Title:
INHIBITOR OF EXTRACELLULAR TRAP FORMATION IN LEUKOCYTES
Document Type and Number:
WIPO Patent Application WO/2014/168253
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel drug for inhibiting extracellular trap formation in leukocytes. The invention provides an inhibitor of extracellular trap formation in leukocytes which contain lactoferrin, and a composition for treating disorders related to extracellular trap formation in leukocytes which contain lactoferrin.
Inventors:
HIRAHASHI JUNICHI (JP)
URANO YASUTERU (JP)
OKUBO KOUSHU (JP)
KAMIYA MAKO (JP)
KAGAYA SHINJI (JP)
URANO YASUTERU (JP)
OKUBO KOUSHU (JP)
KAMIYA MAKO (JP)
KAGAYA SHINJI (JP)
Application Number:
PCT/JP2014/060561
Publication Date:
October 16, 2014
Filing Date:
April 08, 2014
Export Citation:
Assignee:
UNIV TOKYO (JP)
NRL PHARMA INC (JP)
NRL PHARMA INC (JP)
International Classes:
A61K38/16; A23L1/30; A61K9/08; A61P7/00; A61P9/10; A61P13/12; A61P37/02; A61P43/00; A23J3/08; C07K14/79
Domestic Patent References:
| WO2009113743A1 | 2009-09-17 |
Foreign References:
| JP2001048804A | 2001-02-20 | |||
| JP2011524748A | 2011-09-08 | |||
| JP2008189637A | 2008-08-21 | |||
| JP4195486B2 | 2008-12-10 | |||
| JP4261531B2 | 2009-04-30 | |||
| JP2012098085A | 2012-04-23 | |||
| JP4050784B2 | 2008-02-20 | |||
| JP4592041B2 | 2010-12-01 |
Other References:
BOURNAZOU, I. ET AL.: "Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 119, no. 1, 2009, pages 20 - 32, XP002552533
CAIELLI, S. ET AL.: "Neutrophils come of age in chronic inflammation", CURRENT OPINION IN IMMUNOLOGY, vol. 24, no. 6, 2012, pages 671 - 677, XP055285148
VOLKER BRINKMANN ET AL., SCIENCE, vol. 303, 2004, pages 1532 - 1535
Q REMIJSEN ET AL., CELL DEATH AND DIFFERENTIATION, vol. 18, 2011, pages 581 - 588
MAREN VON KOECKRITZ-BLICKWEDE ET AL., BLOOD, vol. 111, 2008, pages 3070 - 3080
JOHN D. LIPPOLIS ET AL., VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 113, 2006, pages 248 - 255
FUCHS TA ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 15880 - 15885
GARCIA-ROMO GS ET AL., SCI TRANSL MED, vol. 3, 2011, pages 73RA20
LANDE R ET AL., SCI TRANSL MED, vol. 3, 2011, pages 73RA19 9
KESSENBROCK K ET AL., NAT MED, vol. 6, 2009, pages 623 - 625
BOSCH X, J AM SOC NEPHROL, vol. 8, 2009, pages 1654 - 1656
TOBIAS A. FUCHS ET AL., J CELL BIOL, vol. 176, 2007, pages 231 - 241
K. AKONG-MOORE ET AL., PLOS ONE, vol. 7, 2012, pages E42984
MAKOTO NAITO ET AL., SEIBUTSU SHIRYO BUNSEKI, vol. 33, 2010, pages 329 - 338
BRINKMANN, V. ET AL., SCIENCE, vol. 303, 2004, pages 1532 - 1535
YOUSEFI, S. ET AL., NAT MED, vol. 14, 2008, pages 949 - 953
VON KOECKRITZ-BLICKWEDE M ET AL., BLOOD, vol. 111, 2008, pages 3070 - 3080
WEBSTER SJ ET AL., J IMMUNOL, vol. 185, 2010, pages 2968 - 2979
CHOW, O.A. ET AL., CELL HOST & MICROBE, vol. 8, no. 5, 18 November 2010 (2010-11-18), pages 445 - 454
SIMON, D. ET AL., ALLERGY, vol. 68, 2013, pages 409 - 416
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
A. K GUPTA, FEBS LETTERS, vol. 584, 2010, pages 3193 - 3197
D J NOVO, ANTIMICROB AGENTS CHEMOTHER., vol. 44, no. 4, 2000, pages 827 - 34
VON KOCKRITZ-BLICKWEDE M ET AL., BLOOD, vol. 111, 2008, pages 3070 - 3080
VON BRUHL, M. L. ET AL., J EXP MED., vol. 209, no. 4, 9 April 2012 (2012-04-09), pages 819 - 35
DE BOER, O. J., THROMB HAEMOST., vol. 109, no. 2, February 2013 (2013-02-01), pages 290 - 7
DEMERS, M., PROC NATL ACAD SCI USA, vol. 109, no. 32, 7 August 2012 (2012-08-07), pages 13076 - 81
TOBIAS A. ET AL., BLOOD, vol. 118, no. 13, 29 September 2011 (2011-09-29), pages 3708 - 3714
TAKEUCHI ET AL., EXP PHYSIOL., vol. 91, no. 6, November 2006 (2006-11-01), pages 1033 - 40
KENMOKU, S. ET AL., J AM CHEM SOC, vol. 129, 2007, pages 7313 - 7318
SETSUKINAI, K. ET AL., J BIOL CHEM, vol. 278, 2003, pages 3170 - 3175
ISHIDA-OKAWARA, A. ET AL., NEPHROL DIAL TRANSPLANT, vol. 19, 2004, pages 1708 - 1715
TOBIAS A ET AL., BLOOD, vol. 118, 2011, pages 3708 - 3714
