Title:
INDUCIBLE MODIFICATION OF A CELL GENOME
Document Type and Number:
WIPO Patent Application WO/2017/064566
Kind Code:
A3
Abstract:
The present disclosure is directed, in some embodiments, to compositions and methods for inducible modification of a cell genome.
Inventors:
MARESCA MARCELLO (SE)
BOHLOOLY-YEGANEH MOHAMMAD (SE)
JAISWAL HIMJYOT (SE)
MAYR LORENZ M (SE)
XU XIUFENG (SE)
BOHLOOLY-YEGANEH MOHAMMAD (SE)
JAISWAL HIMJYOT (SE)
MAYR LORENZ M (SE)
XU XIUFENG (SE)
Application Number:
PCT/IB2016/001902
Publication Date:
May 26, 2017
Filing Date:
October 14, 2016
Export Citation:
Assignee:
ASTRAZENECA AB (SE)
International Classes:
C12N15/11; C12N15/79
Domestic Patent References:
| WO2014018423A2 | 2014-01-30 | |||
| WO2014093595A1 | 2014-06-19 |
Other References:
H. ZHU ET AL.: "Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells", NUCLEIC ACIDS RESEARCH, vol. 41, no. 19, 13 August 2013 (2013-08-13), pages e180 - e180, XP055362250, ISSN: 0305-1048, DOI: 10.1093/nar/gkt721
BERND ZETSCHE ET AL.: "Cpf1 is a single RNA-guided Endonuclease of a class 2 CRISPR-Cas system", CELL, vol. 163, no. 3, 25 September 2015 (2015-09-25), US, pages 759 - 771, XP055267511, ISSN: 0092-8674, DOI: 10.1016/j.cell.2015.09.038
UTOMO AHMAD R.H. ET AL.: "Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice", NATURE BIOTECHNOLOGY, vol. 17, no. 11, 1 November 1999 (1999-11-01), pages 1091 - 1096, XP002186984, ISSN: 1087-0156, DOI: 10.1038/15073
KAIWEN IVY LIU ET AL: "A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing", NATURE CHEMICAL BIOLOGY, vol. 12, no. 11, 12 September 2016 (2016-09-12), pages 980 - 987, XP055362630, ISSN: 1552-4450, DOI: 10.1038/nchembio.2179
BERND ZETSCHE ET AL.: "Cpf1 is a single RNA-guided Endonuclease of a class 2 CRISPR-Cas system", CELL, vol. 163, no. 3, 25 September 2015 (2015-09-25), US, pages 759 - 771, XP055267511, ISSN: 0092-8674, DOI: 10.1016/j.cell.2015.09.038
UTOMO AHMAD R.H. ET AL.: "Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice", NATURE BIOTECHNOLOGY, vol. 17, no. 11, 1 November 1999 (1999-11-01), pages 1091 - 1096, XP002186984, ISSN: 1087-0156, DOI: 10.1038/15073
KAIWEN IVY LIU ET AL: "A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing", NATURE CHEMICAL BIOLOGY, vol. 12, no. 11, 12 September 2016 (2016-09-12), pages 980 - 987, XP055362630, ISSN: 1552-4450, DOI: 10.1038/nchembio.2179
Attorney, Agent or Firm:
WINTER, Christopher, Spencer et al. (GB)
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