Title:
CARTILAGE/BONE INDUCING MATERIALS FOR REPARATION
Document Type and Number:
WIPO Patent Application WO/1997/018829
Kind Code:
A1
Abstract:
Cartilage/bone inducing materials for reparation which contain a bone inducer and polyoxyethylene polyoxypropylene glycol. In a particularly preferable example, the molecular weight of the polypropylene glycol constituting the polyoxyethylene polyoxypropylene glycol falls within the range of from about 1,500 to 4,000, the weight ratio of the ethylene oxide units falls within the range of from about 40 to 80 %/molecule, and the concentration of the polyoxyethylene polyoxypropylene glycol is about 10 to 50 % based on the aqueous solution. These materials are used in the cartilage/bone induction method without requiring any operation. Because of being composed of a bone inducer and a carrier which is easily absorbed in vivo, highly compatible with the bone inducer and undergoes reversible sol-gel change depending on the temperature, they can be highly applicable to fracture and bone-defective sites and thus exert excellent therapeutic effects.
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Inventors:
SHIMURA TAKESADA (JP)
TORIYAMA SATSUKI (JP)
TORIYAMA SATSUKI (JP)
Application Number:
PCT/JP1996/003333
Publication Date:
May 29, 1997
Filing Date:
November 14, 1996
Export Citation:
Assignee:
HOECHST JAPAN (JP)
SHIMURA TAKESADA (JP)
TORIYAMA SATSUKI (JP)
SHIMURA TAKESADA (JP)
TORIYAMA SATSUKI (JP)
International Classes:
A61F2/28; A61F2/30; A61K38/00; A61K38/18; C12N15/09; A61K47/32; A61K47/34; A61L27/22; A61P3/00; A61P43/00; C07K14/51; C12P21/02; A61F2/02; C12R1/19; (IPC1-7): A61K38/18; A61K47/32; A61F2/28; A61B17/56; A61M37/00
Domestic Patent References:
| WO1996021427A1 | 1996-07-18 | |||
| WO1994001483A1 | 1994-01-20 |
Foreign References:
| JPS61277612A | 1986-12-08 | |||
| JPH06508777A | 1994-10-06 | |||
| JPS62135431A | 1987-06-18 | |||
| JPH01265968A | 1989-10-24 |
Other References:
See also references of EP 0884052A4
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