Title:
INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/007321
Kind Code:
A1
Abstract:
Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor compound, a preparation method therefor, and an application thereof. The indoleamine-2,3-dioxygenase inhibitor compound provided by the present invention is as represented by formula I. Compared with a corresponding non-deuterated compound, the deuterated compound in the present invention has obviously more excellent pharmacodynamic properties and pharmacokinetic properties, and Cmax is increased by 50% or more, and AUC is increased by 10% or more. Thus, the exposure of the deuterated compound in animal bodies is significantly increased. Therefore, the deuterated compound is more suitable as an indoleamine-2,3-dioxygenase inhibitor, and is accordingly more suitable for preparation of drugs for treatment of diseases associated with indoleamine-2,3-dioxygenase inhibitors.
Inventors:
ZHANG FUYAO (CN)
LIU JIAQING (CN)
SHEN XIAOMING (CN)
LIU JIAQING (CN)
SHEN XIAOMING (CN)
Application Number:
PCT/CN2018/094234
Publication Date:
January 10, 2019
Filing Date:
July 03, 2018
Export Citation:
Assignee:
SELECTION BIOSCIENCE LLC (CN)
International Classes:
C07D271/08; A61K31/41; A61K31/4245; A61K39/395; A61P1/00
Domestic Patent References:
| WO2017143874A1 | 2017-08-31 | |||
| WO2015070007A1 | 2015-05-14 |
Other References:
JIANG, W., ET. AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 12 July 2012 (2012-07-12), pages 682 - 684, XP008173943, ISSN: 1672-7738
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF: