Title:
INFECTION INHIBITOR FOR NOVEL CORONAVIRUS (SARS-COV-2)
Document Type and Number:
WIPO Patent Application WO/2023/063325
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide therapeutic and preventive agents for COVID-19. The present invention provides a therapeutic or preventive composition for COVID-19, said composition containing an ADAM10 inhibitor. The ADAM10 inhibitor is, for example, a small molecule, a nuclear acid, an siRNA, or the like. The composition of the present invention may be used in combination with a drug other than the ADAM10 inhibitor.
Inventors:
INOUE JUN-ICHIRO (JP)
KAWAGUCHI YASUSHI (JP)
GOHDA JIN (JP)
AKIYAMA TETSU (JP)
YAMAMOTO MIZUKI (JP)
KAWAGUCHI YASUSHI (JP)
GOHDA JIN (JP)
AKIYAMA TETSU (JP)
YAMAMOTO MIZUKI (JP)
Application Number:
PCT/JP2022/037941
Publication Date:
April 20, 2023
Filing Date:
October 11, 2022
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K45/00; A61K31/16; A61K31/396; A61K31/4704; A61K31/541; A61K33/20; A61K45/06; A61K48/00; A61P31/14
Domestic Patent References:
| WO2021076712A1 | 2021-04-22 |
Other References:
ATHANASIOS DIDANGELOS: "ABSTRACT", MSPHERE, vol. 5, no. 3, XP055752095, DOI: 10.1128/mSphere.00367-20
IMBERT ISABELLE, GUILLEMOT JEAN-CLAUDE, BOURHIS JEAN-MARIE, BUSSETTA CÉCILE, COUTARD BRUNO, EGLOFF MARIE-PIERRE, FERRON FRANÇOIS, : "A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus", THE EMBO JOURNAL / EUROPEAN MOLECULAR BIOLOGY ORGANIZATION, IRL PRESS, OXFORD, vol. 25, no. 20, 18 October 2006 (2006-10-18), Oxford , pages 4933 - 4942, XP093055307, ISSN: 0261-4189, DOI: 10.1038/sj.emboj.7601368
SHEKHAWAT JYOTI; GAUBA KAVYA; GUPTA SHRUTI; PUROHIT PURVI; MITRA PRASENJIT; GARG MAHENDRA; MISRA SANJEEV; SHARMA PRAVEEN; BANERJEE: "Interleukin-6 Perpetrator of the COVID-19 Cytokine Storm", INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY, SPRINGER PRIVATE LTD., IN, vol. 36, no. 4, 21 June 2021 (2021-06-21), IN , pages 440 - 450, XP037568810, ISSN: 0970-1915, DOI: 10.1007/s12291-021-00989-8
NGUYEN HANH T., SHIJIAN ZHANG, QIAN WANG, SAUMYA ANANG, JIA WANG, HAITAO DING, JOHN C. KAPPES, JOSEPH SODROSKI: "Spike Glycoprotein and Host Cell Determinants of SARS-CoV-2 Entry and Cytopathic Effects", JOURNAL OF VIROLOGY, vol. 95, no. 5, pages 10.1128/jvi.02304 - 20, XP093057303, DOI: 10.1128/jvi.02304-20
TOMITA YURIKO, MATSUYAMA SHUTOKU, FUKUHARA HIDEO, MAENAKA KATSUMI, KATAOKA HIROAKI, HASHIGUCHI TAKAO, TAKEDA MAKOTO: "The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 95, no. 12, 24 May 2021 (2021-05-24), US , XP093057300, ISSN: 0022-538X, DOI: 10.1128/JVI.00434-21
LIU TIANXIAO; LUO SONGYUAN; LIBBY PETER; SHI GUO-PING: "Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients", PHARMACOLOGY & THERAPEUTICS, ELSEVIER., GB, vol. 213, 26 May 2020 (2020-05-26), GB , XP086249684, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2020.107587
MA YUANCHEN, HUANG YINONG, WANG TAO, XIANG ANDY PENG, HUANG WEIJUN: "ACE2 Shedding and Furin Abundance in Target Organs may Influence the Efficiency of SARS-CoV-2 Entry", THE OPEN BIOINFORMATICS JOURNAL, vol. 14, no. 1, 22 March 2021 (2021-03-22), pages 1 - 12, XP093057298, ISSN: 1875-0362, DOI: 10.2174/1875036202114010001
