Title:
INDUCED REJUVENATED MESENCHYMAL STEM CELLS (irMSCs) AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/213796
Kind Code:
A1
Abstract:
Provided a method to produce induced rejuvenated mesenchymal stem cells(irMSCs) from a primary fibroblast. Also provided are pharmaceutical compositons comprising at least one irMSC, and methods to use irMSC for treating bone injury or promoting bone repair in a subject, or for eliciting cartilage regeneration.
Inventors:
HU MIN (CN)
SUN YI (US)
SUN YI (US)
Application Number:
PCT/CN2018/085752
Publication Date:
November 14, 2019
Filing Date:
May 05, 2018
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
HU MIN (CN)
HU MIN (CN)
International Classes:
C12N5/07; A61K35/36; A61P19/00; C12N5/071
Domestic Patent References:
| WO2016009446A2 | 2016-01-21 |
Other References:
LAI, P.L. ET AL.: "Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts", SCIENTIFIC REPORTS, vol. 7, no. 1, 17 March 2017 (2017-03-17), pages 1 - 13, XP055650768, ISSN: 2045-2322, DOI: 10.1038/srep44534
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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