Title:
INDIVIDUAL METHODS FOR MEASUREMENT OF SPECIFIC LYMPHOCYTE FUNCTION
Document Type and Number:
WIPO Patent Application WO/2004/059319
Kind Code:
A1
Abstract:
The present invention disclosed a method for successively measuring in vitro the responses of individual to immunocytes from organ transplants or tumor, which comprises the steps of: 1) adding antigen from donor or MHC/HLA molecular library including donor's MHC/HLA type or antigen from recipient self or its same tumor type to the sample from desired subject, and incubating for sufficient time for immunocytes activation, 2) separating and/or typing the immunocytes and measuring the activation index; thereof so-called antigen from the donor of organ transplants is whole-cell or subcelluar components having MHC/HLA or MHC/HLA molecular, or so-called antigen from recipient self is whole-cell of tumor or celluar extractives including most celluar components; this method also including make so-called antigen from individual self or non-tumor antigen as contrast for stimulating antigen.
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Inventors:
CHEN GE (CN)
LIU XIANGJUN (CN)
LIU XIANGJUN (CN)
Application Number:
PCT/CN2003/001120
Publication Date:
July 15, 2004
Filing Date:
December 25, 2003
Export Citation:
Assignee:
PEL FREEZ BIOTECHNOLOGY BEIJIN (CN)
CHEN GE (CN)
LIU XIANGJUN (CN)
CHEN GE (CN)
LIU XIANGJUN (CN)
International Classes:
C12Q1/04; C12Q1/24; C12Q1/70; G01N33/50; G01N33/53; G01N33/566; G01N33/569; (IPC1-7): G01N33/53
Foreign References:
| US5773232A | 1998-06-30 | |||
| CN1311437A | 2001-09-05 | |||
| US5948627A | 1999-09-07 |
Attorney, Agent or Firm:
KING & WOOD PRC LAWYERS (Office Tower A 39 Dongsanhuan Zhongl, Chaoyang District Beijing 2, CN)
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