 23, no. 2, 15 January 2016 (2016-01-15), pages 190 - 196, XP009512842, ISSN: 1344-6932
See also references of EP 3450978A4
YUKO MATSUMOTO ET AL.: "Nyuyoji Atopi-sei Hifuen o Taisho to shita Tei Shigekisei Skincare no Koka to Kakusochu no SCCA1 Tanpakushitsu no Hendo", THE ANNUAL MEETING OF THE JAPANESE SOCIETY OF PEDIATRIC DERMATOLOGY PROGRAM . SHOROKUSHU, vol. 36, 2012, pages 112, XP009516414
KENJI IDEHARA: "Allergy Shikkan no Transcriptome Kaiseki II Shinki Allergy Shikkan Marker to shite no Henpei Johi Saibo Gan Kogen (SCCA) no Dotei", CLINICAL TESTING, vol. 49, no. 7, 15 July 2005 (2005-07-15), pages 769 - 772, XP009516413, ISSN: 0485-1420
TAKASHI ABE: "Skincare Keshohin no Kenkyu Kaihatsu Doko (2007 Nen", FRAGRANCE JOURNAL, vol. 36, no. 4, 15 April 2008 (2008-04-15), pages 78 - 83, XP009516412, ISSN: 0288-9803
SHOICHIRO OTA, KENJI IDEHARA: "III. Atopy-sei Hifuen no Atarashii Biomarker = [III. New Biomarkers for Atopic Dermatitis]", ALLERGOLOGY & IMMUNOLOGY, vol. 23, no. 2, 15 January 2016 (2016-01-15), pages 190 - 196, XP009512842, ISSN: 1344-6932
See also references of EP 3450978A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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