Title:
INHIBITOR FOR CELLULAR AGING
Document Type and Number:
WIPO Patent Application WO/2007/102572
Kind Code:
A1
Abstract:
A novel inhibitor for cellular aging which can effectively and fundamentally
inhibit cellular aging. This inhibitor for cellular aging contains, as the active
ingredient, a substance capable of inhibiting the expression of a gene encoding
G protein γ subunit 11 or a substance capable of inhibiting the cellular
aging effect of G protein γ subunit 11. Because of being capable of preventing
the induction of cellular aging by oxidation stress, this inhibitor for cellular
aging is applicable to various purposes on the basis of the cellular rejuvenation.
In particular, it is usable in developing cosmetics having anti-aging effects,
health foods, drugs and so on.
Inventors:
AYUSAWA DAI (JP)
HOSSAIN MOHAMMAD NAZIR (JP)
HOSSAIN MOHAMMAD NAZIR (JP)
Application Number:
PCT/JP2007/054513
Publication Date:
September 13, 2007
Filing Date:
March 08, 2007
Export Citation:
Assignee:
UNIV YOKOHAMA CITY (JP)
AYUSAWA DAI (JP)
HOSSAIN MOHAMMAD NAZIR (JP)
AYUSAWA DAI (JP)
HOSSAIN MOHAMMAD NAZIR (JP)
International Classes:
A61K45/00; A61K8/60; A61K31/711; A61K48/00; A61P17/18; A61P39/06; A61Q19/08; C12N5/00; A23L1/30; C12N15/00
Other References:
HOSSAIN M.N. ET AL.: "G-protein gamma subunit GNG11 strongly regulates cellular senescence", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 351, no. 3, 22 December 2006 (2006-12-22), pages 645 - 650, XP005726083
BALCUEVA E.A. ET AL.: "Human G Protein gamma11 and gamma14 Subtypes Define a New Functional Subclass", EXPERIMENTAL CELL RESEARCH, vol. 257, no. 2, 2000, pages 310 - 319, XP003017625
DHANASEKARAN N. ET AL.: "G protein subunits and cell proliferation", BIOLOGICAL, SIGNALS AND RECEPTORS, vol. 7, no. 2, 1998, pages 109 - 117, XP003017626
BALCUEVA E.A. ET AL.: "Human G Protein gamma11 and gamma14 Subtypes Define a New Functional Subclass", EXPERIMENTAL CELL RESEARCH, vol. 257, no. 2, 2000, pages 310 - 319, XP003017625
DHANASEKARAN N. ET AL.: "G protein subunits and cell proliferation", BIOLOGICAL, SIGNALS AND RECEPTORS, vol. 7, no. 2, 1998, pages 109 - 117, XP003017626
Attorney, Agent or Firm:
TANIGAWA, Hidejiro (Patent Firm 6F, Iwata Bldg., 5-12, Iidabashi 4-chom, Chiyoda-ku Tokyo 72, JP)
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