Title:
INHIBITION OF SYK KINASE EXPRESSION
Document Type and Number:
WIPO Patent Application WO2005007623
Kind Code:
A3
Abstract:
The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).
Inventors:
SCHREIBER ALAN D (US)
INDIK ZENA (US)
KIM MOO-KYUNG (US)
INDIK ZENA (US)
KIM MOO-KYUNG (US)
Application Number:
PCT/US2004/020990
Publication Date:
May 18, 2006
Filing Date:
July 01, 2004
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
SCHREIBER ALAN D (US)
INDIK ZENA (US)
KIM MOO-KYUNG (US)
SCHREIBER ALAN D (US)
INDIK ZENA (US)
KIM MOO-KYUNG (US)
International Classes:
C07H21/04; A61K48/00; C12N15/113; C12N15/85; C12Q1/68; C07D
Domestic Patent References:
| WO2002044321A2 | 2002-06-06 |
Foreign References:
| US6242427B1 | 2001-06-05 |
Other References:
STENTON G R.: "Aerosolized Syk Antisense Suppresses Syk Expression, Mediator Release from Macrophages, and Pulmonary Inflammation.", JOURNAL OF IMMUNOLOGY., vol. 164, 2000, pages 3790 - 3797, XP002336038
HAMMOND S M.: "Post Transcriptional Gene Silencing by Double Stranded RNA.", NATURE., vol. 2, February 2001 (2001-02-01), pages 110 - 119, XP001146153
HAMMOND S M.: "Post Transcriptional Gene Silencing by Double Stranded RNA.", NATURE., vol. 2, February 2001 (2001-02-01), pages 110 - 119, XP001146153
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