Title:
INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO1999057117
Kind Code:
A3
Abstract:
The invention relates to tyrosine kinase inhibitors of bis-indolyl compounds of formula (I), to the medicaments containing said inhibitors and to their use in treating malignant and other diseases caused by pathological cell proliferation.
Inventors:
MAHBOOBI SIAVOSH
KUHR SABINE
PONGRATZ HERWIG
POPP ALFRED
HUFSKY HARALD
BOEHMER FRANK-D
TELLER STEFFEN
UECKER ANDREA
BECKERS THOMAS
KUHR SABINE
PONGRATZ HERWIG
POPP ALFRED
HUFSKY HARALD
BOEHMER FRANK-D
TELLER STEFFEN
UECKER ANDREA
BECKERS THOMAS
Application Number:
PCT/DE1999/001214
Publication Date:
April 12, 2001
Filing Date:
April 22, 1999
Export Citation:
Assignee:
ASTA MEDICA AG (DE)
International Classes:
A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/407; A61K31/443; A61K31/4433; A61K31/454; A61K31/47; A61K31/496; A61K31/5377; A61K31/7042; A61K31/7052; A61K31/7056; A61P5/04; A61P35/00; C07D209/12; C07D209/14; C07D315/00; C07D333/56; C07D401/14; C07D403/14; C07D405/06; C07D405/14; C07D409/06; C07D471/22; C07D487/14; C07D487/22; C07D491/14; C07D491/147; C07F7/10; C07H19/04; (IPC1-7): C07D209/14; A61K31/40; A61K31/38; A61K31/47; C07D333/56; C07D409/06; C07D405/06; C07D487/14; C07D491/14; C07D403/14; C07H19/04; C07F7/10; C07D401/14; C07D487/22; C07D471/22
Domestic Patent References:
| WO1995017182A1 | 1995-06-29 | |||
| WO1994024117A1 | 1994-10-27 |
Foreign References:
| EP0778274A1 | 1997-06-11 |
Other References:
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O. DANN ET AL.: "Trypanocide Diamidine mit vier Ringen in einem oder zwei Ringsystemen", JUSTUS LIEBIGS ANNALEN DER CHEMIE., 1973, VERLAG CHEMIE GMBH. WEINHEIM., DE, pages 1112 - 1140, XP002120347, ISSN: 0075-4617
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CHEMICAL ABSTRACTS, vol. 115, no. 15, 1991, Columbus, Ohio, US; abstract no. 158875s, C.F. NUTAITIS ET AL.: "Reduction of heterocyclic alcohols with sodium borohydridr-trifluoroacetic acid. preparation of bis-heterocyclic methanes" page 911; XP002120350
E. FISCHER ET AL: "Synthesis of new sulfur heteroaromatics isoelectronic with dibenzo[g,p]chrysene by photocylization of thienyl- and phenyl-sunstituted ethenes", JOURNAL OF ORGANIC CHEMISTRY., vol. 61, no. 20, 1996, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 6997 - 7005, XP002120346, ISSN: 0022-3263
CHEMICAL ABSTRACTS, vol. 107, no. 5, 1987, Columbus, Ohio, US; abstract no. 39594z, J.M. GONZALEZ: "Process for the preparaton of 2,2'-dibenzofurylic compounds" page 678; XP002120351
CHEMICAL ABSTRACTS, vol. 105, no. 21, 1986, Columbus, Ohio, US; abstract no. 190793t, M. NAGAHARA ET AL.: "Synthesis and antiviral activity of bis(hydroxy-2-benzofuranyl)ketone derivative" page 702; XP002120352
O. DANN ET AL.: "Trypanocide Diamidine mit vier Ringen in einem oder zwei Ringsystemen", JUSTUS LIEBIGS ANNALEN DER CHEMIE., 1973, VERLAG CHEMIE GMBH. WEINHEIM., DE, pages 1112 - 1140, XP002120347, ISSN: 0075-4617
M. AHMED ET AL.: "The direct Bradsher reaction. Part I. Synthesis of thiophen analogues of linear polycyclic hydrocarbons", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1., no. 10, 1973, CHEMICAL SOCIETY. LETCHWORTH., GB, pages 1099 - 103, XP002120348, ISSN: 0300-922X
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