Title:
INHIBITION OR TREATMENT OF DYSKINESIA
Document Type and Number:
WIPO Patent Application WO2006087577
Kind Code:
A3
Abstract:
Prevention or treatment of dyskinesia induced by L-dopa or dopamine agonist can be effected by use of a selective inhibitor of neuronal nitric oxide synthase.
Inventors:
IRVANI MAHMOUD (GB)
JENNER PETER (GB)
JENNER PETER (GB)
Application Number:
PCT/GB2006/000583
Publication Date:
October 19, 2006
Filing Date:
February 20, 2006
Export Citation:
Assignee:
PROXIMAGEN LTD (GB)
IRVANI MAHMOUD (GB)
JENNER PETER (GB)
IRVANI MAHMOUD (GB)
JENNER PETER (GB)
International Classes:
A61K31/00; A61K31/195; A61K45/06; A61P25/14
Domestic Patent References:
| WO2004073712A1 | 2004-09-02 | |||
| WO1998034919A1 | 1998-08-13 | |||
| WO1998024766A1 | 1998-06-11 | |||
| WO1997036871A1 | 1997-10-09 | |||
| WO2003030993A1 | 2003-04-17 | |||
| WO2005026111A2 | 2005-03-24 |
Foreign References:
| US20030087891A1 | 2003-05-08 | |||
| US20010034348A1 | 2001-10-25 | |||
| US6235747B1 | 2001-05-22 | |||
| US20030119751A1 | 2003-06-26 | |||
| US6274557B1 | 2001-08-14 |
Other References:
ITOKAWA ET AL: "Effect of l-DOPA on nitric oxide production in striatum of freely mobile mice", NEUROSCIENCE LETTERS, LIMERICK, IE, vol. 402, no. 1-2, 10 July 2006 (2006-07-10), pages 142 - 144, XP005457923, ISSN: 0304-3940
PAVON ET AL: "ERK Phosphorylation and FosB Expression Are Associated with L-DOPA-Induced Dyskinesia in Hemiparkinsonian Mice", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 59, no. 1, 1 January 2006 (2006-01-01), pages 64 - 74, XP005229854, ISSN: 0006-3223
NEL A ET AL: "Haloperidol-induced dyskinesia is associated with striatal NO synthase suppression: reversal with olanzapine.", BEHAVIOURAL PHARMACOLOGY. MAY 2003, vol. 14, no. 3, May 2003 (2003-05-01), pages 251 - 255, XP009070205, ISSN: 0955-8810
PAVON ET AL: "ERK Phosphorylation and FosB Expression Are Associated with L-DOPA-Induced Dyskinesia in Hemiparkinsonian Mice", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 59, no. 1, 1 January 2006 (2006-01-01), pages 64 - 74, XP005229854, ISSN: 0006-3223
NEL A ET AL: "Haloperidol-induced dyskinesia is associated with striatal NO synthase suppression: reversal with olanzapine.", BEHAVIOURAL PHARMACOLOGY. MAY 2003, vol. 14, no. 3, May 2003 (2003-05-01), pages 251 - 255, XP009070205, ISSN: 0955-8810
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