Title:
INHIBITOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/228341
Kind Code:
A1
Abstract:
An inhibitor containing a tricyclic derivative, a preparation method therefor and a pharmaceutical composition comprising the inhibitor, as well as a use thereof as a phosphoinositide 3 kinase (PI3K) inhibitor in the treatment of cancer and diseases or conditions mediated by or dependent on PI3K imbalance.
Inventors:
GAO PENG (CN)
SUN GUANGJUN (CN)
WANG SHAOBAO (CN)
XIU WENHUA (CN)
TAN SONGLIANG (CN)
BAO RUDI (CN)
SUN GUANGJUN (CN)
WANG SHAOBAO (CN)
XIU WENHUA (CN)
TAN SONGLIANG (CN)
BAO RUDI (CN)
Application Number:
PCT/CN2019/088788
Publication Date:
December 05, 2019
Filing Date:
May 28, 2019
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
C07D498/04; A61K31/4162; A61K31/4188; A61K31/4196; A61K31/553; A61P35/00; C07D498/14
Domestic Patent References:
| WO2010029082A1 | 2010-03-18 | |||
| WO2011022439A1 | 2011-02-24 |
Foreign References:
| CN107873032A | 2018-04-03 | |||
| CN107995911A | 2018-05-04 | |||
| CN102762576A | 2012-10-31 | |||
| CN103562210A | 2014-02-05 |
Other References:
TIMOTHY P. HEFFRON ET AL.: "The Rational Design of Selective Benzoxaze- pin Inhibitors of the a-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1, 2, 4-triazol-5-yl)-5, 6- dihydrobenzo [f ]imidazo[1, 2-d][1, 4]oxazepin-9-yl)oxy)propanamide (GDC-0326", J. MED. CHEM., vol. 59, 7 January 2016 (2016-01-07), XP055296322
See also references of EP 3805231A4
See also references of EP 3805231A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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