Title:
INFECTIOUS DISEASE VACCINE USING NON-INFECTIOUS PARAMYXOVIRUS PARTICLE
Document Type and Number:
WIPO Patent Application WO/2018/092887
Kind Code:
A1
Abstract:
In this invention, a non-infectious particle has been produced, comprising a pathogen antigen protein caused to be expressed on the surface of a virus particle having at least one species of paramyxovirus envelope protein missing from the particle. This particle has been found to hold within the particle a large amount of antigen protein compared to an infectious particle, and to be capable of eliciting a host immune response with extremely high efficiency. The non-infectious particle according to the present invention is useful as a vaccine against a pathogenic virus, or the like.
Inventors:
MATANO TETSURO (JP)
INOUE MAKOTO (JP)
HARA HIROTO (JP)
SHU TSUGUMINE (JP)
INOUE MAKOTO (JP)
HARA HIROTO (JP)
SHU TSUGUMINE (JP)
Application Number:
PCT/JP2017/041492
Publication Date:
May 24, 2018
Filing Date:
November 17, 2017
Export Citation:
Assignee:
JAPAN AS REPRESENTED BY THE DIRECTOR GENERAL OF NAT INSTITUTE OF INFECTIOUS DISEASES (JP)
ID PHARMA CO LTD (JP)
ID PHARMA CO LTD (JP)
International Classes:
A61K39/21; A61K35/76; A61P31/18
Domestic Patent References:
| WO2014103310A1 | 2014-07-03 | |||
| WO2016069518A2 | 2016-05-06 | |||
| WO2000070070A1 | 2000-11-23 | |||
| WO2016069518A2 | 2016-05-06 | |||
| WO2000070055A1 | 2000-11-23 | |||
| WO2000070070A1 | 2000-11-23 | |||
| WO1997016539A1 | 1997-05-09 | |||
| WO1997016538A1 | 1997-05-09 | |||
| WO2001018223A1 | 2001-03-15 | |||
| WO2005071092A1 | 2005-08-04 | |||
| WO2000070070A1 | 2000-11-23 | |||
| WO2005071085A1 | 2005-08-04 |
Other References:
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SHARP PMHAHN BH, COLD SPRING HARB PERSPECTIVES IN MEDICINE, vol. 1, no. 1, 2011, pages a006841
CAMPO JE ET AL., AIDS AND CLINICAL RESEARCH, vol. S5, 2012, pages 002
TSUKASAKI KTOBINAI K, CLIN CANCER RES., vol. 20, 2014, pages 5217 - 25
SATAKE M ET AL., J MED VIROL, vol. 84, 2012, pages 327 - 35
GONCALVES DU ET AL., CLINICAL MICROBIOL REV, vol. 23, 2010, pages 577 - 589
CARNEIRO-PROIETTI ABF ET AL., JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, vol. 3, 2014, pages s24 - s29
HAYNES BF ET AL., CELL HOST MICROBEL, vol. 9, 2016, pages 292 - 303
STEPHENSON KE ET AL., CURRENT OPINION IN IMMUNOLOGY, vol. 41, 2016, pages 39 - 46
GROSS CTHOMAS-KRESS AK, VIRUSES, vol. 8, 2016, pages 74 - 95
RERKS-NGARM S ET AL., NEW ENGLAN JOURNAL OF MEDICINE, vol. 361, 2009, pages 2209 - 2220
ZHAO ET AL., VACINES, vol. 4, 2016, pages 2 - 21
WHO WORLD HEALTH STATISTICS, 2016
ZWAHLEN MEGGER M, REPORT ON UNAIDS OBLIGATION HQ/05/422204, 2006
"The State of the World Population", UNFPA, 2011
UNAIDS FACT SHEET, 2016
"HIV infection: recommendations for a public health approach", June 2013, WHO, article "Consolidated guidelines on the use of antiretroviral drugs for treating and preventing"
HAYNES BF ET AL., CELL HOST MICROBE, vol. 19, 2016, pages 292 - 303
ZHAO ET AL., VACINES, vol. 4, 21 February 2016 (2016-02-21)
LAMB, R.A.D. KOLAKOFSKY, PARAMYXOVIRIDAE: THE VIRUSES AND THEIR REPLICATION, 1996, pages 1177 - 1204
MEDICAL JOURNAL OF OSAKA UNIVERSITY, vol. 6, no. 1, March 1955 (1955-03-01), pages 1 - 15
LI, H.-O. ET AL., J. VIROL., vol. 74, no. 14, 2000, pages 6564 - 6569
ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ALTSCHUL S.F. ET AL., NATURE GENET., vol. 3, 1993, pages 266 - 272
MADDEN, T. L. ET AL., METH. ENZYMOL., vol. 266, 1996, pages 131 - 141
ALTSCHUL S.F. ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ZHANG J.MADDEN T. L., GENOME RES., vol. 7, 1997, pages 649 - 656
