Title:
INHIBITOR OF EXPRESSION OF BONE FORMATION-RELATED FACTOR OR CALCIFICATION-RELATED FACTOR IN EXTRASKELETAL TISSUE
Document Type and Number:
WIPO Patent Application WO/2019/176693
Kind Code:
A1
Abstract:
Provided is an inhibitor of the expression of a bone formation-related factor or a calcification-related factor in an extraskeletal tissue. An inhibitor of the expression of a bone formation-related factor in an extraskeletal tissue, the inhibitor being characterized by comprising phytic acid. The bone formation-related factor is any one of ALPL, RUNX2, BGLAP and the like. An inhibitor of the expression of a calcification-related factor in an extraskeletal tissue, the inhibitor being characterized by comprising phytic acid. The calcification-related factor is any one of SLC20A1, SLC20A2, ENPP1, ALPL, SPP1 and the like. These inhibitors can prevent heterotopic ossification and ectopic calcification, respectively, when administered intravenously.
Inventors:
YOSHIKO YUJI (JP)
MINAMIZAKI TOMOKO (JP)
MINAMIZAKI TOMOKO (JP)
Application Number:
PCT/JP2019/008900
Publication Date:
September 19, 2019
Filing Date:
March 06, 2019
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
RAFFINEE INT CO LTD (JP)
RAFFINEE INT CO LTD (JP)
International Classes:
A61K31/6615; A61P9/10; A61P19/00; A61P21/00; A61P43/00; C07K14/46
Domestic Patent References:
| WO2014042265A1 | 2014-03-20 |
Foreign References:
| JP2007510710A | 2007-04-26 | |||
| JP2012015539A | 2012-01-19 | |||
| JP2009079033A | 2009-04-16 | |||
| JP2000159677A | 2000-06-13 | |||
| JPH0776523A | 1995-03-20 |
Other References:
GRASES, F. ET AL.: "Phytate reduces age-related cardiovascular calcification", FRONTIERS IN BIOSCIENCE, vol. 13, 2008, pages 7115 - 7122, ISSN: 1093-4715
TOSHISHIGE, M. ET AL.: "Phytic acid, a phosphate store in plants, inhibits osteogenic differentiation in ectopic calcifications but not in bone", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 33, no. 1, November 2018 (2018-11-01), pages 293 - 294, ISSN: 0884-0431
TOSHISHIGE, M. ET AL.: "Phytic acid, a phosphate store in plants, inhibits osteogenic differentiation in ectopic calcifications but not in bone", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 33, no. 1, November 2018 (2018-11-01), pages 293 - 294, ISSN: 0884-0431
Attorney, Agent or Firm:
MAEDA & PARTNERS (JP)
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