Title:
INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ
Document Type and Number:
WIPO Patent Application WO/2010/003225
Kind Code:
A8
Abstract:
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Inventors:
D AOUST MARC-ANDRE (CA)
COUTURE MANON (CA)
ORS FREDERIC (CA)
TREPANIER SONIA (CA)
LAVOIE PIERRE-OLIVIER (CA)
DARGIS MICHELE (CA)
VEZINA LOUIS-PHILIPPE (CA)
LANDRY NATHALIE (CA)
COUTURE MANON (CA)
ORS FREDERIC (CA)
TREPANIER SONIA (CA)
LAVOIE PIERRE-OLIVIER (CA)
DARGIS MICHELE (CA)
VEZINA LOUIS-PHILIPPE (CA)
LANDRY NATHALIE (CA)
Application Number:
PCT/CA2009/000926
Publication Date:
July 22, 2010
Filing Date:
July 02, 2009
Export Citation:
Assignee:
MEDICAGO INC (CA)
D AOUST MARC-ANDRE (CA)
COUTURE MANON (CA)
ORS FREDERIC (CA)
TREPANIER SONIA (CA)
LAVOIE PIERRE-OLIVIER (CA)
DARGIS MICHELE (CA)
VEZINA LOUIS-PHILIPPE (CA)
LANDRY NATHALIE (CA)
D AOUST MARC-ANDRE (CA)
COUTURE MANON (CA)
ORS FREDERIC (CA)
TREPANIER SONIA (CA)
LAVOIE PIERRE-OLIVIER (CA)
DARGIS MICHELE (CA)
VEZINA LOUIS-PHILIPPE (CA)
LANDRY NATHALIE (CA)
International Classes:
C12N15/82; A61K39/145; A61P31/16; C07K14/11; C12N7/00; C12N7/01; C12N15/44
Attorney, Agent or Firm:
SECHLEY, Konrad, A. et al. (P.O. Box 30Suite 2300,550 Burrard Stree, Vancouver British Columbia V6C 2B5, CA)
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