Title:
INDOLE MACROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2020/221272
Kind Code:
A1
Abstract:
The present disclosure relates to an indole macrocyclic derivative, a preparation method therefor and use thereof in medicine. Specifically, the present disclosure relates to an indole macrocyclic derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, use thereof as a therapeutic agent, especially as an MCL-1 inhibitor, and use thereof for treating tumors, autoimmune diseases or immune system diseases, each substituent of the general formula (I) has the same definition as that in the description.
Inventors:
ZHANG XIAOMIN (CN)
FEI HONGBO (CN)
HE FENG (CN)
TAO WEIKANG (CN)
FEI HONGBO (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2020/087671
Publication Date:
November 05, 2020
Filing Date:
April 29, 2020
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D515/22; A61P35/00; A61P35/02; C07D209/42; C07D498/04
Domestic Patent References:
| WO2018178226A1 | 2018-10-04 |
Foreign References:
| CN109071566A | 2018-12-21 | |||
| CN101743224A | 2010-06-16 | |||
| CN110845520A | 2020-02-28 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
Download PDF: