INDOLE-TYPE INHIBITORS OF P38 KINASE

WIPO Patent Application WO2002044168

A3

The invention is directed to inhibition of p38- alpha kinase using compounds of formula (I) and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein Ar is an aryl group substituted with 0-5 non-interfering substituents, wherein two adjacent noninterfering substituents can form a fused aromatic or nonaromatic ring; L<1> and L<2> are linkers; X is an aliphatic monocyclic or aliphatic polycyclic moiety optionally comprising one or more hetero ring atoms wherein the cyclic moiety may be optionally substituted with one or more noninterfering substituents and where said optional substituents may constitute a ring fused to X; n is 0-3; each R<1> is hydrogen or a noninterfering substituent; (2) represents a single or double bond; one Z<2> is CA or CR<2>A; the other Z<2> is CR<3>, CR<3>2, NR<4> or N; and each R<2>, R<3> and R<4> is independently hydrogen or a noninterfering substituent; Z<3> is NR<5> or O; where R<5> is hydrogen or a noninterfering substituent.

DUGAR SUNDEEP
LUEDTKE GREGORY R
TESTER RICHLAND
LU QING
PERUMATTAM JOHN
TAN XUEFEI

PCT/US2001/043439

May 22, 2003

November 20, 2001

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SCIOS INC (US)

A61K31/404; A61K31/407; A61K31/454; A61K31/573; A61K39/395; A61K45/00; A61P1/04; A61P9/10; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P25/00; A61P25/08; A61P25/28; A61P29/00; A61P31/04; A61P33/06; A61P35/00; A61P37/06; A61P43/00; C07D209/18; C07D401/06; C07D401/12; C07D403/12; C07D487/04; C07D487/10; (IPC1-7): C07D403/12; A61K31/404; A61P43/00; C07D487/10; C07D487/04; C07D209/18; C07D401/12; C07D401/14

WO2001064676A2	2001-09-07
WO1999061426A1	1999-12-02
WO2000071535A1	2000-11-30

See also references of EP 1339708A2

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