Title:
INDUCED EXTENDED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USING
Document Type and Number:
WIPO Patent Application WO/2017/025061
Kind Code:
A1
Abstract:
Factors for extending the ability of isolated pluripotent stem cells to generate extraembryonic lineages in vivo, following in vitro culture, herein, chemical extenders of pluripotency (CEP). Methods of extending the ability of a pluripotent cell to generate embryonic and extraembryonic lineages. The cell to be reprogrammed is contacted with effective amounts of the CEPs for a sufficient period of time to reprogram the cell into a chemically induced extended pluripotent cell (ciEPSC). ciEPSC are identified as an extended pluripotent cell based on properties including: (i) morphologically and (ii) functionally for example, based on their ability contribute to both TE and ICM, in vivo. The ciEPSCs can be cultured or induced to differentiate into cells of a desired type, and used in a number of applications, including but not limited to cell therapy and tissue engineering.
Inventors:
DENG HONGKUI (CN)
YANG YANG (CN)
LIU BEI (CN)
XU JUN (CN)
YANG YANG (CN)
LIU BEI (CN)
XU JUN (CN)
Application Number:
PCT/CN2016/094828
Publication Date:
February 16, 2017
Filing Date:
August 12, 2016
Export Citation:
Assignee:
UNIV BEIJING (CN)
HONG GUAN LTD (CN)
HONG GUAN LTD (CN)
International Classes:
C07K14/54; C12N5/00; C07K14/715; C07K16/38; C07K16/40; C12N5/07; C12N5/074; C12N5/0789; C12N5/0797; C12N5/095
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See also references of EP 3334820A4
TACHIBANA ET AL., CELL, vol. 148, no. 1-2, 2012, pages 285 - 295
TAKASHIMA ET AL., CELL, vol. 158, 2014, pages 1254 - 1269
CHAN ET AL., CELL STEM CELL, vol. 13, 2013, pages 663 - 675
THEUNISSEN ET AL., CELL STEM CELL, vol. 15, 2014, pages 471 - 487
EVANS ET AL., NATURE, vol. 292, 1981, pages 154 - 156
BUEHR ET AL., CELL, vol. 135, 2008, pages 1287 - 1298
THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 2072 - 2075
GAFNI ET AL., NATURE, vol. 502, no. 7479, 2013, pages 340 - 345
HAN ET AL., CELL, vol. 143, 2010, pages 617 - 627
CAS, no. 1127442-82-3
CAS , no. 284028-89-3
HOU ET AL., SCIENCE, vol. 341, no. 6146, 2013, pages 651 - 4
BALLADUR ET AL., SURGERY, vol. 117, 1995, pages 189 - 94
DIXIT ET AL., CELL TRANSPLANTATION, vol. 1, 1992, pages 275 - 79
SHAPIRO ET AL., N ENGL J MED., vol. 343, no. 4, 2000, pages 230 - 8
WILLERTH, S.M.SAKIYAMA-ELBERT, S.E.: "Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery", 9 July 2008, THE STEM CELL RESEARCH COMMUNITY
ITO ET AL., CELLULAR & MOLECULAR IMMUNOLOGY, vol. 9, 2012, pages 208 - 214
NISHINAKAMURA ET AL., DEVELOPMENT, vol. 128, 2001, pages 3105 - 3115
OFFIELD ET AL., DEVELOPMENT, vol. 122, 1996, pages 881 - 894
MCMAHON ET AL., CELL, vol. 62, 1990, pages 1073 - 1085
KIMURA ET AL., GENES AND DEVELOPMENT, vol. 10, 1996, pages 60 - 69
CELLI ET AL., EMBO J., vol. 17, 1998, pages 1642 - 655
TESAR ET AL., NATURE, vol. 448, 2007, pages 196 - 199
TESAR ET AL., DEV.,, vol. 448, 2007, pages 196 - 199
JAMES ET AL., DEV., vol. 132, 2005, pages 1273 - 1282
VALLIER ET AL., J. CELL. SCI., vol. 118, 2005, pages 4495 - 4509
OKITA ET AL., NAT. METHODS, vol. 8, no. 5, 2011, pages 409 - 12
SUMMERS ET AL., J. ASSIST REPROD. DENET., vol. 30, no. 8, 2013, pages 995 - 999
LONGO ET AL., TRANSGENIC RES., vol. 6, 1997, pages 321 - 328
HUANG ET AL., NATURE PROTOCOLS, vol. 4, 2009, pages 44 - 57
TANG ET AL., PLOS ONE, vol. 6, 2011, pages e21208
YAN ET AL., NAT. STRUCT. MOL. BIOL., vol. 20, 2013, pages 1131 - 1139
BLAKELEY ET AL., DEV., vol. 142, 2015, pages 3151 - 3156
PICELLI ET AL., NATURE PROTOCOLS, vol. 9, 2014, pages 171 - 181
BEDDINGTON ET AL., DEV., vol. 105, 1989, pages 733 - 737
DE LOS ANGELES, NATURE, vol. 525, 2015, pages 569 - 478
JAMES ET AL., DEV. BIOL., vol. 295, 2006, pages 90 - 102
ROSSANT ET AL., NAT. REV. GEN., vol. 2, 2001, pages 538 - 548
THEUSEN ET AL., CELL STEM CELL, vol. 8, 2011, pages 318 - 325
MALASSIE ET AL., HUMAN REPROD, vol. 9, 2003, pages 531 - 539
MACFARLAN ET AL., NATURE, vol. 487, 2011, pages 57 - 63
PFAFF ET AL., EUR. J., PHAMACOL., vol. 286, 1995, pages 229 - 240
ALANO ET AL., PROC. NATL., ACAD. SCI. USA, vol. 103, 2006, pages 9685 - 9690
MORSE ET AL., J. PHARMACOL. EXP. THER., vol. 296, 2001, pages 1058 - 1066
OCKENGA ET AL., GENES (BASEL), vol. 4, 2013, pages 171 - 79
MACFARLAN ET AL., NATURE, vol. 487, 2012, pages 57 - 63
MORGANI ET AL., CELL REP., vol. 3, 2012, pages 1945 - 4957
MARTIN ET AL., PROC NATL ACAD SCI USA, vol. 78, 1981, pages 7634 - 7638
See also references of EP 3334820A4
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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