INHIBITOR OF POSTOPERATIVE CANCER RECURRENCE AND/OR METASTASIS

WIPO Patent Application WO/2019/004419

A1

The present inventors found that postoperative cancer recurrence and/or metastasis were inhibited by administering a β blocker to a cancer patient in the perioperative period. Thus, the present disclosure provides an inhibitor of postoperative cancer recurrence and/or metastasis, said inhibitor comprising a β blocker, characterized by being to be administered in the perioperative period.

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SAKAMOTO ATSUHIRO (JP)
OKAMURA TATSUAKI (JP)
HARADA TOMOHIRO (JP)

PCT/JP2018/024782

January 03, 2019

June 29, 2018

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ONO PHARMACEUTICAL CO (JP)
NIPPON MEDICAL SCHOOL FOUNDATION (JP)

A61K45/00; A61K31/216; A61K31/5375; A61P35/00; A61P35/04; A61P43/00

JP2016526049A

2016-09-01

AL-NIAIMI, A. ET AL.: "The impact of perioperative beta blocker use on patient outcomes after primary cytoreductive surgery in high-grade epithelial ovarian carcinoma", GYNECOLOGIC ONCOLOGY, vol. 143, 2016, pages 521 - 525, XP029813705, DOI: doi:10.1016/j.ygyno.2016.09.019
MIO, YASUMI: "Landiolol and esmolol (ultra-short acting beta1-blocking agent) [1] Action to heart", MASUI = THE JAPANESE JOURNAL OF ANESTHESIOLOGY, vol. 55, 2006, pages 841 - 848, XP009514248, ISSN: 0021-4892
CATA, JP ET AL.: "Perioerative beta-blocker use and survival in lung cancer patients", JOURNAL OF CLINICAL ANESTHESIA, vol. 26, no. 2, 2014, pages 106 - 117, XP055583974, ISSN: 0952-8180, DOI: 10.1016/j.jclinane.2013.10.004

SAMEJIMA, Mutsumi et al. (JP)

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