Title:
INHIBITORS OF AQUAGLYCEROPORINS, METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/005170
Kind Code:
A4
Abstract:
The present invention discloses metal-based modulators that selectively bind to cell transmembrane proteins aquaglyceroporins AQPs, such as AQP3, AQP7 and AQP9, leading to its inhibition. The selective inhibition of AQP channels is accomplished by compounds tetracoordinated to gold (III) complexes. The present invention also discloses the uses thereof in manufacturing pharmaceuticals, cosmetics and chemical reagents for diagnostic, treatment, prophilaxys and prevention of clinical conditions directly or indirectly related to aquaglyceroporins AQPs functions. The present invention applies in healthcare and cosmetic industries and in chemistry industry.
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Inventors:
TAVARES REBELO DE SOVERAL RODRIGUES MARIA DA GRACA (PT)
CASINI ANGELA (PT)
CASINI ANGELA (PT)
Application Number:
PCT/IB2012/053418
Publication Date:
May 10, 2013
Filing Date:
July 04, 2012
Export Citation:
Assignee:
UNIV LISBOA (PT)
TAVARES REBELO DE SOVERAL RODRIGUES MARIA DA GRACA (PT)
CASINI ANGELA (PT)
TAVARES REBELO DE SOVERAL RODRIGUES MARIA DA GRACA (PT)
CASINI ANGELA (PT)
International Classes:
C07F1/12; A61K31/28; A61P35/00
Attorney, Agent or Firm:
VIEIRA PEREIRA FERREIRA, Maria Silvina (Modet & Co.Rua Castilh, 50-9ยบ -163 Lisboa, PT)
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