Title:
INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/149255
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I). The present invention also relates to a pharmaceutical composition containing the compound of formula (I) and use of the compound in the preparation of an indoleamine-2,3-dioxygenase (IDO) inhibitor drug. The compound prepared in the present invention has an obvious inhibition effect on IDO protease, and metabolizes stably in the body. The present compound or pharmaceutical composition thereof can be used for preparing an IDO inhibitor drug, and can also be used for preparing a drug for preventing and/or treating diseases having IDO-mediated tryptophan metabolic pathway pathological features.
Inventors:
DU WU (CN)
REN WEN (CN)
LV HAIBIN (CN)
LI HAIBO (CN)
WEN KUN (CN)
HE JINYUN (CN)
QIN DEKUN (CN)
LI XINGHAI (CN)
CHEN YUANWEI (CN)
REN WEN (CN)
LV HAIBIN (CN)
LI HAIBO (CN)
WEN KUN (CN)
HE JINYUN (CN)
QIN DEKUN (CN)
LI XINGHAI (CN)
CHEN YUANWEI (CN)
Application Number:
PCT/CN2019/074274
Publication Date:
August 08, 2019
Filing Date:
January 31, 2019
Export Citation:
Assignee:
HINOVA PHARMACEUTICALS INC (CN)
International Classes:
C07D271/08; A61K31/4245; A61P25/00; A61P25/22; A61P25/24; A61P27/12; A61P35/00; A61P37/02
Domestic Patent References:
| WO2007075598A2 | 2007-07-05 | |||
| WO2016155545A1 | 2016-10-06 | |||
| WO2010005958A2 | 2010-01-14 | |||
| WO2013174947A1 | 2013-11-28 | |||
| WO2014066834A1 | 2014-05-01 | |||
| WO2016155545A1 | 2016-10-06 | |||
| WO2017106062A1 | 2017-06-22 |
Foreign References:
| CN108863976A | 2018-11-23 | |||
| CN102164902A | 2011-08-24 | |||
| CN105646389A | 2016-06-08 | |||
| CN107176933A | 2017-09-19 | |||
| CN201610059454A | 2016-01-28 | |||
| CN201710000610A | 2017-01-03 | |||
| US20080146642A1 | 2008-06-19 |
Other References:
"Fundamentals of New Drug Design and Development", 30 November 2015, SHANDONG UNIVERSITY PRESS, CN, article ZHAO GUISEN ET AL : "Passage; Fundamentals of New Drug Design and Development", pages: 139 - 140, XP009523008
BIOORANIC&MEDICINAL CHEMISTRY, vol. 9, 2001, pages 2709
JOUMAL OF MEDICINAL CHEMISTRY, vol. 53, 2010, pages 2390
BIOORANIC& MEDICINAL CHEMISTRY, vol. 9, 2001, pages 2709
See also references of EP 3747875A4
BIOORANIC&MEDICINAL CHEMISTRY, vol. 9, 2001, pages 2709
JOUMAL OF MEDICINAL CHEMISTRY, vol. 53, 2010, pages 2390
BIOORANIC& MEDICINAL CHEMISTRY, vol. 9, 2001, pages 2709
See also references of EP 3747875A4
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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