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Title:
INDOLE MACROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2020/063792
Kind Code:
A1
Abstract:
The present invention relates to an indole macrocyclic derivative, a preparation method therefor and an application thereof in medicine. Specifically, the present invention relates to an indole macrocyclic derivative represented by general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and a use thereof as a therapeutic agent, especially as an MCL-1 inhibitor. Each substituent of general formula (IM) is the same as those defined in the description.

Inventors:
ZHANG GUOBAO (CN)
FEI HONGBO (CN)
ZHANG XIAOMIN (CN)
HU WEIMIN (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2019/108322
Publication Date:
April 02, 2020
Filing Date:
September 27, 2019
Export Citation:
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Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D515/22; A61K31/395; A61P35/00
Domestic Patent References:
WO2018178226A12018-10-04
WO2017156181A12017-09-14
WO2017182625A12017-10-26
WO2018178226A12018-10-04
Foreign References:
US20170305926A12017-10-26
US20170305926A12017-10-26
CN101711235A2010-05-19
CN101711235A2010-05-19
Other References:
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 23, 2003, pages 9116 - 9118
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 16, 2013, pages 4523 - 4527
"NCBI", Database accession no. 043521
See also references of EP 3858840A4
Attorney, Agent or Firm:
GE CHENG & CO.LTD (CN)
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