TATIANA A ET AL., FEMS MICROBIOL LETT., vol. 174, 1999, pages 247 - 250
WU ET AL., J. VIROL., vol. 80, no. 2, 2006, pages 835 - 844
SHINGAI, M. ET AL., PROC NATL ACAD SCI U.S.A., vol. 109, no. 48, 2012, pages 19769 - 19774
HASAN, MK ET AL., J GEN VIROL, vol. 78, 1997, pages 2813 - 2820
KATO A ET AL., EMBO J, vol. 16, 1997, pages 578 - 587
YU D ET AL., GENES CELLS, vol. 2, 1997, pages 457 - 466
KATO A ET AL., GENES CELLS, vol. 1, 1996, pages 569 - 579
TOKUSUMI T ET AL., VIRUS RES, vol. 86, 2002, pages 33 - 38
LI HO ET AL., J VIROL, vol. 74, 2000, pages 6564 - 6569
HASAN, M. K. ET AL., J. GENERAL VIROLOGY, vol. 78, 1997, pages 2813 - 2820
SEIKI, M. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 80, no. 12, 1983, pages 3618 - 3622
LI, H.-O. ET AL., J. VIROLOGY, vol. 74, 2000, pages 6564 - 6569
See also references of EP 3542818A4
SHARP PMHAHN BH, COLD SPRING HARB PERSPECTIVES IN MEDICINE, vol. 1, no. 1, 2011, pages a006841
CAMPO JE ET AL., AIDS AND CLINICAL RESEARCH, vol. S5, 2012, pages 002
TSUKASAKI KTOBINAI K, CLIN CANCER RES., vol. 20, 2014, pages 5217 - 25
SATAKE M ET AL., J MED VIROL, vol. 84, 2012, pages 327 - 35
GONCALVES DU ET AL., CLINICAL MICROBIOL REV, vol. 23, 2010, pages 577 - 589
CARNEIRO-PROIETTI ABF ET AL., JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, vol. 3, 2014, pages s24 - s29
HAYNES BF ET AL., CELL HOST MICROBEL, vol. 9, 2016, pages 292 - 303
STEPHENSON KE ET AL., CURRENT OPINION IN IMMUNOLOGY, vol. 41, 2016, pages 39 - 46
GROSS CTHOMAS-KRESS AK, VIRUSES, vol. 8, 2016, pages 74 - 95
RERKS-NGARM S ET AL., NEW ENGLAN JOURNAL OF MEDICINE, vol. 361, 2009, pages 2209 - 2220
ZHAO ET AL., VACINES, vol. 4, 2016, pages 2 - 21
WHO WORLD HEALTH STATISTICS, 2016
ZWAHLEN MEGGER M, REPORT ON UNAIDS OBLIGATION HQ/05/422204, 2006
"The State of the World Population", UNFPA, 2011
UNAIDS FACT SHEET, 2016
"HIV infection: recommendations for a public health approach", June 2013, WHO, article "Consolidated guidelines on the use of antiretroviral drugs for treating and preventing"
HAYNES BF ET AL., CELL HOST MICROBE, vol. 19, 2016, pages 292 - 303
ZHAO ET AL., VACINES, vol. 4, 21 February 2016 (2016-02-21)
LAMB, R.A.D. KOLAKOFSKY, PARAMYXOVIRIDAE: THE VIRUSES AND THEIR REPLICATION, 1996, pages 1177 - 1204
MEDICAL JOURNAL OF OSAKA UNIVERSITY, vol. 6, no. 1, March 1955 (1955-03-01), pages 1 - 15
LI, H.-O. ET AL., J. VIROL., vol. 74, no. 14, 2000, pages 6564 - 6569
ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ALTSCHUL S.F. ET AL., NATURE GENET., vol. 3, 1993, pages 266 - 272
MADDEN, T. L. ET AL., METH. ENZYMOL., vol. 266, 1996, pages 131 - 141
ALTSCHUL S.F. ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ZHANG J.MADDEN T. L., GENOME RES., vol. 7, 1997, pages 649 - 656
TATIANA A ET AL., FEMS MICROBIOL LETT., vol. 174, 1999, pages 247 - 250
WU ET AL., J. VIROL., vol. 80, no. 2, 2006, pages 835 - 844
SHINGAI, M. ET AL., PROC NATL ACAD SCI U.S.A., vol. 109, no. 48, 2012, pages 19769 - 19774
HASAN, MK ET AL., J GEN VIROL, vol. 78, 1997, pages 2813 - 2820
KATO A ET AL., EMBO J, vol. 16, 1997, pages 578 - 587
YU D ET AL., GENES CELLS, vol. 2, 1997, pages 457 - 466
KATO A ET AL., GENES CELLS, vol. 1, 1996, pages 569 - 579
TOKUSUMI T ET AL., VIRUS RES, vol. 86, 2002, pages 33 - 38
LI HO ET AL., J VIROL, vol. 74, 2000, pages 6564 - 6569
HASAN, M. K. ET AL., J. GENERAL VIROLOGY, vol. 78, 1997, pages 2813 - 2820
SEIKI, M. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 80, no. 12, 1983, pages 3618 - 3622
LI, H.-O. ET AL., J. VIROLOGY, vol. 74, 2000, pages 6564 - 6569
See also references of EP 3542818A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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