Title:
INDOLES AS NAALADASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2003057670
Kind Code:
A3
Abstract:
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALAdase levels are altered, effecting neuronal activity, effecting TGF- beta activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
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Inventors:
TSUKAMOTO TAKASHI (US)
GRELLA BRIAN (US)
MAJER PAVEL (US)
GRELLA BRIAN (US)
MAJER PAVEL (US)
Application Number:
PCT/US2002/037617
Publication Date:
November 06, 2003
Filing Date:
December 19, 2002
Export Citation:
Assignee:
GUILFORD PHARM INC (US)
TSUKAMOTO TAKASHI (US)
GRELLA BRIAN (US)
MAJER PAVEL (US)
TSUKAMOTO TAKASHI (US)
GRELLA BRIAN (US)
MAJER PAVEL (US)
International Classes:
A61K31/405; A61P43/00; C07D209/02; C07D209/42; (IPC1-7): C07D209/42; A61K31/404; A61P43/00; G01N33/00
Domestic Patent References:
| WO2001092273A2 | 2001-12-06 | |||
| WO2000001668A2 | 2000-01-13 |
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