Title:
INHIBITOR OF DENATURED LDL FORMATION
Document Type and Number:
WIPO Patent Application WO/1991/011994
Kind Code:
A1
Abstract:
A pharmaceutical composition containing as the active ingredient a compound which presents low-density lipoproteins (LDL) represented by the compounds of formula (I) from being negatively charged. This composition inhibits the LDL from undergoing denaturation (oxidation) necessary for the recognition by a scavenger acceptor, and is used for treating arteriosclerosis, peptic ulcer, cancer, ischemic organ disease, inflammation and pulmonary silicosis.
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Inventors:
KATO YASUYUKI (JP)
TAMURA KUNIO (JP)
OHBA YASUHIRO (JP)
KAWANABE YOSHIKI (JP)
SHINSHI OSAMU (JP)
TAMURA KUNIO (JP)
OHBA YASUHIRO (JP)
KAWANABE YOSHIKI (JP)
SHINSHI OSAMU (JP)
Application Number:
PCT/JP1991/000179
Publication Date:
August 22, 1991
Filing Date:
February 14, 1991
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/10; A61K31/135; A61K31/165; A61K31/17; A61K31/19; A61K31/195; A61K31/215; A61K31/22; A61K31/275; A61K31/335; A61K31/34; A61K31/35; A61K31/36; A61K31/38; A61K31/40; A61K31/415; A61K31/44; A61K31/47; A61K31/495; A61K31/535; C07C215/50; C07C215/74; C07C215/76; C07C217/84; C07C229/18; C07C229/38; C07C229/60; C07C233/25; C07C233/29; C07C233/43; C07C233/75; C07C235/50; C07C235/56; C07C271/28; C07C275/34; C07C279/28; C07C309/73; C07C311/21; C07C323/20; C07C323/32; C07C323/36; C07C323/60; C07C335/18; C07D207/335; C07D213/38; C07D213/75; C07D213/82; C07D215/20; C07D215/233; C07D233/54; C07D235/06; C07D261/20; C07D295/192; C07D307/52; C07D311/32; C07D311/58; C07D317/58; C07D317/66; C07D333/20; C07D521/00; C07F7/18; C07D207/32; C07D215/22; (IPC1-7): A61K31/10; A61K31/12; A61K31/135; A61K31/155; A61K31/16; A61K31/17; A61K31/18; A61K31/185; A61K31/19; A61K31/415; A61K31/42; A61K31/695; G01N27/26
Foreign References:
| JPS57175119A | 1982-10-28 | |||
| JPS62145049A | 1987-06-29 |
Other References:
CHEMICAL ABSTRACTS, Vol. 97, No. 25, (1982), Abstract No. 216157g.
CHEMICAL ABSTRACTS, Vol. 108, No. 5, (1988), Abstract No. 37726r.
CHEMICAL ABSTRACTS, Vol. 98, No. 19, (1983), Abstract No. 160638r.
CHEMICAL ABSTRACTS, Vol. 91, No. 3, (1979), Abstract No. 20144g.
CHEMICAL ABSTRACTS, Vol. 111, No. 25, (1989), Abstract No. 229966c.
CHEMICAL ABSTRACTS, Vol. 107, No. 13, (1987), Abstract No. 113589v.
CHEMICAL ABSTRACTS, Vol. 106, No. 7, (1987), Abstract No. 48497b.
See also references of EP 0515684A4
CHEMICAL ABSTRACTS, Vol. 108, No. 5, (1988), Abstract No. 37726r.
CHEMICAL ABSTRACTS, Vol. 98, No. 19, (1983), Abstract No. 160638r.
CHEMICAL ABSTRACTS, Vol. 91, No. 3, (1979), Abstract No. 20144g.
CHEMICAL ABSTRACTS, Vol. 111, No. 25, (1989), Abstract No. 229966c.
CHEMICAL ABSTRACTS, Vol. 107, No. 13, (1987), Abstract No. 113589v.
CHEMICAL ABSTRACTS, Vol. 106, No. 7, (1987), Abstract No. 48497b.
See also references of EP 0515684A4
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