Title:
INDUSTRIAL PREPARATION METHOD OF MIDAZOLAM
Document Type and Number:
WIPO Patent Application WO/2016/146049
Kind Code:
A1
Abstract:
Provided is an industrial preparation method of midazolam, characterized in that a compound A and a compound B have a ring reaction under a catalyst condition. The preparation method is simple, differs from a complex production manner and a severe production condition in the prior art, and synthesizes a target product by one step. A production rate of the method is increased by at least 50% relative to a multi-step synthesis in the prior art. Since a production process and a synthesis route are optimized, the present invention has less side reaction in the production process, is convenient for post-processing, requires a mild production condition, and is suitable for an industrial production mode.
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Inventors:
WANG ZHIXUN (CN)
Application Number:
PCT/CN2016/076319
Publication Date:
September 22, 2016
Filing Date:
March 14, 2016
Export Citation:
Assignee:
WANG ZHIXUN (CN)
International Classes:
C07D487/04; C07D243/16
Foreign References:
US5831089A | 1998-11-03 | |||
CN103319486A | 2013-09-25 | |||
CN1315953A | 2001-10-03 | |||
CN103804384A | 2014-05-21 |
Attorney, Agent or Firm:
SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
上海精晟知识产权代理有限公司 (CN)
上海精晟知识产权代理有限公司 (CN)
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