Title:
INHIBITOR USING PLANT CYCLOPEPTIDE AS EFFECTIVE COMPONENT FOR LIPID METABOLIC ABNORMALITIES IN CANCER CELLS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/109594
Kind Code:
A1
Abstract:
The invention relates to an inhibitor using plant cyclopeptide as effective component for lipid metabolic abnormalities in cancer cells, and to the uses thereof for the preparation of a drug for inhibiting lipid metabolic abnormalities in cancer cells. The invention can particularly be used for preparing a drug for treating and preventing dyslipidemia-related cancers, such as liver cancer, colorectal cancer, rectal cancer, and prostate cancer. The inhibitor for lipid metabolic abnormalities in cells can be used for effectively inhibiting lipid metabolic abnormalities in cancer cells.
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| WO/1999/006062 | CYCLIC PEPTIDE ANTIFUNGAL AGENTS |
Inventors:
TAN NINGHUA (CN)
WANG YURONG (CN)
SONG LIHUA (CN)
WANG YURONG (CN)
SONG LIHUA (CN)
Application Number:
PCT/CN2018/086727
Publication Date:
June 13, 2019
Filing Date:
May 14, 2018
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
A61K38/12; A61K38/14; A61P35/00
Foreign References:
| CN107970432A | 2018-05-01 | |||
| CN107496901A | 2017-12-22 | |||
| CN103877562A | 2014-06-25 | |||
| CN103880929A | 2014-06-25 |
Other References:
LEUNG, H.W. ET AL.: "RA-XII Inhibits Tumour Growth and Metastasis in Breast Tumour- Bearing Mice via Reducing Cell Adhesion and Invasion and Promoting Matrix Degradation", SCIENTIFIC REPORTS, vol. 5, no. 16985, 23 November 2015 (2015-11-23), pages 1 - 17, XP055616419
FANG, XIANYING ET AL.: "Plant Cyclopeptide RA-V Kills Human Breast Cancer Cells by Inducing Mitochondria-Mediated Apoptosis through Blocking PDK1-AKT Interaction", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 267, no. 1, 15 February 2013 (2013-02-15), pages 95 - 103, XP055616422
FANG, XIANYING ET AL.: "Plant Cyclopeptide RA-V Kills Human Breast Cancer Cells by Inducing Mitochondria-Mediated Apoptosis through Blocking PDK1-AKT Interaction", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 267, no. 1, 15 February 2013 (2013-02-15), pages 95 - 103, XP055616422
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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