Title:
INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/013624
Kind Code:
A1
Abstract:
Disclosed is a compound of formula (I), which has EP1 receptor antagonist activity, or a pharmacologically acceptable salt thereof. (In formula (I), A represents a benzene ring or the like; Y1 represents a C1-6 alkylene group; Y2 represents a single bond or the like; R1 represents a hydrogen atom, a C1-6 alkyl group or the like; R2 represents an optionally substituted phenyl group, an optionally substituted five-membered aromatic heterocyclic group, an optionally substituted six-membered aromatic heterocyclic group or the like; R3 represents a halogen atom, a C1-6 alkoxy group or the like; R4 represents a hydrogen atom or the like; and R5 represents a hydrogen atom or the like.) The compound of formula (I) is able to be used as an agent for treatment or prevention of LUTS, in particular symptoms of OABS.
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Inventors:
TATANI KAZUYA (JP)
KAWAMURA NAOHIRO (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
KAWAMURA NAOHIRO (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
Application Number:
PCT/JP2010/062533
Publication Date:
February 03, 2011
Filing Date:
July 26, 2010
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
TATANI KAZUYA (JP)
KAWAMURA NAOHIRO (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
TATANI KAZUYA (JP)
KAWAMURA NAOHIRO (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
International Classes:
A61K31/404; C07D209/08; A61K31/422; A61K31/427; A61K31/4439; A61P13/02; A61P43/00; C07D401/06; C07D401/14; C07D405/04; C07D405/06; C07D405/14; C07D409/04; C07D409/06; C07D409/14; C07D413/14; C07D417/06; C07D417/14
Domestic Patent References:
| WO1998051667A1 | 1998-11-19 | |||
| WO2006041874A2 | 2006-04-20 |
Foreign References:
| JP2008214224A | 2008-09-18 |
Other References:
HALL, A. ET AL.: "Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 8, 2008, pages 2684 - 2690, XP022606372
NARIHITO SEKI, FOLIA PHARMACOLOGIA JAPONICA, vol. 129, 2007, pages 368 - 373
XIAOJUN WANG ET AL., BIOMEDICAL RESEARCH, vol. 29, 2008, pages 105 - 111
MASAHITO KAWATANI, PAIN RESEARCH, vol. 19, 2004, pages 185 - 190
MASANOBU MAEGAWA, THE JOURNAL OF THE JAPAN NEUROGENIC BLADDER SOCIETY, vol. 19, 2008, pages 169
ADRIAN HALL ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, pages 2684 - 2690
"Greene's Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE
See also references of EP 2460791A4
NARIHITO SEKI, FOLIA PHARMACOLOGIA JAPONICA, vol. 129, 2007, pages 368 - 373
XIAOJUN WANG ET AL., BIOMEDICAL RESEARCH, vol. 29, 2008, pages 105 - 111
MASAHITO KAWATANI, PAIN RESEARCH, vol. 19, 2004, pages 185 - 190
MASANOBU MAEGAWA, THE JOURNAL OF THE JAPAN NEUROGENIC BLADDER SOCIETY, vol. 19, 2008, pages 169
ADRIAN HALL ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, pages 2684 - 2690
"Greene's Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE
See also references of EP 2460791A4
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