Title:
INDOLE DERIVATIVES AND THEIR USE AS 5HT2A LIGANDS
Document Type and Number:
WIPO Patent Application WO2001007434
Kind Code:
A3
Abstract:
The invention relates to compounds of formula (I), wherein R<1> and R<3> have the meaning given in Claim 1. Said compounds are potent 5-HT2A-antagonists and are suitable for the treatment of psychosis, schizophrenia, depression, neurological disorders, memory disorders, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders, e.g. nervous bulimia and anorexia, and premenstrual syndrome and/or for positively influencing compulsive behaviours (obsessive-compulsive disorder, OCD).
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Inventors:
BOETTCHER HENNING (DE)
MAERZ JOACHIM (DE)
GREINER HARTMUT (DE)
HARTING JUERGEN (DE)
BARTOSZYK GERD (DE)
SEYFRIED CHRISTOPH (DE)
VAN AMSTERDAM CHRISTOPH (DE)
MAERZ JOACHIM (DE)
GREINER HARTMUT (DE)
HARTING JUERGEN (DE)
BARTOSZYK GERD (DE)
SEYFRIED CHRISTOPH (DE)
VAN AMSTERDAM CHRISTOPH (DE)
Application Number:
PCT/EP2000/006463
Publication Date:
May 16, 2002
Filing Date:
July 07, 2000
Export Citation:
Assignee:
MERCK PATENT GMBH (DE)
BOETTCHER HENNING (DE)
MAERZ JOACHIM (DE)
GREINER HARTMUT (DE)
HARTING JUERGEN (DE)
BARTOSZYK GERD (DE)
SEYFRIED CHRISTOPH (DE)
AMSTERDAM CHRISTOPH VAN (DE)
BOETTCHER HENNING (DE)
MAERZ JOACHIM (DE)
GREINER HARTMUT (DE)
HARTING JUERGEN (DE)
BARTOSZYK GERD (DE)
SEYFRIED CHRISTOPH (DE)
AMSTERDAM CHRISTOPH VAN (DE)
International Classes:
A61K31/404; A61P15/00; A61P25/00; A61P25/02; A61P25/14; A61K31/496; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C07D209/12; C07D209/42; C07D403/06; C07D405/14; C07D409/06; C07D409/14; (IPC1-7): C07D209/12; A61K31/404; A61P43/00; C07D403/06; C07D409/06
Domestic Patent References:
| WO1999011641A1 | 1999-03-11 |
Foreign References:
| EP0599240A1 | 1994-06-01 |
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