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Title:
INFECTIOUS DISEASE VACCINE USING NON-INFECTIOUS PARAMYXOVIRUS PARTICLE
Document Type and Number:
WIPO Patent Application WO/2018/092887
Kind Code:
A1
Abstract:
In this invention, a non-infectious particle has been produced, comprising a pathogen antigen protein caused to be expressed on the surface of a virus particle having at least one species of paramyxovirus envelope protein missing from the particle. This particle has been found to hold within the particle a large amount of antigen protein compared to an infectious particle, and to be capable of eliciting a host immune response with extremely high efficiency. The non-infectious particle according to the present invention is useful as a vaccine against a pathogenic virus, or the like.

Inventors:
MATANO, Tetsuro (1-23-1 Toyama, Shinjuku-k, Tokyo 40, 〒1628640, JP)
INOUE, Makoto (2-10-2, Fujimi, Chiyoda-k, Tokyo 71, 〒1020071, JP)
HARA, Hiroto (2-10-2, Fujimi, Chiyoda-k, Tokyo 71, 〒1020071, JP)
SHU, Tsugumine (2-10-2, Fujimi, Chiyoda-k, Tokyo 71, 〒1020071, JP)
Application Number:
JP2017/041492
Publication Date:
May 24, 2018
Filing Date:
November 17, 2017
Export Citation:
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Assignee:
JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES (1-23-1, Toyama Shinjuku-k, Tokyo 40, 〒1628640, JP)
ID PHARMA CO., LTD. (2-10-2, Fujimi Chiyoda-k, Tokyo 71, 〒1020071, JP)
International Classes:
A61K39/21; A61K35/76; A61P31/18
Domestic Patent References:
WO2014103310A12014-07-03
WO2016069518A22016-05-06
WO2000070070A12000-11-23
WO2016069518A22016-05-06
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Attorney, Agent or Firm:
HARUNA, Masao et al. (Kantetsu Tsukuba Bldg. 6F, 1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, 〒3000847, JP)
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