FUCHS TA ET AL., BLOOD, vol. 118, 2011, pages 3708 - 3714
TOBIAS A. ET AL., BLOOD, vol. 118, no. 13, 29 September 2011 (2011-09-29), pages 3708 - 3714
HE J; FURMANSKI P.: "Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA", NATURE, vol. 373, no. 6516, 1995, pages 721 - 4
STRYDOM DJ; FETT JW; LOBB RR; ALDERMAN EM; BETHUNE JL; RIORDAN JF; VALLEE BL: "Amino acid sequence of human tumor derived angiogenin", BIOCHEMISTRY, vol. 24, 1985, pages 5486 - 94
SHARMA S; SINGH AK; KAUSHIK S; SINHA M; SINGH RP; SHARMA P; SIROHI H; KAUR P; SINGH TP.: "Lactoperoxidase: structural insights into the function, ligand binding and inhibition", INT J BIOCHEM MOL BIOL., vol. 4, 2013, pages 108 - 28
See also references of EP 3017824A4
CAIELLI, S. ET AL.: "Neutrophils come of age in chronic inflammation", CURRENT OPINION IN IMMUNOLOGY, vol. 24, no. 6, 2012, pages 671 - 677, XP055285148
VOLKER BRINKMANN ET AL., SCIENCE, vol. 303, 2004, pages 1532 - 1535
Q REMIJSEN ET AL., CELL DEATH AND DIFFERENTIATION, vol. 18, 2011, pages 581 - 588
MAREN VON KOECKRITZ-BLICKWEDE ET AL., BLOOD, vol. 111, 2008, pages 3070 - 3080
JOHN D. LIPPOLIS ET AL., VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 113, 2006, pages 248 - 255
FUCHS TA ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 15880 - 15885
GARCIA-ROMO GS ET AL., SCI TRANSL MED, vol. 3, 2011, pages 73RA20
LANDE R ET AL., SCI TRANSL MED, vol. 3, 2011, pages 73RA19 9
KESSENBROCK K ET AL., NAT MED, vol. 6, 2009, pages 623 - 625
BOSCH X, J AM SOC NEPHROL, vol. 8, 2009, pages 1654 - 1656
TOBIAS A. FUCHS ET AL., J CELL BIOL, vol. 176, 2007, pages 231 - 241
K. AKONG-MOORE ET AL., PLOS ONE, vol. 7, 2012, pages E42984
MAKOTO NAITO ET AL., SEIBUTSU SHIRYO BUNSEKI, vol. 33, 2010, pages 329 - 338
BRINKMANN, V. ET AL., SCIENCE, vol. 303, 2004, pages 1532 - 1535
YOUSEFI, S. ET AL., NAT MED, vol. 14, 2008, pages 949 - 953
VON KOECKRITZ-BLICKWEDE M ET AL., BLOOD, vol. 111, 2008, pages 3070 - 3080
WEBSTER SJ ET AL., J IMMUNOL, vol. 185, 2010, pages 2968 - 2979
CHOW, O.A. ET AL., CELL HOST & MICROBE, vol. 8, no. 5, 18 November 2010 (2010-11-18), pages 445 - 454
SIMON, D. ET AL., ALLERGY, vol. 68, 2013, pages 409 - 416
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
A. K GUPTA, FEBS LETTERS, vol. 584, 2010, pages 3193 - 3197
D J NOVO, ANTIMICROB AGENTS CHEMOTHER., vol. 44, no. 4, 2000, pages 827 - 34
VON KOCKRITZ-BLICKWEDE M ET AL., BLOOD, vol. 111, 2008, pages 3070 - 3080
VON BRUHL, M. L. ET AL., J EXP MED., vol. 209, no. 4, 9 April 2012 (2012-04-09), pages 819 - 35
DE BOER, O. J., THROMB HAEMOST., vol. 109, no. 2, February 2013 (2013-02-01), pages 290 - 7
DEMERS, M., PROC NATL ACAD SCI USA, vol. 109, no. 32, 7 August 2012 (2012-08-07), pages 13076 - 81
TOBIAS A. ET AL., BLOOD, vol. 118, no. 13, 29 September 2011 (2011-09-29), pages 3708 - 3714
TAKEUCHI ET AL., EXP PHYSIOL., vol. 91, no. 6, November 2006 (2006-11-01), pages 1033 - 40
KENMOKU, S. ET AL., J AM CHEM SOC, vol. 129, 2007, pages 7313 - 7318
SETSUKINAI, K. ET AL., J BIOL CHEM, vol. 278, 2003, pages 3170 - 3175
ISHIDA-OKAWARA, A. ET AL., NEPHROL DIAL TRANSPLANT, vol. 19, 2004, pages 1708 - 1715
TOBIAS A ET AL., BLOOD, vol. 118, 2011, pages 3708 - 3714
FUCHS TA ET AL., BLOOD, vol. 118, 2011, pages 3708 - 3714
TOBIAS A. ET AL., BLOOD, vol. 118, no. 13, 29 September 2011 (2011-09-29), pages 3708 - 3714
HE J; FURMANSKI P.: "Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA", NATURE, vol. 373, no. 6516, 1995, pages 721 - 4
STRYDOM DJ; FETT JW; LOBB RR; ALDERMAN EM; BETHUNE JL; RIORDAN JF; VALLEE BL: "Amino acid sequence of human tumor derived angiogenin", BIOCHEMISTRY, vol. 24, 1985, pages 5486 - 94
SHARMA S; SINGH AK; KAUSHIK S; SINHA M; SINGH RP; SHARMA P; SIROHI H; KAUR P; SINGH TP.: "Lactoperoxidase: structural insights into the function, ligand binding and inhibition", INT J BIOCHEM MOL BIOL., vol. 4, 2013, pages 108 - 28
See also references of EP 3017824A4
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
Download PDF: