Title:
TGFΒ INHIBITOR CONTAINING REIC/Dkk-3 PROTEIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/217556
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a medicine for preventing or treating TGFβ-related diseases by inhibiting signal transduction of TGFβ. Provided are: a TGFβ inhibitor that contains, as an active ingredient, the REIC/Dkk-3 protein, a partial protein including a Cys-rich domain thereof, or DNA encoding those; and a prophylactic or therapeutic agent for TGFβ-related diseases, containing said TGFβ inhibitor.
Inventors:
KINOSHITA RIE (JP)
FUTAMI JUNICHIRO (JP)
KUMON HIROMI (JP)
FUTAMI JUNICHIRO (JP)
KUMON HIROMI (JP)
Application Number:
PCT/JP2017/022588
Publication Date:
December 21, 2017
Filing Date:
June 19, 2017
Export Citation:
Assignee:
MOMOTARO-GENE INC (JP)
International Classes:
A61K38/02; A61K48/00; A61P1/04; A61P1/16; A61P9/00; A61P9/12; A61P11/00; A61P13/12; A61P19/02; A61P21/02; A61P25/02; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07K14/47
Domestic Patent References:
| WO2012002582A1 | 2012-01-05 | |||
| WO2009119874A1 | 2009-10-01 | |||
| WO2001038528A1 | 2001-05-31 |
Other References:
ROMERO D. ET AL.: "Dickkopf-3 regulates proetate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF- beta-dependent activation of matrix metalloproteases", CARCINOGENESIS, vol. 37, no. 1, 26 October 2015 (2015-10-26), pages 18 - 29, XP055447946, ISSN: 0143-3334
ROMERO D. ET AL.: "Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-beta/Smad signaling", J CELL SCI., vol. 126, no. 8, 2013, pages 1858 - 1867, XP055448678, ISSN: 0021-9533
SNELLING SJB. ET AL.: "Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role", OSTEOARTH CARTIL., vol. 24, no. 5, 2016, pages 883 - 891, XP029512442, ISSN: 1063-4584
PINHO S. ET AL.: "Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction", DIFFERENTIATION, vol. 75, no. 10, 2007, pages 957 - 967, XP055563057, ISSN: 0301-4681
RAMOS RN. ET AL.: "What are the molecules involved in regulatory T-cells induction by dendritic cells in cancer?", CLIN DEV IMMUNOL., vol. 2013, no. 2, pages 1 - 10, XP055448679, ISSN: 1740-2522
CHEN ML. ET AL.: "Regulatory T cells suppress tumor-specific CD 8 T cell cytotoxicity through TGF-beta signals in vivo", PROC NATL ACAD SCI USA, vol. 102, no. 2, 2005, pages 419 - 424, XP055563061, ISSN: 0027-8424
FUJITA T. ET AL.: "DNA encoding soluble TGF-beta receptor can suppress regulatory T cell function and elicit anti-tumor immune responses", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, vol. 66, 2007, pages 338, XP009515790, ISSN: 0546-0476
See also references of EP 3485895A4
ROMERO D. ET AL.: "Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-beta/Smad signaling", J CELL SCI., vol. 126, no. 8, 2013, pages 1858 - 1867, XP055448678, ISSN: 0021-9533
SNELLING SJB. ET AL.: "Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role", OSTEOARTH CARTIL., vol. 24, no. 5, 2016, pages 883 - 891, XP029512442, ISSN: 1063-4584
PINHO S. ET AL.: "Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction", DIFFERENTIATION, vol. 75, no. 10, 2007, pages 957 - 967, XP055563057, ISSN: 0301-4681
RAMOS RN. ET AL.: "What are the molecules involved in regulatory T-cells induction by dendritic cells in cancer?", CLIN DEV IMMUNOL., vol. 2013, no. 2, pages 1 - 10, XP055448679, ISSN: 1740-2522
CHEN ML. ET AL.: "Regulatory T cells suppress tumor-specific CD 8 T cell cytotoxicity through TGF-beta signals in vivo", PROC NATL ACAD SCI USA, vol. 102, no. 2, 2005, pages 419 - 424, XP055563061, ISSN: 0027-8424
FUJITA T. ET AL.: "DNA encoding soluble TGF-beta receptor can suppress regulatory T cell function and elicit anti-tumor immune responses", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, vol. 66, 2007, pages 338, XP009515790, ISSN: 0546-0476
See also references of EP 3485895A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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