Title:
INHIBITOR OF INDUCIBLE NITRIC OXIDE SYNTHASE, BEVERAGE/FOOD, AND NEUTRACEUTICAL FOOD
Document Type and Number:
WIPO Patent Application WO/2007/142096
Kind Code:
A1
Abstract:
Disclosed is an inducible nitric oxide synthase inhibitor which has few adverse side-effects
and can be taken easily. Also disclosed is a beverage/food having an inhibitory
effect on an inducible nitric oxide synthase. The inhibitor comprises a Bacopa
monniera extract as an active ingredient. The inhibitor may comprises
a polyphenol from an olive fruit as an active ingredient.
Inventors:
OHNO SHIGEAKI (JP)
OGAMI KAZUHIRO (JP)
NOGAMI TAKAKO (JP)
KAMEGAI MARI (JP)
ONO YOSHIKIYO (JP)
YOKOTA AKIKO (JP)
YAZAWA KAZUNAGA (JP)
OGAMI KAZUHIRO (JP)
NOGAMI TAKAKO (JP)
KAMEGAI MARI (JP)
ONO YOSHIKIYO (JP)
YOKOTA AKIKO (JP)
YAZAWA KAZUNAGA (JP)
Application Number:
PCT/JP2007/060984
Publication Date:
December 13, 2007
Filing Date:
May 30, 2007
Export Citation:
Assignee:
ORGANO CORP (JP)
EYE AMBITIOUS CO LTD (JP)
OHNO SHIGEAKI (JP)
OGAMI KAZUHIRO (JP)
NOGAMI TAKAKO (JP)
KAMEGAI MARI (JP)
ONO YOSHIKIYO (JP)
YOKOTA AKIKO (JP)
YAZAWA KAZUNAGA (JP)
EYE AMBITIOUS CO LTD (JP)
OHNO SHIGEAKI (JP)
OGAMI KAZUHIRO (JP)
NOGAMI TAKAKO (JP)
KAMEGAI MARI (JP)
ONO YOSHIKIYO (JP)
YOKOTA AKIKO (JP)
YAZAWA KAZUNAGA (JP)
International Classes:
A61K36/80; A23L1/30; A23L1/304; A61K36/00; A61K36/63; A61P11/00; A61P13/08; A61P13/12; A61P17/02; A61P19/02; A61P19/10; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C12N9/99
Domestic Patent References:
| WO1999040897A1 | 1999-08-19 |
Foreign References:
| JP2006328072A | 2006-12-07 | |||
| JP2006342161A | 2006-12-21 | |||
| JP2003531860A | 2003-10-28 | |||
| JP2002262831A | 2002-09-17 |
Other References:
RUSSO A. ET AL.: "Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera", LIFE SCIENCES, vol. 73, no. 12, 2003, pages 1517 - 1526, XP003019792
RUSSO A. ET AL.: "Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage", PHYTOTHERAPY RESEARCH, vol. 17, no. 8, 2003, pages 870 - 875, XP003019793
BITLER C.M. ET AL.: "Hydrolyzed olive vegetation water in mice has anti-inflammatory activity", JOURNAL OF NUTRITION, vol. 135, no. 6, 2005, pages 1475 - 1479, XP002449046
ZASLAVER M. ET AL.: "Natural Compounds Derived from Foods Modulate Nitric Oxide Production and Oxidative Status in Epithelial Lung Cells", J. AGRIC. FOOD CHEM., vol. 53, no. 26, 2005, pages 9934 - 9939, XP003019794
FUJITA H. ET AL.: "Olive Suiyosei Chushutsubutsu Hidrox no Kosanka Sayo to Sono Kaiseki", THE JOURNAL OF MEDICINE, vol. 53, no. 1, 2005, pages 99 - 108, XP003019795
DATABASE BIOSIS [online] SHERMAN M.P. ET AL.: "Zinc and copper inhibit expression of inducible nitric oxide synthase in rat alveolar macrophages: A reason for the production of metal-binding proteins during endotoxemia?", XP003019796, Database accession no. (1997:238322)
TIAN L. ET AL.: "Metal-induced modulation of nitric oxide production in vitro by murine macrophages: lead, nickel, and cobalt utilize different mechanisms", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 141, no. 2, 1996, pages 540 - 547, XP003019797
IDEMURA Y. ET AL.: "Hito Haidomyaku Naihi Saibo no NO Gosei Koso Kassei ni Oyobosu Kinzoku Ion no Koka", RESPIRATION RESEARCH, vol. 18, no. 7, 1999, pages 755 - 759, XP003019798
RUSSO A. ET AL.: "Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage", PHYTOTHERAPY RESEARCH, vol. 17, no. 8, 2003, pages 870 - 875, XP003019793
BITLER C.M. ET AL.: "Hydrolyzed olive vegetation water in mice has anti-inflammatory activity", JOURNAL OF NUTRITION, vol. 135, no. 6, 2005, pages 1475 - 1479, XP002449046
ZASLAVER M. ET AL.: "Natural Compounds Derived from Foods Modulate Nitric Oxide Production and Oxidative Status in Epithelial Lung Cells", J. AGRIC. FOOD CHEM., vol. 53, no. 26, 2005, pages 9934 - 9939, XP003019794
FUJITA H. ET AL.: "Olive Suiyosei Chushutsubutsu Hidrox no Kosanka Sayo to Sono Kaiseki", THE JOURNAL OF MEDICINE, vol. 53, no. 1, 2005, pages 99 - 108, XP003019795
DATABASE BIOSIS [online] SHERMAN M.P. ET AL.: "Zinc and copper inhibit expression of inducible nitric oxide synthase in rat alveolar macrophages: A reason for the production of metal-binding proteins during endotoxemia?", XP003019796, Database accession no. (1997:238322)
TIAN L. ET AL.: "Metal-induced modulation of nitric oxide production in vitro by murine macrophages: lead, nickel, and cobalt utilize different mechanisms", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 141, no. 2, 1996, pages 540 - 547, XP003019797
IDEMURA Y. ET AL.: "Hito Haidomyaku Naihi Saibo no NO Gosei Koso Kassei ni Oyobosu Kinzoku Ion no Koka", RESPIRATION RESEARCH, vol. 18, no. 7, 1999, pages 755 - 759, XP003019798
Attorney, Agent or Firm:
KAJI, Toshikazu (Kuramae Oracion Bldg. 8th Floor4-31-10, Kurama, Taito-ku Tokyo, JP)
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