Title:
INHIBITION OF WDR5 INTERACTION WITH ITS BINDING PARTNERS AND THERAPEUTIC METHODS
Document Type and Number:
WIPO Patent Application WO/2011/159685
Kind Code:
A3
Abstract:
Peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.
Inventors:
WANG SHAOMENG (US)
KARATAS HACER (US)
DOU YALI (US)
TOWNSEND ELIZABETH (US)
BERNARD DENZIL (US)
KARATAS HACER (US)
DOU YALI (US)
TOWNSEND ELIZABETH (US)
BERNARD DENZIL (US)
Application Number:
PCT/US2011/040326
Publication Date:
April 12, 2012
Filing Date:
June 14, 2011
Export Citation:
Assignee:
UNIV MICHIGAN (US)
WANG SHAOMENG (US)
KARATAS HACER (US)
DOU YALI (US)
TOWNSEND ELIZABETH (US)
BERNARD DENZIL (US)
WANG SHAOMENG (US)
KARATAS HACER (US)
DOU YALI (US)
TOWNSEND ELIZABETH (US)
BERNARD DENZIL (US)
International Classes:
A61K38/08; A61K38/06; A61P35/00; C07K7/06
Domestic Patent References:
| WO2007080194A2 | 2007-07-19 |
Foreign References:
| US20030109458A1 | 2003-06-12 | |||
| JPH06220088A | 1994-08-09 | |||
| US20090215986A1 | 2009-08-27 |
Attorney, Agent or Firm:
NAPOLI, James, J. (Gerstein & Borun LLP233 S. Wacker Drive,6300 Willis Towe, Chicago IL, US)
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