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Title:
INFLUENZA VACCINES, ANTIGENS, COMPOSITIONS, AND METHODS
Document Type and Number:
WIPO Patent Application WO/2010/036970
Kind Code:
A3
Abstract:
The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and compositions useful in inducing or enhancing an immune response agains influenza antigens. Provided are recombinant protein antigens, compositions, and methods for the production of such antigens in plants. In some embodiments, influenza antigens include hemagglutinin polypeptides, neuraminidase polypeptides, and/or combinations thereof.

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Inventors:
YUSIBOV VIDADI (US)
METT VADIM (US)
MUSIYCHUK KONSTANTIN (US)
Application Number:
PCT/US2009/058488
Publication Date:
July 01, 2010
Filing Date:
September 25, 2009
Export Citation:
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Assignee:
FRAUNHOFER USA INC (US)
YUSIBOV VIDADI (US)
METT VADIM (US)
MUSIYCHUK KONSTANTIN (US)
International Classes:
C12N15/82; A61K39/145
Domestic Patent References:
WO2007095318A22007-08-23
WO2007149715A22007-12-27
WO2008021959A22008-02-21
WO2009026397A22009-02-26
Other References:
METT VADIM ET AL: "A plant-produced influenza subunit vaccine protects ferrets against virus challenge", INFLUENZA AND OTHER RESPIRATORY VIRUSES, vol. 2, no. 1, January 2008 (2008-01-01), pages 33 - 40, XP009098809, ISSN: 1750-2640(print) 1750-2659(ele
MUSIYCHUK KONSTANTIN ET AL: "A launch vector for the production of vaccine antigens in plants", INFLUENZA AND OTHER RESPIRATORY VIRUSES, vol. 1, no. 1, January 2007 (2007-01-01), pages 19 - 25, XP009058889, ISSN: 1750-2640(print) 1750-2659(ele
DATABASE UniProt [online] 5 September 2006 (2006-09-05), "SubName: Full=Hemagglutinin;", XP002565001, retrieved from EBI accession no. UNIPROT:Q0PDN1 Database accession no. Q0PDN1
DATABASE UniProt [online] 5 February 2008 (2008-02-05), "SubName: Full=Hemagglutinin; Flags: Precursor;", XP002565002, retrieved from EBI accession no. UNIPROT:A9X0E7 Database accession no. A9X0E7
Attorney, Agent or Firm:
PHILLIPS, Eifion et al. (P.C.P.O. Box 102, Minneapolis Minnesota, US)
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