Title:
INDOLE COMPOUND-CONTAINING NEPHROTIC SYNDROME THERAPEUTIC OR PROPHYLACTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2019/225741
Kind Code:
A1
Abstract:
The present invention provides a nephrotic syndrome therapeutic or prophylactic agent which contains N-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-yl)-1H-indole-6-yl]-N-methyl-(2S)-2-(morpholine-4-yl) propanamide, or a pharmaceutically acceptable salt thereof.
Inventors:
UEDA YOSHIFUMI (JP)
KURIMOTO TAKAFUMI (JP)
KURIMOTO TAKAFUMI (JP)
Application Number:
PCT/JP2019/020668
Publication Date:
November 28, 2019
Filing Date:
May 24, 2019
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
A61K31/5377; A61P3/06; A61P7/00; A61P7/10; A61P13/12; A61P37/02; C07D403/04
Domestic Patent References:
| WO2011065402A1 | 2011-06-03 | |||
| WO2011065402A1 | 2011-06-03 | |||
| WO2016002918A1 | 2016-01-07 |
Foreign References:
| JP2007145786A | 2007-06-14 |
Other References:
"Evidence-based nephrotic syndrome treatment guidelines", 2014
KOHDA, T ET AL.: "High nephritogenicity of monoclonal antibodies belonging to IgG2a and IgG2b subclasses in rat anti-GBM nephritis", KIDNEY INT, vol. 66, July 2004 (2004-07-01), pages 177 - 186, XP002722779, DOI: 10.1111/j.1523-1755.2004.00719.x
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
STAHL ET AL.: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
KOHDA, T ET AL.: "High nephritogenicity of monoclonal antibodies belonging to IgG2a and IgG2b subclasses in rat anti-GBM nephritis", KIDNEY INT, vol. 66, July 2004 (2004-07-01), pages 177 - 186, XP002722779, DOI: 10.1111/j.1523-1755.2004.00719.x
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
STAHL ET AL.: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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