JOCHER GEORG, GRASS VINCENT, TSCHIRNER SARAH K, RIEPLER LYDIA, BREIMANN STEPHAN, KAYA TUĞBERK, OELSNER MADLEN, HAMAD M SABRI, HOFM: "ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion", EMBO REPORTS, NATURE PUBLISHING GROUP, LONDON, GB, vol. 23, no. 6, 7 June 2022 (2022-06-07), GB , XP093057297, ISSN: 1469-221X, DOI: 10.15252/embr.202154305
YAMAMOTO MIZUKI, GOHDA JIN, KOBAYASHI AYAKO, TOMITA KEIKO, HIRAYAMA YOUKO, KOSHIKAWA NAOHIKO, SEIKI MOTOHARU, SEMBA KENTARO, AKIYA: "Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein", MBIO, vol. 13, no. 4, 30 August 2022 (2022-08-30), XP093057295, DOI: 10.1128/mbio.00519-22
IMBERT ISABELLE, GUILLEMOT JEAN-CLAUDE, BOURHIS JEAN-MARIE, BUSSETTA CÉCILE, COUTARD BRUNO, EGLOFF MARIE-PIERRE, FERRON FRANÇOIS, : "A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus", THE EMBO JOURNAL / EUROPEAN MOLECULAR BIOLOGY ORGANIZATION, IRL PRESS, OXFORD, vol. 25, no. 20, 18 October 2006 (2006-10-18), Oxford , pages 4933 - 4942, XP093055307, ISSN: 0261-4189, DOI: 10.1038/sj.emboj.7601368
SHEKHAWAT JYOTI; GAUBA KAVYA; GUPTA SHRUTI; PUROHIT PURVI; MITRA PRASENJIT; GARG MAHENDRA; MISRA SANJEEV; SHARMA PRAVEEN; BANERJEE: "Interleukin-6 Perpetrator of the COVID-19 Cytokine Storm", INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY, SPRINGER PRIVATE LTD., IN, vol. 36, no. 4, 21 June 2021 (2021-06-21), IN , pages 440 - 450, XP037568810, ISSN: 0970-1915, DOI: 10.1007/s12291-021-00989-8
NGUYEN HANH T., SHIJIAN ZHANG, QIAN WANG, SAUMYA ANANG, JIA WANG, HAITAO DING, JOHN C. KAPPES, JOSEPH SODROSKI: "Spike Glycoprotein and Host Cell Determinants of SARS-CoV-2 Entry and Cytopathic Effects", JOURNAL OF VIROLOGY, vol. 95, no. 5, pages 10.1128/jvi.02304 - 20, XP093057303, DOI: 10.1128/jvi.02304-20
TOMITA YURIKO, MATSUYAMA SHUTOKU, FUKUHARA HIDEO, MAENAKA KATSUMI, KATAOKA HIROAKI, HASHIGUCHI TAKAO, TAKEDA MAKOTO: "The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 95, no. 12, 24 May 2021 (2021-05-24), US , XP093057300, ISSN: 0022-538X, DOI: 10.1128/JVI.00434-21
LIU TIANXIAO; LUO SONGYUAN; LIBBY PETER; SHI GUO-PING: "Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients", PHARMACOLOGY & THERAPEUTICS, ELSEVIER., GB, vol. 213, 26 May 2020 (2020-05-26), GB , XP086249684, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2020.107587
MA YUANCHEN, HUANG YINONG, WANG TAO, XIANG ANDY PENG, HUANG WEIJUN: "ACE2 Shedding and Furin Abundance in Target Organs may Influence the Efficiency of SARS-CoV-2 Entry", THE OPEN BIOINFORMATICS JOURNAL, vol. 14, no. 1, 22 March 2021 (2021-03-22), pages 1 - 12, XP093057298, ISSN: 1875-0362, DOI: 10.2174/1875036202114010001
JOCHER GEORG, GRASS VINCENT, TSCHIRNER SARAH K, RIEPLER LYDIA, BREIMANN STEPHAN, KAYA TUĞBERK, OELSNER MADLEN, HAMAD M SABRI, HOFM: "ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion", EMBO REPORTS, NATURE PUBLISHING GROUP, LONDON, GB, vol. 23, no. 6, 7 June 2022 (2022-06-07), GB , XP093057297, ISSN: 1469-221X, DOI: 10.15252/embr.202154305
YAMAMOTO MIZUKI, GOHDA JIN, KOBAYASHI AYAKO, TOMITA KEIKO, HIRAYAMA YOUKO, KOSHIKAWA NAOHIKO, SEIKI MOTOHARU, SEMBA KENTARO, AKIYA: "Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein", MBIO, vol. 13, no. 4, 30 August 2022 (2022-08-30), XP093057295, DOI: 10.1128/mbio.00519-22
Attorney, Agent or Firm:
FIELDS IP ATTORNEYS PPC (JP)
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