Title:
INHIBITING INTRACELLULAR PATHOGENS
Document Type and Number:
WIPO Patent Application WO/2023/004188
Kind Code:
A3
Abstract:
A method of treating or preventing infection by an intracellular pathogen in a subject is described. The method includes administering to the subject a therapeutically effective amount of a composition including KH-1, KH-2, or a derivative and/or a pharmaceutically acceptable salt thereof. A method of treating or preventing bacterial inflammation in a subject is also described. New KH-1 and KH-2 derivatives are also described.
Inventors:
HOANG KY VAN (US)
GUNN JOHN S (US)
MELANDER CHRISTIAN (US)
SORGE AMY (US)
WOOLARD KATHERINE (US)
CARPENTER MORGAN (US)
GUNN JOHN S (US)
MELANDER CHRISTIAN (US)
SORGE AMY (US)
WOOLARD KATHERINE (US)
CARPENTER MORGAN (US)
Application Number:
PCT/US2022/038183
Publication Date:
February 23, 2023
Filing Date:
July 25, 2022
Export Citation:
Assignee:
THE RES INSTITUTE AT NATIONWIDE CHILDRENS HOSPITAL (US)
International Classes:
A61K31/407; A61K31/4704; C07D215/22; C07D491/052; A61P31/04
Domestic Patent References:
| WO2020083855A1 | 2020-04-30 | |||
| WO2013048942A1 | 2013-04-04 |
Foreign References:
| US6114349A | 2000-09-05 | |||
| US9790186B2 | 2017-10-17 | |||
| US9353121B2 | 2016-05-31 | |||
| US20170217897A1 | 2017-08-03 | |||
| US20180243333A1 | 2018-08-30 |
Other References:
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "BRD-K74028296-001-01-8", XP093037812, retrieved from PUBCHEM
DAYTON ANDREW I: "Hitting HIV where it hides", RETROVIROLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 5, no. 1, 1 February 2008 (2008-02-01), GB , pages 15, XP021038014, ISSN: 1742-4690
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "BRD-A77936415-001-01-7", XP093037813, retrieved from PUBCHEM
PRYKE KARA M., ABRAHAM JINU, SALI TINA M., GALL BRYAN J., ARCHER IRIS, LIU ANDREW, BAMBINA SHELLY, BAIRD JASON, GOUGH MICHAEL, CHA: "A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 8, no. 3, 5 July 2017 (2017-07-05), US , XP093037814, ISSN: 2161-2129, DOI: 10.1128/mBio.00452-17
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "SID 49784469", XP093037816, retrieved from PUBCHEM
DAYTON ANDREW I: "Hitting HIV where it hides", RETROVIROLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 5, no. 1, 1 February 2008 (2008-02-01), GB , pages 15, XP021038014, ISSN: 1742-4690
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "BRD-A77936415-001-01-7", XP093037813, retrieved from PUBCHEM
PRYKE KARA M., ABRAHAM JINU, SALI TINA M., GALL BRYAN J., ARCHER IRIS, LIU ANDREW, BAMBINA SHELLY, BAIRD JASON, GOUGH MICHAEL, CHA: "A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 8, no. 3, 5 July 2017 (2017-07-05), US , XP093037814, ISSN: 2161-2129, DOI: 10.1128/mBio.00452-17
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "SID 49784469", XP093037816, retrieved from PUBCHEM
Attorney, Agent or Firm:
RUSSELL, Raymond N. (US)
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