Title:
INHIBITOR FOR COGNITIVE FUNCTION DECLINE
Document Type and Number:
WIPO Patent Application WO/2018/079695
Kind Code:
A1
Abstract:
An inhibitor for cognitive function decline or an improver for learning ability is provided.
The inhibitor for cognitive function decline or the improver for learning ability contains, as an active ingredient, a liver hydrolysate having a lipid content less than 2 mass% or a phosphatidylcholine content less than 1 mass%.
Inventors:
YAMADA KOTARO (JP)
SAKURAI HIDETOMO (JP)
NAKAGAWASAI OSAMU (JP)
TANNO KOICHI (JP)
SAKURAI HIDETOMO (JP)
NAKAGAWASAI OSAMU (JP)
TANNO KOICHI (JP)
Application Number:
PCT/JP2017/038831
Publication Date:
May 03, 2018
Filing Date:
October 27, 2017
Export Citation:
Assignee:
ZERIA PHARM CO LTD (JP)
International Classes:
A61K35/407; A23L33/115; A61P25/00; A61P25/28
Domestic Patent References:
WO2015022927A1 | 2015-02-19 | |||
WO2016068267A1 | 2016-05-06 | |||
WO2015046184A1 | 2015-04-02 | |||
WO2008050754A1 | 2008-05-02 |
Foreign References:
JP2016135757A | 2016-07-28 | |||
KR20130029166A | 2013-03-22 | |||
JP2006096747A | 2006-04-13 |
Other References:
AHN, CHANG-BUM ET AL.: "Enzymatic production of bioactive protein hydrolysates from tuna liver: effects of enzymes and molecular weight on bioactivity", INT. J. FOOD SCI. TECHNOL., vol. 45, 2010, pages 562 - 568, XP055606596
INOUE, NAONORI ET AL.,: "Analysis of the components of porcine liver hydrolysate and examination of the antioxidant activity and angiotensin converting enzyme (ACE)- inhibiting activity", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 133, no. 1, 2013, pages 107 - 115, XP055606603
DU, LAI-LING ET AL.: "AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats", J. ALZHEIMERS DIS., vol. 43, 2015, pages 775 - 784
VINGTDEUX, VALERIE ET AL.: "AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-beta Peptide Metabolism", J. BIOL. CHEM., vol. 285, no. 12, 2010, pages 9100 - 9113, XP055606607
INOUE, NAONORI ET AL.,: "Analysis of the components of porcine liver hydrolysate and examination of the antioxidant activity and angiotensin converting enzyme (ACE)- inhibiting activity", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 133, no. 1, 2013, pages 107 - 115, XP055606603
DU, LAI-LING ET AL.: "AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats", J. ALZHEIMERS DIS., vol. 43, 2015, pages 775 - 784
VINGTDEUX, VALERIE ET AL.: "AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-beta Peptide Metabolism", J. BIOL. CHEM., vol. 285, no. 12, 2010, pages 9100 - 9113, XP055606607
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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