Title:
INDOLAMINE 2,3-DIOXYGENASE INHIBITOR AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/101884
Kind Code:
A1
Abstract:
Disclosed are an indolamine 2,3-dioxygenase inhibitor having the structure of formula (I) and a preparation method and use thereof. The indolamine 2,3-dioxygenase (IDO) inhibitor is a (Z)-N'-hydroxy-N-benzamidine derivative, has a very high inhibitory activity on IDO and can effectively inhibit the activity of IDO, and can also be used to inhibit the immunosuppression of a patient. The inhibitor can be widely used to treat or prevent cancers or tumours, viral infections, depression, neurodegenerative diseases, trauma, age-related cataracts, organ-graft refection or autoimmune diseases, and can also be developed into a new generation of immunosuppressors.
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Inventors:
WU SHENGHUA (CN)
GUO FENGYING (CN)
LI KAILONG (CN)
HUANG ZHIQIANG (CN)
BAO RUDI (CN)
GUO FENGYING (CN)
LI KAILONG (CN)
HUANG ZHIQIANG (CN)
BAO RUDI (CN)
Application Number:
PCT/CN2016/111484
Publication Date:
June 22, 2017
Filing Date:
December 22, 2016
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
C07D271/08; A61K31/4245; A61P1/00; A61P11/00; A61P17/00; A61P19/00; A61P25/00; A61P27/00; A61P29/00; A61P31/00; A61P35/00; A61P37/00
Domestic Patent References:
| WO2006122150A1 | 2006-11-16 | |||
| WO2014066834A1 | 2014-05-01 | |||
| WO2015119944A1 | 2015-08-13 | |||
| WO2008036643A2 | 2008-03-27 |
Foreign References:
| CN102164902A | 2011-08-24 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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