INHIBITION OF SPONTANEOUS METASTASIS VIA PROTEIN INHIBITORS OF CYSTEINE PROTEASES

Title:

INHIBITION OF SPONTANEOUS METASTASIS VIA PROTEIN INHIBITORS OF CYSTEINE PROTEASES

Document Type and Number:

WIPO Patent Application WO/2019/055884

Kind Code:

A3

Abstract:

Two disparate biological mechanisms which predispose to the dissemination and metastases of solid tumors is described. The treatment of metastatic lesions via topical and transdermal administration of therapeutic agents, such as Type 1 Cystatins, through intact skin, is directed to the inhibition of lysosomal cysteine cathepsin proteolytic enzymatic degradation of the extracellular matrix.

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Inventors:

BEAL RYAN (US)
SAND BRUCE (US)
BRUNNER SETH (US)
SAND BRANDON (US)
MARTINEZ KILMAR (US)
GONZALES LUKE (US)
MISELL LISA (US)
FITZSIMMONS NATHAN (US)

Application Number:

PCT/US2018/051256

Publication Date:

April 25, 2019

Filing Date:

September 15, 2018

Export Citation:

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Assignee:

AMPERSAND BIOPHARMACEUTICALS INC (US)

International Classes:

A61K31/336; A61K9/70; A61P35/04; C07D303/02

Foreign References:

US20170095460A1	2017-04-06
US20120277245A1	2012-11-01
US20040241646A1	2004-12-02
US20080176841A1	2008-07-24

Other References: