Title:
INDUCER FOR INCREASING OF CONTENT OF CYTOPROTECTIVE AMINO ACID AND METHOD FOR INCREASING THE CONTENT
Document Type and Number:
WIPO Patent Application WO/2007/073006
Kind Code:
A1
Abstract:
Disclosed is an inducer for the increasing of the content of a cytoprotective
amino acid (methionine and/or homocysteine) in a living body, which comprises
at least one component selected from the group consisting of carbon monooxide,
protoheme IX, protoporphyrin IX, dopamine and dobutamine, wherein protoheme
IX, protoporphyrin IX, dopamine and dobutamine have an effect of increasing
the content of carbon monooxide in a living body. Also disclosed is a pharmaceutical
composition (kit) for use in the protection of a cell or the treatment of an disorder
in a cell, which comprises at least one component selected from the group consisting
of carbon monooxide, protoheme IX, protoporphyrin IX, dopamine, dobutamine,
methionine and homocysteine.
Inventors:
SUEMATSU MAKOTO (JP)
Application Number:
PCT/JP2006/326307
Publication Date:
June 28, 2007
Filing Date:
December 22, 2006
Export Citation:
Assignee:
UNIV KEIO (JP)
SUEMATSU MAKOTO (JP)
SUEMATSU MAKOTO (JP)
International Classes:
A61K31/137; A61K31/198; A61K31/409; A61K33/00; A61P39/00; A61P43/00
Foreign References:
| JP2005533021A | 2005-11-04 | |||
| JP2005533812A | 2005-11-10 | |||
| JP2005530737A | 2005-10-13 | |||
| JP2005336167A | 2005-12-08 | |||
| JP2005510537A | 2005-04-21 | |||
| JP2004018418A | 2004-01-22 | |||
| JPH10500137A | 1998-01-06 | |||
| JP2003155242A | 2003-05-27 |
Other References:
SUEMATSU M.: "Morateki Taisha Keisoku Gijutsu ni Motozuku Saibo Kino Simulation to Sono Oyo", MINISTRY OF EDUCATION, CULTURE, SPORTS, SCIENCE AND TECHNOLOGY LEADING PROJECT, SAIBO.SEITAIKINO SIMULATION PROJECT, HEISEI 17 NENDO SEIKA HOKOKUSHO, KEIO UNIVERSITY SHOSAI HOKOKUSHO, 30 May 2006 (2006-05-30), XP003014712
DURANTE W. TE AL.: "cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle", AMERICAN JOURNAL OF PHYSIOLOGY- HEART AND CIRCULATORY PHYSIOLOGY, vol. 273, no. 1, 1997, pages H317 - H323, XP008082014
DURANTE W. TE AL.: "cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle", AMERICAN JOURNAL OF PHYSIOLOGY- HEART AND CIRCULATORY PHYSIOLOGY, vol. 273, no. 1, 1997, pages H317 - H323, XP008082014
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (IKUBO & KATAYAMA Fukuoka, Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-k, Tokyo 28, JP)
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