Title:
INHIBITOR FOR NERVE CELL DEATH DUE TO GLUTAMIC ACID CYTOTOXICITY
Document Type and Number:
WIPO Patent Application WO/2000/043006
Kind Code:
A1
Abstract:
Medicinal compositions for inhibiting nerve cell death due to glutamic acid cytotoxicity which contain thiazolidindione compounds as the active ingredient.
Inventors:
ODA TOMIICHIRO (JP)
DEGUCHI SHIGEKO (JP)
HARADA JUN (JP)
KANEKO ISAO (JP)
DEGUCHI SHIGEKO (JP)
HARADA JUN (JP)
KANEKO ISAO (JP)
Application Number:
PCT/JP2000/000225
Publication Date:
July 27, 2000
Filing Date:
January 19, 2000
Export Citation:
Assignee:
SANKYO CO (JP)
ODA TOMIICHIRO (JP)
DEGUCHI SHIGEKO (JP)
HARADA JUN (JP)
KANEKO ISAO (JP)
ODA TOMIICHIRO (JP)
DEGUCHI SHIGEKO (JP)
HARADA JUN (JP)
KANEKO ISAO (JP)
International Classes:
A61K31/425; A61K31/426; A61K31/427; A61P25/00; C07D277/34; (IPC1-7): A61K31/426; A61K31/427; A61K31/4439; A61P25/00; A61P25/16; A61P25/28; A61P43/00
Domestic Patent References:
| WO1998010760A1 | 1998-03-19 | |||
| WO1998039967A1 | 1998-09-17 | |||
| WO1997046238A1 | 1997-12-11 | |||
| WO1997040017A2 | 1997-10-30 | |||
| WO1997037688A2 | 1997-10-16 | |||
| WO1999025346A1 | 1999-05-27 | |||
| WO2000004890A1 | 2000-02-03 |
Foreign References:
| EP0277836A1 | 1988-08-10 | |||
| JPH05202042A | 1993-08-10 | |||
| JPH09295970A | 1997-11-18 | |||
| US5326770A | 1994-07-05 | |||
| EP0545478A1 | 1993-06-09 | |||
| EP0008203A1 | 1980-02-20 | |||
| EP0306228A1 | 1989-03-08 |
Other References:
BOSMAN, D. K. ET. AL.: "Amino Acid Release from Cerebral Cortex in Experimental Acute Liver Failure, Studied by in Vivo Cerebral Cortex Microdialysis", J. NEUROCHEM, vol. 59, 1992, pages 591 - 599, XP002928425
PLAITAKIS, A. ET. AL.: "Abnormal Glutamate Metabolism in Amyotrophic Lateral Sclerosis", ANN. NEUROL, vol. 22, 1987, pages 575 - 579, XP002928426
MELDRUM, B. ET. AL.: "Excitatory amino acid neurotoxicity andneurodegenerative disease", TRENDS PHARMACOL, SCI.,, vol. 11, 1990, pages 379 - 387, XP002928427
LIPTON S. A. ET. AL.: "Excitatory amino acids as a final common pathway for neurologic disorders", NEW. ENGL. J. MED., vol. 330, no. 9, 1994, pages 613 - 622, XP002928428
AKINORI AKAIKE: "Glutamic Acid Neurotoxicity and Nerve Protective Factor (in Japanese)", FOLIA PHARMACOL, JPN., vol. 103, 1994, pages 193 - 201, XP002946245
AKINORI AKAIKE ET. AL.: "Inhibitor of the Neuron Death by Inherent Protective Factor (in Japanese)", FOLIA PHARMACOL, JPN., vol. 112, 1998, pages 177 - 186, XP002946246
FITCH, M. T. ET. AL.: "Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation: In Vivo and In Vivo Analysis of Inflmammation-Induced Secondary Injury after CNS Trauma", J. NEUROSCI, vol. 19, no. 19, 1999, pages 8182 - 8198, XP002928429
PLAITAKIS, A. ET. AL.: "Abnormal Glutamate Metabolism in Amyotrophic Lateral Sclerosis", ANN. NEUROL, vol. 22, 1987, pages 575 - 579, XP002928426
MELDRUM, B. ET. AL.: "Excitatory amino acid neurotoxicity andneurodegenerative disease", TRENDS PHARMACOL, SCI.,, vol. 11, 1990, pages 379 - 387, XP002928427
LIPTON S. A. ET. AL.: "Excitatory amino acids as a final common pathway for neurologic disorders", NEW. ENGL. J. MED., vol. 330, no. 9, 1994, pages 613 - 622, XP002928428
AKINORI AKAIKE: "Glutamic Acid Neurotoxicity and Nerve Protective Factor (in Japanese)", FOLIA PHARMACOL, JPN., vol. 103, 1994, pages 193 - 201, XP002946245
AKINORI AKAIKE ET. AL.: "Inhibitor of the Neuron Death by Inherent Protective Factor (in Japanese)", FOLIA PHARMACOL, JPN., vol. 112, 1998, pages 177 - 186, XP002946246
FITCH, M. T. ET. AL.: "Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation: In Vivo and In Vivo Analysis of Inflmammation-Induced Secondary Injury after CNS Trauma", J. NEUROSCI, vol. 19, no. 19, 1999, pages 8182 - 8198, XP002928429
Attorney, Agent or Firm:
Ohno, Akio (Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, JP)
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