Title:
INDIVIDUALIZED VACCINES FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2012/159754
Kind Code:
A3
Abstract:
The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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Inventors:
SAHIN UGUR (DE)
KREITER SEBASTIAN (DE)
DIKEN MUSTAFA (DE)
DIEKMANN JAN (DE)
KOSLOWSKI MICHAEL (DE)
BRITTEN CEDRIK (DE)
CASTLE JOHN (DE)
LOEWER MARTIN (DE)
RENARD BERNHARD (DE)
OMOKOKO TANA (DE)
DE GRAAF JOHANNES HENDRIKUS (DE)
KREITER SEBASTIAN (DE)
DIKEN MUSTAFA (DE)
DIEKMANN JAN (DE)
KOSLOWSKI MICHAEL (DE)
BRITTEN CEDRIK (DE)
CASTLE JOHN (DE)
LOEWER MARTIN (DE)
RENARD BERNHARD (DE)
OMOKOKO TANA (DE)
DE GRAAF JOHANNES HENDRIKUS (DE)
Application Number:
PCT/EP2012/002209
Publication Date:
June 27, 2013
Filing Date:
May 23, 2012
Export Citation:
Assignee:
BIONTECH AG (DE)
TRON TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG UNI MAINZ GEMEINNUE (DE)
SAHIN UGUR (DE)
KREITER SEBASTIAN (DE)
DIKEN MUSTAFA (DE)
DIEKMANN JAN (DE)
KOSLOWSKI MICHAEL (DE)
BRITTEN CEDRIK (DE)
CASTLE JOHN (DE)
LOEWER MARTIN (DE)
RENARD BERNHARD (DE)
OMOKOKO TANA (DE)
DE GRAAF JOHANNES HENDRIKUS (DE)
TRON TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG UNI MAINZ GEMEINNUE (DE)
SAHIN UGUR (DE)
KREITER SEBASTIAN (DE)
DIKEN MUSTAFA (DE)
DIEKMANN JAN (DE)
KOSLOWSKI MICHAEL (DE)
BRITTEN CEDRIK (DE)
CASTLE JOHN (DE)
LOEWER MARTIN (DE)
RENARD BERNHARD (DE)
OMOKOKO TANA (DE)
DE GRAAF JOHANNES HENDRIKUS (DE)
International Classes:
A61K39/00; A61P35/00; C12Q1/68; G01N33/50; G16B20/20
Domestic Patent References:
| WO1999034015A2 | 1999-07-08 | |||
| WO1997040156A1 | 1997-10-30 |
Other References:
RAHMA OSAMA E ET AL: "A pilot clinical trial testing mutant von Hippel-Lindau peptide as a novel immune therapy in metastatic Renal Cell Carcinoma", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 8, no. 1, 28 January 2010 (2010-01-28), pages 8, XP021068353, ISSN: 1479-5876
GJERTSEN ET AL: "Mutated ras peptides as vaccines in immunotherapy of cancer", VOX SANGUINIS, S. KARGER AG, BASEL, CH, vol. 74, no. 2, 1 January 1998 (1998-01-01), pages 489 - 495, XP002127145, ISSN: 0042-9007
GIORGIO PARMIANI ET AL: "Unique human tumor antigens: immunobiology and use in clinical trials.", THE JOURNAL OF IMMUNOLOGY, vol. 178, no. 4, 1 February 2007 (2007-02-01), pages 1975 - 1979, XP055044894, ISSN: 0022-1767
J. C. CASTLE ET AL: "Exploiting the mutanome for tumor vaccination", CANCER RESEARCH, 1 January 2012 (2012-01-01), XP055018897, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-11-3722
TOBIAS SJÖBLOM ET AL: "The Consensus Coding Sequences of Human Breast and Colorectal Cancers", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 314, 13 October 2006 (2006-10-13), pages 268 - 274, XP007901261, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1133427
N. H. SEGAL ET AL: "Epitope Landscape in Breast and Colorectal Cancer", CANCER RESEARCH, vol. 68, no. 3, 1 February 2008 (2008-02-01), pages 889 - 892, XP055044926, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-07-3095
KESSLER J H ET AL: "Identification of T-cell epitopes for cancer immunotherapy", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 21, no. 9, 1 September 2007 (2007-09-01), pages 1859 - 1874, XP002516100, ISSN: 0887-6924, [retrieved on 20070705], DOI: 10.1038/SJ.LEU.2404787
MATEO L ET AL: "An HLA-A2 polyepitope vaccine for melanoma immunotherapy", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 163, no. 7, 1 October 1999 (1999-10-01), pages 4058 - 4063, XP002244411, ISSN: 0022-1767
