Title:
INFLAMMATORY DISEASE TREATMENT COMPOSITION INCLUDING ANTI-MYOSIN REGULATORY LIGHT-CHAIN POLYPEPTIDE ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2014/192915
Kind Code:
A1
Abstract:
Provided is a means for inhibiting the function of CD69, wherein inflammatory reactions can be suppressed. Specifically, provided are: an inflammatory disease treatment composition including an antibody that specifically recognises a myosin regulatory light-chain polypeptide (hereinafter abbreviated to Myl), preferably Myl9, Myl12a, and Myl12b, and inhibits the effect of an action when Myl, and CD69 coexist; an inflammatory disease treatment method including the prescription of a therapeutically effective amount of the antibody to a subject diagnosed as having an inflammatory disease; and a method for identification of a compound which inhibits the effect of the action when Myl, and CD69 coexist, and an inflammatory disease treatment candidate compound identification method characterised in that a compound which inhibits the effect is selected.
Inventors:
NAKAYAMA TOSHINORI (JP)
HOSOKAWA HIROYUKI (JP)
TOKOYODA KOJI (JP)
HAYASHIZAKI KOJI (JP)
SUZUKI AKANE (JP)
HOSOKAWA HIROYUKI (JP)
TOKOYODA KOJI (JP)
HAYASHIZAKI KOJI (JP)
SUZUKI AKANE (JP)
Application Number:
PCT/JP2014/064399
Publication Date:
December 04, 2014
Filing Date:
May 30, 2014
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
International Classes:
A61K39/395; A61P11/00; A61P29/00; A61P37/08; G01N33/15; G01N33/50; C07K16/18
Domestic Patent References:
| WO2008105058A1 | 2008-09-04 | |||
| WO1993011161A1 | 1993-06-10 |
Foreign References:
| JP2009508812A | 2009-03-05 | |||
| EP0404097B1 | 1996-09-04 | |||
| US5169939A | 1992-12-08 | |||
| US5750078A | 1998-05-12 | |||
| US6020153A | 2000-02-01 | |||
| US6420113B1 | 2002-07-16 | |||
| US6423511B1 | 2002-07-23 | |||
| US6632927B2 | 2003-10-14 | |||
| US6800738B1 | 2004-10-05 |
Other References:
ICHIRO IKEGAKI: "Atarashii Tanpaku Rinsanka Koso Sogaiyaku Fasudil Kumomakka Shukketsu-go no No Kekkan Renshuku ni Taisuru Yakuri Koka", BRAIN 21, vol. 3, no. 4, 2000, pages 453 - 456, XP008181528
XU J. ET AL.: "Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis- induced lung inflammation by activating beta2 integrins", NAT. IMMUNOL., vol. 9, no. 8, 2008, pages 880 - 886, XP055298644
TESTI, R. ET AL.: "The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells", IMMUNOL. TODAY, vol. 15, 1994, pages 479 - 483
YAMASHITA, I. ET AL.: "CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection", INT. IMMUNOL, vol. 5, 1993, pages 1139 - 1150
NAKAYAMA, T ET AL.: "The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression", J. IMMUNOL., vol. 168, 2002, pages 87 - 94
SHINODA, K. ET AL.: "Type II membrane protein CD69 regulates the formation of resting T-helper memory", PROC. NATL. ACAD. SCI., vol. 109, 2012, pages 7409 - 7414
MURATA, K. ET AL.: "CD69-null mice protected from arthritis induced with anti-type II collagen antibodies", INT. IMMUNOL., vol. 15, 2003, pages 987 - 992
MIKI-HOSOKAWA, T. ET AL.: "CD69 controls the pathogenesis of allergic airway inflammation", J. IMMUNOL., vol. 183, 2009, pages 8203 - 8215
YAMAUCHI, K. ET AL.: "Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin", RESPIR RES, vol. 12, 2011, pages 131
TSUYUSAKI, J. ET AL.: "Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice", J. RECEPT SIGNAL TRANSDUCT RES., vol. 31, 2011, pages 434 - 439
"Molecular Cloning: A Laboratory", 1989, COLD SPRING HARBOR LABORATORY PRESS
ULMER, K.M., SCIENCE, vol. 219, 1983, pages 666 - 671
"PCR Technology. Principles and Applications for DNA Amplification", 1989, STOCKTON PRESS
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495
HARLOW; LANE: "Antibodies, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
GODING: "Monoclonal Antibodies, Principles and Practice", 1986, ACADEMIC PRESS
"Fundamental Immunology", 1989, RAVEN PRESS
ZAPATA ET AL., PROTEIN ENG., vol. 8, no. 10, 1995, pages 1057 - 1062
PLUCKTHUN: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
See also references of EP 3006042A4
XU J. ET AL.: "Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis- induced lung inflammation by activating beta2 integrins", NAT. IMMUNOL., vol. 9, no. 8, 2008, pages 880 - 886, XP055298644
TESTI, R. ET AL.: "The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells", IMMUNOL. TODAY, vol. 15, 1994, pages 479 - 483
YAMASHITA, I. ET AL.: "CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection", INT. IMMUNOL, vol. 5, 1993, pages 1139 - 1150
NAKAYAMA, T ET AL.: "The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression", J. IMMUNOL., vol. 168, 2002, pages 87 - 94
SHINODA, K. ET AL.: "Type II membrane protein CD69 regulates the formation of resting T-helper memory", PROC. NATL. ACAD. SCI., vol. 109, 2012, pages 7409 - 7414
MURATA, K. ET AL.: "CD69-null mice protected from arthritis induced with anti-type II collagen antibodies", INT. IMMUNOL., vol. 15, 2003, pages 987 - 992
MIKI-HOSOKAWA, T. ET AL.: "CD69 controls the pathogenesis of allergic airway inflammation", J. IMMUNOL., vol. 183, 2009, pages 8203 - 8215
YAMAUCHI, K. ET AL.: "Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin", RESPIR RES, vol. 12, 2011, pages 131
TSUYUSAKI, J. ET AL.: "Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice", J. RECEPT SIGNAL TRANSDUCT RES., vol. 31, 2011, pages 434 - 439
"Molecular Cloning: A Laboratory", 1989, COLD SPRING HARBOR LABORATORY PRESS
ULMER, K.M., SCIENCE, vol. 219, 1983, pages 666 - 671
"PCR Technology. Principles and Applications for DNA Amplification", 1989, STOCKTON PRESS
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495
HARLOW; LANE: "Antibodies, A Laboratory Manual", 1988, COLD SPRING HARBOR PRESS
GODING: "Monoclonal Antibodies, Principles and Practice", 1986, ACADEMIC PRESS
"Fundamental Immunology", 1989, RAVEN PRESS
ZAPATA ET AL., PROTEIN ENG., vol. 8, no. 10, 1995, pages 1057 - 1062
PLUCKTHUN: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
See also references of EP 3006042A4
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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