PANTEL K ET AL: "Circulating tumour cells in cancer patients: challenges and perspectives", TRENDS IN MOLECULAR MEDICINE, ELSEVIER CURRENT TRENDS, GB, vol. 16, no. 9, 1 September 2010 (2010-09-01), pages 398 - 406, XP027433109, ISSN: 1471-4914, [retrieved on 20100729], DOI: 10.1016/J.MOLMED.2010.07.001
SEBASTIAN KREITER ET AL: "Tumor vaccination using messenger RNA: prospects of a future therapy", CURRENT OPINION IN IMMUNOLOGY, vol. 23, no. 3, 13 April 2011 (2011-04-13), pages 399 - 406, XP055018902, ISSN: 0952-7915, DOI: 10.1016/j.coi.2011.03.007
JOHN D. STOREY: "A direct approach to false discovery rates", PLOS COMPUTATIONAL BIOLOGY, vol. 64, no. 3, 1 August 2002 (2002-08-01), pages 479 - 498, XP055061495, ISSN: 1369-7412, DOI: 10.1111/1467-9868.00346
FAWCETT ET AL: "An introduction to ROC analysis", PATTERN RECOGNITION LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 8, 1 June 2006 (2006-06-01), pages 861 - 874, XP025053099, ISSN: 0167-8655, [retrieved on 20060601], DOI: 10.1016/J.PATREC.2005.10.010
GJERTSEN ET AL: "Mutated ras peptides as vaccines in immunotherapy of cancer", VOX SANGUINIS, S. KARGER AG, BASEL, CH, vol. 74, no. 2, 1 January 1998 (1998-01-01), pages 489 - 495, XP002127145, ISSN: 0042-9007
GIORGIO PARMIANI ET AL: "Unique human tumor antigens: immunobiology and use in clinical trials.", THE JOURNAL OF IMMUNOLOGY, vol. 178, no. 4, 1 February 2007 (2007-02-01), pages 1975 - 1979, XP055044894, ISSN: 0022-1767
J. C. CASTLE ET AL: "Exploiting the mutanome for tumor vaccination", CANCER RESEARCH, 1 January 2012 (2012-01-01), XP055018897, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-11-3722
TOBIAS SJÖBLOM ET AL: "The Consensus Coding Sequences of Human Breast and Colorectal Cancers", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 314, 13 October 2006 (2006-10-13), pages 268 - 274, XP007901261, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1133427
N. H. SEGAL ET AL: "Epitope Landscape in Breast and Colorectal Cancer", CANCER RESEARCH, vol. 68, no. 3, 1 February 2008 (2008-02-01), pages 889 - 892, XP055044926, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-07-3095
KESSLER J H ET AL: "Identification of T-cell epitopes for cancer immunotherapy", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 21, no. 9, 1 September 2007 (2007-09-01), pages 1859 - 1874, XP002516100, ISSN: 0887-6924, [retrieved on 20070705], DOI: 10.1038/SJ.LEU.2404787
MATEO L ET AL: "An HLA-A2 polyepitope vaccine for melanoma immunotherapy", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 163, no. 7, 1 October 1999 (1999-10-01), pages 4058 - 4063, XP002244411, ISSN: 0022-1767
PANTEL K ET AL: "Circulating tumour cells in cancer patients: challenges and perspectives", TRENDS IN MOLECULAR MEDICINE, ELSEVIER CURRENT TRENDS, GB, vol. 16, no. 9, 1 September 2010 (2010-09-01), pages 398 - 406, XP027433109, ISSN: 1471-4914, [retrieved on 20100729], DOI: 10.1016/J.MOLMED.2010.07.001
SEBASTIAN KREITER ET AL: "Tumor vaccination using messenger RNA: prospects of a future therapy", CURRENT OPINION IN IMMUNOLOGY, vol. 23, no. 3, 13 April 2011 (2011-04-13), pages 399 - 406, XP055018902, ISSN: 0952-7915, DOI: 10.1016/j.coi.2011.03.007
JOHN D. STOREY: "A direct approach to false discovery rates", PLOS COMPUTATIONAL BIOLOGY, vol. 64, no. 3, 1 August 2002 (2002-08-01), pages 479 - 498, XP055061495, ISSN: 1369-7412, DOI: 10.1111/1467-9868.00346
FAWCETT ET AL: "An introduction to ROC analysis", PATTERN RECOGNITION LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 8, 1 June 2006 (2006-06-01), pages 861 - 874, XP025053099, ISSN: 0167-8655, [retrieved on 20060601], DOI: 10.1016/J.PATREC.2005.10.010
Attorney, Agent or Firm:
VOSSIUS, Volker et al. (Munich, DE)
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